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公开(公告)号：US20210121659A1
公开(公告)日：2021-04-29
申请号：US17142375
申请日：2021-01-06
发明人： Zhongjun WU , Bartley P. GRIFFITH , Jun DING
摘要： Disclosed is a self-expanding cannula, systems using such cannulae, and methods of their use. The cannulae may comprise single lumen cannula (“SLC”) configurations and double lumen cannula (“DLC”) configurations, and include at least a first cannula and a self-expanding wire frame attached to the first cannula. Self-expanding wire frame is automatically expandable from a compressed state (providing a reduced cannula diameter as it is moved through a patient's body to the site at which it is to be deployed) to an expanded state (which increases the diameter of the cannula to the diameter intended for its normal use). The expanded wire frame provides radial support to prevent a drainage canal (whether a patient's blood vessel or a portion of the system inserted into the patient's blood vessel) from collapsing as fluid is drained from the patient.
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公开(公告)号：US20170303958A1
公开(公告)日：2017-10-26
申请号：US15526107
申请日：2015-11-11
IPC分类号： A61B17/34
摘要： The present invention discloses a self-sealing cannula and methods of its use. The self-sealing cannula can be minimally invasively placed into the heart for drawing and/or returning blood with a self-sealing function at the interface of the blood access site. The disclosed cannula can be implemented as a single lumen cannula or a double lumen cannula, which can be used with ventricular assist devices for heart support or pump-oxygenators for ECMO and respiratory support. Through a self-sealing mechanism fixed on the ventricular wall or atrial wall, a cannula body is attached to the self-sealing fixture and blood is drawn into the lumen via an external pump and returned to the circulation system through a separate cannula. In the case of the double lumen cannula embodiment, the blood will be drawn into the drainage lumen of the double lumen cannula and returned through an infusion lumen at the desired location. The present invention achieves minimally invasive insertion without surgical sutures to the heart, and allows for optimal drainage of the blood from the heart. With use of the double lumen cannula, it prevents need for multiple cannulation sites, and greatly reduces the blood recirculation. Removal of the cannula is simplified without need for suturing or insertion of a plugging member.
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公开(公告)号：US20210346581A1
公开(公告)日：2021-11-11
申请号：US17380319
申请日：2021-07-20
发明人： Zhongjun WU , Bartley P. GRIFFITH
IPC分类号： A61M1/16 , A61M60/113 , A61M60/205
摘要： A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated.
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公开(公告)号：US20150030664A1
公开(公告)日：2015-01-29
申请号：US14505905
申请日：2014-10-03
CPC分类号： A61L15/24 , A61L15/44 , A61L15/60 , A61L24/0015 , A61L24/0031 , A61L24/06 , A61L2300/204 , A61L2300/402 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/418 , A61L2300/43 , C08L33/26
摘要： The present application is drawn to a synthetic, polymer hydrogel-based material, which is able to actively induce the body's natural hemostatic coagulation process in blood or acellular plasma. The present invention provides the development of a primary amine containing polymer hydrogel capable of inducing blood coagulation and delivering therapeutics for hemostatic or wound care applications, and a method of forming such a primary amine containing polymer hydrogel capable of inducing the blood coagulation process. The primary amine containing polymer hydrogel is able to achieve the same end result as biological-based hemostatics, without the innate risk of disease transmission or immunological response, and at a fraction of the price. Furthermore, due to its inherent hydrogel-based design the material has the capability of arresting blood loss while simultaneously delivering therapeutics in a controlled manner, potentially revolutionizing the way in which wounds are treated.
摘要翻译： 本申请被描述为合成的聚合物水凝胶基材料，其能够主动地诱导身体在血液或无细胞血浆中的天然止血凝血过程。 本发明提供了能够诱导凝血并递送用于止血或伤口护理应用的治疗剂的含伯胺聚合物水凝胶的开发，以及形成能够诱导凝血过程的含伯胺聚合物水凝胶的方法。 含伯胺聚合物水凝胶能够实现与生物基止血剂相同的最终结果，没有疾病传播或免疫应答的先天风险，并且价格仅为一小部分。 此外，由于其固有的基于水凝胶的设计，该材料具有阻止失血的能力，同时以受控的方式递送治疗剂，可能彻底改变伤口的治疗方式。
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公开(公告)号：US20220347362A1
公开(公告)日：2022-11-03
申请号：US17859144
申请日：2022-07-07
IPC分类号： A61M1/16 , A61M1/36 , A61M60/113
摘要： The device of the present invention includes a dual chamber gas exchanger that is configured for increased flexibility and scalability for many clinical applications. The dual chamber oxygenator can be configured and used in various applications, such as in a heart-lung machine for cardiopulmonary support during cardiothoracic surgery, in an extracorporeal membrane oxygenation (ECMO) circuitry, as a respiratory assist device for patients with lung failure, and the like. The dual chamber gas exchanger features two sweep gas flow paths and two gas exchange membrane bundles enclosed in a housing structure with various blood flow distribution and gas distribution mechanisms. The gas exchanger includes an outer housing, an intermediate housing, two gas exchange fiber bundles, a blood inlet, a blood outlet, two gas inlets, two gas outlets, two gas distribution chambers and an optional heat exchanger.
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公开(公告)号：US20200206404A1
公开(公告)日：2020-07-02
申请号：US16791117
申请日：2020-02-14
摘要： The device of the present invention includes a dual chamber gas exchanger that is configured for increased flexibility and scalability for many clinical applications. The dual chamber oxygenator can be configured and used in various applications, such as in a heart-lung machine for cardiopulmonary support during cardiothoracic surgery, in an extracorporeal membrane oxygenation (ECMO) circuitry, as a respiratory assist device for patients with lung failure, and the like. The dual chamber gas exchanger features two sweep gas flow paths and two gas exchange membrane bundles enclosed in a housing structure with various blood flow distribution and gas distribution mechanisms. The gas exchanger includes an outer housing, an intermediate housing, two gas exchange fiber bundles, a blood inlet, a blood outlet, two gas inlets, two gas outlets, two gas distribution chambers and an optional heat exchanger.
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公开(公告)号：US20160296685A1
公开(公告)日：2016-10-13
申请号：US15100871
申请日：2014-12-23
发明人： Zhongjun WU , Bartley P. GRIFFITH
CPC分类号： A61M1/1698 , A61M1/10 , A61M1/1006 , A61M1/1086 , A61M2202/0208 , A61M2205/3334 , A61M2205/3368 , A61M2205/366 , A61M2206/10 , A61M2206/16 , A61M2209/088
摘要： A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated.
摘要翻译： 公开了一种血液充氧器，其包括壳体，血液入口，血液出口，螺旋形蜗壳，气体入口，氧合器纤维束和气体出口。 外壳包围纤维束，并提供血流路径和连接器的结构。 纤维束包括气体交换膜，当血液流过膜时，氧气转移到血液中并去除二氧化碳。 螺旋蜗壳引导血液流过纤维束。 气流室接收含有氧气的吹扫气体并将吹扫气体分配到纤维膜中，然后将这些气体与被氧化的血液交换。
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公开(公告)号：US20240325617A1
公开(公告)日：2024-10-03
申请号：US18739456
申请日：2024-06-11
IPC分类号： A61M1/36 , A61B17/00 , A61B17/34 , A61M60/148 , A61M60/178 , A61M60/38 , A61M60/857 , A61M60/861
CPC分类号： A61M1/3659 , A61B17/3417 , A61B17/3421 , A61B17/3439 , A61M60/178 , A61M60/38 , A61M60/857 , A61M60/861 , A61B2017/00247 , A61B2017/3419 , A61B2017/3425 , A61M60/148
摘要： The present invention discloses a self-sealing cannula and methods of its use. The self-sealing cannula can be minimally invasively placed into the heart for drawing and/or returning blood with a self-sealing function at the interface of the blood access site. The disclosed cannula can be implemented as a single lumen cannula or a double lumen cannula, which can be used with ventricular assist devices for heart support or pump-oxygenators for ECMO and respiratory support. Through a self-sealing mechanism fixed on the ventricular wall or atrial wall, a cannula body is attached to the self-sealing fixture and blood is drawn into the lumen via an external pump and returned to the circulation system through a separate cannula. In the case of the double lumen cannula embodiment, the blood will be drawn into the drainage lumen of the double lumen cannula and returned through an infusion lumen at the desired location. The present invention achieves minimally invasive insertion without surgical sutures to the heart, and allows for optimal drainage of the blood from the heart. With use of the double lumen cannula, it prevents need for multiple cannulation sites, and greatly reduces the blood recirculation. Removal of the cannula is simplified without need for suturing or insertion of a plugging member.
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公开(公告)号：US20190209761A1
公开(公告)日：2019-07-11
申请号：US16221761
申请日：2018-12-17
发明人： Zhongjun WU , Bartley P. GRIFFITH
CPC分类号： A61M1/1698 , A61M1/10 , A61M1/1006 , A61M1/101 , A61M1/1086 , A61M1/1629 , A61M2202/0208 , A61M2205/3334 , A61M2205/3368 , A61M2205/366 , A61M2206/10 , A61M2206/16 , A61M2209/088
摘要： A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated.
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