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    Fungal immunostimulatory compositions
    2.
    发明申请
    Fungal immunostimulatory compositions 有权
    真菌免疫刺激成分

    公开(公告)号：US20070231339A1

    公开(公告)日：2007-10-04

    申请号：US11549215

    申请日：2006-10-13

    申请人： Alice Yu ,  John Yu ,  Kuo-I Lin ,  Wen-Bin Yang ,  Chi-Huey Wong

    发明人： Alice Yu ,  John Yu ,  Kuo-I Lin ,  Wen-Bin Yang ,  Chi-Huey Wong

    IPC分类号： A61K38/16 ,  A61K39/00 ,  C12N5/02

    CPC分类号： A61K36/074 ,  A61K39/39 ,  A61K2039/57 ,  C12N5/0639 ,  C12N2500/74

    摘要： Methods are disclosed which are useful in increasing maturation of dendritic cells from CD14+ mononuclear cells, by contact with a composition comprising a fucose-containing glycoprotein fraction from Ganoderma lucidum. The extract can also be used for increasing production of a cytokine or a chemokine in a dendritic cell or CD19+ B cell. In addition, a fucose-containing glycoprotein fraction from Ganoderma lucidum can be administered to a subject identified as needing increased immunoglobulin, cytokine, or chemokine production.

    摘要翻译： 通过与含有来自灵芝的含岩藻糖的糖蛋白部分的组合物的接触，公开了可用于从CD14 + +单核细胞增加树突状细胞成熟的方法。 提取物也可用于增加树突状细胞或CD19 + B细胞中细胞因子或趋化因子的产生。 此外，来自灵芝的含岩藻糖的糖蛋白部分可以施用于被鉴定为需要增加的免疫球蛋白，细胞因子或趋化因子产生的受试者。

    GLOBO H AND RELATED ANTI-CANCER VACCINES WITH NOVEL GLYCOLIPID ADJUVANTS
    3.
    发明申请
    GLOBO H AND RELATED ANTI-CANCER VACCINES WITH NOVEL GLYCOLIPID ADJUVANTS 有权
    GLOBO H和相关的抗癌药物与新型甘露醇辅剂

    公开(公告)号：US20100136042A1

    公开(公告)日：2010-06-03

    申请号：US12537129

    申请日：2009-08-06

    申请人： Chi-Huey Wong ,  Chung-Yi Wu ,  Alice Yu ,  John Yu

    发明人： Chi-Huey Wong ,  Chung-Yi Wu ,  Alice Yu ,  John Yu

    IPC分类号： A61K39/385 ,  A61P35/04

    CPC分类号： A61K39/0011 ,  A61K2039/55511 ,  A61K2039/6037 ,  A61K2039/6081 ,  A61K2039/627 ,  C12N15/1137 ,  C12N2310/14

    摘要： Immunogenic compositions, cancer vaccines and methods for treating cancer are provided. Compositions comprising: (a) a glycan such as Globo H or an immunogenic fragment thereof, wherein the glycan is conjugated with a carrier protein by a linker such as para-nitrophenyl; and (b) an adjuvant comprising glycolipid capable of binding CD1d on a dendritic cell, such as an α-galactosyl-ceramide derivative, wherein the immunogenic composition induces an immune response that induces a higher relative level of IgG isotype antibodies as compared to IgM isotype antibodies, are provided. Immunogenic compositions comprising the carrier protein diphtheria toxin cross-reacting material 197 (DT-CRM197) and the adjuvant C34 are provided. Antibodies generated by immunogenic compositions disclosed herein further neutralize at least one of the antigens Globo H, stage-specific embryonic antigen-3 (SSEA-3) and stage-specific embryonic antigen-4 (SSEA-4). Therapeutics against breast cancer stem cells comprising immunogenic compositions comprising Globo H, SSEA-3 or SSEA-4 conjugated with DT-CRM197.

    摘要翻译： 提供免疫原性组合物，癌症疫苗和治疗癌症的方法。 组合物，其包含：（a）聚糖如Globo H或其免疫原性片段，其中所述聚糖通过诸如对硝基苯基之类的接头与载体蛋白缀合; 和（b）包含能够结合树突状细胞上的CD1d的糖脂如α-半乳糖基 - 神经酰胺衍生物的佐剂，其中所述免疫原性组合物诱导与IgM同种型相比诱导更高相对水平的IgG同种型抗体的免疫应答 抗体。 提供了包含载体蛋白质白喉毒素交叉反应材料197（DT-CRM197）和佐剂C34的免疫原性组合物。 由本文公开的免疫原性组合物产生的抗体进一步中和至少一种抗原Globo H，阶段特异性胚胎抗原-3（SSEA-3）和阶段特异性胚胎抗原-4（SSEA-4）。 包括含有与DT-CRM197缀合的Globo H，SSEA-3或SSEA-4的免疫原性组合物的乳腺癌干细胞的治疗剂。

    Globo H and related anti-cancer vaccines with novel glycolipid adjuvants
    6.
    发明授权
    Globo H and related anti-cancer vaccines with novel glycolipid adjuvants 有权
    Globo H和具有新型糖脂佐剂的相关抗癌疫苗

    公开(公告)号：US08268969B2

    公开(公告)日：2012-09-18

    申请号：US12537129

    申请日：2009-08-06

    申请人： Chi-Huey Wong ,  Chung-Yi Wu ,  Alice L. Yu ,  John Yu

    发明人： Chi-Huey Wong ,  Chung-Yi Wu ,  Alice L. Yu ,  John Yu

    IPC分类号： C07K16/00 ,  A01N43/04 ,  C07H17/00

    CPC分类号： A61K39/0011 ,  A61K2039/55511 ,  A61K2039/6037 ,  A61K2039/6081 ,  A61K2039/627 ,  C12N15/1137 ,  C12N2310/14

    摘要： Immunogenic compositions, cancer vaccines and methods for treating cancer are provided. Compositions comprising: (a) a glycan such as Globo H or an immunogenic fragment thereof, wherein the glycan is conjugated with a carrier protein by a linker such as para-nitrophenyl; and (b) an adjuvant comprising glycolipid capable of binding CD1d on a dendritic cell, such as an α-galactosyl-ceramide derivative, wherein the immunogenic composition induces an immune response that induces a higher relative level of IgG isotype antibodies as compared to IgM isotype antibodies, are provided. Immunogenic compositions comprising the carrier protein diphtheria toxin cross-reacting material 197 (DT-CRM197) and the adjuvant C34 are provided. Antibodies generated by immunogenic compositions disclosed herein further neutralize at least one of the antigens Globo H, stage-specific embryonic antigen-3 (SSEA-3) and stage-specific embryonic antigen-4 (SSEA-4). Therapeutics against breast cancer stem cells comprising immunogenic compositions comprising Globo H, SSEA-3 or SSEA-4 conjugated with DT-CRM197.

    摘要翻译： 提供免疫原性组合物，癌症疫苗和治疗癌症的方法。 组合物，其包含：（a）聚糖如Globo H或其免疫原性片段，其中所述聚糖通过诸如对硝基苯基之类的接头与载体蛋白缀合; 和（b）包含能够结合树突状细胞上的CD1d的糖脂如α-半乳糖基 - 神经酰胺衍生物的佐剂，其中所述免疫原性组合物诱导与IgM同种型相比诱导更高相对水平的IgG同种型抗体的免疫应答 抗体。 提供了包含载体蛋白质白喉毒素交叉反应材料197（DT-CRM197）和佐剂C34的免疫原性组合物。 由本文公开的免疫原性组合物产生的抗体进一步中和至少一种抗原Globo H，阶段特异性胚胎抗原-3（SSEA-3）和阶段特异性胚胎抗原-4（SSEA-4）。 包括含有与DT-CRM197缀合的Globo H，SSEA-3或SSEA-4的免疫原性组合物的乳腺癌干细胞的治疗剂。

    PUF-A AND RELATED COMPOUNDS FOR TREATMENT OF RETINOPATHIES AND SIGHT-THREATENING OPHTHALMOLOGIC DISORDERS
    7.
    发明申请
    PUF-A AND RELATED COMPOUNDS FOR TREATMENT OF RETINOPATHIES AND SIGHT-THREATENING OPHTHALMOLOGIC DISORDERS 有权
    PUF-A及相关化合物治疗复发性眼病和视力障碍性眼病

    公开(公告)号：US20130202678A1

    公开(公告)日：2013-08-08

    申请号：US13056975

    申请日：2008-07-29

    申请人： John Yu ,  Alice Yu ,  Ming-Wei Kuo ,  Jui-Chin Chang

    发明人： John Yu ,  Alice Yu ,  Ming-Wei Kuo ,  Jui-Chin Chang

    IPC分类号： C07K14/47 ,  G01N33/68 ,  C12Q1/68 ,  C12N15/113 ,  C07K16/18

    CPC分类号： C07K14/4747 ,  A61K48/005 ,  C07K16/18 ,  C12N15/113 ,  C12N2799/025 ,  C12Q1/6876 ,  G01N33/6854

    摘要： Methods and compositions for treating retinal diseases comprising therapeutic amounts of a compound selected from a normal Puf-A gene product, an active polypeptide fragment thereof, an analog thereof or a peptidomimetic thereof. Vectors, including AAV vectors comprising the therapeutic compound are provided. Puf-A compositions suitable for subretinal, intravitreal, topical, subconjunctival, retrobulbar, periocular, suprachoroidal, or intraocular administration are provided. Methods for screening siRNA, RNAi and shRNA, small molecules and monoclonal antibodies that inhibit Puf-A target activity and reduce apoptosis are provided.

    摘要翻译： 用于治疗视网膜疾病的方法和组合物包括治疗量的选自正常Puf-A基因产物，其活性多肽片段，其类似物或肽模拟物的化合物。 提供载体，包括包含治疗化合物的AAV载体。 提供适用于视网膜下，玻璃体内，局部，结膜下结膜，球后，眼周，脉络膜或眼内给药的Puf-A组合物。 提供了筛选siRNA，RNAi和shRNA，抑制Puf-A靶活性和减少细胞凋亡的小分子和单克隆抗体的方法。

    Puf-A and related compounds for treatment of retinopathies and sight-threatening ophthalmologic disorders
    8.
    发明授权
    Puf-A and related compounds for treatment of retinopathies and sight-threatening ophthalmologic disorders 有权
    Puf-A和相关化合物用于治疗视网膜病变和眼睛威胁眼科疾病

    公开(公告)号：US09255130B2

    公开(公告)日：2016-02-09

    申请号：US13056975

    申请日：2009-07-29

    申请人： John Yu ,  Alice Yu ,  Ming-Wei Kuo ,  Jui-Chin Chang

    发明人： John Yu ,  Alice Yu ,  Ming-Wei Kuo ,  Jui-Chin Chang

    IPC分类号： A61K48/00 ,  C07K14/47 ,  C07K16/18 ,  C12N15/113 ,  C12Q1/68 ,  G01N33/68

    CPC分类号： C07K14/4747 ,  A61K48/005 ,  C07K16/18 ,  C12N15/113 ,  C12N2799/025 ,  C12Q1/6876 ,  G01N33/6854

    摘要： Methods and compositions for treating retinal diseases comprising therapeutic amounts of a compound selected from a normal Puf-A gene product, an active polypeptide fragment thereof, an analog thereof or a peptidomimetic thereof. Vectors, including AAV vectors comprising the therapeutic compound are provided. Puf-A compositions suitable for subretinal, intravitreal, topical, subconjunctival, retrobulbar, periocular, suprachoroidal, or intraocular administration are provided. Methods for screening siRNA, RNAi and shRNA, small molecules and monoclonal antibodies that inhibit Puf-A target activity and reduce apoptosis are provided.

    摘要翻译： 用于治疗视网膜疾病的方法和组合物包括治疗量的选自正常Puf-A基因产物，其活性多肽片段，其类似物或肽模拟物的化合物。 提供载体，包括包含治疗化合物的AAV载体。 提供适用于视网膜下，玻璃体内，局部，结膜下结膜，球后，眼周，脉络膜或眼内给药的Puf-A组合物。 提供了筛选siRNA，RNAi和shRNA，抑制Puf-A靶活性和减少细胞凋亡的小分子和单克隆抗体的方法。

    Pulmonary stem cells, related methods and kits of parts
    9.
    发明申请
    Pulmonary stem cells, related methods and kits of parts 审中-公开
    肺干细胞，相关方法和成套工具

    公开(公告)号：US20070087332A1

    公开(公告)日：2007-04-19

    申请号：US11252458

    申请日：2005-10-17

    申请人： John Yu ,  Alice Yu ,  Thai-Yen Ling

    发明人： John Yu ,  Alice Yu ,  Thai-Yen Ling

    IPC分类号： C12Q1/70 ,  C12N7/00 ,  C12N5/08 ,  C12N15/86

    CPC分类号： C12N7/00 ,  C12N5/0689 ,  C12N2500/25 ,  C12N2501/11 ,  C12N2760/16011 ,  C12N2770/20011

    摘要： Isolated pulmonary stem cells, the isolated pulmonary stem cells being slowly dividing Oct-4 expressing cells forming individual colonies and able to undergoing terminal differentiation into a mature phenotype in vitro; a method to identify stem cells of a tissue; a kit for the identification of stem cell of a tissue; a method for identifying an infective agent able to infect pulmonary cells; a method for the production of a virus able to infect pulmonary cells and method for identifying a compound interfering with infection of a cell by an infective agent.

    摘要翻译： 分离的肺干细胞，分离的肺干细胞正在缓慢分化形成单个菌落的Oct-4表达细胞，并能够在体外进行末端分化成成熟表型; 识别组织干细胞的方法; 用于鉴定组织干细胞的试剂盒; 用于鉴定能够感染肺细胞的感染剂的方法; 用于生产能够感染肺细胞的病毒的方法和用于鉴定通过感染剂干扰细胞感染的化合物的方法。