-
公开(公告)号：US06620619B2
公开(公告)日：2003-09-16
申请号：US08210143
申请日：1994-03-16
申请人： William A. Haseltine , Steven Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Craig A. Rosen , Rebecca A. Fuldner , Ewen F. Kirkness
发明人： William A. Haseltine , Steven Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Craig A. Rosen , Rebecca A. Fuldner , Ewen F. Kirkness
IPC分类号： G01N3306
CPC分类号： C07K14/47
摘要： The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hmlh1, has been mapped on chromosome 3. The polynucleotide sequences of DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.
摘要翻译： 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA（RNA）。 DNA修复蛋白可以通过重组DNA技术产生。 人类DNA修复蛋白之一hmlh1已被绘制在染色体3上.DNA修复蛋白的多核苷酸序列可用于诊断遗传性对癌症的易感性。
-
公开(公告)号：US06610477B1
公开(公告)日：2003-08-26
申请号：US08465679
申请日：1995-06-06
申请人： William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen , Bert Vogelstein , Kenneth W. Kinzler , Nicholas C. Nicolaides , Nickolas Papadopoulos
发明人： William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen , Bert Vogelstein , Kenneth W. Kinzler , Nicholas C. Nicolaides , Nickolas Papadopoulos
IPC分类号： C12Q168
CPC分类号： C07K14/47 , Y10T436/143333
摘要： The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.
摘要翻译： 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA（RNA），以及通过重组技术生产此类蛋白质的方法。 人类DNA修复蛋白hMLH1已被映射到染色体3，而hMLH2已被映射到染色体2，并且hMLH3已经被定位到染色体7上.DNA修复蛋白的多核苷酸序列可用于治疗和诊断治疗 遗传易感性癌症。
-
公开(公告)号：US06416984B1
公开(公告)日：2002-07-09
申请号：US08468024
申请日：1995-06-06
申请人： William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen
发明人： William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen
IPC分类号： C12N900
CPC分类号： C07K14/47 , Y10T436/143333
摘要： The invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.
摘要翻译： 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA（RNA），以及通过重组技术生产此类蛋白质的方法。 人类DNA修复蛋白hMLH1已被映射到染色体3，而hMLH2已被映射到染色体2，并且hMLH3已经被定位到染色体7上.DNA修复蛋白的多核苷酸序列可用于治疗和诊断治疗 遗传易感性癌症。
-
公开(公告)号：US06380369B1
公开(公告)日：2002-04-30
申请号：US08294312
申请日：1994-08-23
申请人： Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
发明人： Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
IPC分类号： C07H2102
CPC分类号： C07K14/47
摘要： The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins which may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.
摘要翻译： 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA（RNA）。 可通过重组DNA技术产生的DNA修复蛋白。 人类DNA修复蛋白hMLH1已经被映射到染色体3，而hMLH2已被映射到染色体2，并且hMLH3已经被定位到染色体7上.DNA修复蛋白的多核苷酸序列可以用于诊断遗传易感性 到癌症。
-
公开(公告)号：US06482606B1
公开(公告)日：2002-11-19
申请号：US08187757
申请日：1994-01-27
申请人： Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
发明人： Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
IPC分类号： C12P2102
CPC分类号： C07K14/47
摘要： The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hmlh1, has been mapped on chromosome 3. The polynucleotide sequences of DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.
摘要翻译： 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA（RNA）。 DNA修复蛋白可以通过重组DNA技术产生。 人类DNA修复蛋白之一hmlh1已被绘制在染色体3上.DNA修复蛋白的多核苷酸序列可用于诊断遗传性对癌症的易感性。
-
公开(公告)号：US06790826B2
公开(公告)日：2004-09-14
申请号：US10004832
申请日：2001-12-07
申请人： Ewen F. Kirkness , Mark D. Adams , Henrik Olsen , Craig A. Rosen
发明人： Ewen F. Kirkness , Mark D. Adams , Henrik Olsen , Craig A. Rosen
IPC分类号： A61K3816
CPC分类号： C07K14/475 , A61K38/00
摘要： Disclosed are human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and for using such polypeptides for treating leukemia, auto-immune diseases and blood related disorders. Antagonists against such polypeptides and their use as a therapeutic to prevent expansion of T-cell populations are also disclosed. Diagnostic assays are also disclosed to detect both the presence of mutations in the haemopoietic maturation factor nucleic acid sequences and altered levels of the protein.
摘要翻译： 公开了人类造血成熟因子多肽和编码这种造血成熟因子多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法，并且使用这些多肽来治疗白血病，自身免疫疾病和与血液相关的疾病。 还公开了抗这些多肽的拮抗剂及其作为治疗剂用于预防T细胞群扩增的用途。 还公开了诊断测定以检测造血成熟因子核酸序列中突变的存在和蛋白质的改变的水平。
-
公开(公告)号：US06346246B1
公开(公告)日：2002-02-12
申请号：US09333033
申请日：1999-06-15
IPC分类号： A61K39395
CPC分类号： C07K14/475 , A61K38/00
摘要： Disclosed is human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and the use of such polypeptides for treating leukemia, auto-immune diseases and blood related disorders. Antagonists against such polypeptides and their use as a therapeutic to prevent expansion of T-cell populations is also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the haemopoietic maturation factor nucleic acid sequences and altered levels of the protein.
摘要翻译： 公开了人类造血成熟因子多肽和编码这种造血成熟因子多肽的DNA（RNA）。 还提供了通过重组技术产生此类多肽的方法以及使用这些多肽来治疗白血病，自身免疫疾病和血液相关病症。 还公开了抗这些多肽的拮抗剂及其作为预防T细胞群扩增的治疗剂的用途。 还公开了诊断测定法，其检测造血成熟因子核酸序列中突变的存在和蛋白质的改变水平。
-
公开(公告)号：US5986069A
公开(公告)日：1999-11-16
申请号：US442497
申请日：1995-05-16
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K39/395 , A61K48/00 , A61P7/00 , A61P7/06 , A61P25/00 , A61P35/02 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/475 , C07K16/18 , C12N1/21 , C12N5/10 , C12P21/02 , C12P21/08 , C12Q1/68
CPC分类号： C07K14/475 , A61K38/00
摘要： Disclosed is human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and the use of such polypeptides for treating leukemia, auto-immune diseases and blood related disorders. Antagonists against such polypeptides and their use as a therapeutic to prevent expansion of T-cell populations is also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the haemopoietic maturation factor nucleic acid sequences and altered levels of the protein.
摘要翻译： 公开了人类造血成熟因子多肽和编码这种造血成熟因子多肽的DNA（RNA）。 还提供了通过重组技术产生此类多肽的方法以及使用这些多肽来治疗白血病，自身免疫疾病和血液相关病症。 还公开了抗这些多肽的拮抗剂及其作为预防T细胞群扩增的治疗剂的用途。 还公开了诊断测定法，其检测造血成熟因子核酸序列中突变的存在和蛋白质的改变水平。
-
公开(公告)号：US6156540A
公开(公告)日：2000-12-05
申请号：US171817
申请日：1993-12-22
申请人： Craig A. Rosen , Liang Cao , Mark D. Adams , Rebecca A. Fuldner
发明人： Craig A. Rosen , Liang Cao , Mark D. Adams , Rebecca A. Fuldner
CPC分类号： C07K14/8121
摘要： There is provided a thrombin inhibitor polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. The anti-thrombin polypeptide is used to treat various diseases where prevention of blood clotting is necessary and is of therapeutic value. The present invention also discloses a method of producing the anti-thrombin polypeptide and methods for its use as a pharmaceutical composition.
-
公开(公告)号：US6133422A
公开(公告)日：2000-10-17
申请号：US200965
申请日：1998-11-30
申请人： Craig A. Rosen , Liang Cao , Mark D. Adams , Rebecca A. Fuldner
发明人： Craig A. Rosen , Liang Cao , Mark D. Adams , Rebecca A. Fuldner
CPC分类号： C07K14/8121
摘要： There is provided a thrombin inhibitor polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. The anti-thrombin polypeptide is used to treat various diseases where prevention of blood clotting is necessary and is of therapeutic value. The present invention also discloses a method of producing the anti-thrombin polypeptide and methods for its use as a pharmaceutical composition.
摘要翻译： 提供了一种凝血酶抑制剂多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 抗凝血酶多肽用于治疗需要预防血液凝固并具有治疗价值的各种疾病。 本发明还公开了一种生产抗凝血酶多肽的方法及其用作药物组合物的方法。
-
-
-
-
-
-
-
-
-
搜索结果
403 条记录 (耗时 0.064 秒)