公开(公告)号：US10071263B1

公开(公告)日：2018-09-11

申请号：US14225413

申请日：2014-03-25

申请人： Varian Medical Systems, Inc.

发明人： Steven W. Prince ,  Stanley Mansfield ,  Stuart Scollay

IPC分类号： G21K1/00 ,  A61N5/00 ,  A61N5/10

摘要： A radiation apparatus includes a source operable to generate a radiation beam, a multileaf collimator operable to shape of the radiation beam, and a pivoting mechanism configured to pivot the multileaf collimator about the source. The radiation apparatus may further include a rotating mechanism configured to rotate the multileaf collimator about an axis passing through the source and the multileaf collimator.

公开(公告)号：US10022565B2

公开(公告)日：2018-07-17

申请号：US15206352

申请日：2016-07-11

申请人： Varian Medical Systems, Inc. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Stavros Prionas ,  Michael C. Green ,  Edward Seppi ,  Larry D. Partain ,  James Clayton ,  Stanley Mansfield ,  John Boone

IPC分类号： A61N5/10

摘要： A method of delivering external radiation beams to a target volume in a body portion includes positioning a radioactive isotope source at a plurality of locations spaced apart around the body portion, and collimating radiation beams of the radioactive isotope source from the plurality of locations, whereby the target volume in the body portion is deposited with a predetermined dose distribution. A radiation device employs a member having a configuration adapted to surround a body portion to be irradiated. The member has a channel and a plurality of collimators spaced apart along and coupled to the channel. The plurality of collimators define a plurality of dwelling locations for a radioactive isotope source in the channel and are configured to collimate radiation beams of the radioactive isotope source.

公开(公告)号：US20160317839A1

公开(公告)日：2016-11-03

申请号：US15206352

申请日：2016-07-11

申请人： Varian Medical Systems, Inc. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Stavros Prionas ,  Michael C. Green ,  Edward Seppi ,  Larry D. Partain ,  James Clayton ,  Stanley Mansfield ,  John Boone

IPC分类号： A61N5/10

CPC分类号： A61N5/1084 ,  A61N5/10 ,  A61N5/1048 ,  A61N5/1081

摘要： A method of delivering external radiation beams to a target volume in a body portion includes positioning a radioactive isotope source at a plurality of locations spaced apart around the body portion, and collimating radiation beams of the radioactive isotope source from the plurality of locations, whereby the target volume in the body portion is deposited with a predetermined dose distribution. A radiation device employs a member having a configuration adapted to surround a body portion to be irradiated. The member has a channel and a plurality of collimators spaced apart along and coupled to the channel. The plurality of collimators define a plurality of dwelling locations for a radioactive isotope source in the channel and are configured to collimate radiation beams of the radioactive isotope source.

摘要翻译： 将外部辐射束输送到身体部分中的目标体积的方法包括：将放射性同位素源定位在围绕身体部分间隔开的多个位置处，以及从多个位置准直放射性同位素源的辐射束，由此 以预定剂量分布沉积身体部分中的目标体积。 辐射装置采用具有适于包围待照射的主体部分的构造的构件。 该构件具有通道和多个准直器，沿着并且耦合到通道间隔开。 多个准直器限定了通道中的放射性同位素源的多个住宅位置，并且被配置成准直放射性同位素源的辐射束。

公开(公告)号：US20190022411A1

公开(公告)日：2019-01-24

申请号：US16041636

申请日：2018-07-20

申请人： VARIAN MEDICAL SYSTEMS, INC.

发明人： Renate Parry ,  Eric Abel ,  Swati Girdhani ,  Stanley Mansfield ,  Patrick Kupelian ,  Depak Khuntia

IPC分类号： A61N5/10 ,  A61K9/51 ,  A61P35/00 ,  A61K45/06 ,  G16H20/40

摘要： Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.

公开(公告)号：US09974494B2

公开(公告)日：2018-05-22

申请号：US15188864

申请日：2016-06-21

申请人： VARIAN MEDICAL SYSTEMS, INC.

发明人： Hassan Mostafavi ,  Marcel R. Marc ,  Stanley Mansfield ,  Raymond D. McIntyre ,  Ross B. Hannibal

IPC分类号： A61B5/05 ,  A61B6/03 ,  A61B6/10 ,  A61B6/00 ,  A61N5/10 ,  G01N23/04 ,  G21K1/093 ,  A61B5/06 ,  A61B5/11 ,  A61B6/04 ,  A61B6/08

CPC分类号： A61B6/032 ,  A61B5/06 ,  A61B5/064 ,  A61B5/1127 ,  A61B6/037 ,  A61B6/0414 ,  A61B6/0457 ,  A61B6/08 ,  A61B6/107 ,  A61B6/4085 ,  A61B6/4441 ,  A61B6/482 ,  A61B6/5235 ,  A61B6/5247 ,  A61B6/547 ,  A61N5/10 ,  A61N5/1049 ,  A61N5/1064 ,  A61N5/1069 ,  A61N5/1081 ,  A61N2005/1094 ,  G01N23/04 ,  G21K1/093

摘要： A radiation system includes a radiation source having an accelerator, the radiation source having a magnetic field associated therewith that is resulted from an operation of the accelerator, and a magnetic field source configured to provide a compensating magnetic field to at least partially counteract against the magnetic field that is resulted from the operation of the accelerator. A radiation system includes a radiation device having a radiation source, a patient support, and a protective guard located between the radiation source and the patient support, wherein the protective guard is moveably coupled to the radiation device or the patient support. A radiation system includes a particle generator for generating a particle, an accelerator for accelerating the particle, and a magnetic source for changing a trajectory of the particle, wherein the magnetic source comprises a permanent magnet.

公开(公告)号：US20170258414A1

公开(公告)日：2017-09-14

申请号：US15467930

申请日：2017-03-23

申请人： VARIAN MEDICAL SYSTEMS, INC.

发明人： Timothy E. Guertin ,  Richard H. Stark ,  Raymond D. McIntyre ,  Steven W. Prince ,  Stanley Mansfield ,  George A. Zdasiuk

IPC分类号： A61B6/03 ,  A61B5/06 ,  A61B6/00 ,  A61B6/04 ,  A61B6/10 ,  A61N5/10 ,  G01N23/04 ,  G21K1/093 ,  A61B5/11 ,  A61B6/08

CPC分类号： A61B6/032 ,  A61B5/06 ,  A61B5/064 ,  A61B5/1127 ,  A61B6/037 ,  A61B6/0414 ,  A61B6/0457 ,  A61B6/08 ,  A61B6/107 ,  A61B6/4085 ,  A61B6/4441 ,  A61B6/482 ,  A61B6/5235 ,  A61B6/5247 ,  A61B6/547 ,  A61N5/10 ,  A61N5/1049 ,  A61N5/1064 ,  A61N5/1069 ,  A61N5/1081 ,  A61N2005/1094 ,  G01N23/04 ,  G21K1/093

摘要： A radiation system includes a first ring, a radiation source capable of providing radiation suitable for treating a patient, the radiation source secured to the first ring, a second ring located behind the first ring, and an imager secured to the second ring. A radiation system includes a first device having a radiation source capable of generating a radiation beam suitable for treating a patient, and a second device having imaging capability, wherein the first device is oriented at an angle that is less than 180° relative to the second device. A radiation system includes a structure having a first opening, a radiation source rotatably coupled to the structure, an imaging device rotatable relative to the structure, and a processor for controlling a rotation of the radiation source and a rotation of the imaging device, wherein the radiation source is rotatable relative to the imaging device.

公开(公告)号：US11673003B2

公开(公告)日：2023-06-13

申请号：US17091445

申请日：2020-11-06

申请人： Varian Medical Systems, Inc. ,  Varian Medical Systems International AG.

发明人： Reynald Vanderstraeten ,  Eric Abel ,  Christel Smith ,  Anthony Magliari ,  Timo Koponen ,  Stanley Mansfield ,  Charles Adelsheim

IPC分类号： A61N5/10 ,  G16H40/63 ,  G16H50/50 ,  G16H10/60 ,  G16H20/40 ,  A61B6/03

CPC分类号： A61N5/1031 ,  A61N5/1038 ,  A61N5/1045 ,  G16H10/60 ,  G16H20/40 ,  G16H40/63 ,  G16H50/50 ,  A61B6/032 ,  A61N5/1043 ,  A61N5/1069 ,  A61N5/1071

摘要： Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub-volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.

公开(公告)号：US20180304098A1

公开(公告)日：2018-10-25

申请号：US15494046

申请日：2017-04-21

申请人： Varian Medical Systems, Inc.

发明人： David Humber ,  Josh Star-Lack ,  Stanley Mansfield ,  Ross Hannibal

IPC分类号： A61N5/10 ,  A61B6/03 ,  A61B6/00

CPC分类号： A61N5/1037 ,  A61B6/035 ,  A61B6/4085 ,  A61B6/4441 ,  A61B6/4447 ,  A61B6/547 ,  A61N5/1049 ,  A61N5/1082 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1089

摘要： A radiation system includes a radiation source providing therapeutic radiation, a first gantry supporting a second gantry carrying the radiation source. The first gantry is rotatable about a first axis passing through an isocenter, thereby allowing the radiation source to aim therapeutic radiation at a target volume from a plurality of locations in a first plane. The second gantry carrying the radiation source is rotatable about a second axis passing through the isocenter non-parallel with the first axis, thereby allowing the radiation source to aim therapeutic radiation at the target volume from a plurality of locations in a second plane non-coplanar with the first plane.

公开(公告)号：US10092774B1

公开(公告)日：2018-10-09

申请号：US15657094

申请日：2017-07-21

申请人： Varian Medical Systems, Inc.

发明人： Reynald Vanderstraten ,  Eric Abel ,  Christel Smith ,  Anthony Magliari ,  Timo Koponen ,  Stanley Mansfield ,  Charles Adelsheim

IPC分类号： A61N5/10 ,  A61B6/03 ,  G06F19/00

摘要： Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub-volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.

公开(公告)号：US09082520B2

公开(公告)日：2015-07-14

申请号：US14144509

申请日：2013-12-30

申请人： Varian Medical Systems, Inc.

发明人： Steven W. Prince ,  Stanley Mansfield

IPC分类号： G21F3/00 ,  G21K1/04

CPC分类号： G21K1/046 ,  A61N5/1045

摘要： A multilevel MLC includes a first set and a second set of a plurality of pairs of beam blocking leaves arranged adjacent one another. Leaves of each pair in the first set are disposed in an opposed relationship and longitudinally movable relative to each other in a first direction. Leaves of each pair in the second set are disposed in an opposed relationship and longitudinally movable relative to each other in a second direction generally parallel to the first direction. The first and second sets of pairs of leaves are disposed in different planes.

摘要翻译： 多级MLC包括彼此相邻布置的多对束阻挡叶片的第一组和第二组。 第一组中的每对的叶布置成相对的关系，并且在第一方向上可相对于彼此纵向移动。 第二组中的每对的叶子以相对的关系设置，并且在大致平行于第一方向的第二方向上可相对于彼此纵向移动。 第一组和第二组叶子设置在不同的平面上。