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公开(公告)号：US20080212737A1
公开(公告)日：2008-09-04
申请号：US11911514
申请日：2006-04-12
IPC分类号： A61N5/01
CPC分类号： A61N5/1049 , A61B5/1127 , A61B6/0457 , A61N5/1037 , A61N5/107 , A61N2005/1055 , A61N2005/1059 , A61N2005/1061
摘要： Techniques for improving treatment delivered to a target site in a patient include delivering a treatment from a treatment delivery device to a target site in a patient supported by a patient support structure. During the delivery of treatment, a state of the patient is measured to produce real-time measurement data. Measuring the state is non-invasive; and the measured state is a correlated surrogate for position of the target site. Compensating movement data is determined based on the real-time measurement data to cause the target site to maintain a particular spatial relationship with the treatment delivery device. Either the treatment delivery device, or the support structure, or both, are moved based on the compensating movement data. When the delivery device alone is moved, the correlation between measured state and target site is based on partial least squares applied to pre-treatment measurements of both.
摘要翻译： 用于改善递送到患者的目标部位的治疗的技术包括将治疗从治疗递送装置递送到由患者支撑结构支撑的患者中的目标部位。 在治疗期间，测量患者的状态以产生实时测量数据。 测量状态是非侵入性的; 测量状态是目标位置位置的相关替代。 基于实时测量数据确定补偿运动数据，以使目标站点与治疗传送装置保持特定的空间关系。 基于补偿运动数据来移动治疗递送装置或支撑结构，或两者。 当单独的输送装置移动时，测量状态和目标部位之间的相关性基于应用于两者的预处理测量的偏最小二乘法。
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公开(公告)号：US08042209B2
公开(公告)日：2011-10-25
申请号：US11911514
申请日：2006-04-12
IPC分类号： A47B85/00
CPC分类号： A61N5/1049 , A61B5/1127 , A61B6/0457 , A61N5/1037 , A61N5/107 , A61N2005/1055 , A61N2005/1059 , A61N2005/1061
摘要： Techniques for improving treatment delivered to a target site in a patient include delivering a treatment from a treatment delivery device to a target site in a patient supported by a patient support structure. During the delivery of treatment, a state of the patient is measured to produce real-time measurement data. Measuring the state is non-invasive; and the measured state is a correlated surrogate for position of the target site. Compensating movement data is determined based on the real-time measurement data to cause the target site to maintain a particular spatial relationship with the treatment delivery device. Either the treatment delivery device, or the support structure, or both, are moved based on the compensating movement data. When the delivery device alone is moved, the correlation between measured state and target site is based on partial least squares applied to pre-treatment measurements of both.
摘要翻译： 用于改善递送到患者的目标部位的治疗的技术包括将治疗从治疗递送装置递送到由患者支撑结构支撑的患者中的目标部位。 在治疗期间，测量患者的状态以产生实时测量数据。 测量状态是非侵入性的; 测量状态是目标位置位置的相关替代。 基于实时测量数据确定补偿运动数据，以使目标站点与治疗传送装置保持特定的空间关系。 基于补偿运动数据来移动治疗递送装置或支撑结构，或两者。 当单独的输送装置移动时，测量状态和目标部位之间的相关性基于应用于两者的预处理测量的偏最小二乘法。
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3.发明申请SYSTEM AND METHOD FOR IRRADIATION THERAPY USING VOXEL BASED FUNCTIONAL MEASUREMENTS OF ORGANS AT RISK 有权使用基于VOXEL的风险机构功能测量进行辐射治疗的系统和方法公开(公告)号：US20160023018A1
公开(公告)日：2016-01-28
申请号：US14811207
申请日：2015-07-28
CPC分类号： A61N5/1039 , A61B5/055 , A61B5/08 , A61B5/7278 , A61B5/743 , A61B6/032 , A61B6/037 , A61B6/486 , A61B6/5211 , A61B6/5235 , A61N5/1081 , G06F19/00 , G06F19/321 , G16H30/20 , G16H30/40
摘要： A method and apparatus for irradiation therapy using voxel based function measurements of organs-at-risk (OAR). The method includes determining size and location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that relate to utility of tissue type at each voxel. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure fj at each voxel of the subset based on a corresponding value of the measurements. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function that is based on a computed dose delivered to an OAR voxel multiplied by the utility measure fj for that voxel summed over all voxels.
摘要翻译： 一种使用基于体素的风险器官功能测量（OAR）的放射治疗方法和装置。 该方法包括确定辐射装置的参考系中的多个体元的每个体素的大小和位置。 该方法还包括获得与每个体素上的组织类型的效用相关的测量。 该方法还包括确定包围风险器官（OAR）体积的体素的子集。 该方法还包括基于测量的对应值确定子集的每个体素处的效用度量f i的值。 该方法还包括确定一系列波束形状和强度，其将基于递送到OAR体素的计算剂量乘以乘以所有体素总和的体素的效用度量fj的目标函数的值最小化。
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公开(公告)号：US07578781B2
公开(公告)日：2009-08-25
申请号：US10944034
申请日：2004-09-17
IPC分类号： A61M36/00
CPC分类号： A61M37/0069 , A61N5/1007 , A61N5/1027 , A61N2005/1011
摘要： An automatic stage allows rapid and more precise needle placement for radiation therapy using implantable radioactive seeds.
摘要翻译： 自动平台允许使用可植入放射性种子进行放射治疗的快速且更精确的针放置。
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公开(公告)号：US07876882B2
公开(公告)日：2011-01-25
申请号：US12025588
申请日：2008-02-04
申请人： Robert R. Meyer , Leyuan Shi , Warren D. D'Souza
发明人： Robert R. Meyer , Leyuan Shi , Warren D. D'Souza
IPC分类号： A61N5/10
CPC分类号： A61N5/103
摘要： A novel approach to generating radiation treatment plans through a nested partitions framework provides an optimization of radiation delivery. The nested partitions approach couples beam angle selection and dose optimization to solve treatment planning problems. An optimal beam angle selection is provided to best treat tumors, while minimizing exposure to the surrounding healthy tissues.
摘要翻译： 通过嵌套分区框架生成辐射治疗计划的新方法提供了辐射递送的优化。 嵌套分区方法耦合波束角选择和剂量优化来解决治疗规划问题。 提供最佳的束角选择以最佳地治疗肿瘤，同时最小化对周围健康组织的暴露。
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6.发明申请公开(公告)号：US20080310590A1
公开(公告)日：2008-12-18
申请号：US12025588
申请日：2008-02-04
申请人： Robert R. Meyer , Leyuan Shi , Warren D. D'Souza
发明人： Robert R. Meyer , Leyuan Shi , Warren D. D'Souza
IPC分类号： A61N5/10
CPC分类号： A61N5/103
摘要： A novel approach to generating radiation treatment plans through a nested partitions framework provides an optimization of radiation delivery. The nested partitions approach couples beam angle selection and dose optimization to solve treatment planning problems. An optimal beam angle selection is provided to best treat tumors, while minimizing exposure to the surrounding healthy tissues.
摘要翻译： 通过嵌套分区框架生成辐射治疗计划的新方法提供了辐射递送的优化。 嵌套分区方法耦合波束角选择和剂量优化来解决治疗规划问题。 提供最佳的束角选择以最佳地治疗肿瘤，同时最小化对周围健康组织的暴露。
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公开(公告)号：US10828511B2
公开(公告)日：2020-11-10
申请号：US16324060
申请日：2017-08-03
申请人： Hao H. Zhang , Gokhan Kirlik , Warren D. D'Souza , Byong Young Yi
发明人： Hao H. Zhang , Gokhan Kirlik , Warren D. D'Souza , Byong Young Yi
IPC分类号： A61N5/10
摘要： A method and apparatus is presented for optimizing a treatment plan for irradiation therapy. The method includes determining voxels in a reference frame of a radiation source that rotates at an angular rate of change and emits a beam at a plurality of angles. The beam has a beam intensity and a cross sectional shape based on an aperture of a collimator at each angle. The method includes determining an initial aperture value at each angle and minimizing a single objective function subject to a constraint on an aperture rate of change to determine an aperture and beam intensity at each angle. The method also includes delivering a beam of radiation with controlled intensity at each angle based on the beam intensity and aperture and turning the beam of radiation off at an intervening angle not included in the plurality of angles.
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公开(公告)号：US20200022248A1
公开(公告)日：2020-01-16
申请号：US16491507
申请日：2018-03-08
申请人： Byong Yong Yi , Warren D. D'Souza , Ulrich Langner
发明人： Byong Yong Yi , Warren D. D'Souza , Ulrich Langner
摘要： A method for beam therapy is provided. The method includes receiving first data indicating a plurality of target volumes within a target region inside a subject for particle beam therapy relative to a particle beam outlet on a gantry for directing a particle beam from a particle beam source. The method further includes moving automatically, one or more energy modulator components to reduce an energy of the particle beam and deliver the particle beam to the target region such that a Bragg Peak is delivered to at least one target volume of the plurality of target volumes. The method further includes repeating the moving automatically as the particle beam source rotates with the gantry around the subject, without changing the energy of the particle beam at the particle beam outlet, until every target volume is subjected to a Bragg Peak.
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公开(公告)号：US09943703B2
公开(公告)日：2018-04-17
申请号：US14811207
申请日：2015-07-28
CPC分类号： A61N5/1039 , A61B5/055 , A61B5/08 , A61B5/7278 , A61B5/743 , A61B6/032 , A61B6/037 , A61B6/486 , A61B6/5211 , A61B6/5235 , A61N5/1081 , G06F19/00 , G06F19/321 , G16H30/20 , G16H30/40
摘要： A method and apparatus for irradiation therapy using voxel based function measurements of organs-at-risk (OAR). The method includes determining size and location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that relate to utility of tissue type at each voxel. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure ƒj at each voxel of the subset based on a corresponding value of the measurements. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function that is based on a computed dose delivered to an OAR voxel multiplied by the utility measure ƒj for that voxel summed over all voxels.
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10.发明申请公开(公告)号：US20170246477A1
公开(公告)日：2017-08-31
申请号：US15445073
申请日：2017-02-28
申请人： Hao H. Zhang , Gokhan Kirlik , Warren D. D'Souza
发明人： Hao H. Zhang , Gokhan Kirlik , Warren D. D'Souza
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/1039 , A61N5/1047
摘要： A method and apparatus is presented for optimizing a treatment plan for irradiation therapy. The method includes defining a single objective function based on a plurality of objective functions that are each associated with a plurality of tissue types within a subject, upper and lower bounds for each objective function and a plurality of apertures. The method also includes determining a radiation dose delivered to voxels of each tissue type based on minimizing the single objective function based on the plurality of apertures with initial values at each angle. The method also includes delivering a beam of radiation with controlled intensity and beam cross-sectional shape at each angle based on the plurality of apertures.
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