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公开(公告)号：US20220064245A1
公开(公告)日：2022-03-03
申请号：US17415355
申请日：2019-12-20
发明人： Jan Steyaert , Els Pardon , Alexandre Wohlkönig , Valentina Kalichuk , Wim Vranken , Tomasz Uchanski , Andy Chevigné , Martyna Szpakowska
IPC分类号： C07K14/52
摘要： The present invention relates to the field of structural biology. More specifically, the present invention relates to novel fusion proteins, their uses and methods in three-dimensional structural analysis of macromolecules, such as X-ray crystallography and high-resolution Cryo-EM, and their use in structure-based drug design and screening. Even more specifically, the invention relates to a functional fusion protein of a cytokine and a scaffold protein wherein the scaffold is a folded protein that interrupts the topology of the cytokine to form a rigid fusion protein that retains its receptor binding and activation capacity. More specifically, chemokine- and interleukin-based functional fusion proteins, and their production and uses, are disclosed herein.
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公开(公告)号：US20240174767A1
公开(公告)日：2024-05-30
申请号：US18516777
申请日：2023-11-21
发明人： Jan Steyaert , Els Pardon , Tomasz Uchanski , Wim Vranken
IPC分类号： C07K16/46 , C07K14/005 , C07K14/195 , C07K14/705 , C12N7/00 , G01N23/20 , G01N33/68
CPC分类号： C07K16/465 , C07K14/005 , C07K14/195 , C07K14/705 , C12N7/00 , G01N23/20 , G01N33/6845 , C07K2299/00 , C07K2317/569 , C07K2319/03 , C07K2319/30 , C12N2795/00022 , C12N2795/00023
摘要： The present invention relates to the field of structural biology. More specifically, the present invention relates to novel antigen-binding chimeric proteins, their uses and methods in three-dimensional structural analysis of macromolecules, such as X-ray crystallography and high-resolution Cryo-EM, and their use as a therapeutic, diagnostic, or imaging tool. Even more specifically, the invention relates to a fusion of a scaffold protein and an antigen-binding domain wherein the scaffold protein of said fusion interrupts the Immunoglobulin domain topology to form a rigid chimer.
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公开(公告)号：US20210206880A1
公开(公告)日：2021-07-08
申请号：US16760394
申请日：2018-10-31
发明人： Jan Steyaert , Els Pardon , Tomasz Uchanski , Wim Vranken
IPC分类号： C07K16/46 , C07K14/195 , G01N33/68 , C07K14/005 , C12N7/00 , G01N23/20
摘要： The present invention relates to the field of structural biology. More specifically, the present invention relates to novel antigen-binding chimeric proteins, their uses and methods in three-dimensional structural analysis of macromolecules, such as X-ray crystallography and high-resolution Cryo-EM, and their use as a therapeutic, diagnostic, or imaging tool. Even more specifically, the invention relates to a fusion of a scaffold protein and an antigen-binding domain wherein the scaffold protein of said fusion interrupts the Immunoglobulin domain topology to form a rigid chimer.
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公开(公告)号：US11873347B2
公开(公告)日：2024-01-16
申请号：US16760394
申请日：2018-10-31
发明人： Jan Steyaert , Els Pardon , Tomasz Uchanski , Wim Vranken
IPC分类号： C07K16/46 , C07K14/195 , G01N23/20 , G01N33/68 , C07K14/705 , C07K14/005 , C12N7/00
CPC分类号： C07K16/465 , C07K14/005 , C07K14/195 , C07K14/705 , C12N7/00 , G01N23/20 , G01N33/6845 , C07K2299/00 , C07K2317/569 , C07K2319/03 , C12N2795/00022 , C12N2795/00023
摘要： The present invention relates to the field of structural biology. More specifically, the present invention relates to novel antigen-binding chimeric proteins, their uses and methods in three-dimensional structural analysis of macromolecules, such as X-ray crystallography and high-resolution Cryo-EM, and their use as a therapeutic, diagnostic, or imaging tool. Even more specifically, the invention relates to a fusion of a scaffold protein and an antigen-binding domain wherein the scaffold protein of said fusion interrupts the Immunoglobulin domain topology to form a rigid chimer.
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公开(公告)号：US20220380456A1
公开(公告)日：2022-12-01
申请号：US17770776
申请日：2020-10-21
IPC分类号： C07K16/28 , C07K14/775 , C12N15/63
摘要： The present invention relates to the field of structural biology. More specifically, the present invention relates to an antigen-binding chimeric protein, called a MegaBody™, specifically binding a nanodisc, more specifically a membrane-scaffold protein (MSP)n which may be part of the nanodisc. The invention further provides for methods and uses of said nanodisc-specific antigen-binding chimeric proteins in three-dimensional high-resolution structural analysis of membrane proteins assembled within nanodiscs. The MSP-binding MegaBodies of the invention provide for a generic tool in membrane protein structural biology, more particular in Cryo-EM, by reducing preferred particle orientation of nanodiscs and of the entrapped target membrane proteins.
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