公开(公告)号：US20130116560A1

公开(公告)日：2013-05-09

申请号：US13418702

申请日：2012-03-13

申请人： Wen-Shiang CHEN ,  Der-Hsien Lien ,  Chuin-Shan Chen ,  Jay Shieh ,  Chiung-Nien Chen ,  Chien-Cheng Chang ,  Yu-Chen Shu ,  Chang-Wei Huang

发明人： Wen-Shiang CHEN ,  Der-Hsien Lien ,  Chuin-Shan Chen ,  Jay Shieh ,  Chiung-Nien Chen ,  Chien-Cheng Chang ,  Yu-Chen Shu ,  Chang-Wei Huang

IPC分类号： A61B5/01 ,  A61B8/13

CPC分类号： G01S7/52036 ,  A61B5/015 ,  A61B8/00

摘要： The present application relates to an ultrasound temperature mapping system and method. The ultrasound temperature mapping system for measuring a temperature of an object comprises an ultrasound transducer and a processing module. The ultrasound transducer is configured to acquire a first image and a second image with respect to the object. The processing module implements a zero-crossing algorithm to process the first image to yield a plurality of first zero-crossing points and implements a cross-correlation algorithm to process the first image and the second images based on the plurality of first zero-crossing points so as to obtain a plurality of displacements. The processing module further calculates the temperature based on the plurality of displacements.

摘要翻译： 本申请涉及超声波温度测绘系统和方法。 用于测量物体温度的超声波温度测绘系统包括超声换能器和处理模块。 超声波换能器被配置为相对于物体获取第一图像和第二图像。 所述处理模块实施过零算法来处理所述第一图像以产生多个第一过零点，并且实现互相关算法以基于所述多个第一过零点处理所述第一图像和所述第二图像 以便获得多个位移。 处理模块还基于多个位移进一步计算温度。

公开(公告)号：US20070232912A1

公开(公告)日：2007-10-04

申请号：US11707109

申请日：2007-02-16

申请人： Chiung-Nien Chen ,  Po-Huang Lee ,  Wen-Shiang Chen ,  Ming-Chih Ho ,  Chih-Ching Wu

发明人： Chiung-Nien Chen ,  Po-Huang Lee ,  Wen-Shiang Chen ,  Ming-Chih Ho ,  Chih-Ching Wu

IPC分类号： A61B8/00

CPC分类号： A61N7/02 ,  A61B8/08 ,  G01S7/5205 ,  G01S15/899

摘要： A non-invasive positioning system for determining the focus location of a HIFU device comprises a diagnostic ultrasound and the HIFU for ablating and removing tumor tissue. The imaging plane of the diagnostic ultrasound probe and the geometrical axis of a probe of the HIFU define an inclining angle during operation. When the imaging plane of the diagnostic ultrasound intersected to the focus of the HIFU transducer, a maximal convergent interference signals was obtained, so as to position the HIFU focus within tumors for precise ablation.

摘要翻译： 用于确定HIFU装置的焦点位置的无创定位系统包括诊断超声波和用于消融和去除肿瘤组织的HIFU。 诊断超声探头的成像平面和HIFU探针的几何轴在运行过程中定义倾斜角度。 当诊断超声波的成像平面与HIFU传感器的焦点相交时，获得最大的收敛干涉信号，以将HIFU焦点定位在肿瘤内用于精确的消融。

公开(公告)号：US07955263B2

公开(公告)日：2011-06-07

申请号：US11707109

申请日：2007-02-16

申请人： Chiung-Nien Chen ,  Po-Huang Lee ,  Wen-Shiang Chen ,  Ming-Chih Ho ,  Chih-Ching Wu

发明人： Chiung-Nien Chen ,  Po-Huang Lee ,  Wen-Shiang Chen ,  Ming-Chih Ho ,  Chih-Ching Wu

IPC分类号： A61B8/00

CPC分类号： A61N7/02 ,  A61B8/08 ,  G01S7/5205 ,  G01S15/899

摘要： A non-invasive positioning system for determining the focus location of a HIFU device comprises a diagnostic ultrasound and the HIFU for ablating and removing tumor tissue. The imaging plane of the diagnostic ultrasound probe and the geometrical axis of a probe of the HIFU define an inclining angle during operation. When the imaging plane of the diagnostic ultrasound intersected to the focus of the HIFU transducer, a maximal convergent interference signals was obtained, so as to position the HIFU focus within tumors for precise ablation.

摘要翻译： 用于确定HIFU装置的焦点位置的无创定位系统包括诊断超声波和用于消融和去除肿瘤组织的HIFU。 诊断超声探头的成像平面和HIFU探针的几何轴在运行过程中定义倾斜角度。 当诊断超声波的成像平面与HIFU传感器的焦点相交时，获得最大的收敛干涉信号，以将HIFU焦点定位在肿瘤内用于精确的消融。

公开(公告)号：US20090264755A1

公开(公告)日：2009-10-22

申请号：US12107723

申请日：2008-04-22

申请人： Wen-Shiang Chen ,  Chih-Ching Wu ,  Chiung-Nien Chen ,  Ming-Chih Ho ,  Po-Huang Lee

发明人： Wen-Shiang Chen ,  Chih-Ching Wu ,  Chiung-Nien Chen ,  Ming-Chih Ho ,  Po-Huang Lee

IPC分类号： A61B8/06 ,  A61N7/02

CPC分类号： A61N7/02 ,  A61B8/4483 ,  A61B2017/00106 ,  A61B2017/00128 ,  A61B2090/378

摘要： The present invention relates to a precise blood vessel positioning and high-intensity focused ultrasound ablator by use of one ultrasound transducer.

摘要翻译： 本发明涉及通过使用一个超声换能器的精确血管定位和高强度聚焦超声波消融器。

公开(公告)号：US20080154140A1

公开(公告)日：2008-06-26

申请号：US11783447

申请日：2007-04-10

申请人： Chien-Cheng Chang ,  Po-Hsiang Tsui ,  Chien-Chung Chang ,  King-Jen Chang ,  Chung-Li Wang ,  Juey-Jen Hwang ,  Chin-Chou Chu ,  Chiung-Nien Chen ,  Lian-Yu Lin

发明人： Chien-Cheng Chang ,  Po-Hsiang Tsui ,  Chien-Chung Chang ,  King-Jen Chang ,  Chung-Li Wang ,  Juey-Jen Hwang ,  Chin-Chou Chu ,  Chiung-Nien Chen ,  Lian-Yu Lin

IPC分类号： A61B5/02

CPC分类号： A61B5/022 ,  A61B5/02007 ,  A61B5/02116 ,  A61B5/6822

摘要： A carotid pulse measurement device provided for measuring carotid pulse of a user's neck includes a band, an artery-pressing air cell, an inflating/deflating device, and a pressure detection unit. The band functions to surround the user's neck. The air cell is arranged in the band and is fluidly connected to the inflating/deflating device for selectively inflating/deflating the air cell. The pressure detection unit detects variation of pressure inside the air cell. To use the measurement device, the band is put around the user's neck with the air cell positioned exactly corresponding to the carotid artery of the neck so that the pressure detection device detects the pressure variation and generates a digital pulse signal, which is employed to calculate arteriosclerosis index of the user for evaluation the degree of arteriosclerosis of the user.

摘要翻译： 用于测量使用者颈部颈动脉脉搏的颈动脉搏动测量装置包括带，动脉压气囊，充气/放气装置和压力检测单元。 乐队的功能是围绕用户的脖子。 气囊布置在带中并且流体地连接到充气/放气装置，用于选择性地使空气室膨胀/放气。 压力检测单元检测气囊内的压力变化。 为了使用测量装置，将带放在用户颈部周围，其中气囊正好对应于颈部的颈动脉，使得压力检测装置检测压力变化并产生用于计算的数字脉冲信号 用户的动脉硬化指数用于评估用户的动脉硬化程度。

公开(公告)号：US20100304419A1

公开(公告)日：2010-12-02

申请号：US12612904

申请日：2009-11-05

申请人： Hsueh-Fen Juan ,  Chiung-Nien Chen ,  Chien-Wei Tseng ,  King-Jen Chang

发明人： Hsueh-Fen Juan ,  Chiung-Nien Chen ,  Chien-Wei Tseng ,  King-Jen Chang

IPC分类号： C12Q1/02 ,  G01N33/574 ,  G01N33/53 ,  G01N33/68 ,  C07K16/00

CPC分类号： G01N33/57446 ,  G01N2500/00 ,  G01N2800/56

摘要： The 14-3-3β protein is used herein as a tumor marker for prognosis in gastric cancer. The method comprises steps of providing a biological sample, qualifying the 14-3-3β protein level in the sample, and comparing the 14-3-3β protein level in the sample with a normal sample. Upon the 14-3-3β protein level in the biological sample is higher than in the normal sample, which represents the patient providing the sample has a poor prognosis. Having the higher sensitivity and specificity, 14-3-3β protein can be used as a tumor marker for prognosis of gastric cancer.

摘要翻译： 14-3-3＆bgr 蛋白质在本文中用作胃癌预后的肿瘤标志物。 该方法包括提供生物样品的步骤，符合14-3-3＆bgr; 样品中的蛋白质水平，并比较14-3-3＆bgr; 样品中的蛋白质水平与正常样品。 在14-3-3＆bgr 生物样品中的蛋白质水平高于正常样品，这表明提供样品的患者预后差。 具有较高的灵敏度和特异性，14-3-3＆bgr; 蛋白质可用作胃癌预后的肿瘤标志物。

公开(公告)号：US20140162950A1

公开(公告)日：2014-06-12

申请号：US13709534

申请日：2012-12-10

申请人： Cheng-Chi Chang ,  Chiung-Nien Chen ,  Hsin-Yu Li ,  Min-Liang Kuo

发明人： Cheng-Chi Chang ,  Chiung-Nien Chen ,  Hsin-Yu Li ,  Min-Liang Kuo

IPC分类号： A61K38/18

CPC分类号： A61K38/18 ,  G01N33/5088 ,  G01N33/57446 ,  G01N2800/50 ,  G01N2800/52

摘要： The present invention provides a method for inhibiting peritoneal metastasis caused by gastric cancer cells in a subject in need thereof comprising administering to the subject a pharmaceutically effective amount of a connective tissue growth factor (CTGF), wherein the CTGF binds to an integrin α3β1 of the gastric cancer cells. The present invention also provides a method for predicting peritoneal metastasis caused by gastric cancer cells in a subject comprising providing a peritoneal tissue from the subject; measuring a first expression amount of a connective tissue growth factor (CTGF) from the peritoneal tissue; and comparing the first expression amount to a reference expression amount of the CTGF from a non-peritoneal metastasis gastric cancer tissue.

摘要翻译： 本发明提供一种抑制需要治疗的受试者胃癌细胞引起的腹膜转移的方法，包括向受试者施用药学有效量的结缔组织生长因子（CTGF），其中CTGF与整联蛋白α3和bgr1结合 的胃癌细胞。 本发明还提供一种预测受试者胃癌细胞引起的腹膜转移的方法，包括从受试者提供腹膜组织; 测量来自腹膜组织的结缔组织生长因子（CTGF）的第一表达量; 并将第一表达量与来自非腹膜转移性胃癌组织的CTGF的参照表达量进行比较。

公开(公告)号：US20070048749A1

公开(公告)日：2007-03-01

申请号：US11284845

申请日：2005-11-23

申请人： Chiung-Nien Chen ,  Jen-Jen Lin ,  Fon-Jou Hsieh ,  King-Jen Chang

发明人： Chiung-Nien Chen ,  Jen-Jen Lin ,  Fon-Jou Hsieh ,  King-Jen Chang

IPC分类号： C12Q1/68 ,  G06F19/00

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118

摘要： Disclosed is a method for survival prediction in gastric cancer patents after surgical operation, which uses a survival prediction model determined by known statistical method and gene expression microarray profiles. The survival prediction model is established by selecting special genes expressing significantly differential from pairs of cancerous and noncancerous tissue samples from patients with known survival conditions after surgical operation, confirming the concordance of RT-PCR analysis with the microarray gene expression profile, identifying most specific genes among the special genes using a statistical method, and determining the survival prediction model based on training set samples. The method of the present invention can be applied in gastric cancer patients to predict survival conditions after surgical operation and to provide a strategy for succeeding treatment and a reference for adjuvant chemotherapy.

摘要翻译： 公开了一种外科手术后胃癌专利生存预测方法，该方法采用已知统计学方法和基因表达微阵列分析确定的生存预测模型。 生存预测模型是通过选择在外科手术后具有已知生存条件的患者的癌组织和非癌组织样品的表达显着差异的特异基因来确定的，证实了RT-PCR分析与微阵列基因表达谱的一致性，鉴定了大多数特异性基因 在使用统计学方法的特殊基因中，并且基于训练集样本确定生存预测模型。 本发明的方法可应用于胃癌患者，以预测手术后的生存条件，并提供后续治疗策略和辅助化疗参考。