公开(公告)号：US20150320913A1

公开(公告)日：2015-11-12

申请号：US14646723

申请日：2013-11-24

申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL

发明人： Jie Song ,  Pingsheng Liu ,  David C. Ayers

IPC分类号： A61L31/10 ,  A61L29/16 ,  A61L29/08 ,  A61L27/54 ,  C08F122/10 ,  A61L31/02 ,  A61L29/02 ,  A61L27/06 ,  C08F222/10 ,  A61L31/16 ,  A61L27/34

CPC分类号： A61L27/04 ,  A61L27/06 ,  A61L27/34 ,  A61L27/54 ,  A61L29/02 ,  A61L29/085 ,  A61L29/16 ,  A61L31/022 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/606 ,  A61L2300/80 ,  C08F122/10 ,  C08F222/10 ,  C08F293/005 ,  C08F2220/387 ,  C09D133/08

摘要： The invention provides novel surface coatings having surface polymer brushes with zwitterionic and antibiotics-conjugated side chains and synergistic anti-fouling and bactericidal properties. The surface coatings may be prepared using highly efficient surface-initiated “living” polymerization. The design of the surface polymer brushes are highly modular, allowing independent tuning of the anti-fouling and bactericidal properties, e.g., by varying the chemical nature of the zwitterionic motif and the antibiotic agent, the chemistry through which the antibiotic agent is conjugated to the polymer side chains, the molecular weight of the polymer brushes (e.g., thickness of coating and density of respective functional motifs), and the spatial arrangement of the respective functional motifs (e.g., homopolymers, block copolymers, random copolymers) to achieve optimal and sustained anti-infection outcome for a given application.

摘要翻译： 本发明提供具有表面聚合物刷的新型表面涂层，其具有两性离子和抗生素缀合的侧链和协同的抗结垢和杀菌性质。 表面涂层可以使用高效的表面引发的“活性”聚合来制备。 表面聚合物刷的设计是高度模块化的，允许独立调节抗污垢和杀菌性能，例如通过改变两性离子基序和抗生素剂的化学性质，抗生素试剂与其结合的化学性质 聚合物侧链，聚合物刷子的分子量（例如，涂层的厚度和相应功能基序的密度）以及相应功能基序（例如均聚物，嵌段共聚物，无规共聚物）的空间排列以实现最佳和持续的 针对给定应用的抗感染结果。

公开(公告)号：US09943624B2

公开(公告)日：2018-04-17

申请号：US14646723

申请日：2013-11-24

申请人： University of Massachusetts Medical School

发明人： Jie Song ,  Pingsheng Liu ,  David C. Ayers

IPC分类号： C08F122/10 ,  A61L27/04 ,  A61L27/06 ,  C08F222/10 ,  A61L27/34 ,  A61L29/16 ,  A61L31/16 ,  A61L27/54 ,  A61L29/02 ,  A61L29/08 ,  A61L31/02 ,  A61L31/10 ,  C09D133/08 ,  C08F293/00 ,  C08F220/38

CPC分类号： A61L27/04 ,  A61L27/06 ,  A61L27/34 ,  A61L27/54 ,  A61L29/02 ,  A61L29/085 ,  A61L29/16 ,  A61L31/022 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/606 ,  A61L2300/80 ,  C08F122/10 ,  C08F222/10 ,  C08F293/005 ,  C08F2220/387 ,  C09D133/08

摘要： The invention provides novel surface coatings having surface polymer brushes with zwitterionic and antibiotics-conjugated side chains and synergistic anti-fouling and bactericidal properties. The surface coatings may be prepared using highly efficient surface-initiated “living” polymerization. The design of the surface polymer brushes are highly modular, allowing independent tuning of the anti-fouling and bactericidal properties, e.g., by varying the chemical nature of the zwitterionic motif and the antibiotic agent, the chemistry through which the antibiotic agent is conjugated to the polymer side chains, the molecular weight of the polymer brushes (e.g., thickness of coating and density of respective functional motifs), and the spatial arrangement of the respective functional motifs (e.g., homopolymers, block copolymers, random copolymers) to achieve optimal and sustained anti-infection outcome for a given application.

公开(公告)号：US20150335790A1

公开(公告)日：2015-11-26

申请号：US14652636

申请日：2013-12-13

申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL

发明人： Jie Song ,  Pingsheng Liu

IPC分类号： A61L27/46 ,  A61L27/58 ,  A61L27/38

CPC分类号： A61L27/46 ,  A61C8/0016 ,  A61L27/3821 ,  A61L27/427 ,  A61L27/58 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2430/12 ,  C08L33/12

摘要： The invention provides novel compositions and methods for three-dimensional mineralization templated by synthetic scaffolds having zwitterionic mediators. The invention enables 3-D mineralization nucleation and growth of minerals in a well-controlled and defined manner. The composite materials prepared by the disclosed methods are cytocompatible and/or biodegradable and are suitable for use as medical implants in a variety of applications in skeletal tissue repair and regeneration. For example, cytocompatible zwitterionic sulfobetaine ligands are employed to facilitate 3-D mineralization of HA across covalently crosslinked hydrogels. The overall charge-neutral zwitterionic hydrogel effectively recruited oppositely charged precursor ions while overcame excessive swelling exhibited by anionic and cationic hydrogels under physiological conditions, resulting in denser and structurally well-integrated mineralized composite materials.

摘要翻译： 本发明提供了由具有两性离子介体的合成支架模板化的三维矿化的新型组合物和方法。 本发明能够以良好控制和限定的方式实现三维矿化成核和矿物生长。 通过公开的方法制备的复合材料是细胞相容性和/或可生物降解的，并且适合用作骨骼组织修复和再生中各种应用中的医学植入物。 例如，使用细胞相容的两性离子磺基甜菜碱配体来促进HA通过共价交联的水凝胶的3-D矿化。 总体电荷中性两性离子水凝胶在生理条件下有效地引入相反电荷的前体离子，同时克服了阴离子和阳离子水凝胶表现出的过度溶胀，导致更致密和结构完全一体化的矿化复合材料。