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公开(公告)号：US20170296656A1
公开(公告)日：2017-10-19
申请号：US15469689
申请日：2017-03-27
申请人： Valneva Austria GmbH
发明人： ROBERT SCHLEGL , Michael Möhlen , Jürgen Wruss , Michael Weber
摘要： The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminium content. The invention further relates to aqueous compositions comprising a protein and an aluminium-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition.
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公开(公告)号：US20160114033A1
公开(公告)日：2016-04-28
申请号：US14873344
申请日：2015-10-02
申请人： Valneva Austria GmbH
发明人： Robert Schlegl , Michael Möhlen , Jürgen Wruss , Michael Weber
CPC分类号： A61K39/39 , A61K38/162 , A61K38/164 , A61K39/104 , A61K39/12 , A61K2039/525 , A61K2039/5252 , A61K2039/55505 , A61K2039/70 , C12N7/00 , C12N2770/24134 , Y02A50/39
摘要： The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminium content. The invention further relates to aqueous compositions comprising a protein and an aluminium-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition.
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公开(公告)号：US11110170B2
公开(公告)日：2021-09-07
申请号：US16734866
申请日：2020-01-06
申请人： Valneva Austria GmbH
IPC分类号： A61K39/395 , A61K39/39 , A61K38/16 , A61K39/12 , C12N7/00 , A61K39/104 , A61K39/00
摘要： The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminium content. The invention further relates to aqueous compositions comprising a protein and an aluminium-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition.
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4.发明授权公开(公告)号：US10668146B2
公开(公告)日：2020-06-02
申请号：US15469689
申请日：2017-03-27
申请人： Valneva Austria GmbH
IPC分类号： A61K39/395 , A61K39/39 , A61K38/16 , A61K39/104 , A61K39/12 , C12N7/00 , A61K39/00
摘要： The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminium content. The invention further relates to aqueous compositions comprising a protein and an aluminium-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition.
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公开(公告)号：US09884115B2
公开(公告)日：2018-02-06
申请号：US14873344
申请日：2015-10-02
申请人： Valneva Austria GmbH
发明人： Robert Schlegl , Michael Möhlen , Jürgen Wruss , Michael Weber
IPC分类号： A61K39/00 , A61K39/39 , C07D487/04 , C09K13/00 , H01L21/02 , A61K38/16 , A61K39/12 , C12N7/00 , A61K39/104
CPC分类号： A61K39/39 , A61K38/162 , A61K38/164 , A61K39/104 , A61K39/12 , A61K2039/525 , A61K2039/5252 , A61K2039/55505 , A61K2039/70 , C12N7/00 , C12N2770/24134 , Y02A50/39
摘要： The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminium content. The invention further relates to aqueous compositions comprising a protein and an aluminium-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition.
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公开(公告)号：US20240293531A1
公开(公告)日：2024-09-05
申请号：US17913638
申请日：2021-04-06
申请人： Valneva Austria GmbH
IPC分类号： A61K39/215 , A61K39/00 , A61P31/14 , C12N7/00
CPC分类号： A61K39/215 , A61P31/14 , C12N7/00 , A61K2039/5252 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/575 , C12N2770/20034 , C12N2770/20063
摘要： Described herein are SARS-CoV-2 vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof.
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公开(公告)号：US11684669B2
公开(公告)日：2023-06-27
申请号：US17471904
申请日：2021-09-10
发明人： Andreas Meinke , Michael Möhlen , Christoph Reinisch , Robert Schlegl , Christian Taucher , John Campbell , David Novack , Robert S. Janssen , Jürgen Heindl-Wruss
IPC分类号： C12N7/00 , A61K39/215 , A61K39/00
CPC分类号： A61K39/215 , A61K2039/545 , A61K2039/55561
摘要： Described herein are CpG-adjuvanted SARS-CoV-2 vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof.
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公开(公告)号：US09913898B2
公开(公告)日：2018-03-13
申请号：US15223027
申请日：2016-07-29
申请人： Valneva Austria GmbH
发明人： Robert Schlegl , Michael Möhlen , Jürgen Wruss , Michael Weber
IPC分类号： A61K39/00 , A61K39/39 , C07D487/04 , C09K13/00 , A61K38/43 , A61K38/16 , A61K39/12 , C12N7/00 , A61K39/104
CPC分类号： A61K39/39 , A61K38/162 , A61K38/164 , A61K39/104 , A61K39/12 , A61K2039/525 , A61K2039/5252 , A61K2039/55505 , A61K2039/70 , C12N7/00 , C12N2770/24134 , Y02A50/39
摘要： The invention relates to means and methods for preparing aqueous composition comprising aluminum and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminum content. The invention further relates to aqueous compositions comprising a protein and an aluminum-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition.
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公开(公告)号：US20160324959A1
公开(公告)日：2016-11-10
申请号：US15223027
申请日：2016-07-29
申请人： Valneva Austria GmbH
发明人： ROBERT SCHLEGL , Michael Möhlen , Jürgen Wruss , Michael Weber
IPC分类号： A61K39/39 , C12N7/00 , A61K39/104 , A61K39/12
CPC分类号： A61K39/39 , A61K38/162 , A61K38/164 , A61K39/104 , A61K39/12 , A61K2039/525 , A61K2039/5252 , A61K2039/55505 , A61K2039/70 , C12N7/00 , C12N2770/24134 , Y02A50/39
摘要： The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminium content. The invention further relates to aqueous compositions comprising a protein and an aluminium-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition.
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公开(公告)号：US20230092650A1
公开(公告)日：2023-03-23
申请号：US17802361
申请日：2021-03-01
发明人： John D. Campbell , Robert S. Janssen , David Novack , Christian Taucher , Christoph Reinisch , Andreas Meinke , Michael Möhlen , Robert Schlegl , Jürgen Heindl-Wruss
IPC分类号： A61K39/215 , C12N7/00 , A61P31/14
摘要： The present disclosure relates to immunogenic compositions comprising a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen, and a toll-like receptor 9 (TLR9) agonist, such as an oligonucleotide comprising an unmethylated cytidine-phospho-guano sine (CpG) motif. The immunogenic compositions are suitable for stimulating an immune response against a SARS-CoV-2 in an individual in need thereof.
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