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84 条记录 (耗时 0.051 秒)

    Human DNA topoisomerase I &agr;
    6.
    发明授权
    Human DNA topoisomerase I &agr; 有权
    人类DNA拓扑异构酶Iα

    公开(公告)号：US06255077B1

    公开(公告)日：2001-07-03

    申请号：US09325430

    申请日：1999-06-04

    申请人： Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann

    发明人： Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann

    IPC分类号： C12N1563

    CPC分类号： C12N9/90 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12Y599/01002

    摘要： Disclosed is a human is a hTopI-&agr; polypeptide and DNA (RNA) encoding such hTopI-&agr; polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-&agr; for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

    摘要翻译： 公开了人是hTopI-α多肽和编码这种hTopI-α多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用抗体和拮抗剂抑制剂抑制hTopI-α用于治疗目的如抗肿瘤剂的作用以检测自身免疫性疾病或逆转录病毒感染并治疗结肠腺癌的方法。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

    Human DNA topoisomerase I .alpha.
    7.
    发明授权
    Human DNA topoisomerase I .alpha. 失效
    人类DNA拓扑异构酶Iα

    公开(公告)号：US5968803A

    公开(公告)日：1999-10-19

    申请号：US33153

    申请日：1998-03-02

    申请人： Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann

    发明人： Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C12N1/21 ,  C12N9/90 ,  C12N15/12 ,  C07K14/435

    CPC分类号： C12N9/90 ,  C12Y599/01002 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： Disclosed is a human is a hTopI-.alpha. polypeptide and DNA (RNA) encoding such hTopI-.alpha. polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-.alpha. for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

    摘要翻译： 公开了人是hTopI-α多肽和编码这种hTopI-α多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用抗体和拮抗剂抑制剂抑制hTopI-α用于治疗目的的作用的方法，例如抗肿瘤剂，以检测自身免疫疾病或逆转录病毒感染并治疗结肠腺癌。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

    Human DNA topoisomerase I .alpha.
    8.
    发明授权
    Human DNA topoisomerase I .alpha. 失效

    公开(公告)号：US5723311A

    公开(公告)日：1998-03-03

    申请号：US458477

    申请日：1995-06-02

    申请人： Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann

    发明人： Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C12N9/90 ,  C12P21/02 ,  C12N15/12

    CPC分类号： C12N9/90 ,  A61K38/00 ,  A61K48/00

    摘要： Disclosed is a human is a hTopI-.alpha. polypeptide and DNA (RNA) encoding such hTopI-.alpha. polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-.alpha. for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

    Human MutT2
    9.
    发明授权
    Human MutT2 失效
    人类MutT2

    公开(公告)号：US06344547B1

    公开(公告)日：2002-02-05

    申请号：US09432253

    申请日：1999-11-02

    申请人： Ying-Fei Wei ,  Ewen F. Kirkness

    发明人： Ying-Fei Wei ,  Ewen F. Kirkness

    IPC分类号： C07H1900

    CPC分类号： C12N9/16 ,  A61K38/00 ,  Y10S530/809

    摘要： A human hMutT2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for hydrolyzing and eliminating oxidized guanine nucleotides from the nucleotide pool to ensure correct DNA synthesis. Diagnostic assays are also disclosed which detect the presence of a mutated form of hMutT2 and over-expression of the hMutT2 protein.

    摘要翻译： 公开了编码这种多肽的人hMutT2多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽从核苷酸库水解和消除氧化的鸟嘌呤核苷酸以确保正确的DNA合成的方法。 还公开了诊断测定法，其检测突变形式的hMutT2的存在和hMutT2蛋白的过表达。

    Human mutT2
    10.
    发明授权
    Human mutT2 失效
    人类mutT2

    公开(公告)号：US6103871A

    公开(公告)日：2000-08-15

    申请号：US916989

    申请日：1997-08-21

    申请人： Ying-Fei Wei ,  Ewen F. Kirkness

    发明人： Ying-Fei Wei ,  Ewen F. Kirkness

    IPC分类号： A61K38/00 ,  C12N9/16 ,  C07H21/02 ,  C07K1/00 ,  C12Q1/68

    CPC分类号： C12N9/16 ,  A61K38/00 ,  Y10S530/809

    摘要： A human hMutT2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for hydrolyzing and eliminating oxidized guanine nucleotides from the nucleotide pool to ensure correct DNA synthesis. Diagnostic assays are also disclosed which detect the presence of a mutated form of hMutT2 and over-expression of the hMutT2 protein.

    摘要翻译： 公开了编码这种多肽的人hMutT2多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽从核苷酸库水解和消除氧化的鸟嘌呤核苷酸以确保正确的DNA合成的方法。 还公开了诊断测定法，其检测突变形式的hMutT2的存在和hMutT2蛋白的过表达。