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公开(公告)号:US06620619B2
公开(公告)日:2003-09-16
申请号:US08210143
申请日:1994-03-16
申请人: William A. Haseltine , Steven Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Craig A. Rosen , Rebecca A. Fuldner , Ewen F. Kirkness
发明人: William A. Haseltine , Steven Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Craig A. Rosen , Rebecca A. Fuldner , Ewen F. Kirkness
IPC分类号: G01N3306
CPC分类号: C07K14/47
摘要: The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hmlh1, has been mapped on chromosome 3. The polynucleotide sequences of DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.
摘要翻译: 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA(RNA)。 DNA修复蛋白可以通过重组DNA技术产生。 人类DNA修复蛋白之一hmlh1已被绘制在染色体3上.DNA修复蛋白的多核苷酸序列可用于诊断遗传性对癌症的易感性。
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公开(公告)号:US06416984B1
公开(公告)日:2002-07-09
申请号:US08468024
申请日:1995-06-06
申请人: William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen
发明人: William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen
IPC分类号: C12N900
CPC分类号: C07K14/47 , Y10T436/143333
摘要: The invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.
摘要翻译: 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA(RNA),以及通过重组技术生产此类蛋白质的方法。 人类DNA修复蛋白hMLH1已被映射到染色体3,而hMLH2已被映射到染色体2,并且hMLH3已经被定位到染色体7上.DNA修复蛋白的多核苷酸序列可用于治疗和诊断治疗 遗传易感性癌症。
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公开(公告)号:US06380369B1
公开(公告)日:2002-04-30
申请号:US08294312
申请日:1994-08-23
申请人: Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
发明人: Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
IPC分类号: C07H2102
CPC分类号: C07K14/47
摘要: The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins which may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.
摘要翻译: 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA(RNA)。 可通过重组DNA技术产生的DNA修复蛋白。 人类DNA修复蛋白hMLH1已经被映射到染色体3,而hMLH2已被映射到染色体2,并且hMLH3已经被定位到染色体7上.DNA修复蛋白的多核苷酸序列可以用于诊断遗传易感性 到癌症。
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公开(公告)号:US06610477B1
公开(公告)日:2003-08-26
申请号:US08465679
申请日:1995-06-06
申请人: William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen , Bert Vogelstein , Kenneth W. Kinzler , Nicholas C. Nicolaides , Nickolas Papadopoulos
发明人: William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen , Bert Vogelstein , Kenneth W. Kinzler , Nicholas C. Nicolaides , Nickolas Papadopoulos
IPC分类号: C12Q168
CPC分类号: C07K14/47 , Y10T436/143333
摘要: The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.
摘要翻译: 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA(RNA),以及通过重组技术生产此类蛋白质的方法。 人类DNA修复蛋白hMLH1已被映射到染色体3,而hMLH2已被映射到染色体2,并且hMLH3已经被定位到染色体7上.DNA修复蛋白的多核苷酸序列可用于治疗和诊断治疗 遗传易感性癌症。
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公开(公告)号:US06482606B1
公开(公告)日:2002-11-19
申请号:US08187757
申请日:1994-01-27
申请人: Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
发明人: Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
IPC分类号: C12P2102
CPC分类号: C07K14/47
摘要: The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hmlh1, has been mapped on chromosome 3. The polynucleotide sequences of DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.
摘要翻译: 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA(RNA)。 DNA修复蛋白可以通过重组DNA技术产生。 人类DNA修复蛋白之一hmlh1已被绘制在染色体3上.DNA修复蛋白的多核苷酸序列可用于诊断遗传性对癌症的易感性。
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公开(公告)号:US5501969A
公开(公告)日:1996-03-26
申请号:US208007
申请日:1994-03-08
申请人: Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
发明人: Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
IPC分类号: G01N33/53 , A61K31/70 , A61K38/00 , A61K38/46 , A61K38/48 , A61K39/395 , A61K48/00 , A61P19/08 , A61P19/10 , A61P35/00 , A61P43/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K14/47 , C07K16/40 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/48 , C12N9/50 , C12N9/64 , C12N15/09 , C12N15/11 , C12N15/57 , C12N15/66 , C12P19/34 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q1/37 , G01N33/535 , C12N15/63
CPC分类号: C12N9/6472 , C07K16/40 , A61K38/00
摘要: Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
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公开(公告)号:US06680375B2
公开(公告)日:2004-01-20
申请号:US10114464
申请日:2002-04-03
申请人: Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
发明人: Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
IPC分类号: C07K1600
CPC分类号: C12N9/6472 , A61K38/00 , C07K16/40
摘要: Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
摘要翻译: 公开了一种人破骨细胞来源的组织蛋白酶(组织蛋白酶O)多肽和编码这种组织蛋白酶O多肽的DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法。 本发明还公开了这种多肽的抗体,拮抗剂和抑制剂,其可用于预防这种多肽的作用,因此可用于治疗性治疗骨疾病如骨质疏松症和癌症如肿瘤转移。
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公开(公告)号:US06475766B1
公开(公告)日:2002-11-05
申请号:US08553125
申请日:1995-11-07
申请人: Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
发明人: Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
IPC分类号: C12N964
CPC分类号: C12N9/6472 , A61K38/00 , C07K16/40
摘要: Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
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公开(公告)号:US5861298A
公开(公告)日:1999-01-19
申请号:US852807
申请日:1997-05-07
申请人: Mark D. Adams , Judith A. Blake , Christine M. Debouck , Fred H. Drake , Lisa M. Fitzgerald , Claire M. Fraser , Maxine Gowen , Gregg A. Hastings , Ewen F. Kirkness , Norman H. Lee , Julie Rood
发明人: Mark D. Adams , Judith A. Blake , Christine M. Debouck , Fred H. Drake , Lisa M. Fitzgerald , Claire M. Fraser , Maxine Gowen , Gregg A. Hastings , Ewen F. Kirkness , Norman H. Lee , Julie Rood
CPC分类号: C12N9/6472 , A61K38/00 , A61K48/00
摘要: The invention relates to cathepsin K polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译: 本发明涉及组织蛋白酶K多肽,编码多肽的多核苷酸,产生多肽的方法,特别是通过表达多核苷酸,多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸,多肽,激动剂和拮抗剂的方法,其部分涉及研究,诊断和临床领域。
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公开(公告)号:US20080317754A1
公开(公告)日:2008-12-25
申请号:US11756638
申请日:2007-06-01
申请人: Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
发明人: Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
IPC分类号: A61K39/395 , C12N15/11 , C12N15/00 , C12N1/20 , C12P21/04 , G01N33/53 , A61P31/00 , C12N9/50 , C07K16/18 , A61K38/43 , A61K31/7088
CPC分类号: C12N9/6472 , A61K38/00 , C07K16/40
摘要: Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
摘要翻译: 公开了一种人破骨细胞来源的组织蛋白酶(组织蛋白酶O)多肽和编码这种组织蛋白酶O多肽的DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法。 本发明还公开了这种多肽的抗体,拮抗剂和抑制剂,其可用于预防这种多肽的作用,因此可用于治疗性治疗骨疾病如骨质疏松症和癌症如肿瘤转移。
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