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公开(公告)号：US20170226072A1
公开(公告)日：2017-08-10
申请号：US15494789
申请日：2017-04-24
IPC分类号： C07D295/096 , C07D295/073 , C07D211/22 , C07D211/18 , C07D211/14 , C07D295/03
CPC分类号： C07D295/096 , C07D211/08 , C07D211/14 , C07D211/18 , C07D211/22 , C07D295/02 , C07D295/03 , C07D295/073
摘要： The present invention is directed to 1,4-disubstituted piperidines, 1,4-disubstituted piperazines, 1,4-disubstituted diazepanes, and 1,3-disubstituted pyrrolidine compounds and their use.
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公开(公告)号：US20140011836A1
公开(公告)日：2014-01-09
申请号：US14019709
申请日：2013-09-06
发明人： Joseph R. HOLTMAN , Peter Anthony CROOKS , Linda P. DWOSKIN , J. Michael MCINTOSH , Elzbieta Pogonowska WALA
IPC分类号： C07D401/14 , C07D401/10 , C07D401/12 , C07D401/06
CPC分类号： C07D401/14 , A61K31/03 , A61K31/047 , A61K31/4425 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4725 , C07D401/06 , C07D401/10 , C07D401/12
摘要： Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
摘要翻译： 提供使用双季铵化合物治疗炎性疼痛，神经性疼痛和伤害性疼痛的方法。
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3.发明申请公开(公告)号：US20220315523A1
公开(公告)日：2022-10-06
申请号：US17842425
申请日：2022-06-16
发明人： Linda P. DWOSKIN , David WATT , Jon THORSON , Mark LEGGAS , Rodney Kip GUY , Jared HAMMILL , Stefan KWIATKOWSKI , Derong DING , Guangrong ZHENG , Peter Anthony CROOKS , Na-Ra LEE
IPC分类号： C07C211/53 , C07C233/43 , C07D209/14 , C07D215/12 , C07D213/38
摘要： The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse/addiction and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.
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4.发明申请公开(公告)号：US20200290948A1
公开(公告)日：2020-09-17
申请号：US16848462
申请日：2020-04-14
发明人： Linda P. DWOSKIN , David WATT , Jon THORSON , Mark LEGGAS , Kip GUY , Jared HAMMILL , Stefan KWIATKOWSKI , Derong DING , Guangrong ZHENG , Peter Anthony CROOKS , Na-Ra LEE
IPC分类号： C07C211/53 , C07C233/43 , C07D213/38 , C07D215/12 , C07D209/14
摘要： The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.
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5.发明申请公开(公告)号：US20200237688A1
公开(公告)日：2020-07-30
申请号：US16846989
申请日：2020-04-13
发明人： Linda P. DWOSKIN , Peter Anthony CROOKS , Guangrong ZHENG , Justin R. NICKELL , Zheng CAO , Na-Ra LEE
IPC分类号： A61K31/137 , A61K31/138
摘要： The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.
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6.发明申请1,4-Disubstituted Piperidines, 1,4-Disubstituted Piperazines, 1,4-Disubstituted Diazepines, and 1,3-Disubstituted Pyrrolidine Compounds 审中-公开1,4-二取代哌啶，1,4-二取代哌嗪，1,4-二取代二氮杂和1,3-二取代吡咯烷化合物公开(公告)号：US20160031840A1
公开(公告)日：2016-02-04
申请号：US14776306
申请日：2014-03-14
IPC分类号： C07D295/03 , C07D211/08
CPC分类号： C07D295/096 , C07D211/08 , C07D211/14 , C07D211/18 , C07D211/22 , C07D295/02 , C07D295/03 , C07D295/073
摘要： The present invention is directed to 1,4-disubstituted piperidines, 1,4-disubstituted piperazines, 1,4-disubstituted diazepanes, and 1,3-disubstituted pyrrolidine compounds and their use.
摘要翻译： 本发明涉及1,4-二取代的哌啶，1,4-二取代的哌嗪，1,4-二取代的二氮杂环庚烷和1,3-二取代的吡咯烷化合物及其用途。
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公开(公告)号：US20160340335A9
公开(公告)日：2016-11-24
申请号：US14019709
申请日：2013-09-06
发明人： Joseph R. HOLTMAN , Peter Anthony CROOKS , Linda P. DWOSKIN , J. Michael MCINTOSH , Elzbieta Pogonowska WALA
IPC分类号： C07D401/14 , C07D401/10 , C07D401/12 , C07D401/06
CPC分类号： C07D401/14 , A61K31/03 , A61K31/047 , A61K31/4425 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4725 , C07D401/06 , C07D401/10 , C07D401/12
摘要： Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
摘要翻译： 提供使用双季铵化合物治疗炎性疼痛，神经性疼痛和伤害性疼痛的方法。
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8.发明申请Mono Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors 审中-公开单体季铵盐和调节神经元烟碱乙酰胆碱受体的方法公开(公告)号：US20140371266A1
公开(公告)日：2014-12-18
申请号：US14470715
申请日：2014-08-27
IPC分类号： C07D401/14 , C07D215/10 , C07D217/10 , C07D401/06 , C07D213/20 , C07D213/30
CPC分类号： C07D401/14 , C07C17/16 , C07D213/20 , C07D213/30 , C07D215/10 , C07D217/10 , C07D401/06 , C07C22/04
摘要： Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and gastrointestinal tract disorders.
摘要翻译： 提供作为烟碱乙酰胆碱受体调节剂的单季铵化合物。 还提供了使用化合物调节烟碱乙酰胆碱受体的功能以及预防和/或治疗中枢神经系统疾病，物质使用和/或滥用以及胃肠道疾病的方法。
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9.发明申请Use of a Novel Alpha-7 Nachr Antagonist to Suppress Pathogenic Signal Transduction in Cancer and Aids 审中-公开使用新型Alpha-7 Nachr拮抗剂抑制癌症和艾滋病中的致病信号转导公开(公告)号：US20130231366A1
公开(公告)日：2013-09-05
申请号：US13772147
申请日：2013-02-20
发明人： Roger L. PAPKE , Peter A. CROOKS , Linda P. DWOSKIN , Gretchen Lopez HERNANDEZ , Zhenfa ZHANG , Jeffrey S. THINSCHMIDT , Guangrong ZHENG
IPC分类号： A61K31/4725 , A61K31/4709 , A61K31/444
CPC分类号： A61K31/4725 , A61K31/03 , A61K31/047 , A61K31/444 , A61K31/47 , A61K31/4709
摘要： This application provides a method for the use of select quaternary ammonium antagonists to alpha-7 nAChR for the treatment of cancer and HIV and AIDS.
摘要翻译： 该应用提供了使用选择性季铵拮抗剂至α-7nAChR用于治疗癌症和HIV和AIDS的方法。
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10.发明申请Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors 有权三季铵盐和调节神经元烟碱乙酰胆碱受体的方法公开(公告)号：US20130030018A1
公开(公告)日：2013-01-31
申请号：US13624322
申请日：2012-09-21
IPC分类号： A61K31/444 , A61P25/00 , A61P25/28 , A61P25/16 , A61P25/14 , A61P25/24 , A61P25/22 , A61P25/18 , A61P25/08 , A61P25/30 , A61P25/34 , A61P25/32 , A61P1/00 , A61P1/12 , A61P1/04 , A61K31/4709
CPC分类号： C07D213/06 , C07D213/02 , C07D215/06 , C07D217/04 , C07D401/04 , C07D401/14
摘要： Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse and or gastrointestinal tract disorders.
摘要翻译： 提供了三季铵化合物，其是烟碱型乙酰胆碱受体的调节剂。 还提供了使用化合物调节烟碱乙酰胆碱受体的功能以及用于预防和/或治疗中枢神经系统疾病，物质使用和/或滥用和/或胃肠道疾病的方法。
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