公开(公告)号：US20050182365A1

公开(公告)日：2005-08-18

申请号：US11107271

申请日：2005-04-15

申请人： Willard Hennemann ,  Michael Urick ,  Domenic Santoianni ,  Claudia Luckge ,  Sean Carroll ,  Dan Wittenberger ,  Teresa Mihalik

发明人： Willard Hennemann ,  Michael Urick ,  Domenic Santoianni ,  Claudia Luckge ,  Sean Carroll ,  Dan Wittenberger ,  Teresa Mihalik

IPC分类号： A61B5/053 ,  A61B17/00 ,  A61B18/02 ,  A61B5/00 ,  A61F7/12 ,  H05B1/00

CPC分类号： A61B5/6853 ,  A61B5/02007 ,  A61B5/053 ,  A61B18/02 ,  A61B2017/00026 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262

摘要： A method and apparatus for detecting plaque proximate an area of a human body is described, the method comprising the steps of moving one or more electrically sensitive sensors substantially near an area where plaque may be present, obtaining electrical signal readings from the sensors, and determining the presence or absence of plaque. The presence or absence of the plaque corresponds to the electrical signal readings. Another aspect of the invention provides a method for inhibiting plaque formation and passivating plaque formed on a lumenal surface of a body lumen. A cooling device is positioned at the lumenal surface at a point proximate to a plaque formation. The lumenal surface is cooled at the point proximate to the plaque formation to inhibit the progression of plaque formation in which the lumenal surface is cooled to a temperature of less than about zero degrees Celsius. As another aspect, a method is provided for reducing the risk of plaque rupture in a vessel. A catheter is inserted into a patient's vessel. The catheter is manipulated to a region of the vessel proximate to a plaque formation such that an outer surface of the catheter is positioned at tissue proximate to the plaque formation. The catheter is activated such that the outer surface of the catheter cools the contacting tissue to a temperature of less than about zero degrees Celsius.

摘要翻译： 描述了一种用于在人体区域附近检测斑块的方法和装置，该方法包括以下步骤：基本上靠近可能存在斑块的区域移动一个或多个电敏感传感器，从传感器获得电信号读数，并确定 斑块的存在或不存在。 斑块的存在或不存在对应于电信号读数。 本发明的另一方面提供了一种抑制形成在体腔内腔表面上的斑块形成和钝化斑块的方法。 冷却装置位于靠近斑块形成的点处的内腔表面。 腔表面在靠近斑块形成的点处被冷却，以抑制斑块形成的进展，其中腔表面被冷却到小于约零摄氏度的温度。 另一方面，提供了一种减少血管中斑块破裂风险的方法。 将导管插入病人的血管。 导管被操纵到容器的靠近斑块形成的区域，使得导管的外表面位于靠近斑块形成的组织处。 导管被激活，使得导管的外表面将接触组织冷却至小于约零摄氏度的温度。

公开(公告)号：US20050222649A1

公开(公告)日：2005-10-06

申请号：US11119368

申请日：2005-04-29

申请人： Leonilda Capuano ,  Daniel Nahon ,  Michael Urick ,  Willard Hennemann ,  Patrick Chauvet ,  Claudia Luckge

发明人： Leonilda Capuano ,  Daniel Nahon ,  Michael Urick ,  Willard Hennemann ,  Patrick Chauvet ,  Claudia Luckge

IPC分类号： A61B17/22 ,  A61B18/00 ,  A61B18/02 ,  A61B18/22 ,  A61F7/00 ,  A61F7/12 ,  A61N5/06

CPC分类号： A61B18/02 ,  A61B18/22 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2018/00095 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61N5/045 ,  A61N5/0601

摘要： A method is disclosed for treating an aneurysm or vascular defect by cooling a target tissue region of the aneurysm or vascular defect to a temperature below body temperature for a preselected time period. The method entails thickening, strengthening, or increasing the density of a blood vessel wall by cooling the blood vessel wall with a cryogenically cooled device. The method also includes irradiating the inner wall of a blood vessel around an aneurysm or vascular defect with various forms of energy to delay or halt aneurysm or vascular defect formation. An energy-emitting element is disposed on the distal end portion of a catheter device to be disposed proximate the aneurysm. Various forms of energy, including visible light energy, laser light energy, ultrasound, microwave and radiofrequency sources may be used to irradiate and treat the aneurysm. In addition, the method may include irradiating a tissue site concomitantly with other treatments, including the delivery of vaso-occlusive compounds, mechanical intravascular devices, or an endovascular graft to the target tissue region.

摘要翻译： 公开了一种用于通过将动脉瘤或血管缺陷的靶组织区域冷却到低于体温的温度预处理时间段来治疗动脉瘤或血管缺陷的方法。 该方法通过用低温冷却装置冷却血管壁来增加，增强或增加血管壁的密度。 该方法还包括以各种形式的能量照射动脉瘤或血管缺损周围的血管内壁，以延迟或停止动脉瘤或血管缺损形成。 能量发射元件设置在导管装置的远端部分上以靠近动脉瘤设置。 可以使用包括可见光能量，激光能量，超声波，微波和射频源在内的各种形式的能量照射和治疗动脉瘤。 此外，该方法可以包括与其它治疗伴随地照射组织部位，包括将血管闭塞化合物，机械血管内装置或血管内移植物递送至靶组织区域。

公开(公告)号：US20060089689A1

公开(公告)日：2006-04-27

申请号：US11257331

申请日：2005-10-24

申请人： Willard Hennemann ,  Daniel Nahon ,  Fredric Milder

发明人： Willard Hennemann ,  Daniel Nahon ,  Fredric Milder

IPC分类号： A61F7/00 ,  A61F7/12

CPC分类号： A61F7/123 ,  A61B2017/22001 ,  A61F2007/126

摘要： A method is disclosed for cooling a limited portion of a body organ by placing a cooling device into a blood vessel within a target organ; and activating the cooling device to cool tissue proximate the cooling device to a temperature below +34 degrees Centigrade. The blood vessel can be a vein or an artery and the cooling device can be a fixed diameter catheter or it can include a balloon. More particularly, the method of cooling can provide a method for treating injured ischemic and infarcted tissue by placing a device capable of passage through the vasculature into a target organ, wherein the device is capable of providing sufficient thermal exchange at a working region thereof to cool adjacent tissue; and activating the device to cool adjacent tissue to a temperature in the range of 0 degrees Centigrade to +36 degrees Centigrade. The method can further include placement of a second device capable of passage through the vasculature into the target organ, wherein the second device is capable of at least partially removing a blockage from a blood vessel.

摘要翻译： 公开了一种通过将冷却装置放置在目标器官内的血管中来冷却身体器官的有限部分的方法; 并且激活冷却装置以将冷却装置附近的组织冷却至低于+ 34摄氏度的温度。 血管可以是静脉或动脉，并且冷却装置可以是固定直径的导管，也可以包括气囊。 更具体地，冷却方法可以提供一种通过将能够通过脉管系统通过脉管系统的装置放置到靶器官中来治疗受伤的缺血和梗死组织的方法，其中该装置能够在其工作区域提供足够的热交换以冷却 相邻组织; 并激活该装置以将相邻组织冷却至0摄氏度至+36摄氏度的温度。 该方法还可以包括能够穿过脉管系统进入目标器官的第二装置的放置，其中第二装置能够至少部分地从血管中去除堵塞物。

公开(公告)号：US20070270792A1

公开(公告)日：2007-11-22

申请号：US11745579

申请日：2007-05-08

申请人： Willard Hennemann ,  Donald Carlin ,  Christian Toma

发明人： Willard Hennemann ,  Donald Carlin ,  Christian Toma

IPC分类号： A61B18/18

CPC分类号： A61B18/24 ,  A61B5/0059 ,  A61B5/0066 ,  A61B18/1492 ,  A61B2017/00057

摘要： An apparatus including an ablation catheter having one or more optical probes attached, a system including such an apparatus and methods for using such an apparatus are disclosed herein. The optical probes may be utilized to monitor the depth of ablation in real-time during an ablation procedure, thus, reducing or eliminating the incidence of unintended injury to healthy or normal tissue during ablation.

摘要翻译： 本文公开了包括具有附接的一个或多个光学探针的消融导管的装置，包括这种装置的系统和使用这种装置的方法。 光学探针可用于在消融过程期间实时监测消融深度，从而减少或消除在消融期间对健康或正常组织的意外损伤的发生。

公开(公告)号：US20070185445A1

公开(公告)日：2007-08-09

申请号：US11347854

申请日：2006-02-06

申请人： Daniel Nahon ,  Willard Hennemann

发明人： Daniel Nahon ,  Willard Hennemann

IPC分类号： A61M29/00

CPC分类号： A61M25/104 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61M25/1011 ,  A61M2025/1095 ,  A61M2025/1097 ,  A61M2202/03

摘要： The present invention provides a method and apparatus for treating a vascular occlusion and preventing or reducing ischemic consequences of such an obstruction. The medical device of the present invention may include an elongate body defining a proximal end and a distal end, where the elongate body may also define an injection lumen, an exhaust lumen, and a guidewire lumen. A first expandable element may be coupled to the elongate body, where the first expandable element is in fluid communication with the injection lumen and the exhaust lumen. Further, a perfusion path may be disposed within the elongate body, and a sheath may be movably disposed about at least a portion of the elongate body. The medical device may further include a second expandable element disposed about the elongate body, as well as second inflation and exhaust lumens.

摘要翻译： 本发明提供了一种用于治疗血管闭塞并预防或减少这种梗阻的缺血性后果的方法和装置。 本发明的医疗装置可以包括限定近端和远端的细长主体，其中细长主体还可以限定注射腔，排气腔和导丝腔。 第一可膨胀元件可以联接到细长体，其中第一可膨胀元件与注射腔和排气腔流体连通。 此外，灌注路径可以设置在细长体内，并且护套可以围绕细长体的至少一部分可移动地设置。 医疗装置还可以包括围绕细长体设置的第二可膨胀元件以及第二充气和排出腔。