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公开(公告)号：US08444989B1
公开(公告)日：2013-05-21
申请号：US12423658
申请日：2009-04-14
申请人： Wiliam Charles Ohnesorge , Isabelle Freiin von Richthofen , Marika Genzow , Martina von Freyburg , Carola Kissel , Luc-Etienne Fabry , Knut Elbers , Kathleen Park
发明人： Wiliam Charles Ohnesorge , Isabelle Freiin von Richthofen , Marika Genzow , Martina von Freyburg , Carola Kissel , Luc-Etienne Fabry , Knut Elbers , Kathleen Park
CPC分类号： A61K39/0241 , A61K39/40 , A61K2039/521 , A61K2039/552 , C12N1/20 , C12R1/35
摘要： The present invention provides a one phase, aqueous vaccine composition for immunizing an animal against infection by Mycoplasma hyopneumoniae, comprising: an immunizing amount of a Mycoplasma hyopneumoniae bacterin, an acrylic acid polymer in the concentration range between 0.8 and 1.2 mg/ml, and a pharmaceutically acceptable carrier, and substantially no oil. It is especially useful for immunizing a pig against infection by Mycoplasma hyopneumoniae for at least 20 weeks after a single administration, which effective immunity is reached within 4 weeks after vaccination.
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公开(公告)号：US08852613B2
公开(公告)日：2014-10-07
申请号：US13869574
申请日：2013-04-24
申请人： William Charles Ohnesorge , Isabelle Freiin von Richthofen , Marika Christine Genzow , Martina von Freyburg , Carola Kissel , Luc-Etienne Fabry , Knut Elbers , Kathleen Kwan Young Park
发明人： William Charles Ohnesorge , Isabelle Freiin von Richthofen , Marika Christine Genzow , Martina von Freyburg , Carola Kissel , Luc-Etienne Fabry , Knut Elbers , Kathleen Kwan Young Park
CPC分类号： A61K39/0241 , A61K39/40 , A61K2039/521 , A61K2039/552 , C12N1/20 , C12R1/35
摘要： The present invention provides a one phase, aqueous vaccine composition for immunizing an animal against infection by Mycoplasma hyopneumoniae, comprising: an immunizing amount of a Mycoplasma hyopneumoniae bacterin, an acrylic acid polymer in the concentration range between 0.8 and 1.2 mg/ml, and a pharmaceutically acceptable carrier, and substantially no oil. It is especially useful for immunizing a pig against infection by Mycoplasma hyopneumoniae for at least 20 weeks after a single administration, which effective immunity is reached within 4 weeks after vaccination.
摘要翻译： 本发明提供一种用于免疫动物免受猪肺炎支原体感染的单相水性疫苗组合物，其包含：免疫量的猪肺炎支原体菌苗，浓度范围为0.8-1.2mg / ml的丙烯酸聚合物和 药学上可接受的载体，基本上不含油。 在单次给药后至少20周免疫猪免于猪肺炎支原体感染特别有用，在接种后4周内有效免疫。
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公开(公告)号：US20120201850A1
公开(公告)日：2012-08-09
申请号：US13364259
申请日：2012-02-01
CPC分类号： C12N7/00 , A61K2039/5254 , A61K2039/53 , C12N2770/24361 , C12N2770/24362
摘要： The invention belongs to the field of animal health and in particular Bovine Viral Diarrhea Virus (BVDV). The invention provides infectious BVDV clones and methods to produce said BVDV clones. The invention further relates to methods of attenuating said clones, attenuated BVDV clones and vaccines comprising said attenuated clones.
摘要翻译： 本发明属于动物健康领域，特别是牛病毒性腹泻病毒（BVDV）。 本发明提供感染性BVDV克隆和产生所述BVDV克隆的方法。 本发明还涉及减毒所述克隆，减毒BVDV克隆和包含所述减毒克隆的疫苗的方法。
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公开(公告)号：US08778355B2
公开(公告)日：2014-07-15
申请号：US13364259
申请日：2012-02-01
IPC分类号： A61K39/12 , A61K39/295 , C12P19/34
CPC分类号： C12N7/00 , A61K2039/5254 , A61K2039/53 , C12N2770/24361 , C12N2770/24362
摘要： The invention belongs to the field of animal health and in particular Bovine Viral Diarrhea Virus (BVDV). The invention provides infectious BVDV clones and methods to produce said BVDV clones. The invention further relates to methods of attenuating said clones, attenuated BVDV clones and vaccines comprising said attenuated clones.
摘要翻译： 本发明属于动物健康领域，特别是牛病毒性腹泻病毒（BVDV）。 本发明提供感染性BVDV克隆和产生所述BVDV克隆的方法。 本发明还涉及减毒所述克隆，减毒BVDV克隆和包含所述减毒克隆的疫苗的方法。
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公开(公告)号：US07572455B2
公开(公告)日：2009-08-11
申请号：US11132686
申请日：2005-05-19
CPC分类号： C12N7/00 , A61K2039/5252 , C07K14/005 , C12N2770/24322 , C12N2770/24361
摘要： Attenuated pestiviruses, in particular attenuated BVDV, wherein at least one mutation is in the coding sequence for glycoprotein Erns and at least another mutation in the coding sequence for Npro which preferably leads to combined inactivation of the RNase activity residing in glycoprotein Erns in addition to the inactivation of the (hypothesized) immunomodulating activity residing in Npro. Methods for attenuating pestiviruses such as BVDV, nucleic acids encoding the pestiviruses, in particular BVDV, compositions and vaccines comprising the attenuated pestiviruses, in particular BVDV, of the invention.
摘要翻译： 减毒瘟病毒，特别是减毒BVDV，其中至少一个突变位于糖蛋白Erns的编码序列中，并且在Npro的编码序列中至少有一个突变，其优选导致除了存在于糖蛋白Erns中的糖蛋白Erns之外的RNase活性的组合失活 灭活Npro的（假设的）免疫调节活性。 用于减毒瘟病毒如BVDV，编码瘟病毒的核酸，特别是BVDV，包含本发明的减毒瘟病毒，特别是BVDV的组合物和疫苗的方法。
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公开(公告)号：US20050287171A1
公开(公告)日：2005-12-29
申请号：US11132686
申请日：2005-05-19
CPC分类号： C12N7/00 , A61K2039/5252 , C07K14/005 , C12N2770/24322 , C12N2770/24361
摘要： Attenuated pestiviruses, in particular attenuated BVDV, wherein at least one mutation is in the coding sequence for glycoprotein Erns and at least another mutation in the coding sequence for Npro which preferably leads to combined inactivation of the RNase activity residing in glycoprotein Erns in addition to the inactivation of the (hypothesized) immunomodulating activity residing in Npro. Methods for attenuating pestiviruses such as BVDV, nucleic acids encoding the pestiviruses, in particular BVDV, compositions and vaccines comprising the attenuated pestiviruses, in particular BVDV, of the invention.
摘要翻译： 减毒瘟病毒，特别是减毒BVDV，其中至少一个突变位于糖蛋白E编码序列和至少另一个突变的编码序列中， 导致存在于糖蛋白ENA中的RNase活性的组合失活除了灭活N（pro）的（假设的）免疫调节活性。 用于减毒瘟病毒如BVDV，编码瘟病毒的核酸，特别是BVDV，包含本发明的减毒瘟病毒，特别是BVDV的组合物和疫苗的方法。
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