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公开(公告)号:US5616555A
公开(公告)日:1997-04-01
申请号:US482168
申请日:1995-06-07
IPC分类号: C12P21/00 , A61K38/00 , C07K20060101 , C07K14/47 , C07K14/52 , C07K14/53 , C07K14/535 , C12N15/27 , C12R1/19 , A61K38/16 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号: C07K14/535 , Y10S930/145
摘要: This invention provides a crystalline form of recombinant human granulocyte-macrophage colony-stimulating factor (r-h-GM-CSF) and methods for making such crystals.
摘要翻译: 本发明提供重组人粒细胞 - 巨噬细胞集落刺激因子(r-h-GM-CSF)的结晶形式及其制备方法。
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公开(公告)号:US5109119A
公开(公告)日:1992-04-28
申请号:US362187
申请日:1989-06-06
IPC分类号: C12P21/00 , A61K38/00 , C07K20060101 , C07K14/47 , C07K14/52 , C07K14/53 , C07K14/535 , C12N15/27 , C12R1/19
CPC分类号: C07K14/535 , Y10S930/145
摘要: This invention provides a crystalline form of recombinant human granulocyte-macrophage colony-stimulating factor (r-h-GM-CSF) and methods for making such crystals.
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公开(公告)号:US5741485A
公开(公告)日:1998-04-21
申请号:US469332
申请日:1995-06-06
IPC分类号: A61K9/00 , A61K38/00 , A61K38/21 , C07K1/14 , C07K1/36 , C07K14/52 , C07K14/555 , C07K14/56 , A61K38/19
摘要: A method for making crystals of zinc interferon alpha-2, and the use thereof in depot formulations, are disclosed.
摘要翻译: 公开了一种制备锌干扰素α-2晶体的方法及其在贮库制剂中的应用。
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公开(公告)号:US5460956A
公开(公告)日:1995-10-24
申请号:US952840
申请日:1992-12-01
IPC分类号: A61K9/00 , A61K38/00 , A61K38/21 , C07K1/14 , C07K1/36 , C07K14/52 , C07K14/555 , C07K14/56 , C12P21/00
摘要: A method for making crystals of interferon alpha-2 and the use thereof in depot formulations are disclosed.
摘要翻译: PCT No.PCT / US91 / 03660。 371日期1992年12月1日 102(e)日期1992年12月1日PCT PCT 1991年6月3日PCT公布。 WO91 / 18927 PCT出版物 1991年12月12日,公开了一种制备干扰素α-2晶体的方法及其在贮库制剂中的用途。
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公开(公告)号:US4751078A
公开(公告)日:1988-06-14
申请号:US751706
申请日:1985-07-03
CPC分类号: C07K14/57 , Y10S435/811
摘要: A process is disclosed for purifying gamma interferon from various contaminants resulting from disruption of the cell in which the interferon was produced. The process provides for sequential removal of (a) nucleic acids, (b) negatively charged contaminating proteins, (c) positively charged contaminating proteins and (d) low and high molecular weight impurities.
摘要翻译: 公开了一种用于从产生干扰素的细胞破裂导致的各种污染物中纯化γ-干扰素的方法。 该方法提供(a)核酸,(b)带负电荷的污染蛋白质,(c)带正电荷的污染蛋白质和(d)低分子量和高分子量杂质的顺序去除。
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公开(公告)号:US5597900A
公开(公告)日:1997-01-28
申请号:US376536
申请日:1995-01-20
申请人: Gerald Hammond , Hung V. Le , T. L. Nagabhushan , Paul Reichert , Paul P. Trotta
发明人: Gerald Hammond , Hung V. Le , T. L. Nagabhushan , Paul Reichert , Paul P. Trotta
CPC分类号: C07K14/5406 , A61K38/00
摘要: A process for crystallizing recombinant human interleukin 4 (rhulL-4) from a solution containing a sulfate or citrate salt is described. The crystalline form is suitable for x-ray diffraction and has wide applications in several pharmaceutical processes including purification, formulation and manufacturing.
摘要翻译: 描述了从含有硫酸盐或柠檬酸盐的溶液中结晶重组人白细胞介素4(rhILL-4)的方法。 结晶形式适用于x射线衍射,并且在多种药物方法中广泛应用,包括纯化,配制和制造。
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公开(公告)号:US07888474B2
公开(公告)日:2011-02-15
申请号:US12723184
申请日:2010-03-12
申请人: Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
发明人: Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
IPC分类号: C07K14/00
CPC分类号: C07K14/82 , C07K2299/00
摘要: The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e.g., HDM2 inhibitors.
摘要翻译: 本发明涉及与各种化合物例如HDM2抑制剂复合的HDM2多肽及其突变体。
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公开(公告)号:US07705127B1
公开(公告)日:2010-04-27
申请号:US12249314
申请日:2008-10-10
申请人: Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
发明人: Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
IPC分类号: C07K14/00
CPC分类号: C07K14/82 , C07K2299/00
摘要: The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e.g., HDM2 inhibitors.
摘要翻译: 本发明涉及与各种化合物例如HDM2抑制剂复合的HDM2多肽及其突变体。
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公开(公告)号:US08440443B1
公开(公告)日:2013-05-14
申请号:US11749550
申请日:2007-05-16
申请人: Thierry O. Fischmann , Hung V. Le , Vincent S. Madison , Anthony F. Mannarino , Todd W. Mayhood , Paul Reichert , Catherine Smith , Tin-Yau Chan
发明人: Thierry O. Fischmann , Hung V. Le , Vincent S. Madison , Anthony F. Mannarino , Todd W. Mayhood , Paul Reichert , Catherine Smith , Tin-Yau Chan
IPC分类号: C12N9/12
CPC分类号: C12N9/1205 , C07K2299/00 , C07K2319/40
摘要: The present invention provides, inter alia, crystals of the MEK1 polypeptide which are particularly useful for structure based drug design as well as methods of use thereof.
摘要翻译: 本发明特别提供了特别可用于基于结构的药物设计的MEK1多肽的晶体及其使用方法。
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公开(公告)号:US5863537A
公开(公告)日:1999-01-26
申请号:US290793
申请日:1994-08-16
申请人: Barbara Dalie , Hung V. Le , Kenneth Miller , Nicholas J. Murgolo , Hanh Nguyen , Stephen Tindall , Paul J. Zavodny
发明人: Barbara Dalie , Hung V. Le , Kenneth Miller , Nicholas J. Murgolo , Hanh Nguyen , Stephen Tindall , Paul J. Zavodny
IPC分类号: A61K38/00 , A61K39/395 , A61P43/00 , C07K14/47 , C07K14/52 , C07K14/54 , C07K16/00 , C07K16/24 , C07K16/46 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/13 , C12P21/02 , C12P21/08 , C12R1/91 , A61K39/40
CPC分类号: C07K16/465 , C07K16/247 , A61K38/00 , C07K2317/24 , C07K2319/00 , C07K2319/02
摘要: Monoclonal antibodies are provided which are specific for human interleukin-4. Also provided are complementary DNAs which encode the heavy and light chain variable regions of such monoclonal antibodies and complementarity determining regions from such DNAs; and kits and methods for detecting, measuring and immunopurifying human interleukin-4, and for blocking the biological activity of human interleukin-4.
摘要翻译: PCT No.PCT / US93 / 01301 Sec。 371日期:1994年8月16日 102(e)日期1994年8月16日PCT提交1993年2月18日PCT公布。 出版物WO93 / 17106 日期1993年9月2日提供对人白细胞介素-4特异性的单克隆抗体。 还提供了编码这些单克隆抗体的重链和轻链可变区和来自这些DNA的互补决定区的互补DNA; 以及用于检测,测量和免疫人白细胞介素-4并用于阻断人白细胞介素-4的生物活性的试剂盒和方法。
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