公开(公告)号：US20240189505A1

公开(公告)日：2024-06-13

申请号：US18287684

申请日：2022-04-21

申请人： NORTHWESTERN UNIVERSITY ,  WILLIAM MARSH RICE UNIVERSITY

发明人： Jonathan Rivnay ,  Omid Veiseh ,  Jacob Robinson

IPC分类号： A61M5/142 ,  A61M5/172 ,  G16H20/17

CPC分类号： A61M5/14276 ,  A61M5/1723 ,  G16H20/17 ,  A61M2205/3306

摘要： A bioelectronic wearable device includes engineered cells and an electronically controlled stimulator that regulates a quantity and timing of therapeutic agent produced by the engineered cells.

公开(公告)号：US20230233085A1

公开(公告)日：2023-07-27

申请号：US18160509

申请日：2023-01-27

申请人： William Marsh Rice University

发明人： Yongyi Zhao ,  Ankit Raghuram ,  Ashok Veeraraghavan ,  Jacob Robinson

IPC分类号： A61B5/00

CPC分类号： A61B5/0073 ,  A61B5/0068 ,  A61B2562/046 ,  A61B2560/029

摘要： A system for imaging a target embedded in a scattering media includes: one or more light sources that are pulsed lights at one or more wavelengths in a range of visible to near-infrared; a detector, including a photodetector array with a time-gating function, configured to collect a scattered light after a gate start time; and a processor configured to determine an image of the target based on the scattered light.

公开(公告)号：US20240254507A1

公开(公告)日：2024-08-01

申请号：US18287709

申请日：2022-04-21

申请人： NORTHWESTERN UNIVERSITY ,  WILLIAM MARSH RICE UNIVERSITY

发明人： Omid Veiseh ,  Jacob Robinson ,  Jonathan Rivnay ,  Isaac Hilton ,  Samantha T. Fleury ,  Matthew C. Parker ,  Jacob H. Goell ,  Jing Li ,  Kaiyuan Wang

IPC分类号： C12N15/85 ,  C07K14/435 ,  C12N9/22 ,  C12N9/50

CPC分类号： C12N15/85 ,  C07K14/435 ,  C12N9/22 ,  C12N9/50 ,  C12Y304/22062 ,  C12N2830/001

摘要： An engineered cell expressing a therapeutic agent and a reporter agent, the engineered cell comprising a first transgene containing a light sensing DNA sequence encoding a light sensing protein, and a second transgene containing a calcium activated promoter, a therapeutic agent DNA encoding a therapeutic agent, and a reporter agent DNA encoding a reporter agent.

公开(公告)号：US20240207508A1

公开(公告)日：2024-06-27

申请号：US18287671

申请日：2022-04-21

申请人： NORTHWESTERN UNIVERSITY ,  WILLIAM MARSH RICE UNIVERSITY

发明人： Jonathan Rivnay ,  Omid Veiseh ,  Jacob Robinson ,  Samantha T. Fleury ,  Matthew C. Parker ,  Fatima T. Alrashdan

IPC分类号： A61M5/142 ,  A61M5/172 ,  G16H40/67

CPC分类号： A61M5/14276 ,  A61M5/1723 ,  G16H40/67 ,  A61M2205/3306

摘要： A bioelectronic implantable device includes engineered cells and an electronically controlled stimulator that regulates a quantity and timing of therapeutic agent produced by the engineered cells.

公开(公告)号：US10753869B2

公开(公告)日：2020-08-25

申请号：US16321309

申请日：2017-07-28

申请人： William Marsh Rice University

发明人： Ashok Veeraraghavan ,  Richard Baraniuk ,  Jacob Robinson ,  Vivek Boominathan ,  Jesse Adams ,  Benjamin Avants

IPC分类号： G01N21/47 ,  A61B5/00 ,  G06K9/00 ,  G02B21/36 ,  G01N21/64 ,  G01N21/76 ,  G06T7/55 ,  G02B21/16 ,  A61B5/1172 ,  G02B21/00 ,  A61B90/20

摘要： In one aspect, embodiments disclosed herein relate to a lens-free imaging system. The lens-free imaging system includes: an image sampler, a radiation source, a mask disposed between the image sampler and a scene, and an image sampler processor. The image sampler processor obtains signals from the image sampler that is exposed, through the mask, to radiation scattered by the scene which is illuminated by the radiation source. The image sampler processor then estimates an image of the scene based on the signals from the image sampler, processed using a transfer function that relates the signals and the scene.

公开(公告)号：US20160131637A1

公开(公告)日：2016-05-12

申请号：US14936384

申请日：2015-11-09

申请人： William Marsh Rice University

发明人： Jacob Robinson ,  Daniel L. Gonzales ,  Andrew Martin Bell ,  Daniel Vercosa ,  Benjamin Wesley Avants

IPC分类号： G01N33/487

CPC分类号： G01N33/48728

摘要： A microfluidic device includes a first microfluidic channel comprising a side wall and an electrode, disposed on the side wall. The microfluidic device further includes an intersection of the first microfluidic channel and a second microfluidic channel proximate to the electrode. The electrode is suspended into an interior region of the first microfluidic chamber.

摘要翻译： 微流体装置包括设置在侧壁上的包括侧壁和电极的第一微流体通道。 微流体装置还包括第一微流体通道和靠近电极的第二微流体通道的相交。 电极悬挂在第一微流体室的内部区域中。

公开(公告)号：US20190178796A1

公开(公告)日：2019-06-13

申请号：US16321309

申请日：2017-07-28

申请人： William Marsh Rice University

发明人： Ashok Veeraraghavan ,  Richard Baraniuk ,  Jacob Robinson ,  Vivek Boominathan ,  Jesse Adams ,  Benjamin Avants

IPC分类号： G01N21/47 ,  G01N21/64 ,  G01N21/76 ,  G02B21/36 ,  G02B21/16 ,  G06K9/00 ,  G06T7/55

CPC分类号： G01N21/4795 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0077 ,  A61B5/1172 ,  A61B90/20 ,  G01N21/6458 ,  G01N21/763 ,  G02B21/0008 ,  G02B21/16 ,  G02B21/361 ,  G02B21/367 ,  G06K9/00013 ,  G06T7/55 ,  G06T2207/10048 ,  G06T2207/10056 ,  G06T2207/30024

摘要： In one aspect, embodiments disclosed herein relate to a lens-free imaging system. The lens-free imaging system includes: an image sampler, a radiation source, a mask disposed between the image sampler and a scene, and an image sampler processor. The image sampler processor obtains signals from the image sampler that is exposed, through the mask, to radiation scattered by the scene which is illuminated by the radiation source. The image sampler processor then estimates an image of the scene based on the signals from the image sampler, processed using a transfer function that relates the signals and the scene.