-
公开(公告)号:US06825009B2
公开(公告)日:2004-11-30
申请号:US10105101
申请日:2002-03-22
申请人: Vince P. Stanton, Jr. , Jia Liu Wolfe , Tomohiko Kawate , Gregory L. Verdine , Jeffrey Olson , Colin W Dykes
发明人: Vince P. Stanton, Jr. , Jia Liu Wolfe , Tomohiko Kawate , Gregory L. Verdine , Jeffrey Olson , Colin W Dykes
IPC分类号: C12Q168
CPC分类号: C12Q1/6858 , C07H19/10 , C07H19/14 , C07H19/20 , C07H21/00 , C12N9/1252 , C12N15/11 , C12P19/34 , C12Q1/6827 , C12Q1/683 , C12Q1/6872 , C12Q2525/117 , C12Q2523/107 , C12Q2527/107 , C12Q2565/627 , C12Q2525/101
摘要: The present invention relates to methods for the detection of polymorphism in polynucleotides by using hybridization of fragments of segments of a polynucleotide suspected of containing a polymorphism with an oligonucleotide having a sequence complementary to a fragment identifying the polymorphism and subsequent detection of incorporated labels in the oligonucleotide-fragment duplex.
摘要翻译: 本发明涉及通过使用疑似含有多态性的多核苷酸的片段的片段与具有与鉴定多态性的片段互补的序列的寡核苷酸杂交并随后检测寡核苷酸中的并入标记的方法来检测多核苷酸中的多态性的方法 碎片双工。
-
公开(公告)号:US06500650B1
公开(公告)日:2002-12-31
申请号:US09655104
申请日:2000-09-05
IPC分类号: C12Q168
CPC分类号: C12Q1/6858 , C07H19/10 , C07H19/14 , C07H19/20 , C07H21/00 , C12N9/1252 , C12N15/11 , C12P19/34 , C12Q1/6827 , C12Q1/683 , C12Q1/6872 , C12Q2525/117 , C12Q2523/107 , C12Q2527/107 , C12Q2565/627 , C12Q2525/101
摘要: The present invention relates to methods for the detection of polymorphism in polynucleotides by using hybridization of fragments of segments of a polynucleotide suspected of containing a polymorphism with an oligonucleotide having a sequence complementary to a fragment identifying the polymorphism and subsequent detection of incorporated labels in the oligonucleotide-fragment duplex.
摘要翻译: 本发明涉及通过使用疑似含有多态性的多核苷酸的片段的片段与具有与鉴定多态性的片段互补的序列的寡核苷酸杂交并随后检测寡核苷酸中的并入标记的方法来检测多核苷酸中的多态性的方法 碎片双工。
-