公开(公告)号：US20190134533A1

公开(公告)日：2019-05-09

申请号：US16182401

申请日：2018-11-06

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Timothy J. Becker ,  Frank John Marszalkowski, JR. ,  Matthew A. Lauber ,  Raymond P. Fisk ,  Mary Elizabeth Lame

IPC: B01D15/38 ,  B01D15/42 ,  B01D15/22 ,  B01D15/12 ,  B01D15/14

Abstract: The present disclosure pertains to sample preparation devices useful for affinity capture and purification that include one or more internal structures that comprise a reservoir, a well, a fluid passageway, sorbent particles, and a filter element that blocks passage of the affinity sorbent particles, which sample preparation devices combine the attributes of both dispersive and flow through designs into a single sample preparation device. The present disclosure also pertains to kits that contain and methods that use such sample preparation devices.

公开(公告)号：US20150266019A1

公开(公告)日：2015-09-24

申请号：US14434316

申请日：2013-09-25

Applicant: Waters Technologies Corporation

Inventor： Pamela J. Longenbach ,  Moon Chul Jung ,  Frank John Marszalkowski, JR.

IPC: B01L3/00

CPC classification number: B01L3/5082 ,  B01L3/502 ,  B01L2200/0631 ,  B01L2300/047 ,  B01L2300/0609 ,  B01L2300/0618 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2300/0832 ,  B01L2300/087 ,  B01L2300/105 ,  B01L2400/0457 ,  B01L2400/0478 ,  G01N1/4055 ,  G01N30/06 ,  G01N2001/4061 ,  G01N2030/062

Abstract: Described is a matrix spot processing device comprising a tubular apparatus. An absorbent media is located either separate from, or attached to, the tubular apparatus. A sample is spotted on the absorbent media. A reservoir is in the tubular apparatus. A first region of the reservoir is constructed and arranged to have an extraction solvent. A second region of the reservoir, which may or may not be the same as the first region, is constructed and arranged to receive an extract generated from an interaction between the extraction solvent and the spotted sample at the absorbent media.

Abstract translation: 描述了一种包括管状装置的矩阵点处理装置。 吸收介质与管状设备分开或连接到管状设备上。 样品被点在吸收介质上。 管状设备中有一个储存器。 储存器的第一区域被构造和布置成具有提取溶剂。 储存器的第二区域可以或可以不与第一区域相同，被构造和布置成接收由吸收介质上的提取溶剂和点样样品之间的相互作用产生的提取物。

公开(公告)号：US20220032210A1

公开(公告)日：2022-02-03

申请号：US17500460

申请日：2021-10-13

Applicant: Waters Technologies Corporation

Inventor： Pamela C. Iraneta ,  Xin Zhang ,  Frank John Marszalkowski, JR.

IPC: B01D15/38 ,  B01J20/28 ,  B01J20/287 ,  B01J20/288 ,  B01J20/32

Abstract: Disclosed is a device for a solid phase extraction comprising two or more of the sorbents to remove phospholipids and salts from a sample, to thereby eliminate matrix effects during mass spectrometry analysis. In particular, the sorbents includes at least one sorbent which is water-wettable and contains at least one hydrophobic component and at least one hydrophilic component and at least one of sorbent having a specific affinity for a matrix interference like phospholipids. Further disclosed is a method using the device of the present invention.

公开(公告)号：US20150285714A1

公开(公告)日：2015-10-08

申请号：US14679605

申请日：2015-04-06

Applicant: Waters Technologies Corporation

Inventor： Pamela J. Longenbach ,  Moon Chul Jung ,  Frank John Marszalkowski, JR. ,  Geoff Gerhardt

IPC: G01N1/10 ,  B01L3/00

CPC classification number: B01L3/502 ,  B01L3/5453 ,  B01L2300/021 ,  B01L2300/044 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2400/0478 ,  G01N1/38 ,  G01N2001/288

Abstract: Provided are devices and methods for sample collection and processing. A tubular body has a chamber closed at a first end by a thin penetrable barrier and open at a second end opposite the first end. The tubular body further includes a partition that divides the chamber into two adjacent compartments, wherein a first compartment of the two adjacent compartments has the partition facing opposite the open end of the chamber and a second compartment of the two adjacent compartments has the partition facing opposite the closed end of the chamber. The partition has one or more holes to allow passage of fluid from the first compartment into the second compartment. A tracking identification may be permanently affixed to the first end of the tubular body.

Abstract translation: 提供了用于样品收集和处理的装置和方法。 管状体具有在第一端处由薄的可穿透屏障封闭并且在与第一端相对的第二端处打开的腔室。 管状体还包括将腔室分成两个相邻隔室的隔板，其中两个相邻隔室的第一隔室具有面向腔室的开口端的隔板，并且两个相邻室的第二隔室具有面向相对的隔板 封闭的腔室。 分隔件具有一个或多个孔，以允许流体从第一隔室进入第二隔室。 跟踪识别可以永久地固定在管状体的第一端。