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    AMPLIFICATION AND DETECTION OF NUCLEIC ACIDS
    2.
    发明申请
    AMPLIFICATION AND DETECTION OF NUCLEIC ACIDS 审中-公开

    公开(公告)号：US20190009276A1

    公开(公告)日：2019-01-10

    申请号：US16036430

    申请日：2018-07-16

    Applicant: GENERAL ELECTRIC COMPANY ,  University of Washington

    Inventor： David Roger Moore ,  Matthew Jeremiah Misner ,  Andrew Arthur Paul Burns ,  Joshua Bishop ,  Lisa K. Lafleur ,  Maxwell Wheeler

    IPC: B01L7/00 ,  C12Q1/6844 ,  B01L3/00 ,  C12Q1/6806

    Abstract: The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

    AMPLIFICATION AND DETECTION OF NUCLEIC ACIDS
    3.
    发明申请
    AMPLIFICATION AND DETECTION OF NUCLEIC ACIDS 审中-公开
    核酸的放大和检测

    公开(公告)号：US20170022550A1

    公开(公告)日：2017-01-26

    申请号：US14807497

    申请日：2015-07-23

    Applicant: GENERAL ELECTRIC COMPANY ,  University of Washington

    Inventor： David Roger Moore ,  Matthew Jeremiah Misner ,  Andrew Arthur Paul Burns ,  John Bishop ,  Lisa K. Lafleur ,  Maxwell Wheeler

    IPC: C12Q1/68 ,  B01L7/00

    CPC classification number: B01L7/52 ,  B01L3/5023 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/126 ,  B01L2300/18 ,  B01L2400/06 ,  C12Q1/6806 ,  C12Q1/6844 ,  C12Q2565/629

    Abstract: The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

    Abstract translation: 本公开涉及一种样本评估装置。 作为示例，样本评估装置可以包括包括样本应用区域的基板; 包含多个扩增试剂的扩增区; 废物区域，包括流体耦合到所述放大区域并远离所述放大区域延伸的入口; 以及与放大区域间隔开的检测区域。 样品评估装置还可以包括连接到衬底并被配置为在闭合配置中将放大区域与检测区域分开的阀，其中放大区域和阀被定位在样品评估装置之间，样品施加区域和 检测区域，并且其中所述样本评估装置被配置为当所述阀处于打开构型时允许从所述放大区域到所述检测区域的横向流动。

    Amplification and detection of nucleic acids
    5.
    发明授权
    Amplification and detection of nucleic acids 有权

    公开(公告)号：US11173490B2

    公开(公告)日：2021-11-16

    申请号：US16036430

    申请日：2018-07-16

    Applicant: GENERAL ELECTRIC COMPANY ,  University of Washington

    Inventor： David Roger Moore ,  Matthew Jeremiah Misner ,  Andrew Arthur Paul Burns ,  Joshua Bishop ,  Lisa K. Lafleur ,  Maxwell Wheeler

    IPC: B01L7/00 ,  C12Q1/6806 ,  C12Q1/6844 ,  B01L3/00

    Abstract: The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

    Amplification and detection of nucleic acids
    7.
    发明授权
    Amplification and detection of nucleic acids 有权

    公开(公告)号：US10040069B2

    公开(公告)日：2018-08-07

    申请号：US14807497

    申请日：2015-07-23

    Applicant: GENERAL ELECTRIC COMPANY ,  University of Washington

    Inventor： David Roger Moore ,  Matthew Jeremiah Misner ,  Andrew Arthur Paul Burns ,  Joshua Bishop ,  Lisa K. Lafleur ,  Maxwell Wheeler

    IPC: C12Q1/68 ,  C12P19/34 ,  B01L7/00 ,  C12Q1/6806 ,  C12Q1/6844 ,  B01L3/00

    Abstract: The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

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