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1.发明申请Method and apparatus for remote sensing utilizing a reverse photoacoustic effect 审中-公开使用反向光声效应的遥感方法和装置公开(公告)号：US20070220979A1
公开(公告)日：2007-09-27
申请号：US11386023
申请日：2006-03-21
申请人： Ming Su , Thomas Thundat , David Hedden
发明人： Ming Su , Thomas Thundat , David Hedden
CPC分类号： G01N29/075 , G01N29/0681 , G01N29/2418 , G01N2291/0423 , G01N2291/044 , G01N2291/048 , G01N2291/102
摘要： A method and apparatus for identifying a sample, involves illuminating the sample with light of varying wavelengths, transmitting an acoustic signal against the sample from one side and receiving a resulting acoustic signal on another side, detecting a change of phase in the acoustic signal corresponding to the light of varying wavelengths, and analyzing the change of phase in the acoustic signal for the varying wavelengths of illumination to identify the sample. The apparatus has a controlled source for illuminating the sample with light of varying wavelengths, a transmitter for transmitting an acoustic wave, a receiver for receiving the acoustic wave and converting the acoustic wave to an electronic signal, and an electronic circuit for detecting a change of phase in the acoustic wave corresponding to respective ones of the varying wavelengths and outputting the change of phase for the varying wavelengths to allow identification of the sample. The method and apparatus can be used to detect chemical composition or visual features. A transmission mode and a reflection mode of operation are disclosed.
摘要翻译： 用于识别样品的方法和装置包括用变化波长的光照射样品，从一侧向样品传输声信号，并在另一侧接收所得到的声信号，检测对应于 变化波长的光，并分析用于变化的照明波长的声信号中的相位变化以识别样品。 该装置具有用于用不同波长的光照射样品的受控源，用于传输声波的发射器，用于接收声波并将声波转换为电子信号的接收器，以及用于检测变化的电子电路 声波中相应于相应变化波长的相位，并输出变化波长的相位变化，以允许样本的识别。 该方法和装置可用于检测化学成分或视觉特征。 公开了传输模式和反射操作模式。
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2.发明申请公开(公告)号：US20070220978A1
公开(公告)日：2007-09-27
申请号：US11639184
申请日：2006-12-14
申请人： Ming Su , Thomas Thundat , David Hedden
发明人： Ming Su , Thomas Thundat , David Hedden
IPC分类号： G01N29/00
CPC分类号： G01N29/075 , G01N29/0681 , G01N29/2418 , G01N2291/012 , G01N2291/02466 , G01N2291/0423 , G01N2291/0427 , G01N2291/044 , G01N2291/048 , G01N2291/102
摘要： A method and apparatus for identifying a sample, involves illuminating the sample with light of varying wavelengths, transmitting an acoustic signal against the sample from one portion and receiving a resulting acoustic signal on another portion, detecting a change of phase in the acoustic signal corresponding to the light of varying wavelengths, and analyzing the change of phase in the acoustic signal for the varying wavelengths of illumination to identify the sample. The apparatus has a controlled source for illuminating the sample with light of varying wavelengths, a transmitter for transmitting an acoustic wave, a receiver for receiving the acoustic wave and converting the acoustic wave to an electronic signal, and an electronic circuit for detecting a change of phase in the acoustic wave corresponding to respective ones of the varying wavelengths and outputting the change of phase for the varying wavelengths to allow identification of the sample. The method and apparatus can be used to detect chemical composition or visual features. A transmission mode and a reflection mode of operation are disclosed. The method and apparatus can be applied at nanoscale to detect molecules in a biological sample.
摘要翻译： 用于识别样品的方法和装置包括用变化的波长的光照射样品，从一个部分发射针对样品的声信号，并在另一部分上接收所得到的声信号，检测对应的声信号中的相位变化 变化波长的光，并分析用于变化的照明波长的声信号中的相位变化以识别样品。 该装置具有用于用不同波长的光照射样品的受控源，用于传输声波的发射器，用于接收声波并将声波转换成电子信号的接收器，以及用于检测变化的电子电路 声波中相应于相应变化波长的相位，并输出变化波长的相位变化，以允许样本的识别。 该方法和装置可用于检测化学成分或视觉特征。 公开了传输模式和反射操作模式。 该方法和装置可应用于纳米尺度以检测生物样品中的分子。
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3.发明申请Method of Making Gold Thiolate and Photochemically Functionalized Microcantilevers 失效制备金硫醇和光化学官能化微悬臂梁的方法公开(公告)号：US20080085379A1
公开(公告)日：2008-04-10
申请号：US11859047
申请日：2007-09-21
申请人： Vassil Boiadjiev , Gilbert Brown , Lal Pinnaduwage , Thomas Thundat , Peter Bonnesen , Gudrun Goretzki
发明人： Vassil Boiadjiev , Gilbert Brown , Lal Pinnaduwage , Thomas Thundat , Peter Bonnesen , Gudrun Goretzki
IPC分类号： B05D3/10
CPC分类号： G01N29/022 , B82Y30/00 , B82Y35/00 , B82Y40/00 , G01N2291/0256 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427
摘要： Highly sensitive sensor platforms for the detection of specific reagents, such as chromate, gasoline and biological species, using microcantilevers and other microelectromechanical systems (MEMS) whose surfaces have been modified with photochemically attached organic monolayers, such as self-assembled monolayers (SAM), or gold-thiol surface linkage are taught. The microcantilever sensors use photochemical hydrosilylation to modify silicon surfaces and gold-thiol chemistry to modify metallic surfaces thereby enabling individual microcantilevers in multicantilever array chips to be modified separately. Terminal vinyl substituted hydrocarbons with a variety of molecular recognition sites can be attached to the surface of silicon via the photochemical hydrosilylation process. By focusing the activating UV light sequentially on selected silicon or silicon nitride hydrogen terminated surfaces and soaking or spotting selected metallic surfaces with organic thiols, sulfides, or disulfides, the microcantilevers are functionalized. The device and photochemical method are intended to be integrated into systems for detecting specific agents including chromate groundwater contamination, gasoline, and biological species.
摘要翻译： 用于检测特定试剂（如铬酸盐，汽油和生物物种）的高灵敏度传感器平台，使用微型悬臂梁和其表面已经用光化学附着的有机单层如自组装单层（SAM）进行了改性的其他微机电系统（MEMS） 或金 - 硫醇表面连接。 微悬臂传感器使用光化学氢化硅烷化来改性硅表面和金 - 硫醇化学，以改变金属表面，从而使多单元阵列芯片中的单个微悬臂梁可以单独修改。 具有多种分子识别位点的末端乙烯基取代的烃可以通过光化学氢化硅烷化方法连接到硅的表面。 通过将激活的UV光依次聚焦在选定的硅或氮化硅氢终止表面上，并用有机硫醇，硫化物或二硫化物浸泡或点样选定的金属表面，微悬臂梁被功能化。 该装置和光化学方法旨在集成到用于检测特定试剂的系统中，包括铬酸盐地下水污染物，汽油和生物物质。
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公开(公告)号：US20180266404A1
公开(公告)日：2018-09-20
申请号：US15923496
申请日：2018-03-16
IPC分类号： F03H99/00
CPC分类号： F03H99/00
摘要： This patent seeks to describe a design and method of production of a solid state radiometric thruster for the intent of producing a new method of powered flight at varying scales of operation. By using modern nano-manufacturing techniques it is possible to create surface microstructures of the same size as the mean free path for gases at any desired operational pressure, allowing for radiometric forces to be harnessed for propulsion even when the total part dimensions are several orders of magnitude larger than would normally allow this effect to create a noticeable force.
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5.发明申请公开(公告)号：US20160209369A1
公开(公告)日：2016-07-21
申请号：US14995998
申请日：2016-01-14
IPC分类号： G01N29/036 , G01N33/00
CPC分类号： G01N29/036 , G01N29/022 , G01N33/0027 , G01N2291/0215 , G01N2291/02809
摘要： A dissipation-based sensor includes a single resonator with a nano-structured surface. The sensor exhibits improved sensitivity, up to about 2 orders of magnitude higher than a single resonator without a nano-structured surface. The sensor operates by measuring and estimating the fluid friction per oscillation cycle, operating in normal conditions without vacuum (e.g., in air or other ambient gas) at room temperature. The sensor can provide measurement data at a speed that is orders of magnitude faster than pre-existing resonance-based methods, as it is based on measurements from a few cycles only. The dissipation-based sensor may be utilized in a broad range of fast, inexpensive, hand-held measuring devices. Additionally, the sensor is capable of operating at standard temperature and pressure.
摘要翻译： 基于耗散的传感器包括具有纳米结构表面的单个谐振器。 该传感器具有提高的灵敏度，比没有纳米结构表面的单个谐振器高出约2个数量级。 传感器通过测量和估计每个振荡周期的流体摩擦力，在正常条件下在室温下无真空（例如在空气或其它环境气体中）运行。 传感器可以以比现有的基于共振的方法快几个数量级的速度提供测量数据，因为它仅基于几个周期的测量。 基于耗散的传感器可以用于宽范围的快速，便宜的手持测量装置中。 此外，传感器能够在标准温度和压力下运行。
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公开(公告)号：US20070175760A1
公开(公告)日：2007-08-02
申请号：US11731952
申请日：2007-04-02
申请人： Thomas Thundat , Thomas Ferrell , Gilbert Brown
发明人： Thomas Thundat , Thomas Ferrell , Gilbert Brown
IPC分类号： G01N27/00
CPC分类号： G01N27/305
摘要： A method, system, and apparatus are provided for separating molecules, such as biomolecules. The method, system, and apparatus utilize an electrochemical cell having at least to electrodes, one electrode comprising a photo-sensitive material capable of generating a photopotential. Molecules are moved through an electrolyte medium between the at least two electrodes based upon localized photopotentials.
摘要翻译： 提供了一种分离分子的方法，系统和装置，例如生物分子。 该方法，系统和装置利用至少具有电极的电化学电池，一个电极包括能够产生光致电位的光敏材料。 基于局部的光电势，分子在至少两个电极之间移动通过电解质介质。
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7.发明申请Gold thiolate and photochemically functionalized microcantilevers using molecular recognition agents 审中-公开金硫醇和光化学功能化的微悬臂梁使用分子识别剂公开(公告)号：US20060057026A1
公开(公告)日：2006-03-16
申请号：US11152627
申请日：2005-06-14
申请人： Vassil Boiadjiev , Gilbert Brown , Lal Pinnaduwage , Thomas Thundat , Peter Bonnesen , Gudrun Goretzki
发明人： Vassil Boiadjiev , Gilbert Brown , Lal Pinnaduwage , Thomas Thundat , Peter Bonnesen , Gudrun Goretzki
IPC分类号： G01N31/00 , G01N27/416 , B32B37/02 , B05D5/12 , B05D3/00
CPC分类号： G01N29/022 , B82Y30/00 , B82Y35/00 , B82Y40/00 , G01N2291/0256 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427
摘要： Highly sensitive sensor platforms for the detection of specific reagents, such as chromate, gasoline and biological species, using microcantilevers and other microelectromechanical systems (MEMS) whose surfaces have been modified with photochemically attached organic monolayers, such as self-assembled monolayers (SAM), or gold-thiol surface linkage are taught. The microcantilever sensors use photochemical hydrosilylation to modify silicon surfaces and gold-thiol chemistry to modify metallic surfaces thereby enabling individual microcantilevers in multicantilever array chips to be modified separately. Terminal vinyl substituted hydrocarbons with a variety of molecular recognition sites can be attached to the surface of silicon via the photochemical hydrosilylation process. By focusing the activating UV light sequentially on selected silicon or silicon nitride hydrogen terminated surfaces and soaking or spotting selected metallic surfaces with organic thiols, sulfides, or disulfides, the microcantilevers are functionalized. The device and photochemical method are intended to be integrated into systems for detecting specific agents including chromate groundwater contamination, gasoline, and biological species.
摘要翻译： 用于检测特定试剂（如铬酸盐，汽油和生物物种）的高灵敏度传感器平台，使用微型悬臂梁和其表面已经用光化学附着的有机单层如自组装单层（SAM）进行了改性的其他微机电系统（MEMS） 或金 - 硫醇表面连接。 微悬臂传感器使用光化学氢化硅烷化来改性硅表面和金 - 硫醇化学，以改变金属表面，从而使多单元阵列芯片中的单个微悬臂梁可以单独修改。 具有多种分子识别位点的末端乙烯基取代的烃可以通过光化学氢化硅烷化方法连接到硅的表面。 通过将激活的UV光依次聚焦在选定的硅或氮化硅氢终止表面上，并用有机硫醇，硫化物或二硫化物浸泡或点样选定的金属表面，微悬臂梁被功能化。 该装置和光化学方法旨在集成到用于检测特定试剂的系统中，包括铬酸盐地下水污染物，汽油和生物物质。
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公开(公告)号：US20060047283A1
公开(公告)日：2006-03-02
申请号：US10926216
申请日：2004-08-25
CPC分类号： A61F2/38 , A61B5/0031 , A61B5/076 , A61B5/1076 , A61B5/412 , A61B5/4519 , A61B5/4523 , A61B5/4528 , A61B5/6846 , A61F2/32 , A61F2/3877 , A61F2/40 , A61F2/4657 , A61F2002/4672 , A61F2002/488 , Y10S623/914
摘要： A device for providing in vivo diagnostics of loads, wear, and infection in orthopedic implants having at least one load sensor associated with the implant, at least one temperature sensor associated with the implant, at least one vibration sensor associated with the implant, and at least one signal processing device operatively coupled with the sensors. The signal processing device is operable to receive the output signal from the sensors and transmit a signal corresponding with the output signal.
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公开(公告)号：US10767637B2
公开(公告)日：2020-09-08
申请号：US15923496
申请日：2018-03-16
摘要： This patent seeks to describe a design and method of production of a solid state radiometric thruster for the intent of producing a new method of powered flight at varying scales of operation. By using modern nano-manufacturing techniques it is possible to create surface microstructures of the same size as the mean free path for gases at any desired operational pressure, allowing for radiometric forces to be harnessed for propulsion even when the total part dimensions are several orders of magnitude larger than would normally allow this effect to create a noticeable force.
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10.发明申请公开(公告)号：US20200173898A1
公开(公告)日：2020-06-04
申请号：US16204303
申请日：2018-11-29
申请人： Selemani Seif , Kenneth Cadien , Thomas Thundat
发明人： Selemani Seif , Kenneth Cadien , Thomas Thundat
IPC分类号： G01N5/02 , G01N29/036 , G01G3/13
摘要： A measurement probe system is provided that includes a housing, a Quartz Crystal Microbalance (QCM) mass sensor in the housing, a first cover and a second cover attached to the ends of the housing. A chamber is defined between the housing, the mass sensor, and the second cover. An electrical input in electrical communication with the mass sensor and an electrical output in electrical communication with the second cover are also included. The measurement probe system is used to detect nanoparticle levels in an ionic solution includes inputting an ionic solution sample into the chamber, applying a frequency from a signal generator to the QCM via the electrical input, detecting frequency noises with the second cover and transmitting those frequency noises to a frequency counter via the electrical output, and assessing the level of nanoparticles present in the sample based on the frequency measured by the frequency counter.
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