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    Compositions and methods for producing enhanced antibodies
    1.
    发明申请
    Compositions and methods for producing enhanced antibodies 审中-公开
    用于产生增强型抗体的组合物和方法

    公开(公告)号：US20060204492A1

    公开(公告)日：2006-09-14

    申请号：US11439071

    申请日：2006-05-22

    申请人： William Huse ,  Scott Glaser

    发明人： William Huse ,  Scott Glaser

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06 ,  C07K16/44

    CPC分类号： C07K16/2848 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2319/00

    摘要： The invention provides a Vitaxin antibody and a LM609 grafted antibody exhibiting selective binding affinity to αcβ3. The Vitaxin antibody consists of at least one Vitaxin heavy chain polypeptide and at least one Vitaxin light chain polypeptide or functional fragments thereof. Also provided are the Vitaxin heavy and light chain polypeptides and functional fragments. The LM609 grafted antibody consists of at least one CDR grafted heavy chain polypeptide and at least one CDR grafted light chain polypeptide or functional fragment thereof. The invention additionally provides a high affinity LM609 grafted antibody comprising one or more CDRs having at least one amino acid substitution, where the αvβ3 binding activity of the high affinity LM609 grafted antibody is enhanced. Nucleic acids encoding Vitaxin and LM609 grafted heavy and light chains as well as nucleic acids encoding the parental non-human antibody LM609 are additionally provided. Functional fragments of such encoding nucleic acids are similarly provided. The invention also provides a method of inhibiting a function of αvβ3. The method consists of contacting αvβ3 with Vitaxin or a LM609 grafted antibody or functional fragments thereof under conditions which allow binding to αvβ3. Finally, the invention provides for a method of treating an αvβ3-mediated disease. The method consists of administering an effective amount of Vitaxin or a LM609 grafted antibody or functional fragment thereof under conditions which allow binding to αvβ3.

    摘要翻译： 本发明提供了一种Vitaxin抗体和显示与α3β3的选择性结合亲和力的LM609接枝抗体。 维生素A抗体由至少一种维生素原重链多肽和至少一种维生素C轻链多肽或其功能片段组成。 还提供了维生素原重链和轻链多肽和功能片段。 LM609接枝抗体由至少一个CDR移植的重链多肽和至少一个CDR接枝的轻链多肽或其功能片段组成。 本发明另外提供了高亲和力LM609接枝抗体，其包含一个或多个具有至少一个氨基酸取代的CDR，其中高亲和力LM609的α3β3β3结合活性 接枝抗体增强。 编码维生素和LM609接枝的重链和轻链的核酸以及编码亲本非人抗体LM609的核酸。 类似地提供了这种编码核酸的功能性片段。 本发明还提供了抑制α3β3的功能的方法。 该方法包括在允许结合α睾丸激素的条件下，将α3β3β3和Vitaxin或LM609接枝抗体或其功能片段接触 3 。 最后，本发明提供了一种治疗α3β3介导的疾病的方法。 该方法包括在允许结合α3β3的条件下施用有效量的维生素或维生素LM609接枝抗体或其功能片段。

    Integrating cloud applications and remote jobs
    4.
    发明授权
    Integrating cloud applications and remote jobs 有权
    集成云应用程序和远程作业

    公开(公告)号：US08903943B2

    公开(公告)日：2014-12-02

    申请号：US13210208

    申请日：2011-08-15

    申请人： Scott Glaser ,  Nitin Patlola ,  Poonguzhali Balasubramanian

    发明人： Scott Glaser ,  Nitin Patlola ,  Poonguzhali Balasubramanian

    IPC分类号： G06F15/16 ,  G06F9/50

    CPC分类号： G06F9/5027 ,  G06F2209/509

    摘要： Disclosed herein are techniques for integrating cloud applications and remote jobs. In some implementations, a request to initiate a remote execution procedure may be received at a first computing system. The first computing system may be controlled by a first entity and may be configured to provide on-demand computing services to a plurality of entities including a second entity. The remote execution procedure may include an instruction to perform a remote computing task capable of being performed by a second computing system. A request message may be transmitted from the first computing system to the second computing system, which may be controlled by the second entity. The request message may include an instruction to perform the remote computing task. A response message indicating a result of performing the remote computing task may be received from the second computing system.

    摘要翻译： 这里公开了用于集成云应用和远程作业的技术。 在一些实现中，可以在第一计算系统处接收到发起远程执行过程的请求。 第一计算系统可以由第一实体控制，并且可以被配置为向包括第二实体的多个实体提供按需计算服务。 远程执行过程可以包括执行能够被第二计算系统执行的远程计算任务的指令。 请求消息可以从第一计算系统发送到第二计算系统，其可以由第二实体来控制。 请求消息可以包括执行远程计算任务的指令。 可以从第二计算系统接收指示执行远程计算任务的结果的响应消息。

    ON-DEMAND SERVICES ENVIRONMENT TESTING FRAMEWORK
    5.
    发明申请
    ON-DEMAND SERVICES ENVIRONMENT TESTING FRAMEWORK 有权
    需求服务环境测试框架

    公开(公告)号：US20120042210A1

    公开(公告)日：2012-02-16

    申请号：US12939092

    申请日：2010-11-03

    申请人： Scott Glaser ,  Poonguzhali Balasubramanian

    发明人： Scott Glaser ,  Poonguzhali Balasubramanian

    IPC分类号： G06F11/00

    CPC分类号： G06F11/3692 ,  G06F11/3684 ,  G06F11/3688

    摘要： In one embodiment, a method of providing a test framework in an on-demand services environment can include: accessing a plurality of tests via plug-ins to a core platform of the test framework; receiving, by a user interface, a selection of tests for execution from the plurality of tests, where the selected tests are configured to test a plurality of layers of a product; executing, by an execution engine coupled to the core platform, the selected tests; storing test results for the executed selected tests on a configurable repository; and reporting the stored test results in a summarized form on the user interface.

    摘要翻译： 在一个实施例中，在按需服务环境中提供测试框架的方法可以包括：通过插件将多个测试访问到测试框架的核心平台; 通过用户界面从所述多个测试中接收用于执行的测试的选择，其中所选择的测试被配置为测试产品的多个层; 由耦合到所述核心平台的执行引擎执行所选择的测试; 将所执行的所选测试的测试结果存储在可配置的存储库上; 并在用户界面上以汇总形式报告存储的测试结果。

    Methods and apparatus for cell based screening
    6.
    发明申请
    Methods and apparatus for cell based screening 审中-公开
    用于细胞筛选的方法和装置

    公开(公告)号：US20070037205A1

    公开(公告)日：2007-02-15

    申请号：US11585565

    申请日：2006-10-24

    申请人： Michael Palladino ,  Scott Glaser

    发明人： Michael Palladino ,  Scott Glaser

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/574 ,  C40B30/06

    CPC分类号： G01N33/5011 ,  G01N33/5008 ,  G01N33/5014 ,  G01N2510/00

    摘要： Methods, kits and systems for identifying at least one compound, from a set of compounds, that modulates the growth or biological activity of a cell. Also high-throughput, tumor cell-based screening assay methods for identifying one or more cell-growth modulating compounds from among a library of compounds.

    摘要翻译： 用于鉴定调节细胞的生长或生物活性的一组化合物中的至少一种化合物的方法，试剂盒和系统。 还可以从化合物文库中鉴定一种或多种细胞生长调节化合物的高通量，基于肿瘤细胞的筛选测定方法。

    Upset Recovery Training Using A Sustained-G Multi-Axis Platform Or A Centrifuge
    8.
    发明申请
    Upset Recovery Training Using A Sustained-G Multi-Axis Platform Or A Centrifuge 有权
    使用持续G多轴平台或离心机进行恢复训练

    公开(公告)号：US20110045446A1

    公开(公告)日：2011-02-24

    申请号：US12851723

    申请日：2010-08-06

    申请人： Scott Glaser ,  Glenn B. King ,  Richard A. Leland

    发明人： Scott Glaser ,  Glenn B. King ,  Richard A. Leland

    IPC分类号： G09B9/08

    CPC分类号： G09B9/12

    摘要： A process for providing upset recovery training (URT) includes using a sustained-G multi-axis platform (e.g., a centrifuge-based simulator). Various embodiments of the present invention address an important aspect of URT that is not present in the prior art, namely the placing of physiological stresses on the trainees during URT, such as sustained motions including, but not limited to, sustained, elevated G-forces and continuous rotational cues. Elevated, sustained, G-forces and continuous rotational cues can create many physiological challenges to aircrew. These challenges can include motion discomfort, disorientation, and visual disturbances. Embodiments of the present invention provide URT that includes physiological stresses on the pilot. If a pilot learns the correct procedures for recovery from an upset, as in the prior art URT programs, but cannot execute the procedures in the real world because he or she has not been prepared for the physiological environment to be faced, then safety is compromised. Embodiments of the present invention address this deficiency.

    摘要翻译： 用于提供不适的恢复训练（URT）的过程包括使用持续G多轴平台（例如，基于离心机的模拟器）。 本发明的各种实施例解决了现有技术中不存在的URT的一个重要方面，即在URT期间将生理压力放置在学员身上，例如持续运动，包括但不限于持续升高的G力 和连续旋转线索。 升高，持续，G力和连续的旋转线索可能对机组人员造成许多生理挑战。 这些挑战可能包括运动不适，定向障碍和视觉障碍。 本发明的实施例提供了包括导频上的生理应力的URT。 如果飞行员从现在开始的URT程序中学习正确的恢复程序，而不能执行现实世界中的程序，因为他或她没有为生理环境做好准备，那么安全性就会受到损害 。 本发明的实施例解决了这种缺陷。

    Anti-IGF-1R Antibodies and Uses Thereof
    9.
    发明申请
    Anti-IGF-1R Antibodies and Uses Thereof 审中-公开
    抗IGF-1R抗体及其用途

    公开(公告)号：US20100099147A1

    公开(公告)日：2010-04-22

    申请号：US12559411

    申请日：2009-09-14

    申请人： Kandasamy Hariharan ,  Scott Glaser

    发明人： Kandasamy Hariharan ,  Scott Glaser

    IPC分类号： C12P21/00 ,  C07K16/00 ,  C07H21/00 ,  C12N15/63 ,  C12N5/00

    CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/00

    摘要： The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-1R-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies which block the ability of the ligands, insulin like growth factor 1 (IGF-1) and insulin like growth factor 2 (IGF-2) to bind to IGF-1R, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention.

    摘要翻译： 本发明涉及结合胰岛素样生长因子受体-1（IGF-1R）的抗体及其用途，特别是癌症的诊断和治疗。 提供了抑制IGF-1R介导的原始存活和肿瘤增殖途径的特异性人和鼠单克隆抗体及其变体，片段及其衍生物。 还提供阻断配体，胰岛素样生长因子1（IGF-1）和胰岛素样生长因子2（IGF-2）与IGF-1R结合的能力的特异性人和鼠单克隆抗体，以及片段， 这些抗体的变体和衍生物。 本发明还包括编码上述抗体或其片段，变体或衍生物的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。 本发明还包括使用本发明的抗体诊断和治疗癌症的方法。