公开(公告)号：US11511213B2

公开(公告)日：2022-11-29

申请号：US15752121

申请日：2016-08-12

Applicant: Waters Technologies Corporation

Inventor： Jonathan L. Belanger ,  Hua Yang ,  Edouard S. P. Bouvier ,  Mathew DeLano ,  Raymond P. Fisk ,  Hillary B. Hewitson ,  Wade P. Leveille ,  Kevin Daniel Wyndham

IPC: B01D15/22 ,  G01N30/60 ,  B01D53/02 ,  C12M1/40 ,  C12M1/00 ,  B01L3/00 ,  G01N30/72 ,  G01N30/88

Abstract: Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors. A device includes a wall having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the wall includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %. A component includes a body having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the body includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %.

公开(公告)号：US10338038B2

公开(公告)日：2019-07-02

申请号：US14367245

申请日：2012-12-10

Applicant: Waters Technologies Corporation

Inventor： Peter Kirby ,  Marcos O. Peroza ,  Steven D. Trudeau ,  Ryan Hill ,  Raymond P. Fisk ,  Jonathan Belanger ,  Wade P. Leveille

IPC: G01N30/60 ,  F16L19/00 ,  B01D15/10 ,  G01N30/02 ,  G01N30/30

Abstract: A clamp assembly includes a rail configured to receive a first fluidic assembly, and a carriage slidably mounted to the rail and configured to receive a second fluidic assembly. The carriage is operable to establish a first fluid tight seal between the first fluidic assembly and a chromatography column received within the clamp assembly, and to establish a second fluid tight seal between the second fluidic assembly and the chromatography column.

公开(公告)号：US20180236379A1

公开(公告)日：2018-08-23

申请号：US15752121

申请日：2016-08-12

Applicant: Waters Technologies Corporation

Inventor： Jonathan L. Belanger ,  Hua Yang ,  Edouard S.P. Bouvier ,  Mathew DeLano ,  Raymond P. Fisk ,  Hillary B. Hewitson ,  Wade P. Leveille ,  Kevin Daniel Wyndham

IPC: B01D15/22 ,  G01N30/60 ,  C12M1/40 ,  C12M1/00

CPC classification number: B01D15/22 ,  B01D53/02 ,  B01D53/025 ,  B01D2253/1122 ,  B01L3/502753 ,  C12M21/18 ,  C12M23/20 ,  G01N30/6052 ,  G01N30/6073 ,  G01N30/6095 ,  G01N30/7266 ,  G01N2030/8831

Abstract: Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors. A device includes a wall having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the wall includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %. A component includes a body having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the body includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %.

公开(公告)号：US09211524B2

公开(公告)日：2015-12-15

申请号：US14206538

申请日：2014-03-12

Applicant: Waters Technologies Corporation

Inventor： Zhiping Jiang ,  John E. O'Gara ,  Raymond P. Fisk ,  Kevin D. Wyndham ,  Darryl W. Brousmiche

IPC: B32B27/30 ,  B01J20/285 ,  B01J20/26 ,  B01J20/28 ,  B01J20/286 ,  C08F230/08 ,  C08G77/442 ,  C08L53/00

CPC classification number: C08J9/35 ,  B01J20/26 ,  B01J20/265 ,  B01J20/28019 ,  B01J20/28042 ,  B01J20/285 ,  B01J20/286 ,  B01J2220/82 ,  C08F230/08 ,  C08G77/442 ,  C08J2329/04 ,  C08J2383/06 ,  C08L53/00 ,  C08L53/005 ,  Y10T428/2982 ,  C08L2666/02

Abstract: The present invention relates to porous inorganic/organic homogenous copolymeric hybrid material materials, including particulates and monoliths, methods for their manufacture, and uses thereof, e.g., as chromatographic separations materials.

Abstract translation: 本发明涉及多孔无机/有机均相共聚混合材料材料，包括颗粒和整料，其制造方法及其用途，例如作为色谱分离材料。

公开(公告)号：US11951417B2

公开(公告)日：2024-04-09

申请号：US17231808

申请日：2021-04-15

Applicant: Waters Technologies Corporation

Inventor： Pamela C. Iraneta ,  Stephen James Shiner ,  Raymond P. Fisk ,  Lavelay Kizekai

IPC: B01D15/20 ,  B01D15/34 ,  B01D71/06 ,  G01N30/50

CPC classification number: B01D15/20 ,  B01D15/34 ,  B01D71/06 ,  G01N30/50

Abstract: This disclosure pertains to performance enhancing conditioning and storage solvents containing low levels of buffer and salt for reproducible and improved size exclusion chromatography (SEC). In some embodiments, the present disclosure pertains to storage solvents for protein-based size exclusion chromatography that include water, a water-miscible organic solvent, a phosphate salt, and a neutral salt. In some embodiments, the present disclosure pertains to columns for protein-based size exclusion chromatography that include porous particles and such a storage solvent.

公开(公告)号：US20150323509A1

公开(公告)日：2015-11-12

申请号：US14367245

申请日：2012-12-10

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Peter Kirby ,  Marcos O. Peroza ,  Steven D. Trudeau ,  Ryan Hill ,  Raymond P. Fisk ,  Jonathan Belanger ,  Wade P. Leveille

IPC: G01N30/60 ,  B01D15/10 ,  G01N30/30 ,  G01N30/02 ,  F16L19/00

CPC classification number: G01N30/6026 ,  B01D15/10 ,  F16L19/00 ,  G01N30/02 ,  G01N30/30 ,  G01N30/6039 ,  G01N30/6047 ,  G01N2030/3061 ,  Y10T29/53917 ,  Y10T29/53952

Abstract: A clamp assembly includes a rail configured to receive a first fluidic assembly, and a carriage slidably mounted to the rail and configured to receive a second fluidic assembly. The carriage is operable to establish a first fluid tight seal between the first fluidic assembly and a chromatography column received within the clamp assembly, and to establish a second fluid tight seal between the second fluidic assembly and the chromatography column.

Abstract translation: 夹具组件包括构造成容纳第一流体组件的导轨和可滑动地安装到导轨并被构造成容纳第二流体组件的托架。 托架可操作以在第一流体组件和容纳在夹具组件内的色谱柱之间建立第一流体密封，并且在第二流体组件和色谱柱之间建立第二流体密封。

公开(公告)号：US20230201744A1

公开(公告)日：2023-06-29

申请号：US18179835

申请日：2023-03-07

Applicant: Waters Technologies Corporation

Inventor： Raymond P. Fisk ,  Timothy J. Becker ,  Mary Elizabeth Lame ,  Frank John Marszaikowski ,  Matthew A. Lauber

IPC: B01D15/38 ,  B01D15/42 ,  B01D15/14 ,  B01D15/12 ,  B01D15/22 ,  B01L3/00

CPC classification number: B01D15/3809 ,  B01D15/424 ,  B01D15/14 ,  B01D15/12 ,  B01D15/22 ,  B01L3/5023 ,  B01L2300/0681 ,  B01L2200/0631 ,  B01L3/5021 ,  B01L2400/0433 ,  B01L2400/0409 ,  B01L2300/069 ,  B01L2200/0668 ,  B01L3/0275

Abstract: The present disclosure pertains to sample preparation devices useful for affinity capture and purification that include one or more internal structures that comprise a reservoir, a well, a fluid passageway, sorbent particles, and a filter element that blocks passage of the affinity sorbent particles, which sample preparation devices combine the attributes of both dispersive and flow through designs into a single sample preparation device. The present disclosure also pertains to kits that contain and methods that use such sample preparation devices.

公开(公告)号：US11428674B2

公开(公告)日：2022-08-30

申请号：US16415181

申请日：2019-05-17

Applicant: Waters Technologies Corporation

Inventor： Peter Kirby ,  Marcos O. Peroza ,  Steven D. Trudeau ,  Ryan Hill ,  Raymond P. Fisk ,  Jonathan Belanger ,  Wade P. Leveille

IPC: G01N30/60 ,  B01D15/10 ,  G01N30/02 ,  F16L19/00 ,  G01N30/30

Abstract: A clamp assembly includes a rail configured to receive a first fluidic assembly, and a carriage slidably mounted to the rail and configured to receive a second fluidic assembly. The carriage is operable to establish a first fluid tight seal between the first fluidic assembly and a chromatography column received within the claim assembly, and to establish a second fluid tight seal between the second fluidic assembly and the chromatography column.

公开(公告)号：US20210325352A1

公开(公告)日：2021-10-21

申请号：US17231853

申请日：2021-04-15

Applicant: Waters Technologies Corporation

Inventor： Stephen James Shiner ,  Frank J. Marszalkowski, Jr. ,  Steven M. Byrd ,  Raymond P. Fisk ,  Mathew H. DeLano ,  Lavelay Kizekai

IPC: G01N30/60

Abstract: Chromatographic systems for size exclusion chromatography (SEC) are provided that comprise an inlet, an outlet, an analytic column having a first interior volume that has a first length and a first cross-sectional area normal to the first length, the first interior volume containing a first stationary phase, and a guard column having a second interior volume that has a second length and a second cross-sectional area normal to the second length, the second interior volume containing a second stationary phase. The inlet is in fluid communication with the guard column, the guard column is in fluid communication with the analytic column, and the analytic column is in fluid communication with the outlet. Moreover, the second length is smaller than the first length, and the second cross-sectional area is smaller than the first cross-sectional area.

公开(公告)号：US10800799B2

公开(公告)日：2020-10-13

申请号：US15941338

申请日：2018-03-30

Applicant: Waters Technologies Corporation

Inventor： Pamela C. Iraneta ,  Thomas H. Walter ,  Xin Zhang ,  Daniel P. Walsh ,  Kevin D. Wyndham ,  Raymond P. Fisk

IPC: B01D15/00 ,  B01J20/00 ,  G01N1/00 ,  C07F9/10 ,  B01D15/32 ,  B01J20/28 ,  B01J20/287 ,  B01J20/32 ,  B01J20/10 ,  B01D15/22 ,  B01L3/00 ,  C07K1/30 ,  G01N30/88

Abstract: Methods, kits and devices for separating phospholipids and proteins from small molecules in biochemical samples can feature an apparatus having a wetting barrier, at least one frit and a separation media. For example, an apparatus can include at least one wall defining a chamber having an exit and an entrance; a wetting barrier disposed between the exit and entrance, so as to define a separation media space located between the wetting barrier and the exit and a sample receiving area located between the wetting barrier and the entrance; and a separation media disposed adjacent to the wetting barrier and having a specific affinity for phospholipids.