公开(公告)号：US06379746B1

公开(公告)日：2002-04-30

申请号：US09495166

申请日：2000-01-31

申请人： William Birch ,  Dana C. Bookbinder ,  Alain R. E. Carre ,  David L. Tennent

发明人： William Birch ,  Dana C. Bookbinder ,  Alain R. E. Carre ,  David L. Tennent

IPC分类号： B05D724

CPC分类号： C03C17/28 ,  C03C2218/355

摘要： Methods for temporarily protecting a surface of a glass article by coating the surface are provided. The methods include forming a stable, hydrophobic, removable film on the surface at the end of the glass manufacturing process while the glass is still at an elevated temperature (e.g., above 175° C.). The film reduces chip adhesion to the surface as a result of cutting and grinding. After cutting and grinding, the film is removed allowing the glass to be used in such processes as the manufacture of liquid crystal displays (LCDs).

摘要翻译： 提供了通过涂覆表面暂时保护玻璃制品的表面的方法。 所述方法包括在玻璃制造过程结束时在表面上形成稳定的，疏水的，可移除的膜，同时玻璃仍处于升高的温度（例如高于175℃）。 作为切割和研磨的结果，该膜降低了与表面的切屑附着力。 在切割和研磨之后，去除膜，允许玻璃用于制造液晶显示器（LCD）等工艺。

公开(公告)号：US06233972B1

公开(公告)日：2001-05-22

申请号：US09382164

申请日：1999-08-24

申请人： Michelle R. Foster ,  David L. Tennent

发明人： Michelle R. Foster ,  David L. Tennent

IPC分类号： C03C1700

CPC分类号： C03C17/32 ,  C03C2218/355 ,  C09D5/008

摘要： A method of providing a protective layer for a glass sheet. The protective layer provided by depositing a solution of a polymer and water on a glass sheet at a temperature high enough to provide a layer that is insoluble in water below a temperature of about 20° C. The layer is soluble in water at a temperature above about 60° C., so that the protective layer can be removed by rinsing in hot water.

摘要翻译： 一种为玻璃板提供保护层的方法。 通过在高达足够高的温度下将聚合物和水溶液沉积在玻璃板上以提供不溶于低于约20℃温度的水的层而提供的保护层。该层在高于上述温度下可溶于水 约60℃，使得可以通过在热水中漂洗来除去保护层。

公开(公告)号：US06732551B2

公开(公告)日：2004-05-11

申请号：US09848903

申请日：2001-05-04

申请人： David L. Tennent ,  Joseph M. Whalen

发明人： David L. Tennent ,  Joseph M. Whalen

IPC分类号： C03B1906

CPC分类号： C03B37/01807 ,  C03B19/106 ,  C03B19/1415 ,  C03B37/01413 ,  C03B2201/02 ,  C03B2201/31 ,  C03B2207/32

摘要： A method for making silica includes delivering a silica precursor comprising a pseudohalogen to a conversion site and passing the silica precursor through a flame to produce silica soot.

摘要翻译： 制备二氧化硅的方法包括将包含假卤素的二氧化硅前体输送到转化位点并使二氧化硅前体通过火焰以产生二氧化硅烟灰。

公开(公告)号：US20080145280A1

公开(公告)日：2008-06-19

申请号：US11978863

申请日：2007-10-30

申请人： Dana Craig Bookbinder ,  Edward John Fewkes ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

发明人： Dana Craig Bookbinder ,  Edward John Fewkes ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

IPC分类号： B01L3/00 ,  B01L11/00 ,  B01L3/02 ,  B05D3/12

CPC分类号： C07H21/00 ,  B01L3/50 ,  B01L3/5082 ,  B01L2200/12 ,  B01L2300/16 ,  B05D7/02 ,  C07B2200/11 ,  C08J7/047 ,  C08J7/065 ,  C08J2471/00 ,  C09D5/00 ,  G01N33/54393

摘要： Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions. Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.

摘要翻译： 蛋白质结合水平小于约50-80ng / cm 2的疏水性聚合物表面通过以下方式实现：（1）施加由溶剂和具有HLB的非离子表面活性剂组成的涂布溶液 数量小于5的表面; 和（2）干燥表面以除去溶剂，从而使表面活性剂与疏水性聚合物直接接触。 已经发现低HLB值和干燥步骤的组合产生低结合表面，其可以经受多次用水和/或蛋白质溶液洗涤。 或者，低结合表面可以通过将非离子表面活性剂施加到与熔融聚合物接触的模具表面并将聚合物形成所需形状，例如多孔板，移液管尖端等来制备。 此外，低粘合表面可以通过将HLB数小于或等于10的非可溶性非离子表面活性剂在模制制品之前加入到聚合物共混物中来制备。

公开(公告)号：US06698247B2

公开(公告)日：2004-03-02

申请号：US09848904

申请日：2001-05-04

申请人： David L. Tennent ,  Joseph M. Whalen

发明人： David L. Tennent ,  Joseph M. Whalen

IPC分类号： C03B37075

CPC分类号： C03B37/01413 ,  C03B19/106 ,  C03B19/1415 ,  C03B2201/06 ,  C03B2201/07 ,  C03B2201/075 ,  C03B2201/12 ,  C03B2201/20 ,  C03B2207/30 ,  C03B2207/38

摘要： A method for making silica includes delivering a silica precursor comprising a perfluorinated group to a conversion site and passing the silica precursor through a conversion flame to produce silica soot.

摘要翻译： 制备二氧化硅的方法包括将包含全氟化基团的二氧化硅前体输送到转化位点并使二氧化硅前体通过转化火焰以产生二氧化硅烟灰。

公开(公告)号：US6093559A

公开(公告)日：2000-07-25

申请号：US918354

申请日：1997-08-26

申请人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

发明人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

IPC分类号： B05D5/08 ,  B01L99/00 ,  B05D3/02 ,  C07H21/00 ,  C08J7/04 ,  C08J7/06 ,  G01N33/543 ,  C12N9/00 ,  C07K17/00 ,  G01N33/53

CPC分类号： C07H21/00 ,  C08J7/047 ,  C08J7/065 ,  C09D5/00 ,  G01N33/54393 ,  B01L2200/12 ,  B01L2300/16 ,  B01L3/50 ,  B01L3/5082 ,  B05D7/02 ,  C07B2200/11 ,  C08J2471/00

摘要： Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm.sup.2 are achieved by: (1) applying to a hydrophobic polymer surface a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 and at least one hydrophilic element which can extend into an aqueous solution; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions. Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.

摘要翻译： 蛋白质结合水平小于约50-80ng / cm 2的疏水性聚合物表面通过以下方式实现：（1）将疏水性聚合物表面施用由HLB值少的溶剂和非离子表面活性剂组成的涂布溶液 可以延伸至水溶液中的至少一种亲水性元素; 和（2）干燥表面以除去溶剂，从而使表面活性剂与疏水性聚合物直接接触。 已经发现低HLB值和干燥步骤的组合产生低结合表面，其可以经受多次用水和/或蛋白质溶液洗涤。 或者，低结合表面可以通过将非离子表面活性剂施加到与熔融聚合物接触的模具表面并将聚合物形成期望的形状，例如多孔板，移液管尖端等来制备。 此外，低粘合表面可以通过将HLB数小于或等于10的非可溶性非离子表面活性剂在模制制品之前加入到聚合物共混物中来制备。

公开(公告)号：US06565789B2

公开(公告)日：2003-05-20

申请号：US09507421

申请日：2000-02-18

申请人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

发明人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

IPC分类号： B28B722

CPC分类号： C07H21/00 ,  B01L3/50 ,  B01L3/5082 ,  B01L2200/12 ,  B01L2300/16 ,  B05D7/02 ,  C07B2200/11 ,  C08J7/047 ,  C08J7/065 ,  C08J2471/00 ,  C09D5/00 ,  G01N33/54393

摘要： Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions. Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.

摘要翻译： 蛋白质结合水平小于约50-80ng / cm 2的疏水性聚合物表面通过以下方式实现：（1）将由溶剂和HLB数小于5的非离子表面活性剂组成的涂布溶液施加到表面 ; 和（2）干燥表面以除去溶剂，从而使表面活性剂与疏水性聚合物直接接触。 已经发现低HLB值和干燥步骤的组合产生低结合表面，其可以经受多次用水和/或蛋白质溶液洗涤。 或者，低结合表面可以通过将非离子表面活性剂施加到与熔融聚合物接触的模具表面并将聚合物形成所需形状，例如多孔板，移液管尖端等来制备。 此外，低粘合表面可以通过将HLB数小于或等于10的非可溶性非离子表面活性剂在模制制品之前加入到聚合物共混物中来制备。

公开(公告)号：US06319664B1

公开(公告)日：2001-11-20

申请号：US09507422

申请日：2000-02-18

申请人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

发明人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

IPC分类号： C12Q100

CPC分类号： C07H21/00 ,  B01L3/50 ,  B01L3/5082 ,  B01L2200/12 ,  B01L2300/16 ,  B05D7/02 ,  C07B2200/11 ,  C08J7/047 ,  C08J7/065 ,  C08J2471/00 ,  C09D5/00 ,  G01N33/54393

摘要： Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying to a hydrophobic polymer surface a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 and at least one hydrophilic element which can extend into an aqueous solution; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions. Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article. Molding uses shear condition that cause the surfactant to move to the surface of a polymer product formed by the molding such that a hydrophilic part of the surfactant extends from the surface to provide a surface having low binding for proteins.

摘要翻译： 蛋白质结合水平小于约50-80ng / cm 2的疏水性聚合物表面通过以下方式实现：（1）将疏水性聚合物表面施用由HLB值少的溶剂和非离子表面活性剂组成的涂布溶液 可以延伸至水溶液中的至少一种亲水性元素; 和（2）干燥表面以除去溶剂，从而使表面活性剂与疏水性聚合物直接接触。 已经发现低HLB值和干燥步骤的组合产生低结合表面，其可以经受多次用水和/或蛋白质溶液洗涤。 或者，低结合表面可以通过将非离子表面活性剂施加到与熔融聚合物接触的模具表面并将聚合物形成期望的形状，例如多孔板，移液管尖端等中来制备。 此外，低粘合表面可以通过将HLB数小于或等于10的非可溶性非离子表面活性剂在模制制品之前加入到聚合物共混物中来制备。 成型使用剪切条件，使得表面活性剂移动到通过模制形成的聚合物产品的表面，使得表面活性剂的亲水部分从表面延伸，以提供具有低蛋白质结合的表面。

公开(公告)号：US4522924A

公开(公告)日：1985-06-11

申请号：US594855

申请日：1984-03-29

申请人： David L. Tennent ,  Bhavender P. Sharma

发明人： David L. Tennent ,  Bhavender P. Sharma

IPC分类号： C12N11/14 ,  C12P19/24

CPC分类号： C12N11/14 ,  C12P19/24

摘要： The present invention relates to an immobilized enzyme composite having a mica carrier. More particularly, the composite comprises a mixture of an enzyme and a water-swelling mica selected from fluorohectorite, boron fluorophlogopite, hydroxyl boron phlogopite and solid solutions of at least one mica and a structurally compatible species selected from talc, fluorotalc, polylithonite, fluoropolylithonite, phlogopite, and fluorophlogopite.

摘要翻译： 本发明涉及具有云母载体的固定化酶复合物。 更具体地说，该复合材料包括选自氟代锂蒙脱石，氟化闪锌矿，羟基硼金云母和至少一种云母的固溶体和选自滑石，氟代，多硅石，氟聚硅酸钠的结构上相容的物质的酶和水溶胀云母的混合物， 金云母和氟金云母。

公开(公告)号：US08062881B2

公开(公告)日：2011-11-22

申请号：US12832522

申请日：2010-07-08

申请人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

发明人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

IPC分类号： C12M1/00 ,  A01N1/02 ,  C12Q1/00 ,  C12P1/00 ,  C12N9/00 ,  C12N11/00 ,  C12N5/00 ,  C12N1/00 ,  G01N33/53 ,  C07K17/00 ,  A61K38/00 ,  C07H21/00

CPC分类号： C07H21/00 ,  B01L3/50 ,  B01L3/5082 ,  B01L2200/12 ,  B01L2300/16 ,  B05D7/02 ,  C07B2200/11 ,  C08J7/047 ,  C08J7/065 ,  C08J2471/00 ,  C09D5/00 ,  G01N33/54393

摘要： Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.

摘要翻译： 蛋白质结合水平小于约50-80ng / cm 2的疏水性聚合物表面通过以下方式实现：（1）将由溶剂和HLB数小于5的非离子表面活性剂组成的涂布溶液施加到表面 ; 和（2）干燥表面以除去溶剂，从而使表面活性剂与疏水性聚合物直接接触。 已经发现低HLB值和干燥步骤的组合产生低结合表面，其可以经受水和/或蛋白质溶液的多次洗涤。或者，低结合表面可以通过将非离子表面活性剂施加到 接触熔融聚合物并将聚合物形成所需形状的模具表面，例如多孔板，移液管尖端等。 此外，低粘合表面可以通过将HLB数小于或等于10的非可溶性非离子表面活性剂在模制制品之前加入到聚合物共混物中来制备。