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    Fungal immunostimulatory compositions
    1.
    发明申请
    Fungal immunostimulatory compositions 有权
    真菌免疫刺激成分

    公开(公告)号：US20070231339A1

    公开(公告)日：2007-10-04

    申请号：US11549215

    申请日：2006-10-13

    Applicant: Alice Yu ,  John Yu ,  Kuo-I Lin ,  Wen-Bin Yang ,  Chi-Huey Wong

    Inventor： Alice Yu ,  John Yu ,  Kuo-I Lin ,  Wen-Bin Yang ,  Chi-Huey Wong

    IPC: A61K38/16 ,  A61K39/00 ,  C12N5/02

    CPC classification number: A61K36/074 ,  A61K39/39 ,  A61K2039/57 ,  C12N5/0639 ,  C12N2500/74

    Abstract: Methods are disclosed which are useful in increasing maturation of dendritic cells from CD14+ mononuclear cells, by contact with a composition comprising a fucose-containing glycoprotein fraction from Ganoderma lucidum. The extract can also be used for increasing production of a cytokine or a chemokine in a dendritic cell or CD19+ B cell. In addition, a fucose-containing glycoprotein fraction from Ganoderma lucidum can be administered to a subject identified as needing increased immunoglobulin, cytokine, or chemokine production.

    Abstract translation: 通过与含有来自灵芝的含岩藻糖的糖蛋白部分的组合物的接触，公开了可用于从CD14 + +单核细胞增加树突状细胞成熟的方法。 提取物也可用于增加树突状细胞或CD19 + B细胞中细胞因子或趋化因子的产生。 此外，来自灵芝的含岩藻糖的糖蛋白部分可以施用于被鉴定为需要增加的免疫球蛋白，细胞因子或趋化因子产生的受试者。

    Pulmonary stem cells, related methods and kits of parts
    2.
    发明申请
    Pulmonary stem cells, related methods and kits of parts 审中-公开
    肺干细胞，相关方法和成套工具

    公开(公告)号：US20070087332A1

    公开(公告)日：2007-04-19

    申请号：US11252458

    申请日：2005-10-17

    Applicant: John Yu ,  Alice Yu ,  Thai-Yen Ling

    Inventor： John Yu ,  Alice Yu ,  Thai-Yen Ling

    IPC: C12Q1/70 ,  C12N7/00 ,  C12N5/08 ,  C12N15/86

    CPC classification number: C12N7/00 ,  C12N5/0689 ,  C12N2500/25 ,  C12N2501/11 ,  C12N2760/16011 ,  C12N2770/20011

    Abstract: Isolated pulmonary stem cells, the isolated pulmonary stem cells being slowly dividing Oct-4 expressing cells forming individual colonies and able to undergoing terminal differentiation into a mature phenotype in vitro; a method to identify stem cells of a tissue; a kit for the identification of stem cell of a tissue; a method for identifying an infective agent able to infect pulmonary cells; a method for the production of a virus able to infect pulmonary cells and method for identifying a compound interfering with infection of a cell by an infective agent.

    Abstract translation: 分离的肺干细胞，分离的肺干细胞正在缓慢分化形成单个菌落的Oct-4表达细胞，并能够在体外进行末端分化成成熟表型; 识别组织干细胞的方法; 用于鉴定组织干细胞的试剂盒; 用于鉴定能够感染肺细胞的感染剂的方法; 用于生产能够感染肺细胞的病毒的方法和用于鉴定通过感染剂干扰细胞感染的化合物的方法。

    Methods and systems for managing financial accounts
    3.
    发明申请
    Methods and systems for managing financial accounts 审中-公开
    管理财务账目的方法和系统

    公开(公告)号：US20060129471A1

    公开(公告)日：2006-06-15

    申请号：US11186278

    申请日：2005-07-21

    Applicant: Susan Moon ,  B. Ballman ,  Evan Minskoff ,  Alice Yu ,  Kevin Hung

    Inventor： Susan Moon ,  B. Ballman ,  Evan Minskoff ,  Alice Yu ,  Kevin Hung

    IPC: G06Q40/00

    CPC classification number: G06Q40/02 ,  G06Q40/00

    Abstract: Computer-implemented methods and systems for managing a special-purpose financial account involve establishing the account by a financial institution for a consumer relating to at least one consumer-designated future purchase for a pre-determined purchase price. Thereafter, contributions to a principal balance of the account are received and interest is accrued on the principal balance by the financial institution until the principal balance and accrued interest reaches a consumer-designated target amount, at which time, the principal balance and accrued interest are disposed of according to pre-defined parameters that can involve forfeiture of the accrued interest, depending on the consumer's actions.

    Abstract translation: 用于管理专用金融账户的计算机实现的方法和系统涉及由金融机构为消费者建立与至少一个消费者指定的未来购买预定购买价格的消费者的账户。 此后，收到对该账户本金余额的会费，并由金融机构在本金余额上计提利息，直至本金余额和应计利息达到消费者指定的目标金额，此时本金余额和应计利息为 根据预先定义的参数进行处置，这些参数可能涉及到没收应计利息，具体取决于消费者的行为。

    Methods and systems for implementing a group buy
    4.
    发明申请
    Methods and systems for implementing a group buy 审中-公开
    实施小组购买的方法和系统

    公开(公告)号：US20060129454A1

    公开(公告)日：2006-06-15

    申请号：US11205825

    申请日：2005-08-17

    Applicant: Susan Moon ,  Eric Yellin ,  Alice Yu ,  Kevin Hung ,  Evan Minskoff ,  B. Ballman

    Inventor： Susan Moon ,  Eric Yellin ,  Alice Yu ,  Kevin Hung ,  Evan Minskoff ,  B. Ballman

    IPC: G06Q30/00

    CPC classification number: G06Q30/02 ,  G06Q30/0255 ,  G06Q30/06 ,  G06Q30/0601

    Abstract: Methods and systems for utilizing consumer transaction data to target and aggregate consumers for a group purchase involve maintaining a database storing transaction data consisting at least in part of data related to product purchase transactions for a plurality of consumers and analyzing the data related to product purchase transactions to identify members of a group of said plurality of consumers with a purchase history indicative of a preference for purchasing products in at least one pre-defined category of products. Based on such “data mining”, each member of the identified group of consumers is provided an offer to participate in a group purchase in which each member of the group who accepts the offer agrees to purchase a pre-designated product within the at least one category of products, and a purchase of a quantity of the pre-designated product from a vendor is negotiated at a discounted price based at least on part on an aggregation of purchasing power of the members of the group who accept the offer to participate in the group purchase.

    Abstract translation: 用于利用消费者交易数据来定价和聚集消费者进行组购买的方法和系统包括维护数据库，存储至少部分由多个消费者的产品购买交易相关数据组成的数据，并分析与产品购买交易有关的数据 以具有指示在至少一个预定义类别的产品中购买产品的偏好的购买历史来识别一组所述多个消费者的成员。 基于这样的“数据挖掘”，所识别的消费群体的每个成员被提供参与群组购买的提议，其中接受该优惠的组的每个成员同意在至少一个内部购买预先指定的产品 至少部分地基于接受要约参与的组的成员的购买力的集合，以折扣价格协商商品类别和从供应商购买一定数量的预先指定的产品。 团购。

    Puf-A and related compounds for treatment of retinopathies and sight-threatening ophthalmologic disorders
    5.
    发明授权
    Puf-A and related compounds for treatment of retinopathies and sight-threatening ophthalmologic disorders 有权
    Puf-A和相关化合物用于治疗视网膜病变和眼睛威胁眼科疾病

    公开(公告)号：US09255130B2

    公开(公告)日：2016-02-09

    申请号：US13056975

    申请日：2009-07-29

    Applicant: John Yu ,  Alice Yu ,  Ming-Wei Kuo ,  Jui-Chin Chang

    Inventor： John Yu ,  Alice Yu ,  Ming-Wei Kuo ,  Jui-Chin Chang

    IPC: A61K48/00 ,  C07K14/47 ,  C07K16/18 ,  C12N15/113 ,  C12Q1/68 ,  G01N33/68

    CPC classification number: C07K14/4747 ,  A61K48/005 ,  C07K16/18 ,  C12N15/113 ,  C12N2799/025 ,  C12Q1/6876 ,  G01N33/6854

    Abstract: Methods and compositions for treating retinal diseases comprising therapeutic amounts of a compound selected from a normal Puf-A gene product, an active polypeptide fragment thereof, an analog thereof or a peptidomimetic thereof. Vectors, including AAV vectors comprising the therapeutic compound are provided. Puf-A compositions suitable for subretinal, intravitreal, topical, subconjunctival, retrobulbar, periocular, suprachoroidal, or intraocular administration are provided. Methods for screening siRNA, RNAi and shRNA, small molecules and monoclonal antibodies that inhibit Puf-A target activity and reduce apoptosis are provided.

    Abstract translation: 用于治疗视网膜疾病的方法和组合物包括治疗量的选自正常Puf-A基因产物，其活性多肽片段，其类似物或肽模拟物的化合物。 提供载体，包括包含治疗化合物的AAV载体。 提供适用于视网膜下，玻璃体内，局部，结膜下结膜，球后，眼周，脉络膜或眼内给药的Puf-A组合物。 提供了筛选siRNA，RNAi和shRNA，抑制Puf-A靶活性和减少细胞凋亡的小分子和单克隆抗体的方法。

    Alpha-galactosyl ceramide analogs and their use as immunotherapies
    7.
    发明申请
    Alpha-galactosyl ceramide analogs and their use as immunotherapies 审中-公开
    α-半乳糖基神经酰胺类似物及其作为免疫治疗的用途

    公开(公告)号：US20080260774A1

    公开(公告)日：2008-10-23

    申请号：US12082751

    申请日：2008-04-14

    Applicant: Chi-Huey Wong ,  Alice Yu ,  Ya-Jen Chang

    Inventor： Chi-Huey Wong ,  Alice Yu ,  Ya-Jen Chang

    IPC: A61K39/00 ,  A61K31/35 ,  C07D315/00 ,  A61P37/00

    CPC classification number: C07H15/26 ,  A61K8/68 ,  A61K2800/91 ,  A61Q17/005 ,  C07H15/06 ,  C07H15/18

    Abstract: The present disclosure relates to synthetic alpha-galactosyl ceramide (α-GalCer) analogs, and their use as immunotherapies. In one aspect, a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1: wherein, n is 0 to 25; X is selected from O and S; R1 is selected from H, CH3, and phenyl, where phenyl is optionally substituted with H, OH, OCH3, F, CF3, phenyl, phenyl-F, C1-C6 alkyl, or C2-C6 branched alkyl; R2 is selected from OH and H; R3 is selected from C1-C15 alkyl, and phenyl, where phenyl is optionally substituted with H, OH, OCH3, F, CF3, phenyl, C1-C6 alkyl, or C2-C6 branched alkyl; R4 is selected from OH, OSO3H, OSO3Na, and OSO3K; and R5 is selected from CH2OH and CO2H; or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.

    Abstract translation: 本公开涉及合成的α-半乳糖神经酰胺（α-GalCer）类似物，以及它们作为免疫治疗的用途。 一方面，在受试者中激活细胞因子应答的方法包括向受试者施用有效量的化合物，其中所述受试者具有包括细胞群的适应性免疫系统，所述群体包括至少一种淋巴细胞，并且在 至少一种抗原呈递细胞，并且其中所述化合物由式1的结构表示：其中n为0至25; X选自O和S; R 1选自H，CH 3和苯基，其中苯基任选被H，OH，OCH 3，F，CF 苯基，苯基-F，C 1 -C 6烷基或C 2 -C 6亚烷基 >支链烷基; R 2选自OH和H; R 3选自C 1 -C 15烷基和苯基，其中苯基任选被H，OH，OCH 3取代， 3，F，CF 3，苯基，C 1 -C 6烷基或C 2 H 2 -C 6 -C 6支链烷基; R 4选自OH，OSO 3 H，OSO 3 Na和OSO 3 K; 和R 5选自CH 2 OH和CO 2 H; 或其药学上可接受的盐; 在化合物和抗原呈递细胞之间形成复合物，其中复合物的形成导致淋巴细胞上受体的活化; 并激活淋巴细胞以产生细胞因子反应。

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