公开(公告)号：US09901256B2

公开(公告)日：2018-02-27

申请号：US14372388

申请日：2013-01-18

Applicant: University of Washington through its Center for Commercialization

Inventor： Eric J. Seibel ,  Liang Zhang ,  Richard S. Johnston ,  Charles D. Melville ,  Leonard Nelson ,  Cameron M. Lee ,  Joel Berg

IPC: A61B5/00 ,  G01J3/10 ,  G01N21/64 ,  G01J3/02 ,  G01J3/06 ,  G01J3/44 ,  A61B1/00 ,  A61B1/015 ,  A61B1/07 ,  A61B1/247 ,  A61C19/04

CPC classification number: A61B5/0088 ,  A61B1/00009 ,  A61B1/00096 ,  A61B1/00142 ,  A61B1/015 ,  A61B1/07 ,  A61B1/247 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4547 ,  A61C19/04 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/06 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/645 ,  G01N21/6486 ,  G01N2021/6421 ,  G01N2021/6484 ,  G01N2021/6493

Abstract: Methods and systems for detecting early stage dental caries and decays are provided. In particular, in an embodiment, laser-induced autofluorescence (AF) from multiple excitation wavelengths is obtained and analyzed. Endogenous fluorophores residing in the enamel naturally fluoresce when illuminated by wavelengths ranging from ultraviolet into the visible spectrum. The relative intensities of the AF emission changes between different excitation wavelengths when the enamel changes from healthy to demineralized. By taking a ratio of AF emission spectra integrals between different excitation wavelengths, a standard is created wherein changes in AF ratios within a tooth are quantified and serve as indicators of early stage enamel demineralization. The techniques described herein may be used in conjunction with a scanning fiber endoscope (SFE) to provide a reliable, safe and low-cost means for identifying dental caries or decays.

公开(公告)号：US20150010878A1

公开(公告)日：2015-01-08

申请号：US14372388

申请日：2013-01-18

Applicant: University of Washington Through Its Center for Commercialization

Inventor： Eric J. Seibel ,  Liang Zhang ,  Richard S. Johnston ,  Charles D. Melville ,  Leonard Nelson ,  Cameron M. Lee ,  Joel Berg

IPC: A61B5/00 ,  A61B1/015 ,  A61B1/247 ,  A61B1/00 ,  A61C19/04 ,  A61B1/07

CPC classification number: A61B5/0088 ,  A61B1/00009 ,  A61B1/00096 ,  A61B1/00142 ,  A61B1/015 ,  A61B1/07 ,  A61B1/247 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4547 ,  A61C19/04 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/06 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/645 ,  G01N21/6486 ,  G01N2021/6421 ,  G01N2021/6484 ,  G01N2021/6493

Abstract: Methods and systems for detecting early stage dental caries and decays are provided. In particular, in an embodiment, laser-induced autofluorescence (AF) from multiple excitation wavelengths is obtained and analyzed. Endogenous fluorophores residing in the enamel naturally fluoresce when illuminated by wavelengths ranging from ultraviolet into the visible spectrum. The relative intensities of the AF emission changes between different excitation wavelengths when the enamel changes from healthy to demineralized. By taking a ratio of AF emission spectra integrals between different excitation wavelengths, a standard is created wherein changes in AF ratios within a tooth are quantified and serve as indicators of early stage enamel demineralization. The techniques described herein may be used in conjunction with a scanning fiber endoscope (SFE) to provide a reliable, safe and low-cost means for identifying dental caries or decays.

Abstract translation: 提供了检测早期龋齿和衰老的方法和系统。 特别地，在一个实施例中，获得并分析来自多个激发波长的激光诱导自发荧光（AF）。 当从紫外线到可见光谱的波长照射时，驻留在釉质中的内源性荧光团自然发荧光。 当釉质从健康变为软化时，AF发射的相对强度在不同的激发波长之间变化。 通过采用不同激发波长之间的AF发射光谱积分的比例，创建了一种标准，其中量化牙齿内AF比的变化，并用作早期釉质脱矿质的指标。 本文描述的技术可以与扫描光纤内窥镜（SFE）一起使用，以提供用于识别龋齿或衰变的可靠，安全和低成本的方法。