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1.发明申请Methods and Kits for Treating Lacerations and Puncture Wounds Using Inverse Therosensitive Polymers 审中-公开使用反向敏感聚合物治疗撕裂和穿刺伤口的方法和试剂盒公开(公告)号：US20120029558A1
公开(公告)日：2012-02-02
申请号：US13272025
申请日：2011-10-12
申请人： William E. Cohn , Jean-Marie Vogel
发明人： William E. Cohn , Jean-Marie Vogel
IPC分类号： A61B17/08
CPC分类号： A61L26/0019 , A61K31/74 , A61K31/765 , A61K31/785 , A61K45/06 , A61L26/0066 , A61L26/0095 , A61L2400/04 , A61L2400/06 , A61L2430/36 , A61M25/10 , A61M29/02
摘要： In certain embodiments, the present invention relates to methods and kits for treating wounds, comprising the step of introducing into said wound a composition comprising at least one optionally purified inverse thermosensitive polymer, wherein said at least one optionally purified inverse thermosensitive polymer forms a gel in said wound, thereby temporarily occluding said wound. In certain embodiments, the present invention relates to the aforementioned method wherein a wound to a blood vessel or a segment of the GI tract is occluded, thereby preventing exsanguination and/or septicemia. In other embodiments, the inventive methods and kits described herein may be used to ameliorate (e.g., fill) temporarily a defect in a biological lumen, thereby strengthening said defect, preventing rupture of, or maintaining, improving or optimizing fluid flow through said lumen.
摘要翻译： 在某些实施方案中，本发明涉及用于治疗伤口的方法和试剂盒，其包括将包含至少一种任选纯化的反相热敏聚合物的组合物引入所述伤口的步骤，其中所述至少一种任选纯化的反相热敏聚合物在 所述伤口，从而暂时封闭所述伤口。 在某些实施方案中，本发明涉及上述方法，其中伤口到血管或胃肠道的一部分被阻塞，从而防止放血和/或败血症。 在其它实施方案中，本文所述的本发明的方法和试剂盒可用于临时改善（例如，填充）生物腔内的缺陷，从而加强所述缺陷，防止破裂或保持，改善或优化通过所述内腔的流体流动。
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公开(公告)号：US08491623B2
公开(公告)日：2013-07-23
申请号：US11851848
申请日：2007-09-07
申请人： Jean-Marie Vogel , William E. Cohn
发明人： Jean-Marie Vogel , William E. Cohn
IPC分类号： A61M29/00
CPC分类号： A61B17/12195 , A61B17/08 , A61B17/12031 , A61B17/1204 , A61B17/12045 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B17/12186 , A61B2017/1205 , A61M29/02 , A61M2025/1052
摘要： One aspect of the present invention relates to catheters that can be placed in or around bodily conduits to occlude or widen a biological lumen without imparting significant trauma to the lumen. In certain embodiments, the invention particularly relates to the use of a polymer composition which can be made to gel upon insertion into said balloon or skirt. In certain embodiments, the inflating viscous polymer composition is a liquid at room temperature and a gel at mammalian physiological temperature. In certain embodiments, the inflating viscous polymer composition comprises an optionally purified inverse thermosensitive polymer.
摘要翻译： 本发明的一个方面涉及可以放置在身体管道中或周围的导管，以封闭或加宽生物腔，而不会对内腔产生显着的创伤。 在某些实施方案中，本发明特别涉及聚合物组合物的用途，所述聚合物组合物可以在插入所述气囊或裙部时使其凝胶化。 在某些实施方案中，充气粘性聚合物组合物在室温下为液体，在哺乳动物生理温度下为凝胶。 在某些实施方案中，充气粘性聚合物组合物包含任选纯化的反相热敏聚合物。
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公开(公告)号：US20080215036A1
公开(公告)日：2008-09-04
申请号：US11851848
申请日：2007-09-07
申请人： Jean-Marie Vogel , William E. Cohn
发明人： Jean-Marie Vogel , William E. Cohn
IPC分类号： A61M25/10
CPC分类号： A61B17/12195 , A61B17/08 , A61B17/12031 , A61B17/1204 , A61B17/12045 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B17/12186 , A61B2017/1205 , A61M29/02 , A61M2025/1052
摘要： One aspect of the present invention relates to catheters that can be placed in or around bodily conduits to occlude or widen a biological lumen without imparting significant trauma to the lumen. In certain embodiments, the invention particularly relates to the use of a polymer composition which can be made to gel upon insertion into said balloon or skirt. In certain embodiments, the inflating viscous polymer composition is a liquid at room temperature and a gel at mammalian physiological temperature. In certain embodiments, the inflating viscous polymer composition comprises an optionally purified inverse thermosensitive polymer.
摘要翻译： 本发明的一个方面涉及可以放置在身体管道中或周围的导管，以封闭或加宽生物腔，而不会对内腔产生显着的创伤。 在某些实施方案中，本发明特别涉及聚合物组合物的用途，所述聚合物组合物可以在插入所述气囊或裙部时使其凝胶化。 在某些实施方案中，充气粘性聚合物组合物在室温下为液体，在哺乳动物生理温度下为凝胶。 在某些实施方案中，充气粘性聚合物组合物包含任选纯化的反相热敏聚合物。
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公开(公告)号：US08697137B2
公开(公告)日：2014-04-15
申请号：US10220982
申请日：2001-03-23
申请人： Jean-Marie Vogel , Egisto Boschetti
发明人： Jean-Marie Vogel , Egisto Boschetti
IPC分类号： A61K9/50
CPC分类号： A61K9/1635 , A61K31/715 , A61K45/06 , A61L2430/36 , Y10T428/2982
摘要： The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
摘要翻译： 本发明涉及包含生物相容的，可溶胀的，基本上亲水的，无毒的和基本上为球形的聚合物材料载体的可注射组合物，其能够有效地输送用于栓塞药物治疗的生物活性治疗因子。 本发明还涉及使用可注射组合物的栓塞基因治疗方法，特别是用于治疗血管生成和非血管生成依赖性疾病的方法。
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公开(公告)号：US20060063732A1
公开(公告)日：2006-03-23
申请号：US11253435
申请日：2005-10-18
申请人： Jean-Marie Vogel , Egisto Boschetti
发明人： Jean-Marie Vogel , Egisto Boschetti
CPC分类号： A61K9/0019 , A61K9/1635 , A61K48/00 , A61K48/0008 , A61K48/0041
摘要： The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) physically linked to a transfection agent for use in embolization gene therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions., using the injectable compositions.
摘要翻译： 本发明涉及包含生物相容的，可溶胀的，基本上亲水的，无毒的和基本上为球形的聚合物材料载体的可注射组合物，其能够有效地递送与用于栓塞基因治疗的转染剂物理连接的生物活性治疗因子。 本发明还涉及使用可注射组合物的栓塞基因治疗方法，特别是用于使用可注射组合物治疗血管生成和非血管生成依赖性疾病的方法。
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公开(公告)号：US06790456B2
公开(公告)日：2004-09-14
申请号：US10222819
申请日：2002-08-19
申请人： Jean-Marie Vogel , Egisto Boschetti
发明人： Jean-Marie Vogel , Egisto Boschetti
IPC分类号： A61F1300
摘要： The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.
摘要翻译： 本发明涉及可注射组合物，其包含生物相容性，可溶胀，亲水，无毒和基本上为球形的微球微球和用于皮肤增生的生物相容性载体。 本发明还涉及使用可注射组合物的皮肤增强方法，特别是用于治疗皮肤轮廓缺陷的方法。
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公开(公告)号：US09308169B2
公开(公告)日：2016-04-12
申请号：US13462004
申请日：2012-05-02
申请人： Jean-Marie Vogel , Egisto Boschetti
发明人： Jean-Marie Vogel , Egisto Boschetti
IPC分类号： A61K9/50 , A61K9/16 , A61K31/715 , A61K45/06
CPC分类号： A61K9/1635 , A61K31/715 , A61K45/06 , A61L2430/36 , Y10T428/2982
摘要： The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
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公开(公告)号：US09017710B2
公开(公告)日：2015-04-28
申请号：US12197187
申请日：2008-08-22
IPC分类号： A61F2/00 , A61K9/14 , A01N65/00 , A61L27/38 , A61L27/50 , A61L31/00 , A61L31/14 , A61K31/78 , A61K31/785
CPC分类号： A61K9/14 , A61K31/78 , A61K31/785 , A61L27/3804 , A61L27/3839 , A61L27/50 , A61L31/005 , A61L31/14 , A61L2400/06
摘要： The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres useful for tissue bulking. The invention also relates to methods of tissue bulking, particularly for the treatment of Gastro-esophageal reflux disease, urinary incontinence, or urinary reflux disease, using the injectable compositions.
摘要翻译： 本发明涉及包含可用于组织膨胀的生物相容性，可溶胀，亲水，无毒和基本上为球形的微球的可注射组合物。 本发明还涉及使用可注射组合物的组织膨胀方法，特别是用于治疗胃食管反流病，尿失禁或尿反流疾病的方法。
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公开(公告)号：US20080181952A1
公开(公告)日：2008-07-31
申请号：US11954109
申请日：2007-12-11
IPC分类号： A61K9/00
CPC分类号： A61L24/046 , A61B17/00491 , A61B17/11 , A61B17/12022 , A61B17/12186 , A61B17/12195 , A61B2017/00252 , A61B2017/1107 , A61B2017/1135 , A61B2017/12004 , A61K31/722 , A61K31/728 , A61K31/765 , A61K45/06 , A61K51/06 , A61L24/0015 , A61L24/0031 , A61L24/06 , A61L2300/406 , A61L2400/04 , C08L71/02
摘要： Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney. In certain embodiments, return of blood flow may be accelerated by cooling the kidney. The compositions, methods and kits for perfusive organ hemostasis can also be used to simplify or to enable other organ surgeries or interventional procedures, including liver surgery, prostate surgery, brain surgery, surgery of the uterus, spleen surgery and any surgery on any highly vascularized organs.
摘要翻译： 公开了通过使用基于聚合物溶液的内部封堵器来控制出血的组合物，方法和试剂盒，包括在肾单位保护手术中使用反向热敏聚合物，其产生完全无血的手术领域，允许快速切除。 在某些实施方案中，在一定量的时间之后，流程逐渐恢复，对肾没有明显的不利后果。 在某些实施方案中，可以通过冷却肾来加速血流量的返回。 用于灌注器官止血的组合物，方法和试剂盒也可用于简化或实现其他器官手术或介入手术，包括肝手术，前列腺手术，脑外科手术，子宫手术，脾脏手术和任何高度血管化的手术 器官。
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公开(公告)号：US06436424B1
公开(公告)日：2002-08-20
申请号：US09528990
申请日：2000-03-20
申请人： Jean-Marie Vogel , Egisto Boschetti
发明人： Jean-Marie Vogel , Egisto Boschetti
IPC分类号： A61F1300
摘要： The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.
摘要翻译： 本发明涉及可注射组合物，其包含生物相容性，可溶胀，亲水，无毒和基本上为球形的微球微球和用于皮肤增生的生物相容性载体。 本发明还涉及使用可注射组合物的皮肤增强方法，特别是用于治疗皮肤轮廓缺陷的方法。
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