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公开(公告)号：US20160168119A1
公开(公告)日：2016-06-16
申请号：US14906187
申请日：2014-07-16
申请人： Urs BAETTIG , David BEATTIE , Darren Mark LEGRAND , Andrew Stuart LISTER , Jeffrey MCKENNA , David William PEARCE , David Andrew SANDHAM , Emily STANLEY , Oliver Ross STEWARD , Christopher THOMSON
发明人： Urs BAETTIG , David BEATTIE , Darren Mark LEGRAND , Andrew Stuart LISTER , Jeffrey MCKENNA , David William PEARCE , David Andrew SANDHAM , Emily STANLEY , Oliver Ross STEWARD , Christopher THOMSON
IPC分类号： C07D401/12 , C07D403/12 , C07D257/04 , C07D405/12 , C07D417/12 , C07D413/12
CPC分类号： C07D401/12 , A61K45/06 , C07D257/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.
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公开(公告)号：US20160184318A1
公开(公告)日：2016-06-30
申请号：US14906161
申请日：2014-07-16
申请人： David BEATTIE , Urs BAETTIG , Darren Mark LEGRAND , Andrew Stuart LISTER , Jeffrey MCKENNA , David William PEARCE , Ddavid Andrew SANDHAM , Oliver Ross STEWARD , Christopher Thomson
发明人： David BEATTIE , Urs BAETTIG , Darren Mark LEGRAND , Andrew Stuart LISTER , Jeffrey MCKENNA , David William PEARCE , Ddavid Andrew SANDHAM , Oliver Ross STEWARD , Christopher Thomson
IPC分类号： A61K31/551 , A61K31/454 , C07D401/10 , A61K31/4245 , C07D401/14 , A61K31/5377 , A61K31/4545 , C07D403/12 , A61K31/506 , C07D403/10 , A61K31/41 , C07D405/12 , A61K31/496 , C07D413/10 , C07D417/10 , A61K31/427 , C07D471/08 , A61K31/439 , C07D417/14 , C07D413/14
CPC分类号： A61K31/551 , A61K31/41 , A61K31/4245 , A61K31/427 , A61K31/439 , A61K31/445 , A61K31/45 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/504 , A61K31/506 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D257/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/08 , A61K2300/00
摘要： The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.
摘要翻译： 本发明涉及自体吸收素抑制剂的新型化合物，其制备方法，药物组合物和含有它们的药物及其在自体吸收素介导的疾病和病症中的用途。
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公开(公告)号：US20140171404A1
公开(公告)日：2014-06-19
申请号：US14109935
申请日：2013-12-17
IPC分类号： C07D451/04 , A61K31/454 , C07D211/32 , A61K31/445 , C07D401/12 , C07D211/60 , C07D265/30 , A61K31/5375 , A61K31/5377 , C07D417/12 , C07D249/04 , A61K31/496 , A61K31/46 , C07D403/12 , A61K31/55 , C07D403/06 , A61K31/4192 , A61K45/06 , C07D413/12
CPC分类号： C07D401/12 , A61K31/4192 , A61K31/445 , A61K31/454 , A61K31/46 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D211/26 , C07D211/32 , C07D211/34 , C07D211/58 , C07D211/60 , C07D249/04 , C07D263/38 , C07D265/30 , C07D401/06 , C07D403/06 , C07D403/12 , C07D413/12 , C07D417/12 , C07D451/04
摘要： The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in the treatment of an ATX-dependent or ATX-mediated disease or condition.
摘要翻译： 本发明涉及自体吸收素抑制剂的新化合物，其制备方法，药物组合物和含有它们的药物及其在治疗ATX依赖性或ATX介导的疾病或病症中的用途。
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公开(公告)号：US20120277232A1
公开(公告)日：2012-11-01
申请号：US13544182
申请日：2012-07-09
申请人： Urs BAETTIG , Kamlesh Jagdis BALA , Emma BUDD , Lee EDWARDS , Catherine Howsham , Glyn HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
发明人： Urs BAETTIG , Kamlesh Jagdis BALA , Emma BUDD , Lee EDWARDS , Catherine Howsham , Glyn HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
IPC分类号： A61K31/44 , C07D405/12 , A61K31/443 , A61P11/00 , A61K31/4545 , A61K31/497 , C07D413/12 , A61K31/5377 , C07D213/81 , C07D401/12
CPC分类号： A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4965 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/38 , C07D213/81 , C07D241/26 , C07D241/28 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供吡啶和吡嗪衍生物，其恢复或增强突变和/或野生型CFTR的功能以治疗囊性纤维化，原发性纤毛运动障碍，慢性支气管炎，慢性阻塞性肺病，哮喘，呼吸道感染，肺癌，口腔干燥症和 角膜结膜炎或便秘（IBS，IBD，阿片样物质诱发）。 还包括包含这些衍生物的药物组合物。
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公开(公告)号：US20150045364A1
公开(公告)日：2015-02-12
申请号：US14521843
申请日：2014-10-23
申请人： Urs BAETTIG , Kamlesh BALA , Emma BUDD , Lee EDWARDS , Catherine HOWSHAM , Glyn Alan HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
发明人： Urs BAETTIG , Kamlesh BALA , Emma BUDD , Lee EDWARDS , Catherine HOWSHAM , Glyn Alan HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
IPC分类号： C07D405/04 , A61K45/06 , C07D401/04 , A61K31/444 , A61K31/44 , C07D241/28 , A61K31/5377 , C07D403/12 , A61K31/497 , A61K31/4412 , C07D213/81 , A61K31/4439
CPC分类号： A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4965 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/38 , C07D213/81 , C07D241/26 , C07D241/28 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供吡啶和吡嗪衍生物，其恢复或增强突变和/或野生型CFTR的功能以治疗囊性纤维化，原发性纤毛运动障碍，慢性支气管炎，慢性阻塞性肺病，哮喘，呼吸道感染，肺癌，口腔干燥症和 角膜结膜炎或便秘（IBS，IBD，阿片样物质诱发）。 还包括包含这些衍生物的药物组合物。
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公开(公告)号：US20140135329A1
公开(公告)日：2014-05-15
申请号：US13923349
申请日：2013-06-20
申请人： Urs BAETTIG , Kamlesh BALA , Emma BUDD , Lee EDWARDS , Catherine HOWSHAM , Glyn Alan HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
发明人： Urs BAETTIG , Kamlesh BALA , Emma BUDD , Lee EDWARDS , Catherine HOWSHAM , Glyn Alan HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
IPC分类号： C07D413/12 , C07D403/12 , A61K31/4965 , A61K31/4545 , A61K31/444 , A61K31/443 , A61K31/4439 , A61K31/44 , C07D241/28 , C07D401/12 , C07D401/04 , C07D413/04 , C07D405/12 , C07D213/81 , C07D213/38 , A61K31/497 , A61K31/5377
CPC分类号： A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4965 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/38 , C07D213/81 , C07D241/26 , C07D241/28 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供吡啶和吡嗪衍生物，其恢复或增强突变和/或野生型CFTR的功能以治疗囊性纤维化，原发性纤毛运动障碍，慢性支气管炎，慢性阻塞性肺病，哮喘，呼吸道感染，肺癌，口腔干燥症和 角膜结膜炎或便秘（IBS，IBD，阿片样物质诱发）。 还包括包含这些衍生物的药物组合物。
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公开(公告)号：US20170071919A1
公开(公告)日：2017-03-16
申请号：US15156528
申请日：2016-05-17
申请人： Urs BAETTIG , Kamlesh BALA , Emma BUDD , Lee EDWARDS , Catherine HOWSHAM , Glyn Alan HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
发明人： Urs BAETTIG , Kamlesh BALA , Emma BUDD , Lee EDWARDS , Catherine HOWSHAM , Glyn Alan HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
IPC分类号： A61K31/44 , C07D213/81 , C07D405/12 , A61K31/443 , A61K31/4545 , A61K31/5377 , C07D241/26 , A61K31/444 , A61K31/4439 , C07D413/04 , C07D413/12 , C07D403/12 , A61K31/497 , C07D401/04 , C07D405/04 , A61K45/06
CPC分类号： A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4965 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/38 , C07D213/81 , C07D241/26 , C07D241/28 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供吡啶和吡嗪衍生物，其恢复或增强突变和/或野生型CFTR的功能以治疗囊性纤维化，原发性纤毛运动障碍，慢性支气管炎，慢性阻塞性肺病，哮喘，呼吸道感染，肺癌，口干燥症和 角膜结膜炎或便秘（IBS，IBD，阿片样物质诱发）。 还包括包含这些衍生物的药物组合物。
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公开(公告)号：US20110230483A1
公开(公告)日：2011-09-22
申请号：US13047319
申请日：2011-03-14
申请人： Urs BAETTIG , Kamlesh Jagdis BALA , Emma BUDD , Lee EDWARDS , Catherine Howsham , Glyn HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
发明人： Urs BAETTIG , Kamlesh Jagdis BALA , Emma BUDD , Lee EDWARDS , Catherine Howsham , Glyn HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
IPC分类号： A61K31/5377 , C07D405/04 , A61K31/497 , C07D401/04 , A61K31/4439 , C07D241/28 , A61K31/4965 , C07D413/12 , C07D213/81 , A61K31/44 , A61K31/444 , A61P29/00 , A61P31/00 , A61P37/08
CPC分类号： A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4965 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/38 , C07D213/81 , C07D241/26 , C07D241/28 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供吡啶和吡嗪衍生物，其恢复或增强突变和/或野生型CFTR的功能以治疗囊性纤维化，原发性纤毛运动障碍，慢性支气管炎，慢性阻塞性肺病，哮喘，呼吸道感染，肺癌，口腔干燥症和 角膜结膜炎或便秘（IBS，IBD，阿片样物质诱发）。 还包括包含这些衍生物的药物组合物。
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