-
公开(公告)号：US06316462B1
公开(公告)日：2001-11-13
申请号：US09289255
申请日：1999-04-09
IPC分类号： C07D47100
CPC分类号： A61K31/4545 , A61K31/00
摘要： Methods are provided for treating cancer, comprising administering (1) a farnesyl protein transferase inhibitor in conjunction with (2) an additional Ras signaling pathway inhibitor to induce cancer cell death and tumor regression.
摘要翻译： 提供用于治疗癌症的方法，其包括与（2）另外的Ras信号传导途径抑制剂一起施用（1）法呢基蛋白转移酶抑制剂以诱导癌细胞死亡和肿瘤消退。
-
公开(公告)号：US08679472B1
公开(公告)日：2014-03-25
申请号：US11973362
申请日：2007-10-05
申请人： Paul Reichert , Marianna Marshall Long , Alan W. Hruza , Peter Orth , Tattanahalli L. Nagabhushan
发明人： Paul Reichert , Marianna Marshall Long , Alan W. Hruza , Peter Orth , Tattanahalli L. Nagabhushan
CPC分类号： A61K38/212
摘要： This application covers a novel PEGylated interferon and a novel crystalline form of interferon which are useful, inter alia, for detailed structural analysis of interferon as well as treatment and prevention of viral infections and hyperproliferative diseases such as leukemia.
摘要翻译： 该应用涵盖了新型聚乙二醇化干扰素和干扰素的新型结晶形式，其特别用于干扰素的详细结构分析以及病毒感染和过度增殖性疾病如白血病的治疗和预防。
-
公开(公告)号：US07538093B2
公开(公告)日：2009-05-26
申请号：US11359997
申请日：2006-02-21
CPC分类号： A61K48/00
摘要： A method and pharmaceutical composition for the enhancement of transfer of a therapeutic agent to a cell wherein the therapeutic agent is formulated in a buffer comprising a compound of Formula I: wherein: n is an integer from 2-8; X1 is a cholic acid group or deoxycholic acid group; and X2 and X3 are each independently selected from the group consisting of a cholic acid group, a deoxycholic acid group, and a saccharide group, wherein the saccharide group is selected from the group consisting of pentose monosaccharide groups, hexose monosaccharide groups, pentose-pentose disaccharide groups, hexose-hexose disaccharide groups, pentose-hexose disaccharide groups, and hexose-pentose disaccharide groups; and wherein at least one of X2 and X3 is a saccharide group.
摘要翻译： 一种用于增强治疗剂转移至细胞的方法和药物组合物，其中所述治疗剂配制在包含式I化合物的缓冲液中：其中：n为2-8的整数; X1是胆酸基或脱氧胆酸基; X2和X3各自独立地选自胆酸基，脱氧胆酸基和糖基，其中所述糖基选自戊糖单糖基，己糖单糖基，戊糖 - 戊糖基 二糖基团，己糖 - 己糖二糖基团，戊糖 - 己糖二糖基团和己糖 - 六糖二糖基团; 并且其中X 2和X 3中的至少一个是糖基团。
-
公开(公告)号：US07534769B2
公开(公告)日：2009-05-19
申请号：US10055863
申请日：2002-01-22
CPC分类号： A61K31/56 , A61K31/7008 , A61K48/00 , C07J9/005 , C07J41/0061 , C12N15/87
摘要： This invention provides methods and compositions for enhancing transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents are modulating agents that can modulate a cellular activity or function when introduced into the cell. The methods and compositions are useful for introducing agents into individual cells, as well as cells that are present as a tissue or organ.
-
公开(公告)号：US4283528A
公开(公告)日：1981-08-11
申请号：US32808
申请日：1979-04-24
IPC分类号： C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07H15/236
摘要： 1-N-(R-.beta.-amino-.alpha.-hydroxypropionyl) gentamicin B, 1-N-(R-.gamma.-amino-.alpha.-hydroxybutyryl) gentamicin B, 1-N-(R-.delta.-amino-.alpha.-hydroxyvaleryl) gentamicin B and the corresponding diastereoisomers derived from the respective S-aminohydroxy acids and the acid addition salts thereof exhibit substantial antibacterial activity, especially against strains of bacteria which are resistant to gentamicin B and acid addition salts thereof.
摘要翻译： 1-N-（R-β-氨基-α-羟基丙酰基）庆大霉素B，1-N-（R-γ-氨基-α-羟基丁酰基）庆大霉素B，1-N-（R-α-氨基-α-羟基戊酰基 ）庆大霉素B和衍生自相应的S-氨基羟酸及其酸加成盐的相应的非对映异构体表现出显着的抗菌活性，特别是抗庆大霉素B及其酸加成盐的细菌菌株。
-
公开(公告)号：US08022044B2
公开(公告)日：2011-09-20
申请号：US12422807
申请日：2009-04-13
IPC分类号： A61K31/70
CPC分类号： A61K48/00
摘要： A method and pharmaceutical composition for the enhancement of transfer of a therapeutic agent to a cell wherein the therapeutic agent is formulated in a buffer comprising a compound of Formula I: wherein: n is an integer from 2-8; X1 is a cholic acid group or deoxycholic acid group; and X2 and X3 are each independently selected from the group consisting of a cholic acid group, a deoxycholic acid group, and a saccharide group, wherein the saccharide group is selected from the group consisting of pentose monosaccharide groups, hexose monosaccharide groups, pentose-pentose disaccharide groups, hexose-hexose disaccharide groups, pentose-hexose disaccharide groups, and hexose-pentose disaccharide groups; and wherein at least one of X2 and X3 is a saccharide group.
摘要翻译： 一种用于增强治疗剂转移至细胞的方法和药物组合物，其中所述治疗剂配制在包含式I化合物的缓冲液中：其中：n为2-8的整数; X1是胆酸基或脱氧胆酸基; X2和X3各自独立地选自胆酸基，脱氧胆酸基和糖基，其中所述糖基选自戊糖单糖基，己糖单糖基，戊糖 - 戊糖基 二糖基团，己糖 - 己糖二糖基团，戊糖 - 己糖二糖基团和己糖 - 六糖二糖基团; 并且其中X 2和X 3中的至少一个是糖基团。
-
公开(公告)号：US5741485A
公开(公告)日：1998-04-21
申请号：US469332
申请日：1995-06-06
IPC分类号： A61K9/00 , A61K38/00 , A61K38/21 , C07K1/14 , C07K1/36 , C07K14/52 , C07K14/555 , C07K14/56 , A61K38/19
摘要： A method for making crystals of zinc interferon alpha-2, and the use thereof in depot formulations, are disclosed.
摘要翻译： 公开了一种制备锌干扰素α-2晶体的方法及其在贮库制剂中的应用。
-
公开(公告)号：US5460956A
公开(公告)日：1995-10-24
申请号：US952840
申请日：1992-12-01
IPC分类号： A61K9/00 , A61K38/00 , A61K38/21 , C07K1/14 , C07K1/36 , C07K14/52 , C07K14/555 , C07K14/56 , C12P21/00
摘要： A method for making crystals of interferon alpha-2 and the use thereof in depot formulations are disclosed.
摘要翻译： PCT No.PCT / US91 / 03660。 371日期1992年12月1日 102（e）日期1992年12月1日PCT PCT 1991年6月3日PCT公布。 WO91 / 18927 PCT出版物 1991年12月12日，公开了一种制备干扰素α-2晶体的方法及其在贮库制剂中的用途。
-
公开(公告)号：US4828990A
公开(公告)日：1989-05-09
申请号：US908707
申请日：1986-10-10
申请人： Naoki Higashi , Shunjiro Sugimoto , Masafumi Tsujimoto , Hounai Shirasawa , Tsutomu Okada , Kazumori Yamamoto , Tattanahalli L. Nagabhushan , Paul P. Trotta
发明人： Naoki Higashi , Shunjiro Sugimoto , Masafumi Tsujimoto , Hounai Shirasawa , Tsutomu Okada , Kazumori Yamamoto , Tattanahalli L. Nagabhushan , Paul P. Trotta
IPC分类号： C12N15/09 , A61K38/21 , C07K1/14 , C07K14/52 , C07K14/555 , C07K14/57 , C12P21/00 , C12P21/02 , C12R1/19
CPC分类号： C07K14/57 , Y10S435/811 , Y10S930/142
摘要： A method of purifying a polypeptide having a physiological activity such as one having interferon activities from a culture mixture of a microorganism obtained by a recombinant DNA technique and capable of producing the polypeptide is disclosed. The method comprises subjecting the cultured cells to extraction and purification in the presence of a salt of zinc or copper and polyethyleneimine thereby inhibiting decomposition and denaturation of the polypeptide. The extracted polypeptide can be further purified by column chromatographies using a column containing an anion exchange resin, column containing a cation exchange resin and column containing a gel filtration resin.
摘要翻译： PCT No.PCT / JP85 / 00715 Sec。 371日期1986年10月10日第 102（e）日期1986年10月10日PCT 1985年12月26日PCT PCT。 第WO86 / 04067号公报 日本1986年7月17日。一种纯化具有生理活性的多肽的方法，例如具有干扰素活性的多肽，其由通过重组DNA技术获得的能够产生该多肽的微生物的培养物混合物中进行。 该方法包括在锌或铜盐和聚乙烯亚胺的存在下使培养的细胞进行提取和纯化，从而抑制多肽的分解和变性。 提取的多肽可以使用含有阴离子交换树脂的柱，含有阳离子交换树脂的柱和含有凝胶过滤树脂的柱，通过柱色谱进一步纯化。
-
10.发明授权Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby 失效使用过渡金属盐和中间体在氨基酸中选择性阻断氨基酸功能的过程
公开(公告)号：US4136254A
公开(公告)日：1979-01-23
申请号：US697297
申请日：1976-06-17
IPC分类号： C07B51/00 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07B31/00 , C07C67/00 , C07C231/02 , C07C239/00 , C07C269/00 , C07F1/00 , C07H1/00 , C07H15/22 , C07H15/222 , C07H15/224 , C07H15/23 , C07H15/232 , C07H15/234 , C07H15/236 , C07H15/238 , C07H23/00
CPC分类号： C07H23/00 , C07H15/222 , C07H15/238
摘要： Selective blocking of some amino groups in a polyamino organic compound having at least one pair of available neighboring hydroxyl and amino groups is effected by first preparing in situ transition metal salt complexes of available neighboring amino and hydroxyl group pairs in said polyamino organic compound, followed by introduction of blocking groups on the non-complexed amino groups and, finally, removing the transition metal cations from the selectively N-blocked polyamino organic compound complex to obtain a polyamino organic compound having selectively blocked amino groups.This process is particularly valuable when carrying out aminocyclitol-aminoglycoside transformations utilizing transition metal salt complexes of cupric acetate, nickel (II) acetate, cobalt (II) acetate or mixtures thereof.
-
-
-
-
-
-
-
-
-
搜索结果
29 条记录 (耗时 0.04 秒)
