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公开(公告)号：US09205138B2
公开(公告)日：2015-12-08
申请号：US14572415
申请日：2014-12-16
发明人： Langzhou Song , Lynda G. Tussey , Alan R. Shaw , Robert S. Becker , Yi Zhang , Scott W. Umlauf , Ge Liu
IPC分类号： A61K39/145 , A61K39/112 , A61K39/295 , C07K14/11 , C07K14/255 , C07K19/00 , A61K39/00 , A61K39/39 , C07K14/005 , C07K14/205 , C07K14/21 , C07K14/24 , C07K14/245 , C07K14/32 , C12N7/00 , A61K39/155 , A61K39/12
CPC分类号： A61K39/39 , A61K9/127 , A61K9/5153 , A61K39/00 , A61K39/0005 , A61K39/0275 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/295 , A61K47/6937 , A61K2039/55516 , A61K2039/55544 , A61K2039/55555 , A61K2039/6031 , A61K2039/6068 , C07K14/005 , C07K14/11 , C07K14/205 , C07K14/21 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/32 , C07K19/00 , C07K2319/40 , C07K2319/75 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , C12N2710/20071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162 , C12N2760/16171 , C12N2760/16222 , C12N2760/16234 , C12N2760/16271 , C12N2760/18522 , C12N2760/18534 , C12N2760/18571 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/394 , Y02A50/412
摘要： Compositions that include Toll-like Receptor 5 agonists and at least a portion of at least one viral antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to viral infection.
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公开(公告)号：US20150110832A1
公开(公告)日：2015-04-23
申请号：US14572415
申请日：2014-12-16
发明人： Langzhou Song , Lynda G. Tussey , Alan R. Shaw , Robert S. Becker , Yi Zhang , Scott W. Umlauf , Ge Liu
IPC分类号： A61K39/00
CPC分类号： A61K39/39 , A61K9/127 , A61K9/5153 , A61K39/00 , A61K39/0005 , A61K39/0275 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/295 , A61K47/6937 , A61K2039/55516 , A61K2039/55544 , A61K2039/55555 , A61K2039/6031 , A61K2039/6068 , C07K14/005 , C07K14/11 , C07K14/205 , C07K14/21 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/32 , C07K19/00 , C07K2319/40 , C07K2319/75 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , C12N2710/20071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162 , C12N2760/16171 , C12N2760/16222 , C12N2760/16234 , C12N2760/16271 , C12N2760/18522 , C12N2760/18534 , C12N2760/18571 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/394 , Y02A50/412
摘要： Compositions that include Toll-like Receptor 5 agonists and at least a portion of at least one viral antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to viral infection.
摘要翻译： 包括Toll样受体5激动剂和至少一部分至少一种病毒抗原的组合物可以用于刺激受试者中的免疫应答的方法，特别是受试者中的保护性免疫应答。 组合物可以与颗粒相关并且在相对低剂量的方法中使用以提供对病毒感染的保护性免疫。
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公开(公告)号：US20160193329A1
公开(公告)日：2016-07-07
申请号：US14932355
申请日：2015-11-04
发明人： Langzhou Song , Lynda G. Tussey , Alan R. Shaw , Robert S. Becker , Yi Zhang , Scott W. Umlauf , Ge Liu
IPC分类号： A61K39/39 , C12N7/00 , A61K39/12 , A61K9/51 , A61K39/155 , A61K9/127 , A61K39/145
CPC分类号： A61K39/39 , A61K9/127 , A61K9/5153 , A61K39/00 , A61K39/0005 , A61K39/0275 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/295 , A61K47/6937 , A61K2039/55516 , A61K2039/55544 , A61K2039/55555 , A61K2039/6031 , A61K2039/6068 , C07K14/005 , C07K14/11 , C07K14/205 , C07K14/21 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/32 , C07K19/00 , C07K2319/40 , C07K2319/75 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , C12N2710/20071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162 , C12N2760/16171 , C12N2760/16222 , C12N2760/16234 , C12N2760/16271 , C12N2760/18522 , C12N2760/18534 , C12N2760/18571 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/394 , Y02A50/412
摘要： Compositions that include at least a portion of a flagellin and an antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to infection.
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公开(公告)号：US20150099859A1
公开(公告)日：2015-04-09
申请号：US14574058
申请日：2014-12-17
发明人： Langzhou Song , Lynda G. Tussey , Alan R. Shaw , Robert S. Becker , Yi Zhang , Scott W. Umlauf , Ge Liu
IPC分类号： C07K14/005 , C07K14/255
CPC分类号： A61K39/39 , A61K9/127 , A61K9/5153 , A61K39/00 , A61K39/0005 , A61K39/0275 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/295 , A61K47/6937 , A61K2039/55516 , A61K2039/55544 , A61K2039/55555 , A61K2039/6031 , A61K2039/6068 , C07K14/005 , C07K14/11 , C07K14/205 , C07K14/21 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/32 , C07K19/00 , C07K2319/40 , C07K2319/75 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , C12N2710/20071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162 , C12N2760/16171 , C12N2760/16222 , C12N2760/16234 , C12N2760/16271 , C12N2760/18522 , C12N2760/18534 , C12N2760/18571 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/394 , Y02A50/412
摘要： Compositions that include at least a portion of a flagellin and an antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to infection.
摘要翻译： 包括鞭毛蛋白和抗原的至少一部分的组合物可用于刺激受试者中的免疫应答的方法，特别是受试者中的保护性免疫应答。 组合物可以与颗粒结合，并且在相对低剂量的方法中使用，以提供对感染的保护性免疫。
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