公开(公告)号：US06696434B2

公开(公告)日：2004-02-24

申请号：US10317464

申请日：2002-12-12

申请人： Michael R. Myers ,  Wei He ,  Alfred P. Spada ,  Martin P. Maguire

发明人： Michael R. Myers ,  Wei He ,  Alfred P. Spada ,  Martin P. Maguire

IPC分类号： A61K3133

CPC分类号： C07D215/38 ,  C07D215/20 ,  C07D241/42 ,  C07D241/44 ,  C07D241/52 ,  C07D241/54 ,  C07D403/04 ,  C07D405/12 ,  C07D453/06

摘要： This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.

摘要翻译： 本发明涉及抑制血小板衍生生长因子或p56酪氨酸激酶活性的喹啉/喹喔啉化合物，包含这些化合物的药物组合物，以及这些化合物用于治疗患有或患有疾病/ 涉及细胞分化，增殖，细胞外基质产生或介体释放和/或T细胞活化和增殖的条件。

公开(公告)号：US06482834B2

公开(公告)日：2002-11-19

申请号：US09828633

申请日：2001-04-06

申请人： Alfred P. Spada ,  Wei He ,  Michael R. Myers

发明人： Alfred P. Spada ,  Wei He ,  Michael R. Myers

IPC分类号： A61K3147

CPC分类号： C07D215/20 ,  C07D215/38 ,  C07D241/42 ,  C07D241/44 ,  C07D241/52 ,  C07D241/54 ,  C07D403/04 ,  C07D405/12 ,  C07D453/06

摘要： This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.

摘要翻译： 本发明涉及抑制血小板衍生生长因子或p56lck酪氨酸激酶活性的喹啉/喹喔啉化合物，包含这些化合物的药物组合物，以及这些化合物用于治疗患有或受到涉及细胞的病症/病症的患者的用途 分化，增殖，细胞外基质产生或介质释放和/或T细胞活化和增殖。

公开(公告)号：US06852712B2

公开(公告)日：2005-02-08

申请号：US10357882

申请日：2003-02-04

申请人： Michael R. Myers ,  Wei He ,  Alfred P. Spada ,  Martin P. Maguire

发明人： Michael R. Myers ,  Wei He ,  Alfred P. Spada ,  Martin P. Maguire

IPC分类号： A61F2/84 ,  A61K31/47 ,  A61K31/495 ,  A61K31/498 ,  A61K31/5377 ,  A61M25/00 ,  A61P9/00 ,  A61P9/10 ,  A61P17/06 ,  A61P19/08 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00 ,  C07D215/20 ,  C07D215/38 ,  C07D241/42 ,  C07D241/44 ,  C07D241/52 ,  C07D241/54 ,  C07D403/04 ,  C07D405/10 ,  C07D405/12 ,  C07D453/06 ,  C07D471/08 ,  A61K31/33 ,  C07D241/36

CPC分类号： C07D215/38 ,  C07D215/20 ,  C07D241/42 ,  C07D241/44 ,  C07D241/52 ,  C07D241/54 ,  C07D403/04 ,  C07D405/12 ,  C07D453/06

摘要： This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.

摘要翻译： 本发明涉及抑制血小板衍生生长因子或p56酪氨酸激酶活性的喹啉/喹喔啉化合物，包含这些化合物的药物组合物，以及这些化合物用于治疗患有或患有疾病/ 涉及细胞分化，增殖，细胞外基质产生或介体释放和/或T细胞活化和增殖的条件。

公开(公告)号：US06245760B1

公开(公告)日：2001-06-12

申请号：US09198720

申请日：1998-11-24

申请人： Wei He ,  Michael R. Myers ,  Alfred P. Spada

发明人： Wei He ,  Michael R. Myers ,  Alfred P. Spada

IPC分类号： A61K31498

CPC分类号： C07D215/20 ,  C07D215/38 ,  C07D241/42 ,  C07D241/44 ,  C07D241/52 ,  C07D241/54 ,  C07D403/04 ,  C07D405/12 ,  C07D453/06

摘要： This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.

公开(公告)号：US06528526B1

公开(公告)日：2003-03-04

申请号：US09675746

申请日：2000-09-29

申请人： Michael R. Myers ,  Wei He ,  Alfred P. Spada ,  Martin P. Maguire

发明人： Michael R. Myers ,  Wei He ,  Alfred P. Spada ,  Martin P. Maguire

IPC分类号： A61K3133

CPC分类号： C07D215/38 ,  C07D215/20 ,  C07D241/42 ,  C07D241/44 ,  C07D241/52 ,  C07D241/54 ,  C07D403/04 ,  C07D405/12 ,  C07D453/06

摘要： This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.

公开(公告)号：US07612075B2

公开(公告)日：2009-11-03

申请号：US10628093

申请日：2003-07-25

申请人： William R. Ewing ,  Michael R. Becker ,  Yong Mi Choi-Sledeski ,  Heinz W. Pauls ,  Wei He ,  Stephen M. Condon ,  Roderick S. Davis ,  Barbara A. Hanney ,  Alfred P. Spada ,  Christopher J. Burns ,  John Z. Jiang ,  Michael R. Myers ,  Wan F. Lau ,  Aiwen Li ,  Gregory B. Poli ,  Mark A. Bobko ,  Robert L. Morris ,  Joseph M. Karpinski ,  Timothy F. Gallagher ,  Kent W. Neuenschwander ,  Robert D. Groneberg ,  Jean-Francois Sabuco

发明人： William R. Ewing ,  Michael R. Becker ,  Yong Mi Choi-Sledeski ,  Heinz W. Pauls ,  Wei He ,  Stephen M. Condon ,  Roderick S. Davis ,  Barbara A. Hanney ,  Alfred P. Spada ,  Christopher J. Burns ,  John Z. Jiang ,  Michael R. Myers ,  Wan F. Lau ,  Aiwen Li ,  Gregory B. Poli ,  Mark A. Bobko ,  Robert L. Morris ,  Joseph M. Karpinski ,  Timothy F. Gallagher ,  Kent W. Neuenschwander ,  Robert D. Groneberg ,  Jean-Francois Sabuco

IPC分类号： A61K31/497 ,  C07D401/06

CPC分类号： C07D471/04 ,  C07D241/08 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D495/04

摘要： This invention is directed to oxoazaheterocycyl compounds which inhibit Factor Xa, to oxoazaheterocycyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa.

摘要翻译： 本发明涉及将因子Xa，抑制因子Xa和因子IIa的含氮杂环化合物，包含这些化合物的药物组合物，可用于制备这些化合物的中间体，抑制因子Xa和直接抑制因子Xa的方法的含氮杂环化合物 同时直接抑制因子Xa和因子IIa的方法。

公开(公告)号：US06821962B2

公开(公告)日：2004-11-23

申请号：US10359983

申请日：2003-02-06

申请人： Michael R. Myers ,  Wei He ,  Alfred P. Spada ,  Martin P. Maguire

发明人： Michael R. Myers ,  Wei He ,  Alfred P. Spada ,  Martin P. Maguire

IPC分类号： A61K3133

CPC分类号： C07D215/38 ,  C07D215/20 ,  C07D241/42 ,  C07D241/44 ,  C07D241/52 ,  C07D241/54 ,  C07D403/04 ,  C07D405/12 ,  C07D453/06

摘要： This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.

摘要翻译： 本发明涉及抑制血小板衍生生长因子或p56酪氨酸激酶活性的喹啉/喹喔啉化合物，包含这些化合物的药物组合物，以及这些化合物用于治疗患有或患有疾病/ 涉及细胞分化，增殖，细胞外基质产生或介体释放和/或T细胞活化和增殖的条件。

公开(公告)号：US06180632B2

公开(公告)日：2001-01-30

申请号：US09198718

申请日：1998-11-24

申请人： Michael R. Myers ,  Wei He ,  Alfred P. Spada ,  Martin P. Maguire

发明人： Michael R. Myers ,  Wei He ,  Alfred P. Spada ,  Martin P. Maguire

IPC分类号： A61K31498

CPC分类号： C07D215/38 ,  C07D215/20 ,  C07D241/42 ,  C07D241/44 ,  C07D241/52 ,  C07D241/54 ,  C07D403/04 ,  C07D405/12 ,  C07D453/06

摘要： This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.

公开(公告)号：US20160351371A1

公开(公告)日：2016-12-01

申请号：US14940102

申请日：2015-11-12

申请人： Shuai Li ,  Wei He ,  Zhongwei Chen

发明人： Shuai Li ,  Wei He ,  Zhongwei Chen

IPC分类号： H01J37/145 ,  H01J37/28 ,  H01J37/21 ,  H01J37/147

CPC分类号： H01J37/145 ,  H01J37/1477 ,  H01J37/21 ,  H01J37/28 ,  H01J2237/0473 ,  H01J2237/2802

摘要： The present invention provides a scanning transmission electron microscope (STEM). In the STEM, a specimen is sandwiched between a variable axis objective lens and a variable axis collection lens. The axis of the collection lens varies along with the variation of the objective lens axis in a coordinated manner. The STEM of the invention exhibits technical merits such as large scanning field, high image resolution across the entire scanning field, and high throughput, among others.

摘要翻译： 本发明提供扫描透射电子显微镜（STEM）。 在STEM中，将样本夹在可变轴物镜和可变轴收集透镜之间。 收集透镜的轴线随着物镜轴的协调变化而变化。 本发明的STEM具有如扫描场大，整个扫描场的高图像分辨率，高通量等技术优点。

公开(公告)号：US20150335046A1

公开(公告)日：2015-11-26

申请号：US14544853

申请日：2015-02-23

申请人： Zhaohua Peng ,  Vivian Peng ,  Wei He

发明人： Zhaohua Peng ,  Vivian Peng ,  Wei He

IPC分类号： A23L1/182

CPC分类号： A21D13/047 ,  A21D13/04 ,  A21D13/06 ,  A23L7/101 ,  A23L7/143 ,  A23L7/196

摘要： The methods of the invention provide improved rice grain nutrition by manipulation of the rice starch crystalline structure leading to easier penetration of nutrients into the rice grain and enhancement of rice grains with nutrients, thereby creating enhanced rice grain products. In addition, methods of direct delivery of nutrients into rice grains are also presented.

摘要翻译： 本发明的方法通过操作大米淀粉结晶结构提供改善的稻谷营养，导致营养物质进入米粒更容易渗透，并增加米粒营养，从而产生增强的米粒产品。 此外，还提出了将营养物质直接输送到稻谷中的方法。