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公开(公告)号：US5811517A
公开(公告)日：1998-09-22
申请号：US483389
申请日：1995-06-07
IPC分类号： A61K38/00 , A61K39/00 , C07K14/705 , C07K16/28 , C12N15/12 , C12N15/85 , C12P21/08 , C12Q1/68 , G01N33/68 , C07K19/00 , C12N15/62
CPC分类号： C12N15/8509 , A01K67/0276 , C07K14/70525 , C07K16/28 , C07K16/2821 , G01N33/6896 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A61K38/00 , A61K39/00 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2319/00 , C07K2319/30 , C12N2799/026 , Y10S436/811
摘要： DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated "ICAM-R") and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Binding molecules specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding biological activities of ICAM-R.
摘要翻译： 公开了编码新的人细胞间粘附分子多肽（命名为“ICAM-R”）及其变体的DNA序列以及通过重组程序制备其的方法和材料。 还公开了针对ICAM-R及其变体的特异性结合分子，可用于从天然细胞来源分离ICAM-R和ICAM-R的配体/受体结合生物活性的调节。
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公开(公告)号：US5663293A
公开(公告)日：1997-09-02
申请号：US433010
申请日：1995-05-03
IPC分类号： A61K35/12 , A01K67/027 , A61K38/00 , A61K39/00 , A61K39/395 , A61P29/00 , A61P37/00 , A61P37/02 , C07K14/705 , C07K14/78 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/85 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/577 , G01N33/68
CPC分类号： A01K67/0271 , C07K14/70525 , C07K16/28 , C07K16/2821 , C12N15/8509 , C12Q1/6876 , C12Q1/6883 , C12Q1/6886 , G01N33/6896 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2267/03 , A61K38/00 , A61K39/00 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2319/00 , C07K2319/30 , C12N2799/026 , C12Q2600/158
摘要： DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated "ICAM-R") and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Binding molecules specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding biological activities of ICAM-R.
摘要翻译： 公开了编码新的人细胞间粘附分子多肽（命名为“ICAM-R”）及其变体的DNA序列以及通过重组程序制备其的方法和材料。 还公开了针对ICAM-R及其变体的特异性结合分子，可用于从天然细胞来源分离ICAM-R和ICAM-R的配体/受体结合生物活性的调节。
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3.发明授权Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein 失效识别ICAM相关蛋白的蛋白激酶C磷酸化调节剂的方法
公开(公告)号：US5989843A
公开(公告)日：1999-11-23
申请号：US720420
申请日：1996-09-27
IPC分类号： A01K67/027 , A61K38/00 , C07K14/705 , C07K16/28 , C12N15/85 , G01N33/68 , C12Q1/48
CPC分类号： C12N15/8509 , A01K67/0271 , C07K14/70525 , C07K16/28 , C07K16/2821 , G01N33/6896 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2267/03 , A01K2267/0368 , A61K38/00 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2319/00 , C07K2319/30 , C12N2799/026
摘要： Modulators of protein kinase C phosphorylation of human intercellular adhesion molecule polypeptide (designated "ICAM-R") are identified through novel methods.
摘要翻译： 通过新的方法鉴定人细胞间粘附分子多肽（称为“ICAM-R”）的蛋白激酶C磷酸化的调节剂。
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公开(公告)号：US5532127A
公开(公告)日：1996-07-02
申请号：US314362
申请日：1994-09-28
IPC分类号： A61K38/00 , A61K39/00 , C07K14/705 , C07K16/28 , C12N15/85 , C12Q1/68 , G01N33/68 , C07H17/00 , C07K14/725
CPC分类号： C12N15/8509 , C07K14/70525 , C07K16/28 , C07K16/2821 , C12Q1/6876 , G01N33/6896 , A01K2217/05 , A01K2267/03 , A61K38/00 , A61K39/00 , C07K2317/24 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2799/026 , C12Q2600/158
摘要： DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated "ICAM-R") and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Antibodies substances specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding reactions involving ICAM-R.
摘要翻译： 公开了编码新的人细胞间粘附分子多肽（命名为“ICAM-R”）及其变体的DNA序列以及通过重组程序制备其的方法和材料。 还公开了针对ICAM-R及其变体的特异性抗体物质，既可用于分离天然细胞来源的ICAM-R和涉及ICAM-R的配体/受体结合反应的调节。
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5.发明授权Method for monitoring an inflammatory disease state by detecting circulating ICAM-R 失效通过检测循环ICAM-R来监测炎性疾病状态的方法
公开(公告)号：US5869262A
公开(公告)日：1999-02-09
申请号：US473503
申请日：1995-06-07
IPC分类号： A61K38/00 , A61K39/00 , C07K14/705 , C07K16/28 , C12N15/12 , C12N15/85 , C12P21/08 , C12Q1/68 , G01N33/68 , G01N33/53
CPC分类号： C12N15/8509 , A01K67/0276 , C07K14/70525 , C07K16/28 , C07K16/2821 , G01N33/6896 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A61K38/00 , A61K39/00 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2319/00 , C07K2319/30 , C12N2799/026 , Y10S436/811
摘要： Methods for monitoring the progression of systemic lupus erythematosus (SLE) in a patient by detecting elevated levels of circulating ICAM-R wherein progression is indicated in an SLE patient whose circulating ICAM-R levels are increased as compared to normal individuals or individuals with in active SLE. Methods for the detection of an inflammatory disease state selected from the group consisting of rheumatoid arthritis, SLE, and Guillain-Barre syndrome and multiple sclerosis in a patient by detecting elevated levels of circulating ICAM-R wherein the presence of the inflammatory disease state is indicated in a patient whose circulating ICAM-R levels are increased as compared to normal healthy individuals. ICAM-R is also known as ICAM-3 and CDw50 in the art.
摘要翻译： 通过检测循环ICAM-R的升高水平来监测患者系统性红斑狼疮（SLE）进展的方法，其中进展在SLE患者中显示，其中循环ICAM-R水平与具有活性的正常个体或个体相比增加 SLE。 用于通过检测指示炎性疾病状态的存在的循环ICAM-R的升高水平来检测选自由类风湿性关节炎，SLE和吉兰 - 巴利综合征组成的组和多发性硬化的炎性疾病状态的方法 在与正常健康人相比，循环ICAM-R水平升高的患者中。 ICAM-R在本领域中也被称为ICAM-3和CDw50。
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6.发明授权Method to identify compounds which modulate ICAM-related protein interactions 失效识别调节ICAM相关蛋白相互作用的化合物的方法
公开(公告)号：US5773218A
公开(公告)日：1998-06-30
申请号：US482882
申请日：1995-06-07
IPC分类号： A61K38/00 , A61K39/00 , C07K14/705 , C07K16/28 , C12N15/12 , C12N15/85 , C12P21/08 , C12Q1/68 , G01N33/68
CPC分类号： C12N15/8509 , A01K67/0276 , C07K14/70525 , C07K16/28 , C07K16/2821 , G01N33/6896 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A61K38/00 , A61K39/00 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2319/00 , C07K2319/30 , C12N2799/026 , Y10S436/811
摘要： DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated "ICAM-R") and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Binding molecules specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding biological activities of ICAM-R.
摘要翻译： 公开了编码新的人细胞间粘附分子多肽（命名为“ICAM-R”）及其变体的DNA序列以及通过重组程序制备其的方法和材料。 还公开了针对ICAM-R及其变体的特异性结合分子，可用于从天然细胞来源分离ICAM-R和ICAM-R的配体/受体结合生物活性的调节。
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公开(公告)号：US06818743B1
公开(公告)日：2004-11-16
申请号：US08314369
申请日：1994-09-28
IPC分类号： C07K1400
CPC分类号： G01N33/6896 , A01K2217/05 , A01K2267/03 , A61K38/00 , A61K39/00 , C07K14/70525 , C07K16/28 , C07K16/2821 , C07K2317/24 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N15/8509 , C12N2799/026
摘要： DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated “ICAM-R”) and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Antibodies substances specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding reactions involving ICAM-R.
摘要翻译： 公开了编码新的人细胞间粘附分子多肽（命名为“ICAM-R”）及其变体的DNA序列以及通过重组程序制备其的方法和材料。 还公开了针对ICAM-R及其变体的特异性抗体物质，既可用于分离天然细胞来源的ICAM-R和涉及ICAM-R的配体/受体结合反应的调节。
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8.发明授权Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions 失效包含ICAM-R多肽和免疫球蛋白恒定区的融合蛋白
公开(公告)号：US6100383A
公开(公告)日：2000-08-08
申请号：US475680
申请日：1995-06-07
CPC分类号： C07K16/28 , C07K16/2821 , C12N15/8509 , G01N33/6896 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2267/03 , A01K2267/0368 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2799/026
摘要： DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated "ICAM-R") and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Binding molecules specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding biological activities of ICAM-R.
摘要翻译： 公开了编码新的人细胞间粘附分子多肽（命名为“ICAM-R”）及其变体的DNA序列以及通过重组程序制备其的方法和材料。 还公开了针对ICAM-R及其变体的特异性结合分子，可用于从天然细胞来源分离ICAM-R和ICAM-R的配体/受体结合生物活性的调节。
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公开(公告)号：US06087130A
公开(公告)日：2000-07-11
申请号：US863790
申请日：1997-05-27
CPC分类号： C07K14/70525 , C07K16/28 , C07K16/2821 , C12N15/8509 , G01N33/68 , G01N33/6896 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0368 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2319/00 , C07K2319/30 , C12N2799/026 , G01N2500/00
摘要： Antibody substances that bind to a novel human intercellular adhesion molecule polypeptide (designated "ICAM-R") and variants thereof are disclosed along with methods and materials producing and screening the same for desired functional and binding properties. Binding molecules specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding biological activities of ICAM-R.
摘要翻译： 公开了与新型人细胞间粘附分子多肽（称为“ICAM-R”）和其变体结合的抗体物质以及产生和筛选相同的所需功能和结合性质的方法和材料。 还公开了针对ICAM-R及其变体的特异性结合分子，可用于从天然细胞来源分离ICAM-R和ICAM-R的配体/受体结合生物活性的调节。
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公开(公告)号：US5770686A
公开(公告)日：1998-06-23
申请号：US474368
申请日：1995-06-07
IPC分类号： C07K14/705 , C07K16/28 , C12N15/85 , C12P21/08 , G01N33/68
CPC分类号： C07K14/70525 , C07K16/28 , C07K16/2821 , C12N15/8509 , G01N33/68 , G01N33/6896 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0368 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2319/00 , C07K2319/30 , C12N2799/026 , G01N2500/00
摘要： DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated "ICAM-R") and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Binding molecules specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding biological activities of ICAM-R.
摘要翻译： 公开了编码新的人细胞间粘附分子多肽（命名为“ICAM-R”）及其变体的DNA序列以及通过重组程序制备其的方法和材料。 还公开了针对ICAM-R及其变体的特异性结合分子，可用于从天然细胞来源分离ICAM-R和ICAM-R的配体/受体结合生物活性的调节。
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