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    Interleukin-1 beta converting enzyme like apoptotic protease-7
    1.
    发明授权
    Interleukin-1 beta converting enzyme like apoptotic protease-7 失效
    白细胞介素-1β转换酶如凋亡蛋白酶-7

    公开(公告)号：US6008042A

    公开(公告)日：1999-12-28

    申请号：US852782

    申请日：1997-05-07

    申请人： Vishva M. Dixit ,  Kristine K. Kikly ,  Steven M. Ruben ,  Jian Ni ,  Craig A. Rosen

    发明人： Vishva M. Dixit ,  Kristine K. Kikly ,  Steven M. Ruben ,  Jian Ni ,  Craig A. Rosen

    IPC分类号： G01N33/566 ,  A61K38/00 ,  A61K38/46 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P31/04 ,  A61P43/00 ,  C07K16/18 ,  C12N5/00 ,  C12N5/10 ,  C12N9/50 ,  C12N9/64 ,  C12N15/09 ,  C12N15/57 ,  C12Q1/68 ,  C12R1/91 ,  C12N15/00

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00

    摘要： Human ICE LAP-7 polypeptides and DNA (RNA) encoding such ICE LAP-7 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-7 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility. Antagonists against such ICE LAP-7 and their use as a therapeutic to treat Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, septic shock, sepsis, stroke, chronic inflammation, acute inflammation, CNS inflammation, osteoporosis, ischemia reperfusion injury, cell death associated with cardiovascular disease, polycystic kidney disease, apoptosis of endothelial cells in cardiovascular disease, degenerative liver disease, MS, ALS, cererbellar degeneration, ischemic injury, myocardial infarction, AIDS, myelodysplastic syndromes, aplastic anemia, male pattern baldness, and head injury damage are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the interleukin-1 beta converting enzyme apoptosis proteases and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人类ICE LAP-7多肽和编码这种ICE LAP-7的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种ICE LAP-7来治疗对病毒感染，肿瘤发生的易感性以及控制胚胎发生和组织稳态中的疾病和缺陷的方法，并且上述核酸序列可用于确定 这种敏感性。 对抗这种ICE LAP-7的拮抗剂及其作为治疗性阿尔茨海默病，帕金森病，类风湿性关节炎，败血性休克，败血症，中风，慢性炎症，急性炎症，CNS炎症，骨质疏松症，缺血再灌注损伤，与 心血管疾病，多囊肾病，心血管疾病中的内皮细胞凋亡，退行性肝病，MS，ALS，小脑变性，缺血性损伤，心肌梗死，AIDS，骨髓增生异常综合征，再生障碍性贫血，男性型秃发和头部损伤也是 披露 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码白细胞介素-1β转换酶凋亡蛋白酶的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

    Interleukin-1 .beta. converting enzyme like apoptotic protease-6
    2.
    发明授权
    Interleukin-1 .beta. converting enzyme like apoptotic protease-6 失效
    白细胞介素-1β转换酶如凋亡蛋白酶-6

    公开(公告)号：US6010878A

    公开(公告)日：2000-01-04

    申请号：US852936

    申请日：1997-05-08

    申请人： Vishva M. Dixit ,  Wei-Wu He ,  Kristine K. Kikly ,  Steven M. Ruben

    发明人： Vishva M. Dixit ,  Wei-Wu He ,  Kristine K. Kikly ,  Steven M. Ruben

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/55 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P31/04 ,  A61P43/00 ,  C07K14/47 ,  C07K16/40 ,  C12N5/00 ,  C12N5/10 ,  C12N9/64 ,  C12N9/99 ,  C12N15/12 ,  C12Q1/68 ,  C12R1/91 ,  C07H21/00 ,  C12N15/57 ,  C12N15/63

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00

    摘要： Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility. Antagonists against such ICE LAP-6 and their use as a therapeutic to treat Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, septic shock, sepsis, stroke, chronic inflammation, acute inflammation, CNS inflammation, osteoporosis, ischemia reperfusion injury, cell death associated with cardiovascular disease, polycystic kidney disease, apoptosis of endothelial cells in cardiovascular disease, degenerative liver disease, MS, ALS, cererbellar degeneration, ischemic injury, myocardial infarction, AIDS, myelodysplastic syndromes, aplastic anemia, male pattern baldness, and head injury damage are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the interleukin-1 beta converting enzyme apoptosis proteases and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人ICE LAP-6多肽和编码这种ICE LAP-6的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种ICE LAP-6用于治疗对病毒感染，肿瘤发生的易感性以及控制胚胎发生和组织稳态中的疾病和缺陷的方法，并且上述核酸序列可用于确定 这种敏感性。 对抗这种ICE LAP-6的拮抗剂及其作为治疗性阿尔茨海默病，帕金森病，类风湿性关节炎，败血性休克，败血症，中风，慢性炎症，急性炎症，CNS炎症，骨质疏松症，缺血再灌注损伤，与 心血管疾病，多囊肾病，心血管疾病中的内皮细胞凋亡，退行性肝病，MS，ALS，小脑变性，缺血性损伤，心肌梗塞，艾滋病，骨髓增生异常综合征，再生障碍性贫血，男性型秃发和头部损伤也是 披露 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码白细胞介素-1β转换酶凋亡蛋白酶的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

    Interleukin-1β converting enzyme like apoptotic protease-6
    3.
    发明授权
    Interleukin-1β converting enzyme like apoptotic protease-6 失效
    白细胞介素-1β转换酶如凋亡蛋白酶-6

    公开(公告)号：US07115260B2

    公开(公告)日：2006-10-03

    申请号：US10961148

    申请日：2004-10-12

    申请人： Vishva M. Dixit ,  Wei-Wu He ,  Kristine K. Kikly ,  Steven M. Ruben

    发明人： Vishva M. Dixit ,  Wei-Wu He ,  Kristine K. Kikly ,  Steven M. Ruben

    IPC分类号： A61K38/17 ,  A61K38/18 ,  A61K39/00 ,  C12P21/00

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00

    摘要： Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility. Antagonists against such ICE LAP-6 and their use as a therapeutic to treat Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, septic shock, sepsis, stroke, chronic inflammation, acute inflammation, CNS inflammation, osteoporosis, ischemia reperfusion injury, cell death associated with cardiovascular disease, polycystic kidney disease, apoptosis of endothelial cells in cardiovascular disease, degenerative liver disease, MS, ALS, cererbellar degeneration, ischemic injury, myocardial infarction, AIDS, myelodysplastic syndromes, aplastic anemia, male pattern baldness, and head injury damage are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the interleukin-1 beta converting enzyme apoptosis proteases and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人ICE LAP-6多肽和编码这种ICE LAP-6的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种ICE LAP-6用于治疗对病毒感染，肿瘤发生的易感性以及控制胚胎发生和组织稳态中的疾病和缺陷的方法，并且上述核酸序列可用于确定 这种敏感性。 对抗这种ICE LAP-6的拮抗剂及其作为治疗性阿尔茨海默病，帕金森病，类风湿性关节炎，败血性休克，败血症，中风，慢性炎症，急性炎症，CNS炎症，骨质疏松症，缺血再灌注损伤，与 心血管疾病，多囊肾病，心血管疾病中的内皮细胞凋亡，退行性肝病，MS，ALS，小脑变性，缺血性损伤，心肌梗塞，艾滋病，骨髓增生异常综合征，再生障碍性贫血，男性型秃发和头部损伤也是 披露 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码白细胞介素-1β转换酶凋亡蛋白酶的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

    Interleukin-1β converting enzyme like apoptotic protease-6
    4.
    发明授权
    Interleukin-1β converting enzyme like apoptotic protease-6 有权
    白细胞介素-1β转换酶如凋亡蛋白酶-6

    公开(公告)号：US06890721B1

    公开(公告)日：2005-05-10

    申请号：US09961201

    申请日：2001-09-24

    申请人： Vishva M. Dixit ,  Wei-Wu He ,  Kristine K. Kikly ,  Steven M. Ruben

    发明人： Vishva M. Dixit ,  Wei-Wu He ,  Kristine K. Kikly ,  Steven M. Ruben

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C12N9/64 ,  C07K16/40 ,  C07K16/18 ,  C12N5/12 ,  G01N33/53 ,  C07K21/08

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00

    摘要： Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilize such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility. Antagonists against such ICE LAP-6 and their use as a therapeutic to treat Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, septic shock, sepsis, stroke, chronic inflammation, acute inflammation, CNS inflammation, osteoporosis, ischemia reperfusion injury, cell death associated with cardiovascular disease, polycystic kidney disease, apoptosis of endothelial cells in cardiovascular disease, degenerative liver disease, MS, ALS, cererbellar degeneration ischemic injury, myocardial infarction, AIDS, myelodysplastic syndromes, aplastic anemia, male pattern baldness, and head injury damage are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the interleukin-1 beta converting enzyme apoptosis proteases and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人ICE LAP-6多肽和编码这种ICE LAP-6的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种ICE LAP-6用于治疗对病毒感染，肿瘤发生的易感性以及控制胚胎发生和组织稳态中的疾病和缺陷的方法，并且上述核酸序列可用于确定 这种敏感性。 对抗这种ICE LAP-6的拮抗剂及其作为治疗性阿尔茨海默病，帕金森病，类风湿性关节炎，败血性休克，败血症，中风，慢性炎症，急性炎症，CNS炎症，骨质疏松症，缺血再灌注损伤，与 还披露了心血管疾病，多囊肾病，心血管疾病中的内皮细胞凋亡，退行性肝病，MS，ALS，小脑变性缺血性损伤，心肌梗死，AIDS，骨髓增生异常综合征，再生障碍性贫血，男性型秃发和头部损伤损伤 。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码白细胞介素-1β转换酶凋亡蛋白酶的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

    Interleukin-1 beta converting enzyme like apoptotic protease-6
    5.
    发明授权
    Interleukin-1 beta converting enzyme like apoptotic protease-6 失效
    白细胞介素-1β转换酶如凋亡蛋白酶-6

    公开(公告)号：US06294169B1

    公开(公告)日：2001-09-25

    申请号：US09300328

    申请日：1999-04-27

    申请人： Vishva M. Dixit ,  Wei-Wu He ,  Kristine K. Kikly ,  Steven M. Ruben

    发明人： Vishva M. Dixit ,  Wei-Wu He ,  Kristine K. Kikly ,  Steven M. Ruben

    IPC分类号： A61K3848

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00

    摘要： Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility. Antagonists against such ICE LAP-6 and their use as a therapeutic to treat Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, septic shock, sepsis, stroke, chronic inflammation, acute inflammation, CNS inflammation, osteoporosis, ischemia reperfusion injury, cell death associated with cardiovascular disease, polycystic kidney disease, apoptosis of endothelial cells in cardiovascular disease, degenerative liver disease, MS, ALS, cererbellar degeneration, ischemic injury, myocardial infarction, AIDS, myelodysplastic syndromes, aplastic anemia, male pattern baldness, and head injury damage are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the interleukin-1 beta converting enzyme apoptosis proteases and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人ICE LAP-6多肽和编码这种ICE LAP-6的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种ICE LAP-6用于治疗对病毒感染，肿瘤发生的易感性以及控制胚胎发生和组织稳态中的疾病和缺陷的方法，并且上述核酸序列可用于确定 这种敏感性。 对抗这种ICE LAP-6的拮抗剂及其作为治疗性阿尔茨海默病，帕金森病，类风湿性关节炎，败血性休克，败血症，中风，慢性炎症，急性炎症，CNS炎症，骨质疏松症，缺血再灌注损伤，与 心血管疾病，多囊肾病，心血管疾病中的内皮细胞凋亡，退行性肝病，MS，ALS，小脑变性，缺血性损伤，心肌梗死，艾滋病，骨髓增生异常综合征，再生障碍性贫血，男性型秃发和头部损伤也是 披露 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码白细胞介素-1β转换酶凋亡蛋白酶的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

    Death domain containing receptor 4 antibodies and methods
    6.
    发明授权
    Death domain containing receptor 4 antibodies and methods 有权
    含有受体4抗体的死亡域和方法

    公开(公告)号：US07452538B2

    公开(公告)日：2008-11-18

    申请号：US10648786

    申请日：2003-08-27

    申请人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    发明人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    IPC分类号： A61K39/395 ,  A61K38/18 ,  A61K38/19 ,  C07K16/30

    CPC分类号： C07K16/2878 ,  A61K38/00 ,  A61K39/39541 ,  C07K14/70578 ,  C07K14/7151 ,  C07K2319/30 ,  C12N2799/026 ,  Y02A50/412 ,  A61K2300/00

    摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。 本发明还涉及使用DR4特异性抗体（其可以是DR4活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。

    I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis
    7.
    发明授权
    I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis 失效
    I-FLICE，一种新型的肿瘤坏死因子受体-1抑制剂和CD-95诱导的细胞凋亡

    公开(公告)号：US06680171B1

    公开(公告)日：2004-01-20

    申请号：US09489155

    申请日：2000-01-21

    申请人： Jian Ni ,  Craig A. Rosen ,  Vishva M. Dixit ,  Reiner L. Gentz ,  Joseph J. Kenny

    发明人： Jian Ni ,  Craig A. Rosen ,  Vishva M. Dixit ,  Reiner L. Gentz ,  Joseph J. Kenny

    IPC分类号： C07H2104

    CPC分类号： C12N9/6475 ,  A61K38/00

    摘要： The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of INFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.

    摘要翻译： 本发明涉及一种新型的I-FLICE-1或I-FLICE-2蛋白，其是INFR-1和CD-95诱导的凋亡的新型抑制剂。 特别地，提供编码人I-FLICE-1或I-FLICE-2蛋白的分离的核酸分子。 还提供I-FLICE-1或I-FLICE-2多肽，载体，宿主细胞和用于制备它的重组方法。 本发明还涉及用于鉴定I-FLICE-1或I-FLICE-2活性的激动剂和拮抗剂的筛选方法。 还提供了用于治疗与凋亡相关的疾病和病症的治疗方法。

    I-flice, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis
    8.
    发明授权
    I-flice, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis 失效
    I-flice，一种新型的肿瘤坏死因子受体-1抑制剂和CD-95诱导的细胞凋亡

    公开(公告)号：US06623938B2

    公开(公告)日：2003-09-23

    申请号：US09009893

    申请日：1998-01-21

    申请人： Jian Ni ,  Craig A. Rosen ,  Vishva M. Dixit ,  Reiner L. Gentz ,  Joseph J. Kenny

    发明人： Jian Ni ,  Craig A. Rosen ,  Vishva M. Dixit ,  Reiner L. Gentz ,  Joseph J. Kenny

    IPC分类号： C12P2106

    CPC分类号： C12N9/6475 ,  A61K38/00

    摘要： The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of TNFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.

    摘要翻译： 本发明涉及一种新型的I-FLICE-1或I-FLICE-2蛋白，其是TNFR-1和CD-95诱导的细胞凋亡的新型抑制剂。 特别地，提供编码人I-FLICE-1或I-FLICE-2蛋白的分离的核酸分子。 还提供I-FLICE-1或I-FLICE-2多肽，载体，宿主细胞和用于制备它的重组方法。 本发明还涉及用于鉴定I-FLICE-1或I-FLICE-2活性的激动剂和拮抗剂的筛选方法。 还提供了用于治疗与凋亡相关的疾病和病症的治疗方法。

    Death domain containing receptor 4 nucleic acids and methods
    9.
    发明授权
    Death domain containing receptor 4 nucleic acids and methods 失效
    含有受体4核酸的死亡域和方法

    公开(公告)号：US06342363B1

    公开(公告)日：2002-01-29

    申请号：US09013895

    申请日：1998-01-27

    申请人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    发明人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    IPC分类号： G01N3353

    CPC分类号： C07K14/70578

    摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法。