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1.发明授权公开(公告)号：US08591909B2
公开(公告)日：2013-11-26
申请号：US13445492
申请日：2012-04-12
申请人： Vidadi Yusibov , Vadim Mett , Konstantin Musiychuk
发明人： Vidadi Yusibov , Vadim Mett , Konstantin Musiychuk
CPC分类号： C12N9/2448 , A61K2039/6031 , C07K16/1027 , C07K16/1278 , C07K2319/35 , C12N15/62 , C12Y302/01073
摘要： Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides) produced in different systems (bacteria, yeast, DNA, cell cultures such as mammalian, plant, insect cell cultures, protoplast and whole plants in vitro or in vivo are provided. The recombinant carrier molecule using sequences from lichenase B (Lic B) were also made and used as part of carrier protein to express, recover and deliver a variety of target polypeptides of interest.
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2.发明申请Recombinant Carrier Molecule for Expression, Delivery and Purification of Target Polypeptides 有权用于表达，递送和纯化靶多肽的重组载体分子公开(公告)号：US20120282288A1
公开(公告)日：2012-11-08
申请号：US13445492
申请日：2012-04-12
申请人： Vidadi Yusibov , Vadim Mett , Konstantin Musiychuk
发明人： Vidadi Yusibov , Vadim Mett , Konstantin Musiychuk
IPC分类号： C12N9/96 , C12N15/62 , C12N15/63 , C12N15/83 , A61P31/04 , C12N1/21 , C12N1/19 , C12N9/24 , A61K39/08 , C12N15/56 , C12N5/10
CPC分类号： C12N9/2448 , A61K2039/6031 , C07K16/1027 , C07K16/1278 , C07K2319/35 , C12N15/62 , C12Y302/01073
摘要： Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides) produced in different systems (bacteria, yeast, DNA, cell cultures such as mammalian, plant, insect cell cultures, protoplast and whole plants in vitro or in vivo are provided. The recombinant carrier molecule using sequences from lichenase B (Lic B) were also made and used as part of carrier protein to express, recover and deliver a variety of target polypeptides of interest.
摘要翻译： 具有来自耐热性酶的氨基酸序列的重组载体分子和用于表达，回收和递送在不同系统（细菌，酵母，DNA，细胞培养物如哺乳动物，植物，昆虫细胞培养物）中产生的外来序列（肽和多肽）的方法 ，体外或体内的原生质体和整株植物，使用来自地衣多糖B（Lic B）的序列的重组载体分子也被制备并用作载体蛋白的一部分，以表达，回收和递送各种目的多肽。
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公开(公告)号：US20120034253A1
公开(公告)日：2012-02-09
申请号：US13120770
申请日：2009-09-25
申请人： Vidadi Yusibov , Vadim Mett , Konstantin Musiychuk
发明人： Vidadi Yusibov , Vadim Mett , Konstantin Musiychuk
IPC分类号： A61K39/145 , A61P37/04 , A61P31/16 , C12P21/02 , C12N9/24
CPC分类号： C12N15/8258 , A61K39/12 , A61K39/145 , A61K2039/55505 , A61K2039/55577 , A61K2039/58 , C12N2710/16134 , C12N2760/16234
摘要： The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and compositions useful in inducing or enhancing an immune response agains influenza antigens. Provided are recombinant protein antigens, compositions, and methods for the production of such antigens in plants. In some embodiments, influenza antigens include hemagglutinin polypeptides, neuraminidase polypeptides, and/or combinations thereof.
摘要翻译： 本发明涉及免疫学和蛋白质工程领域的交叉，特别涉及可用于诱导或增强免疫应答的抗原和组合物再次流感抗原。 提供了用于在植物中产生这种抗原的重组蛋白抗原，组合物和方法。 在一些实施方案中，流感抗原包括血凝素多肽，神经氨酸酶多肽和/或其组合。
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4.发明申请Recombinant Carrier Molecule for Expression, Delivery and Purification of Target Polypeptides 有权用于表达，递送和纯化靶多肽的重组载体分子公开(公告)号：US20100227373A1
公开(公告)日：2010-09-09
申请号：US12625129
申请日：2009-11-24
申请人： Vidadi Yusibov , Vadim Mett , Konstantin Musiychuk
发明人： Vidadi Yusibov , Vadim Mett , Konstantin Musiychuk
CPC分类号： C12N9/2448 , A61K2039/6031 , C07K16/1027 , C07K16/1278 , C07K2319/35 , C12N15/62 , C12Y302/01073
摘要： Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides) produced in different systems (bacteria, yeast, DNA, cell cultures such as mammalian, plant, insect cell cultures, protoplast and whole plants in vitro or in vivo are provided. The recombinant carrier molecule using sequences from lichenase B(Lic B) were also made and used as part of carrier protein to express, recover and deliver a variety of target polypeptides of interest.
摘要翻译： 具有来自耐热性酶的氨基酸序列的重组载体分子和用于表达，回收和递送在不同系统（细菌，酵母，DNA，细胞培养物如哺乳动物，植物，昆虫细胞培养物）中产生的外来序列（肽和多肽）的方法 ，体外或体内的原生质体和整株植物，使用来自地衣多糖B（Lic B）的序列的重组载体分子也被制备并用作载体蛋白的一部分，以表达，回收和递送各种目的多肽。
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公开(公告)号：US08404252B2
公开(公告)日：2013-03-26
申请号：US12668258
申请日：2008-07-11
申请人： Vidadi Yusibov , Vadim Mett , Konstantin Musiychuk
发明人： Vidadi Yusibov , Vadim Mett , Konstantin Musiychuk
IPC分类号： A61K39/102 , A61K39/02 , C07K14/24
CPC分类号： C07K14/24 , A61K39/025 , A61K39/0291 , A61K2039/55505 , A61K2039/6068 , Y02A50/407
摘要： The present invention provides antigens and vaccines useful in prevention of infection by Yersinia pestis. The present invention provides pharmaceutical compositions of such antigens and/or vaccines. The present invention provides methods for the production of Y. pestis protein antigens in plants, as well as methods for their use in the treatment and/or prevention of Y. pestis infection.
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6.发明申请公开(公告)号：US20110027304A1
公开(公告)日：2011-02-03
申请号：US12668258
申请日：2008-07-11
申请人： Vidadi Yusibov , Vadim Mett , Konstantin Musiychuk
发明人： Vidadi Yusibov , Vadim Mett , Konstantin Musiychuk
CPC分类号： C07K14/24 , A61K39/025 , A61K39/0291 , A61K2039/55505 , A61K2039/6068 , Y02A50/407
摘要： The present invention provides antigens and vaccines useful in prevention of infection by Yersinia pestis. The present invention provides pharmaceutical compositions of such antigens and/or vaccines. The present invention provides methods for the production of Y. pestis protein antigens in plants, as well as methods for their use in the treatment and/or prevention of Y. pestis infection.
摘要翻译： 本发明提供可用于预防鼠疫耶尔森氏菌感染的抗原和疫苗。 本发明提供了这种抗原和/或疫苗的药物组合物。 本发明提供了用于在植物中产生鼠疫耶氏菌蛋白抗原的方法，以及它们用于治疗和/或预防鼠疫耶尔森氏杆菌感染的方法。
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7.发明授权Recombinant carrier molecule for expression, delivery and purification of target polypeptides 有权用于表达，递送和纯化靶多肽的重组载体分子公开(公告)号：US08173408B2
公开(公告)日：2012-05-08
申请号：US12625129
申请日：2009-11-24
申请人： Vidadi Yusibov , Vadim Mett , Konstantin Musiychuk
发明人： Vidadi Yusibov , Vadim Mett , Konstantin Musiychuk
CPC分类号： C12N9/2448 , A61K2039/6031 , C07K16/1027 , C07K16/1278 , C07K2319/35 , C12N15/62 , C12Y302/01073
摘要： Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides) produced in different systems (bacteria, yeast, DNA, cell cultures such as mammalian, plant, insect cell cultures, protoplast and whole plants in vitro or in vivo are provided. The recombinant carrier molecule using sequences from lichenase B(Lic B) were also made and used as part of carrier protein to express, recover and deliver a variety of target polypeptides of interest.
摘要翻译： 具有来自耐热性酶的氨基酸序列的重组载体分子和用于表达，回收和递送在不同系统（细菌，酵母，DNA，细胞培养物如哺乳动物，植物，昆虫细胞培养物）中产生的外来序列（肽和多肽）的方法 ，体外或体内的原生质体和整株植物，使用来自地衣多糖B（Lic B）的序列的重组载体分子也被制备并用作载体蛋白的一部分，以表达，回收和递送各种目的多肽。
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公开(公告)号：US20110314575A1
公开(公告)日：2011-12-22
申请号：US13121251
申请日：2009-09-28
IPC分类号： A01H5/00 , C12N15/62 , C12N15/63 , C12N5/10 , A61P37/04 , C12P21/00 , C12P21/02 , C07K14/445 , A61P33/02 , C12N9/96 , A61K39/015
CPC分类号： C12Y302/01073 , A61K39/00 , A61K2039/517 , C07K14/445 , C07K2319/00 , C07K2319/40 , C12N9/2448 , C12N15/8258 , Y02A50/412
摘要： The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection by Plasmodium parasites. Provided are recombinant protein antigens, compositions, and methods for the production of such antigens in plants. In some embodiments, Plasmodium antigens include Pfs25 polypeptides, Pfs28 polypeptides, Pfs48/45 polypeptides, Pfs230 polypeptides, and/or combinations thereof.
摘要翻译： 本发明涉及免疫学和蛋白质工程领域的交叉，特别涉及可用于预防疟原虫感染的抗原和疫苗。 提供了用于在植物中产生这种抗原的重组蛋白抗原，组合物和方法。 在一些实施方案中，疟原虫抗原包括Pfs25多肽，Pfs28多肽，Pfs48 / 45多肽，Pfs230多肽和/或其组合。
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公开(公告)号：US08784819B2
公开(公告)日：2014-07-22
申请号：US13498946
申请日：2010-09-29
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/76 , C12N15/8258
摘要： Antibodies against influenza hemagglutinin, compositions containing the antibodies, and methods of using the antibodies are provided herein.
摘要翻译： 本文提供抗流感血凝素抗体，含有抗体的组合物和使用抗体的方法。
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公开(公告)号：US20080279877A1
公开(公告)日：2008-11-13
申请号：US11706568
申请日：2007-02-13
申请人： Vidadi Yusibov , Vadim Mett
发明人： Vidadi Yusibov , Vadim Mett
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/55577 , A61K2039/585 , A61K2039/6031 , C07K2319/35 , C12N7/00 , C12N9/2448 , C12N2710/20022 , C12N2710/20034 , C12Y302/01073
摘要： The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection by human papilloma virus. Provided are recombinant protein antigens, compositions, and methods for the production and use of such antigens and vaccine compositions.
摘要翻译： 本发明涉及免疫学和蛋白质工程领域的交叉，特别涉及可用于预防人乳头瘤病毒感染的抗原和疫苗。 提供了用于生产和使用这些抗原和疫苗组合物的重组蛋白抗原，组合物和方法。
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