公开(公告)号：US20170131211A1

公开(公告)日：2017-05-11

申请号：US15348926

申请日：2016-11-10

Applicant: University of Washington

Inventor： Paul Yager ,  Joshua Bishop ,  Joshua Buser ,  Louise Lyth Hansen ,  Erin K. Heiniger ,  Enos Kline ,  Sujatha Kumar

IPC: G01N21/64 ,  C12Q1/68

CPC classification number: G01N21/6486 ,  B01L3/00 ,  B01L3/5023 ,  B01L2200/026 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/069 ,  B01L2300/0832 ,  B01L2300/0864 ,  B01L2300/1827 ,  B01L2400/0406 ,  C12Q1/6816 ,  C12Q1/6844 ,  G01N1/286 ,  G01N21/645 ,  G01N2001/4088

Abstract: The present technology relates generally to systems for disrupting biological samples and associated devices and methods. In some embodiments, the system includes a vessel configured to receive a biological sample and a cap assembly that includes a porous membrane having a receiving region and a detection region. When the cap assembly is detachably coupled to an open end portion of the vessel, the system can be moved between a first orientation and a second orientation. When the system is in the first orientation, the biological sample is not in fluid communication with the receiving region. When the vessel contains is in the second orientation, the biological sample is in fluid communication with the receiving region and wicks through the porous membrane to the detection region.

公开(公告)号：US11098346B2

公开(公告)日：2021-08-24

申请号：US16059919

申请日：2018-08-09

Applicant: University of Washington

Inventor： Joshua Bishop ,  Joshua Buser ,  Samantha Byrnes ,  Shivani Dharmaraja ,  Elain S. Fu ,  Jared Houghtaling ,  Peter C. Kauffman ,  Sujatha Kumar ,  Lisa Lafleur ,  Tinny Liang ,  Barry Lutz ,  Bhushan Toley ,  Maxwell Wheeler ,  Paul Yager ,  Xiaohong Zhang

IPC: B01L7/00 ,  C12Q1/6844 ,  B01L3/00

Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a porous receiving element having an input region and a receiving region, a first fluid source and a second fluid source positioned within the input region of the receiving element; wherein the first fluid source is positioned between the second fluid source and the receiving region, and wherein, when both the first and second fluid sources are in fluid connection with the input region, the device is configured to sequentially deliver the first fluid and the second fluid to the receiving region without leakage.

公开(公告)号：US20190134637A1

公开(公告)日：2019-05-09

申请号：US16059919

申请日：2018-08-09

Applicant: University of Washington

Inventor： Joshua Bishop ,  Joshua Buser ,  Samantha Byrnes ,  Shivani Dharmaraja ,  Elain S. Fu ,  Jared Houghtaling ,  Peter C. Kauffman ,  Sujatha Kumar ,  Lisa Lafleur ,  Tinny Liang ,  Barry Lutz ,  Bhushan Toley ,  Maxwell Wheeler ,  Paul Yager ,  Xiaohong Zhang

IPC: B01L7/00 ,  B01L3/00

Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a porous receiving element having an input region and a receiving region, a first fluid source and a second fluid source positioned within the input region of the receiving element; wherein the first fluid source is positioned between the second fluid source and the receiving region, and wherein, when both the first and second fluid sources are in fluid connection with the input region, the device is configured to sequentially deliver the first fluid and the second fluid to the receiving region without leakage.

公开(公告)号：US20160310942A1

公开(公告)日：2016-10-27

申请号：US15135461

申请日：2016-04-21

Applicant: University of Washington

Inventor： Paul Yager ,  Joshua Buser ,  Samantha Byrnes ,  Erin K. Heiniger ,  Peter C. Kauffman ,  Paula Ladd

IPC: B01L3/00 ,  C12Q1/68

CPC classification number: B01L3/50273 ,  B01L2300/069 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0683 ,  C12Q1/6844

Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a first porous element having a first pore size and configured to receive a fluid at its proximal portion, and a second porous element having a second pore size greater than the first pore size and configured to receive a fluid at its proximal portion. The first porous element can be positioned across the second porous element such that an overlapping region exists between the porous elements where the porous elements are in fluid communication. Before delivery of the fluid to the second porous element, the fluid pressure at the overlapping region is greater than the capillary pressure of the second porous element such that a fluid delivered to the first porous element wicks through its overlapping portion without wetting the second porous element.

Abstract translation: 本技术涉及用于执行化学过程和相关系统和方法的基于毛细管的装置。 在一个实施例中，例如，装置可以包括具有第一孔径并被配置为在其近端部分处接收流体的第一多孔元件和具有大于第一孔径的第二孔径的第二多孔元件，并且被配置为 在其近端部分接收流体。 第一多孔元件可以跨越第二多孔元件定位，使得在多孔元件处于流体连通的多孔元件之间存在重叠区域。 在将流体输送到第二多孔元件之前，重叠区域处的流体压力大于第二多孔元件的毛细管压力，使得输送到第一多孔元件的流体通过其重叠部分吸入而不润湿第二多孔元件 。

公开(公告)号：US20150361487A1

公开(公告)日：2015-12-17

申请号：US14761604

申请日：2014-01-22

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Joshua Bishop ,  Joshua Buser ,  Samantha Byrnes ,  Shivani Dharmaraja ,  Elain S. Fu ,  Jared Houghtaling ,  Peter C. Kauffman ,  Sujatha Kumar ,  Lisa Lafleur ,  Tinny Liang ,  Barry Lutz ,  Bhushan Toley ,  Maxwell Wheeler ,  Paul Yager ,  Xiaohong Zhang

IPC: C12Q1/68 ,  B01L7/00 ,  B01L3/00

CPC classification number: B01L7/00 ,  B01L3/5023 ,  B01L7/52 ,  B01L2300/0672 ,  B01L2300/0825 ,  B01L2300/0867 ,  B01L2300/1827 ,  B01L2300/1855 ,  B01L2300/1877 ,  B01L2400/0406 ,  B01L2400/0672 ,  B01L2400/0683 ,  Y10T436/2575

Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a porous receiving element having an input region and a receiving region, a first fluid source and a second fluid source positioned within the input region of the receiving element; wherein the first fluid source is positioned between the second fluid source and the receiving region, and wherein, when both the first and second fluid sources are in fluid connection with the input region, the device is configured to sequentially deliver the first fluid and the second fluid to the receiving region without leakage.

Abstract translation: 本技术涉及用于执行化学过程和相关系统和方法的基于毛细管的装置。 在一个实施例中，例如，设备可以包括具有输入区域和接收区域的多孔接收元件，位于接收元件的输入区域内的第一流体源和第二流体源; 其中所述第一流体源位于所述第二流体源和所述接收区域之间，并且其中当所述第一流体源和所述第二流体源都与所述输入区域流体连接时，所述装置构造成顺序地输送所述第一流体和所述第二流体源 流体到接收区域而没有泄漏。