System, method, and computer product for exon array analysis
    2.
    发明授权
    System, method, and computer product for exon array analysis 有权
    用于外显子阵列分析的系统,方法和计算机产品

    公开(公告)号:US08224586B2

    公开(公告)日:2012-07-17

    申请号:US13101773

    申请日:2011-05-05

    IPC分类号: G06F19/00 G06F15/00

    CPC分类号: G06F19/20

    摘要: In one embodiment, a method for analyzing data generated by probe arrays is described that comprises receiving user selections of two or more data files and an identification of one or more subsets of intensity values acquired from a biological probe array. The method includes iteratively opening each data file, identifying the selected subset of intensity values associated with each open data file, determining parameters for processing, storing the parameters and the identified intensity values, and closing the open data file prior to the subsequent iteration. The method then includes processing the stored intensity values using the parameters to identify one or more biological events.

    摘要翻译: 在一个实施例中,描述了一种用于分析由探针阵列产生的数据的方法,其包括接收两个或多个数据文件的用户选择以及从生物探针阵列获取的一个或多个强度值子集的识别。 该方法包括迭代地打开每个数据文件,识别与每个打开的数据文件相关联的所选择的强度值子集,确定用于处理,存储参数和识别的强度值的参数,以及在随后的迭代之前关闭打开的数据文件。 该方法然后包括使用参数来处理存储的强度值以识别一个或多个生物事件。

    Methods of analysis of alternative splicing in mouse
    3.
    发明授权
    Methods of analysis of alternative splicing in mouse 失效
    小鼠中选择性剪接的分析方法

    公开(公告)号:US07341835B2

    公开(公告)日:2008-03-11

    申请号:US11036317

    申请日:2005-01-13

    摘要: The invention provides nucleic acid sequences which are complementary, in one embodiment, to a wide variety of mouse genes. The invention provides the sequences in such a way as to make them available for a variety of analyses. In one embodiment the nucleic acid sequences provided are present as an array of probes that may be used to measure gene expression of different mature RNA isoforms from at least 5,000 alternatively spliced mouse genes. As such, the invention relates to diverse fields impacted by the nature of molecular interaction, including chemistry, biology, medicine, pharmacology and medical diagnostics.

    摘要翻译: 本发明提供在一个实施方案中与多种小鼠基因互补的核酸序列。 本发明提供了这样的顺序,使得它们可用于各种分析。 在一个实施方案中,提供的核酸序列作为探针阵列存在,其可用于从至少5,000个可变剪接的小鼠基因测量不同成熟RNA同种型的基因表达。 因此,本发明涉及受分子相互作用性质影响的不同领域,包括化学,生物学,医学,药理学和医学诊断。

    System, method, and computer product for exon array analysis
    4.
    发明授权
    System, method, and computer product for exon array analysis 有权
    用于外显子阵列分析的系统,方法和计算机产品

    公开(公告)号:US08855939B2

    公开(公告)日:2014-10-07

    申请号:US13526248

    申请日:2012-06-18

    CPC分类号: G06F19/20

    摘要: In one embodiment, a method for analyzing data generated by probe arrays is described that comprises receiving user selections of two or more data files and an identification of one or more subsets of intensity values acquired from a biological probe array. The method includes iteratively opening each data file, identifying the selected subset of intensity values associated with each open data file, determining parameters for processing, storing the parameters and the identified intensity values, and closing the open data file prior to the subsequent iteration. The method then includes processing the stored intensity values using the parameters to identify one or more biological events.

    摘要翻译: 在一个实施例中,描述了一种用于分析由探针阵列产生的数据的方法,其包括接收两个或多个数据文件的用户选择以及从生物探针阵列获取的一个或多个强度值子集的识别。 该方法包括迭代地打开每个数据文件,识别与每个打开的数据文件相关联的所选择的强度值子集,确定用于处理,存储参数和识别的强度值的参数,以及在随后的迭代之前关闭打开的数据文件。 该方法然后包括使用参数来处理存储的强度值以识别一个或多个生物事件。

    System, method, and computer product for exon array analysis

    公开(公告)号:US07962289B2

    公开(公告)日:2011-06-14

    申请号:US11421941

    申请日:2006-06-02

    IPC分类号: G06F19/00 G06F15/00 C12N15/11

    CPC分类号: G06F19/20

    摘要: In one embodiment, a method for analyzing data generated by probe arrays is described that comprises receiving user selections of two or more data files and an identification of one or more subsets of intensity values acquired from a biological probe array. The method includes iteratively opening each data file, identifying the selected subset of intensity values associated with each open data file, determining parameters for processing, storing the parameters and the identified intensity values, and closing the open data file prior to the subsequent iteration. The method then includes processing the stored intensity values using the parameters to identify one or more biological events.

    System, Method, and Computer Product for Exon Array Analysis
    7.
    发明申请
    System, Method, and Computer Product for Exon Array Analysis 有权
    系统,方法和计算机产品外部子阵列分析

    公开(公告)号:US20120253688A1

    公开(公告)日:2012-10-04

    申请号:US13526248

    申请日:2012-06-18

    IPC分类号: G06F19/00

    CPC分类号: G06F19/20

    摘要: In one embodiment, a method for analyzing data generated by probe arrays is described that comprises receiving user selections of two or more data files and an identification of one or more subsets of intensity values acquired from a biological probe array. The method includes iteratively opening each data file, identifying the selected subset of intensity values associated with each open data file, determining parameters for processing, storing the parameters and the identified intensity values, and closing the open data file prior to the subsequent iteration. The method then includes processing the stored intensity values using the parameters to identify one or more biological events.

    摘要翻译: 在一个实施例中,描述了一种用于分析由探针阵列产生的数据的方法,其包括接收两个或多个数据文件的用户选择以及从生物探针阵列获取的一个或多个强度值子集的识别。 该方法包括迭代地打开每个数据文件,识别与每个打开的数据文件相关联的所选择的强度值子集,确定用于处理,存储参数和识别的强度值的参数,以及在随后的迭代之前关闭打开的数据文件。 该方法然后包括使用参数来处理存储的强度值以识别一个或多个生物事件。

    System, method, and computer product for exon array analysis
    8.
    发明申请
    System, method, and computer product for exon array analysis 有权
    用于外显子阵列分析的系统,方法和计算机产品

    公开(公告)号:US20110213560A1

    公开(公告)日:2011-09-01

    申请号:US13101773

    申请日:2011-05-05

    IPC分类号: G06F19/00

    CPC分类号: G06F19/20

    摘要: In one embodiment, a method for analyzing data generated by probe arrays is described that comprises receiving user selections of two or more data files and an identification of one or more subsets of intensity values acquired from a biological probe array. The method includes iteratively opening each data file, identifying the selected subset of intensity values associated with each open data file, determining parameters for processing, storing the parameters and the identified intensity values, and closing the open data file prior to the subsequent iteration. The method then includes processing the stored intensity values using the parameters to identify one or more biological events.

    摘要翻译: 在一个实施例中,描述了一种用于分析由探针阵列产生的数据的方法,其包括接收两个或多个数据文件的用户选择以及从生物探针阵列获取的一个或多个强度值子集的识别。 该方法包括迭代地打开每个数据文件,识别与每个打开的数据文件相关联的所选择的强度值子集,确定用于处理,存储参数和识别的强度值的参数,以及在随后的迭代之前关闭打开的数据文件。 该方法然后包括使用参数来处理存储的强度值以识别一个或多个生物事件。

    Methods of analysis of degraded nucleic acid samples
    10.
    发明授权
    Methods of analysis of degraded nucleic acid samples 失效
    降解核酸样品的分析方法

    公开(公告)号:US07374927B2

    公开(公告)日:2008-05-20

    申请号:US11121849

    申请日:2005-05-03

    摘要: The invention provides arrays for analysis of compromised nucleic acid samples, for example, nucleic acids obtained from formalin fixed paraffin embedded samples and methods to analyzed these compromised samples. Arrays are disclosed in which the probe selection region used to select probes for the array is the 300 bases of the target MRNA that are immediately upstream of the start of the poly(A) tail of the mRNA. The probes selected for the array are more biased toward the 3′ end of the mRNA than other arrays that are currently available.

    摘要翻译: 本发明提供用于分析受损核酸样品的阵列,例如从福尔马林固定石蜡包埋样品获得的核酸和分析这些受损样品的方法。 公开了阵列,其中用于选择阵列的探针的探针选择区是目标MRNA的300个碱基,其紧邻mRNA的poly(A)尾的起始位置的上游。 针对阵列选择的探针比目前可用的其他阵列更偏向mRNA的3'末端。