公开(公告)号：US20160167048A1

公开(公告)日：2016-06-16

申请号：US14904135

申请日：2014-08-04

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Joseph D. MICHIENZI ,  James P. MURPHY ,  Michael O. FOGWILL ,  Keith FADGEN ,  Geoff GERHARDT ,  Gary W. BERTONE

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502761 ,  B01L7/54 ,  B01L2200/0652 ,  B01L2200/12 ,  B01L2300/0883 ,  B01L2300/1805 ,  B01L2300/1811 ,  B01L2300/1894

Abstract: A microfluidic device, for use in separation systems, includes a substrate having a fluidic channel. One or more heaters made of a thick film material are integrated with the substrate and in thermal communication with the fluidic channel of the substrate. The one or more heaters produce a thermal gradient within the fluidic channel in response to a current flowing through the one or more heaters. A plurality of electrically conductive taps can be in electrically conductive contact with the one or more heaters. The plurality of electrically conductive taps provides an electrically conductive path to the one or more heaters by which an electrical supply can produce the current flowing through the one or more heaters. Alternatively, the thick film material can be ferromagnetic, and the electrical supply can use induction to cause the current to flow through the one or more heaters.

Abstract translation: 用于分离系统的微流体装置包括具有流体通道的基板。 由厚膜材料制成的一个或多个加热器与基板一体化并且与衬底的流体通道热连通。 响应于流过一个或多个加热器的电流，一个或多个加热器在流体通道内产生热梯度。 多个导电抽头可以与一个或多个加热器导电接触。 多个导电抽头提供到一个或多个加热器的导电路径，电源可以通过该导电路径产生流过一个或多个加热器的电流。 或者，厚膜材料可以是铁磁性的，并且电源可以使用感应来使电流流过一个或多个加热器。

公开(公告)号：US20190186485A1

公开(公告)日：2019-06-20

申请号：US16323637

申请日：2017-08-07

Applicant: Waters Technologies Corporation

Inventor： Jeffrey MUSACCHIO ,  Joseph D. MICHIENZI ,  Keith FADGEN

IPC: F04B53/10 ,  F16K15/14 ,  G01N30/20

CPC classification number: F16K15/142 ,  F04B53/10 ,  F16J15/3212 ,  F16K15/147 ,  F16K15/148 ,  G01N30/02 ,  G01N30/20

Abstract: A check valve includes a first valve body having a chamber in which second and third valve bodies are located. The check valve also includes a spring-energized seal disposed in the chamber. The spring-energized seal includes a compliant seal body having an annular shape and a resilient member, such as a cantered spring or O-ring, disposed in a pocket of the seal body. The resilient member applies a force to portions of the seal body to prevent the passage of fluid from a valve inlet port to a valve outlet port unless the differential fluid exceeds the cracking pressure of the check valve.

公开(公告)号：US20190094190A1

公开(公告)日：2019-03-28

申请号：US16092264

申请日：2017-04-19

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. MICHIENZI ,  Geoff Gerhardt

IPC: G01N30/68 ,  G01N30/30

Abstract: A method for detecting an analyte in a chromatography system includes performing a separation using a mobile phase that includes an organic component. The separation is performed with a primary separation module such as a chromatographic column. A first effluent, from the primary separation module, is modulated so that a fluidic plug containing an amount of the organic component and an analyte is provided to a secondary separation module where a secondary separation is performed. A second effluent, from the secondary separation module, includes temporally-resolved organic component and analyte peaks due to selective retention of the analyte. The second effluent is provided to a flame-based detector which is disabled when the organic modifier peak is received and enabled at least during the time when the analyte peak is received. Thus the analyte can be detected without interference from any response of the detector to the organic component peak.