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1.发明公开公开(公告)号：US20230398380A1
公开(公告)日：2023-12-14
申请号：US18029247
申请日：2021-10-08
发明人： Charles F. Caskey , Limin Chen , William A. Grissom , Peter E. Konrad , Benoit M. Dawant , Willliam J. Rodriguez
CPC分类号： A61N7/02 , A61B90/14 , A61B90/11 , A61N2007/0021
摘要： A workflow has been developed that enables initially mapping of a focused ultrasound (FUS) beam using magnetic resonance (MR) thermometry or MR-acoustic radiation force imaging (MR-ARFI) while working within the MRI device. During this procedure, key measurements will be taken including the precise location of the transducer relative to the skull and the transducer parameters (such as amplitudes and phases) required to place the ultrasound focus at the desired focal size and location in the skull. The anatomical measurements will be used to build a patient-specific, device-specific stereotactic frame to hold the transducer in the position relative to the skull and the aberration corrects will be applied. FUS therapy can then be delivered to the patient outside of the MR environment.
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2.发明申请公开(公告)号：US20170157400A1
公开(公告)日：2017-06-08
申请号：US15433433
申请日：2017-02-15
IPC分类号： A61N1/36 , A61B6/03 , A61B6/00 , G06T7/149 , G06F19/00 , G06T7/73 , G06T7/12 , G06T7/33 , A61N1/05 , A61B34/10
CPC分类号： G06T7/74 , A61B5/12 , A61B5/4893 , A61B6/032 , A61B6/501 , A61B6/5235 , A61B34/10 , A61B2034/104 , A61B2034/105 , A61N1/0541 , A61N1/36038 , A61N1/36185 , G06T7/12 , G06T7/149 , G06T7/30 , G06T7/337 , G06T2207/10081 , G06T2207/20124 , G06T2207/20128 , G06T2207/30052 , G16H50/50 , H04R25/50 , H04R25/606
摘要： One aspect of the invention provides a method for customizing cochlear implant stimulation of a living subject. The cochlear implant includes an electrode array having a plurality of electrodes implanted in a cochlea of the living subject. The method includes determining a position for each of the plurality of electrodes and spiral ganglion nerves that the electrode array stimulates, determining a geometric relationship between neural pathways within the cochlea and the electrode array implanted therein, and using one or more electrodes of the electrode array to stimulate a group of SG neural pathways of the cochlea based on the location of the one or more electrodes and their geometric relationship with the neural pathways.
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公开(公告)号：US11027129B2
公开(公告)日：2021-06-08
申请号：US16607507
申请日：2018-04-24
IPC分类号： A61N1/36 , A61B34/10 , A61B5/055 , A61B5/107 , A61N1/05 , G06T7/181 , G06T7/12 , G06T11/00 , A61B6/03
摘要： A method for designing a patient-customized EA or selecting an existing EA that fits the patient best includes segmenting shapes of SOIs of the cochlea in a pre-operative CT image using a shape model; defining a 3D curve of interest within the shape model of the SOIs as a sequence of points-; automatically transforming the defined 3D curve to the pre-operative CT image so as to obtain a structure curve in the cochlea; determining a length and curvatures of the structure curve at the sequence of points; and designing a patient-customized EA or selecting an existing EA based on the determined length and curvatures of the structure curve such that after the EA shape model, which estimates the resting state shape of the EA, is rigidly registered to the structure curve in the cochlea, the EA shape model has a registration error smaller than a preset value.
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4.发明公开公开(公告)号：US20240202914A1
公开(公告)日：2024-06-20
申请号：US18288058
申请日：2022-04-26
CPC分类号： G06T7/0012 , G06T3/02 , G06T3/18 , G06T7/30 , G06T17/20 , G06V10/25 , G06T2207/10081 , G06T2207/20132 , G06T2207/30016 , G06T2207/30048
摘要： Methods and systems for segmentation of structures of interest (SOI) in a CT image post-operatively acquired with an implant user in a region of interest in which an implant is implanted. The method includes inputting the post-operatively acquired CT (Post-CT) image to trained networks to generate a dense deformation field (DDF) from the input Post-CT image to an atlas image; and warping a segmentation mesh of the SOI in the atlas image to the input Post-CT image using the DDF so as to generate the segmentation mesh of the SOI in the input Post-CT image, wherein the segmentation mesh of the SOI in the atlas image is generated by applying an active shape model-based method to the atlas image.
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公开(公告)号：US11872398B2
公开(公告)日：2024-01-16
申请号：US17340303
申请日：2021-06-07
IPC分类号： A61N1/36 , A61B34/10 , A61B5/055 , A61B5/107 , A61N1/05 , G06T7/181 , G06T7/12 , G06T11/00 , A61B6/03
CPC分类号： A61N1/36039 , A61B5/055 , A61B5/1076 , A61B34/10 , A61N1/0541 , G06T7/12 , G06T7/181 , G06T11/005 , A61B6/032 , A61B2034/105 , A61B2034/107 , A61B2034/108 , A61B2505/05 , A61B2562/043 , G06T2207/30008 , G06T2211/424
摘要： A method for designing a patient-customized EA or selecting an existing EA that fits the patient best includes segmenting shapes of SOIs of the cochlea in a pre-operative CT image using a shape model; defining a 3D curve of interest within the shape model of the SOIs as a sequence of points-; automatically transforming the defined 3D curve to the pre-operative CT image so as to obtain a structure curve in the cochlea; determining a length and curvatures of the structure curve at the sequence of points; and designing a patient-customized EA or selecting an existing EA based on the determined length and curvatures of the structure curve such that after the EA shape model, which estimates the resting state shape of the EA, is rigidly registered to the structure curve in the cochlea, the EA shape model has a registration error smaller than a preset value.
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公开(公告)号：US20220285005A1
公开(公告)日：2022-09-08
申请号：US17637875
申请日：2020-08-26
IPC分类号： G16H20/40 , A61B6/12 , A61B6/03 , A61B6/00 , A61N1/05 , G06T7/73 , G06T7/55 , G06T7/33 , G06F30/23
摘要： Systems and methods are provided for performing model-based cochlear implant programming (MOCIP) on a living subject with a cochlear implant (CI) to determine stimulation settings of a patient-customized electro-neural interface (ENI) model. The method includes: localizing an electrode array of the CI and intracochlear structures of the living subject to determine patient-specific electrode positions of the CI and a patient-specific anatomy shape; generating a CI electric field model based on the patient-specific electrodes positions of the CI and the patient-specific anatomy shape; and establishing an auditory nerve fiber (ANF) bundle model using the CI electric field model, and estimating neural health of the living subject using the ANF bundle model applications of the same.
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公开(公告)号：US20210361944A1
公开(公告)日：2021-11-25
申请号：US17340303
申请日：2021-06-07
摘要： A method for designing a patient-customized EA or selecting an existing EA that fits the patient best includes segmenting shapes of SOIs of the cochlea in a pre-operative CT image using a shape model; defining a 3D curve of interest within the shape model of the SOIs as a sequence of points-; automatically transforming the defined 3D curve to the pre-operative CT image so as to obtain a structure curve in the cochlea; determining a length and curvatures of the structure curve at the sequence of points; and designing a patient-customized EA or selecting an existing EA based on the determined length and curvatures of the structure curve such that after the EA shape model, which estimates the resting state shape of the EA, is rigidly registered to the structure curve in the cochlea, the EA shape model has a registration error smaller than a preset value.
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公开(公告)号：US11990222B2
公开(公告)日：2024-05-21
申请号：US17637875
申请日：2020-08-26
IPC分类号： G16H20/40 , A61B6/03 , A61B6/12 , A61B6/50 , A61N1/05 , G06F30/23 , G06T7/33 , G06T7/55 , G06T7/73 , A61B34/10
CPC分类号： G16H20/40 , A61B6/032 , A61B6/12 , A61B6/501 , A61B6/506 , A61N1/0541 , G06F30/23 , G06T7/33 , G06T7/55 , G06T7/73 , A61B2034/102 , A61B2034/105 , G06T2207/10081 , G06T2207/30052 , G06T2207/30172
摘要： Systems and methods are provided for performing model-based cochlear implant programming (MOCIP) on a living subject with a cochlear implant (CI) to determine stimulation settings of a patient-customized electro-neural interface (ENI) model. The method includes: localizing an electrode array of the CI and intracochlear structures of the living subject to determine patient-specific electrode positions of the CI and a patient-specific anatomy shape; generating a CI electric field model based on the patient-specific electrodes positions of the CI and the patient-specific anatomy shape; and establishing an auditory nerve fiber (ANF) bundle model using the CI electric field model, and estimating neural health of the living subject using the ANF bundle model applications of the same.
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9.发明授权公开(公告)号：US10546388B2
公开(公告)日：2020-01-28
申请号：US15433433
申请日：2017-02-15
IPC分类号： A61N1/36 , G06T7/73 , G06T7/30 , G06T7/12 , G06T7/149 , A61N1/05 , A61B5/12 , A61B5/00 , A61B6/03 , A61B6/00 , H04R25/00 , A61B34/10 , G06T7/33
摘要： One aspect of the invention provides a method for customizing cochlear implant stimulation of a living subject. The cochlear implant includes an electrode array having a plurality of electrodes implanted in a cochlea of the living subject. The method includes determining a position for each of the plurality of electrodes and spiral ganglion nerves that the electrode array stimulates, determining a geometric relationship between neural pathways within the cochlea and the electrode array implanted therein, and using one or more electrodes of the electrode array to stimulate a group of SG neural pathways of the cochlea based on the location of the one or more electrodes and their geometric relationship with the neural pathways.
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10.发明申请METHODS AND SYSTEMS FOR CUSTOMIZING COCHLEAR IMPLANT STIMULATION AND APPLICATIONS OF SAME 有权用于定制COCHLEAR IMPLANT刺激的方法和系统及其应用公开(公告)号：US20150088225A1
公开(公告)日：2015-03-26
申请号：US14390503
申请日：2013-04-03
CPC分类号： A61N1/36032 , A61B5/12 , A61B5/4893 , A61B6/032 , A61B6/501 , A61B6/5235 , A61B34/10 , A61B2034/104 , A61B2034/105 , A61N1/0541 , A61N1/36036 , A61N1/36185 , G06F19/00 , G06T7/12 , G06T7/149 , G06T7/30 , G06T7/337 , G06T7/74 , G06T2207/10081 , G06T2207/20124 , G06T2207/20128 , G06T2207/30052 , G16H50/50 , H04R25/50 , H04R25/606
摘要： One aspect of the invention provides a method for customizing cochlear implant stimulation of a living subject. The cochlear implant includes an electrode array having a plurality of electrodes implanted in a cochlea of the living subject. The method includes determining a position for each of the plurality of electrodes and spiral ganglion nerves that the electrode array stimulates, determining a geometric relationship between neural pathways within the cochlea and the electrode array implanted therein, and using one or more electrodes of the electrode array to stimulate a group of SG neural pathways of the cochlea based on the location of the one or more electrodes and their geometric relationship with the neural pathways.
摘要翻译： 本发明的一个方面提供了一种用于定制生物体的人工耳蜗刺激的方法。 耳蜗植入物包括具有植入生物体的耳蜗中的多个电极的电极阵列。 该方法包括确定电极阵列刺激的多个电极和螺旋神经节神经中的每一个的位置，确定耳蜗内的神经通路与其中植入的电极阵列之间的几何关系，以及使用电极阵列的一个或多个电极 基于一个或多个电极的位置及其与神经通路的几何关系来刺激耳蜗的一组SG神经通路。
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