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公开(公告)号：US5552521A
公开(公告)日：1996-09-03
申请号：US386618
申请日：1995-02-10
IPC分类号： A61B17/04 , A61B17/06 , A61K38/00 , A61P31/04 , A61P31/12 , A61P37/04 , C07K1/06 , C07K1/107 , C07K7/56 , C07K7/64
CPC分类号： C07K7/56 , A61B17/06133 , A61B2017/06142 , Y10S930/27
摘要： There is disclosed a novel process for preparing aza cyclohexapeptides of the formula ##STR1## where all variables are defined herein.
摘要翻译： 公开了一种制备式（I）的氮杂环己肽的新方法，其中所有变量在本文中定义。
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公开(公告)号：US5936062A
公开(公告)日：1999-08-10
申请号：US874118
申请日：1997-06-12
申请人： William Leonard , Kevin M. Belyk
发明人： William Leonard , Kevin M. Belyk
摘要： There is disclosed a novel process for preparing aza cyclohexapeptides of the formula ##STR1## where all variables are defined herein.
摘要翻译： 公开了一种制备下式的氮杂环己肽的新方法，其中所有变量在本文中定义。
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公开(公告)号：US08357798B2
公开(公告)日：2013-01-22
申请号：US12793801
申请日：2010-06-04
申请人： Kevin M. Belyk , Henry G. Morrison , Philip Jones , Vincenzo Summa , V. Brett Cooper , Amar J. Mahajan , Daniel J. Kumke , Hsien-Hsin Tung , Lawrence Wai , Vanessa Pruzinsky , Philip Pye , Remy Angelaud , Danny Mancheno
发明人： Kevin M. Belyk , Henry G. Morrison , Philip Jones , Vincenzo Summa , V. Brett Cooper , Amar J. Mahajan , Daniel J. Kumke , Hsien-Hsin Tung , Lawrence Wai , Vanessa Pruzinsky , Philip Pye , Remy Angelaud , Danny Mancheno
IPC分类号： C07D239/54
CPC分类号： C07D239/557 , C07D313/12 , C07D413/12
摘要： Potassium salts of Compound A and methods for their preparation are disclosed, wherein Compound A is of formula: Compound A is an HIV integrase inhibitor useful for treating or prophylaxis of HIV infection, for delaying the onset of AIDS, and for treating or prophylaxis of AIDS.
摘要翻译： 公开了化合物A的钾盐及其制备方法，其中化合物A具有下式：化合物A是可用于治疗或预防HIV感染，延迟AIDS发作和用于治疗或预防艾滋病的HIV整合酶抑制剂 。
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公开(公告)号：US20180179223A1
公开(公告)日：2018-06-28
申请号：US15578777
申请日：2016-06-03
申请人： Jingjun Yin , Tetsuji Itoh , Jianguo Yin , Bangping Xiang , Kevin R. Campos , Alexei Kalinin , Zhuqing Liu , Melodie Deniz Christensen , Kevin M. Belyk , Richard J. Varsolona , Andrew Brunskill
发明人： Jingjun Yin , Tetsuji Itoh , Jianguo Yin , Bangping Xiang , Kevin R. Campos , Alexei Kalinin , Zhuqing Liu , Melodie Deniz Christensen , Kevin M. Belyk , Richard J. Varsolona , Andrew Brunskill
IPC分类号： C07D498/04 , C07F5/02 , C07D403/04 , B01J31/04
CPC分类号： C07D498/04 , B01J31/04 , C07D403/04 , C07F5/025
摘要： The present invention is directed to processes for preparing Substituted Tetracyclic Heterocycle Compounds of formula (I): (I) which may be useful as HCV NS5A inhibitors. The present invention is also directed to compounds that may be useful as synthetic intermediates and catalysts in the processes of the invention.
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公开(公告)号：US09890128B2
公开(公告)日：2018-02-13
申请号：US15102417
申请日：2014-12-08
申请人： Michael Luzung , Guy Humphrey , Bangping Xiang , Kevin M. Belyk , Stephen Mark Dalby , Wilfried Schwab , Burkhard Klenke , Tom Moody , Gareth Brown
发明人： Michael Luzung , Guy Humphrey , Bangping Xiang , Kevin M. Belyk , Stephen Mark Dalby , Wilfried Schwab , Burkhard Klenke , Tom Moody , Gareth Brown
IPC分类号： C07D239/84 , B01J31/02 , C07D295/125
CPC分类号： C07D239/84 , B01J31/0202 , B01J31/0232 , B01J31/0244 , B01J31/0271 , B01J2231/324 , C07D295/125
摘要： The present invention is directed to a process for making Substituted Quinazoline Compounds of formula (I): which are useful for the treatment and prophylaxis of HCMV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).
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公开(公告)号：US20170166586A1
公开(公告)日：2017-06-15
申请号：US15325392
申请日：2015-07-10
申请人： Hongming LI , Jingjun YIN , Kevin M. BELYK , Kevin R. CAMPOS , Qinghao CHEN , Alan M. HYDE , Tetsuji ITOH , Artis KLAPARS , Mathew Thomas TUDGE , Edward CLEATOR , Aaron M. DUMAS , Louis-Charles CAMPEAU , Yonggang CHEN , Ji QI , Wensong XIAO , MERCK SHARP & DOHME CORP. , MERCK SHARP & DOHME LIMITED , MSD R&D (CHINA) CO., LTD
发明人： Hongming Li , Jingjun Yin , Kevin M. Belyk , Kevin R. Campos , Qinghao Chen , Alan M. Hyde , Tetsuji Itoh , Artis Klapars , Matthew Thomas Tudge , Edward Cleator , Aaron M. Dumas , Louis-Charles Campeau , Yonggang Chen , Ji Qi , Wensong Xiao
IPC分类号： C07D498/04 , C07F9/6509 , C07D265/14 , C07D413/04 , C07C251/24 , C07D417/04
CPC分类号： C07D498/04 , C07C251/24 , C07D239/74 , C07D265/14 , C07D265/36 , C07D413/04 , C07D413/14 , C07D417/04 , C07F9/650994 , C07F17/02
摘要： The present invention is directed to a process for making Tetracyclic Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R2 and R3 are defined above herein. The present invention is also directed to compounds that are useful as synthetic intermediates in the process of the invention.
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公开(公告)号：US20160311781A1
公开(公告)日：2016-10-27
申请号：US15102417
申请日：2014-12-08
申请人： Michael Luzung , Guy Humphrey , Bangping Xiang , Kevin M. Belyk , Stephen Mark Dalby , Wilfried Schwab , Burkhard Klenke , Tom Moody , Gareth Brown
发明人： Michael Luzung , Guy Humphrey , Bangping Xiang , Kevin M. Belyk , Stephen Mark Dalby , Wilfried Schwab , Burkhard Klenke , Tom Moody , Gareth Brown
IPC分类号： C07D239/84 , B01J31/02
CPC分类号： C07D239/84 , B01J31/0202 , B01J31/0232 , B01J31/0244 , B01J31/0271 , B01J2231/324 , C07D295/125
摘要： The present invention is directed to a process for making Substituted Quinazoline Compounds of formula (I): which are useful for the treatment and prophylaxis of HCMV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).
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公开(公告)号：US07754731B2
公开(公告)日：2010-07-13
申请号：US11293678
申请日：2005-12-02
申请人： Kevin M. Belyk , Henry G. Morrison , Amar J. Mahajan , Daniel J. Kumke , Hsien-Hsin Tung , Lawrence Wai , Vanessa Pruzinsky
发明人： Kevin M. Belyk , Henry G. Morrison , Amar J. Mahajan , Daniel J. Kumke , Hsien-Hsin Tung , Lawrence Wai , Vanessa Pruzinsky
IPC分类号： C07D239/54 , A61K31/515
CPC分类号： C07D239/557 , C07D313/12 , C07D413/12
摘要： Potassium salts of Compound A and methods for their preparation are disclosed, wherein Compound A is of formula: Compound A is an HIV integrase inhibitor useful for treating or prophylaxis of HIV infection, for delaying the onset of AIDS, and for treating or prophylaxis of AIDS.
摘要翻译： 公开了化合物A的钾盐及其制备方法，其中化合物A具有下式：化合物A是可用于治疗或预防HIV感染，延迟AIDS发作和用于治疗或预防艾滋病的HIV整合酶抑制剂 。
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公开(公告)号：US07214768B2
公开(公告)日：2007-05-08
申请号：US10474893
申请日：2002-04-08
申请人： Kevin M. Belyk , William R. Leonard
发明人： Kevin M. Belyk , William R. Leonard
CPC分类号： C07K7/56 , A61K38/00 , Y10S930/27
摘要： This invention relates to an improved process for the minimization of acid-catalyzed reactions of certain echinocandins of the kind disclosed in U.S. Pat. No. 5,378,804. The process involves the use of a boronic acid.
摘要翻译： 本发明涉及一种用于最小化美国专利中公开的某些棘白菌素的酸催化反应的改进方法。 第5,378,804号。 该方法包括使用硼酸。
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