公开(公告)号：US3471692A

公开(公告)日：1969-10-07

申请号：US3471692D

申请日：1967-03-27

Applicant: VARIAN ASSOCIATES

Inventor： LLEWELLYN PETER M ,  LITTLEJOHN DUANE P

IPC: G01N30/72 ,  G01N30/78 ,  B01D59/44

CPC classification number: G01N30/722 ,  G01N30/78

公开(公告)号：US3649199A

公开(公告)日：1972-03-14

申请号：US3649199D

申请日：1970-03-26

Applicant: VARIAN ASSOCIATES

Inventor： LITTLEJOHN DUANE P

IPC: A61B5/00 ,  G01N33/497 ,  G01N33/16

CPC classification number: A61B5/145 ,  A61B5/14542 ,  A61B5/1477 ,  G01N33/497 ,  Y10S436/90 ,  Y10S436/901 ,  Y10T436/145555 ,  Y10T436/204165 ,  Y10T436/255

Abstract: A method for detecting trace quantities of organic drug material in a living animal under observation wherein samples of gaseous material effusing from the animal either by way of breath, through the skin or from a blood stream are passed through a three-stage membrane gas separator to enrich the concentration of the organic drug material in the gaseous sample. The enriched sample gas output of the membrane separator is fed to a gas analyzer such as a mass spectrometer for detecting the organic drug material, if any, in the sample gas under analysis. The detection of trace quantities of drugs may be employed for monitoring the rate of metabolism and for ascertaining the various metabolites produced by metabolism of drugs in the body.

Abstract translation: 一种用于在观察的活体动物中检测微量有机药物的方法，其中通过呼吸，通过皮肤或从血液中流出动物的气态物质样品通过三级膜气分离器 丰富气态样品中有机药物的浓度。 将膜分离器的富集的样品气体输出物供给到气体分析仪，例如质谱仪，用于检测待分析的样品气体中的有机药物材料（如果有的话）。 可以使用痕量药物的检测来监测代谢速率，以及确定药物在体内代谢产生的各种代谢物。

公开(公告)号：US3429105A

公开(公告)日：1969-02-25

申请号：US3429105D

申请日：1966-07-06

Applicant: VARIAN ASSOCIATES

Inventor： LLEWELLYN PETER M ,  LITTLEJOHN DUANE P

IPC: G01N27/62 ,  G01N1/00 ,  G01N1/22 ,  G01N1/34 ,  G01N30/72 ,  H01J49/04 ,  B01D13/00

CPC classification number: H01J49/0427 ,  G01N1/24 ,  G01N1/34 ,  G01N30/722 ,  G01N2001/4016

公开(公告)号：US3494174A

公开(公告)日：1970-02-10

申请号：US3494174D

申请日：1968-01-30

Applicant: VARIAN ASSOCIATES

Inventor： GREEN DONALD E ,  LITTLEJOHN DUANE P

IPC: G01N30/44 ,  G01N31/08

CPC classification number: G01N30/44

公开(公告)号：US3471691A

公开(公告)日：1969-10-07

申请号：US3471691D

申请日：1967-03-13

Applicant: VARIAN ASSOCIATES

Inventor： GIELOW DAVID E ,  LITTLEJOHN DUANE P

IPC: H01J49/38 ,  B01D59/44

CPC classification number: H01J49/02 ,  H01J49/38

公开(公告)号：US3592044A

公开(公告)日：1971-07-13

申请号：US3592044D

申请日：1968-08-01

Applicant: VARIAN ASSOCIATES

Inventor： GREEN DONALD E ,  LITTLEJOHN DUANE P

IPC: G01N30/62 ,  G01N30/72 ,  G01N30/84 ,  G01N31/08 ,  B01J17/28

CPC classification number: G01N30/84 ,  G01N30/7206 ,  G01N2030/623 ,  G01N2030/8411 ,  G01N2030/122

Abstract: A gaseous sample handling apparatus utilizing the principles of condensation and revaporization to allow selected quantities of sample to be temporarily stored within the flow path connecting a gas chromatograph and a gas analyzer so that the samples can at some later time be reintroduced into the flow stream at predetermined mass flow rates. Likewise, the apparatus permits the preferential reshaping of constituent peaks in the effluent of a gas chromatograph.

公开(公告)号：US3445649A

公开(公告)日：1969-05-20

申请号：US3445649D

申请日：1965-10-11

Applicant: VARIAN ASSOCIATES

Inventor： LITTLEJOHN DUANE P ,  LIEWELLYN PETER M

IPC: H01J49/20 ,  H01J49/38 ,  B01D59/44

CPC classification number: H01J49/20 ,  H01J49/38