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1.发明授权公开(公告)号：US09539233B2
公开(公告)日：2017-01-10
申请号：US12772854
申请日：2010-05-03
申请人： Satoshi Ohtake , Vu Truong-Le , David Lechuga-Ballesteros , Luisa Yee , Binh Pham , Russell Martin , Atul Saxena
发明人： Satoshi Ohtake , Vu Truong-Le , David Lechuga-Ballesteros , Luisa Yee , Binh Pham , Russell Martin , Atul Saxena
CPC分类号： A61K31/28 , A61K9/0078 , A61K9/08 , A61K9/14 , A61K9/1617 , A61K9/1623 , A61K33/24 , A61K47/12 , Y02A50/473 , Y10T428/2982
摘要： A method and composition for treatment of bacterial infections caused by gram negative or gram positive bacteria such as Staphylococcus aureus, Rhodococcus equi, Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a formulation containing gallium (III), in a pharmaceutically acceptable salt or complex thereof.
摘要翻译： 用于治疗由革兰氏阴性或革兰氏阳性细菌如金黄色葡萄球菌，马氏体球菌，结核分枝杆菌，大肠杆菌，肺炎克雷伯菌，克雷伯杆菌，铜绿假单胞菌，流感嗜血杆菌，奇异变形杆菌，肠杆菌属，沙雷氏菌属引起的细菌感染的方法和组合物 粘膜结肠炎以及由伯克霍克伯克伯克霍尔德氏菌，嗜麦芽寡养单胞菌，产碱杆菌xylosoxidans和多药耐药铜绿假单胞菌引起的那些，其使用含有镓（III）的制剂在其药学上可接受的盐或复合物中。
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公开(公告)号：US20110243988A1
公开(公告)日：2011-10-06
申请号：US12896165
申请日：2010-10-01
IPC分类号： A61K39/165 , A61K39/00 , A61K39/12 , A61K39/02 , A61K39/112 , A61K39/235 , A61K39/15 , A61P37/02
CPC分类号： A61K39/165 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1658 , A61K39/0275 , A61K39/12 , A61K2039/522 , A61K2039/55505 , Y02A50/482 , Y02A50/484
摘要： This invention provides compositions and methods for stabilizing a live attenuated virus in dried formulations. In particular, compositions and methods of preparing a dried vaccine are provided that stabilize the viability of live vaccines such as measles and adenovirus at room temperature.
摘要翻译： 本发明提供用于在干燥制剂中稳定活减毒病毒的组合物和方法。 特别地，提供了制备干燥疫苗的组合物和方法，其在室温下稳定活疫苗如麻疹和腺病毒的活力。
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3.发明申请GALLIUM FORMULATION FOR THE TREATMENT AND PREVENTION OF INFECTIOUS DISEASES 有权用于治疗和预防感染性疾病的GALLIUM配方公开(公告)号：US20120148635A1
公开(公告)日：2012-06-14
申请号：US13318774
申请日：2010-05-04
申请人： Satoshi Ohtake , Vu Truong-Le , David Lechuga-Ballesteros , Luisa Yee , Binh V. Pham , Russel Martin , Atul Saxena
发明人： Satoshi Ohtake , Vu Truong-Le , David Lechuga-Ballesteros , Luisa Yee , Binh V. Pham , Russel Martin , Atul Saxena
CPC分类号： A61K31/28 , A61K9/0078 , A61K9/08 , A61K9/14 , A61K9/1617 , A61K9/1623 , A61K33/24 , A61K47/12 , Y02A50/473 , Y10T428/2982
摘要： A method and composition for treatment of bacterial infections caused by gram negative or gram positive bacteria such as Staphylococcus aureus, Rhodococcus equi, Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a formulation containing gallium (III), in a pharmaceutically acceptable salt or complex thereof.
摘要翻译： 用于治疗由革兰氏阴性或革兰氏阳性细菌如金黄色葡萄球菌，马氏体球菌，结核分枝杆菌，大肠杆菌，肺炎克雷伯菌，克雷伯杆菌，铜绿假单胞菌，流感嗜血杆菌，奇异变形杆菌，肠杆菌属，沙雷氏菌属引起的细菌感染的方法和组合物 粘膜结肠炎以及由伯克霍克伯克伯克霍尔德氏菌，嗜麦芽寡养单胞菌，产碱杆菌xylosoxidans和多药耐药铜绿假单胞菌引起的那些，其使用含有镓（III）的制剂在其药学上可接受的盐或复合物中。
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公开(公告)号：US20100226939A1
公开(公告)日：2010-09-09
申请号：US12733920
申请日：2008-09-24
CPC分类号： A61K39/15 , A61K39/12 , A61K2039/542 , C12N2720/12334
摘要： This invention provides formulations and methods for stabilizing viruses in liquid and dried formulations. In particular, formulations are provided including Zn2+ cations that stabilize the viability of Rotaviruses. Methods of vaccination include neutralization of gastric contents and administration of the vaccine formulations of the invention.
摘要翻译： 本发明提供用于在液体和干燥制剂中稳定病毒的制剂和方法。 特别地，提供了包括稳定轮状病毒活力的Zn 2+阳离子的制剂。 接种疫苗的方法包括中和胃内容物和施用本发明的疫苗制剂。
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5.发明授权公开(公告)号：US08637090B2
公开(公告)日：2014-01-28
申请号：US13318774
申请日：2010-05-04
申请人： Satoshi Ohtake , Vu Truong-Le , David Lechuga-Ballesteros , Luisa Yee , Binh V Pham , Russell Martin , Atul Saxena
发明人： Satoshi Ohtake , Vu Truong-Le , David Lechuga-Ballesteros , Luisa Yee , Binh V Pham , Russell Martin , Atul Saxena
IPC分类号： A61K33/24
CPC分类号： A61K31/28 , A61K9/0078 , A61K9/08 , A61K9/14 , A61K9/1617 , A61K9/1623 , A61K33/24 , A61K47/12 , Y02A50/473 , Y10T428/2982
摘要： A method and composition for treatment of bacterial infections caused by gram negative or gram positive bacteria such as Staphylococcus aureus, Rhodococcus equi, Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a formulation containing gallium (III), in a pharmaceutically acceptable salt or complex thereof.
摘要翻译： 用于治疗由革兰氏阴性或革兰氏阳性细菌如金黄色葡萄球菌，马氏体球菌，结核分枝杆菌，大肠杆菌，肺炎克雷伯菌，克雷伯杆菌，铜绿假单胞菌，流感嗜血杆菌，奇异变形杆菌，肠杆菌属，沙雷氏菌属引起的细菌感染的方法和组合物 粘膜结肠炎以及由伯克霍克伯克伯克霍尔德氏菌，嗜麦芽寡养单胞菌，产碱杆菌xylosoxidans和多药耐药铜绿假单胞菌引起的那些，其使用含有镓（III）的制剂在其药学上可接受的盐或复合物中。
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公开(公告)号：US08241886B2
公开(公告)日：2012-08-14
申请号：US12733920
申请日：2008-09-24
CPC分类号： A61K39/15 , A61K39/12 , A61K2039/542 , C12N2720/12334
摘要： This invention provides formulations and methods for stabilizing viruses in liquid and dried formulations. In particular, formulations are provided including Zn2+ cations that stabilize the viability of Rotaviruses. Methods of vaccination include neutralization of gastric contents and administration of the vaccine formulations of the invention.
摘要翻译： 本发明提供用于在液体和干燥制剂中稳定病毒的制剂和方法。 特别地，提供了包括稳定轮状病毒活力的Zn 2+阳离子的制剂。 接种疫苗的方法包括中和胃内容物和施用本发明的疫苗制剂。
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7.发明申请公开(公告)号：US20120128729A1
公开(公告)日：2012-05-24
申请号：US12772854
申请日：2010-05-03
申请人： Satoshi Ohtake , David Lechuga-Ballesteros , Vu Truong-Le , Luisa Yee , Binh V. Pham , Russell Martin , Atul Saxena
发明人： Satoshi Ohtake , David Lechuga-Ballesteros , Vu Truong-Le , Luisa Yee , Binh V. Pham , Russell Martin , Atul Saxena
IPC分类号： A61K9/14 , A61K31/28 , A61P31/00 , B32B5/16 , A61P31/12 , A61P31/10 , A61P33/02 , A61K33/24 , C07F5/00 , A61P31/04
CPC分类号： A61K31/28 , A61K9/0078 , A61K9/08 , A61K9/14 , A61K9/1617 , A61K9/1623 , A61K33/24 , A61K47/12 , Y02A50/473 , Y10T428/2982
摘要： A method and composition for treatment of bacterial infections caused by gram negative or gram positive bacteria such as Staphylococcus aureus, Rhodococcus equi, Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a formulation containing gallium (III), in a pharmaceutically acceptable salt or complex thereof.
摘要翻译： 用于治疗由革兰氏阴性或革兰氏阳性细菌如金黄色葡萄球菌，马氏体球菌，结核分枝杆菌，大肠杆菌，肺炎克雷伯菌，克雷伯杆菌，铜绿假单胞菌，流感嗜血杆菌，奇异变形杆菌，肠杆菌属，沙雷氏菌属引起的细菌感染的方法和组合物 粘膜结肠炎以及由伯克霍克伯克伯克霍尔德氏菌，嗜麦芽寡养单胞菌，产碱杆菌xylosoxidans和多药耐药铜绿假单胞菌引起的那些，其使用含有镓（III）的制剂在其药学上可接受的盐或复合物中。
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8.发明申请Formulation for room temperature stabilization of a live attenuated bacterial vaccine 审中-公开活减毒细菌疫苗的室温稳定化配方公开(公告)号：US20110064723A1
公开(公告)日：2011-03-17
申请号：US12880213
申请日：2010-09-13
申请人： Vu Truong-Le , Satoshi Ohtake , Gary Chiueh , Russell A. Martin , Atul Saxena , Binh V. Pham , David Lechuga-Ballesteros
发明人： Vu Truong-Le , Satoshi Ohtake , Gary Chiueh , Russell A. Martin , Atul Saxena , Binh V. Pham , David Lechuga-Ballesteros
IPC分类号： A61K39/395 , A61K39/00 , A61K39/12 , A61K39/02 , A61K39/085 , A61K39/09 , A61K39/112 , A61K39/108 , A61K39/04 , A61K39/104 , A61K39/07 , A61P37/04
CPC分类号： A61K39/07 , A61K39/0208 , A61K39/0275 , A61K39/0283 , A61K39/12 , A61K39/165 , A61K47/183 , A61K47/26 , A61K47/42 , A61K2039/522 , A61K2039/523 , A61K2039/5254 , A61K2039/55505 , A61K2039/55561 , C12N7/00 , C12N2760/18411 , C12N2760/18434 , C12N2760/18451 , Y02A50/476 , Y02A50/482
摘要： This invention provides methods and compositions for stabilizing proteins and vaccines in dried formulations. In particular, a cavitation method and compositions of preparing a dried vaccine are provided that stabilize the viability of live bacteria and live virus vaccines at room temperature.
摘要翻译： 本发明提供用于在干燥制剂中稳定蛋白质和疫苗的方法和组合物。 特别地，提供空化方法和制备干燥疫苗的组合物，其在室温下稳定活细菌和活病毒疫苗的活力。
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公开(公告)号：US08673357B2
公开(公告)日：2014-03-18
申请号：US13585096
申请日：2012-08-14
申请人： Vu Truong-Le , Satoshi Ohtake , Russell Andrew Martin , Binh V. Pham , Luisa Yee
发明人： Vu Truong-Le , Satoshi Ohtake , Russell Andrew Martin , Binh V. Pham , Luisa Yee
CPC分类号： B01D1/18
摘要： This invention provides methods of spray drying pharmaceutical powders from a vibrating nozzle at low pressures. The method can effectively spray dry thick or viscous solutions or suspensions to provide small uniform particles. The invention includes dry particle compositions prepared by methods of low pressure spraying from vibrating nozzles.
摘要翻译： 本发明提供了在低压下从振动喷嘴喷雾干燥药物粉末的方法。 该方法可以有效地喷洒干燥的稠粘或粘稠溶液或悬浮液以提供小的均匀颗粒。 本发明包括通过从振动喷嘴进行低压喷射的方法制备的干燥颗粒组合物。
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公开(公告)号：US08268354B2
公开(公告)日：2012-09-18
申请号：US12266493
申请日：2008-11-06
申请人： Vu Truong-Le , Satoshi Ohtake , Russell Andrew Martin , Binh V. Pham , Luisa Yee
发明人： Vu Truong-Le , Satoshi Ohtake , Russell Andrew Martin , Binh V. Pham , Luisa Yee
CPC分类号： B01D1/18
摘要： This invention provides methods of spray drying pharmaceutical powders from a vibrating nozzle at low pressures. The method can effectively spray dry thick or viscous solutions or suspensions to provide small uniform particles. The invention includes dry particle compositions prepared by methods of low pressure spraying from vibrating nozzles.
摘要翻译： 本发明提供了在低压下从振动喷嘴喷雾干燥药物粉末的方法。 该方法可以有效地喷洒干燥的稠粘或粘稠溶液或悬浮液以提供小的均匀颗粒。 本发明包括通过从振动喷嘴进行低压喷射的方法制备的干燥颗粒组合物。
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