公开(公告)号：US08202319B2

公开(公告)日：2012-06-19

申请号：US13095731

申请日：2011-04-27

申请人： William Randal Belcher ,  Mannie Lee Clapp ,  Saswati Datta ,  Magda El-Nokaly ,  Sandra Lou Murawski ,  Steven Hardy Page ,  Sohini Paldey ,  Ronald Ray Warner ,  Raphael Warren

发明人： William Randal Belcher ,  Mannie Lee Clapp ,  Saswati Datta ,  Magda El-Nokaly ,  Sandra Lou Murawski ,  Steven Hardy Page ,  Sohini Paldey ,  Ronald Ray Warner ,  Raphael Warren

IPC分类号： A61F2/10 ,  B32B3/00 ,  B32B33/00 ,  B32B27/40 ,  C07C211/21 ,  C07C33/02 ,  C07C22/00 ,  C07C11/00 ,  C09D7/00

CPC分类号： C08J7/065 ,  A61L27/28 ,  A61L27/50 ,  A61L2400/18 ,  B82Y30/00 ,  C08J2375/04 ,  Y10T428/24479 ,  Y10T428/24802 ,  Y10T428/26 ,  Y10T428/31551 ,  Y10T442/2525

摘要： Article of manufacture comprising a substrate and a coating layer. The coating layer comprises at least one coating material, and is stably affixed to the substrate to form a stable, coated surface. The coated surface has a texture that mimics the topography of mammalian keratinous tissue and demonstrates at least one physical property representative of mammalian keratinous tissue, selected from the group consisting of a total surface energy of from about 15 mJ/m2 to about 50 mJ/m2, a dispersive component of the surface energy of from about 15 mJ/m2 to about 50 mJ/m2, a polar component of the total surface energy of from about 1 mJ/m2 to about 14 mJ/m2, a zeta-potential at a pH of about 5.0 of from about −40 mV to about 30 mV, and combinations thereof.

摘要翻译： 包括基材和涂层的制品。 涂层包括至少一种涂层材料，并且稳定地固定到基底上以形成稳定的涂覆表面。 涂覆的表面具有模拟哺乳动物角质组织的形貌的纹理，并且显示代表哺乳动物角质组织的至少一种物理性质，其选自总表面能为约15mJ / m 2至约50mJ / m 2 表面能的分散组分为约15mJ / m 2至约50mJ / m 2，总表面能的极性分数为约1mJ / m 2至约14mJ / m 2，ζ电位为 大约5.0的pH为约-40mV至约30mV，及其组合。

公开(公告)号：US20110202134A1

公开(公告)日：2011-08-18

申请号：US13095731

申请日：2011-04-27

申请人： William Randal Belcher ,  Mannie Lee Clapp ,  Saswati Datta ,  Magda El-Nokaly ,  Sandra Lou Murawski ,  Steven Hardy Page ,  Sohini Paldey ,  Ronald Ray Warner ,  Raphael Warren

发明人： William Randal Belcher ,  Mannie Lee Clapp ,  Saswati Datta ,  Magda El-Nokaly ,  Sandra Lou Murawski ,  Steven Hardy Page ,  Sohini Paldey ,  Ronald Ray Warner ,  Raphael Warren

IPC分类号： A61F2/10 ,  B32B3/00 ,  B32B33/00 ,  C07C211/21 ,  C07C33/02 ,  C07C22/00 ,  C09D7/00 ,  B32B27/40 ,  C07C11/00

CPC分类号： C08J7/065 ,  A61L27/28 ,  A61L27/50 ,  A61L2400/18 ,  B82Y30/00 ,  C08J2375/04 ,  Y10T428/24479 ,  Y10T428/24802 ,  Y10T428/26 ,  Y10T428/31551 ,  Y10T442/2525

摘要： Article of manufacture comprising a substrate and a coating layer. The coating layer comprises at least one coating material, and is stably affixed to the substrate to form a stable, coated surface. The coated surface has a texture that mimics the topography of mammalian keratinous tissue and demonstrates at least one physical property representative of mammalian keratinous tissue, selected from the group consisting of a total surface energy of from about 15 mJ/m2 to about 50 mJ/m2, a dispersive component of the surface energy of from about 15 mJ/m2 to about 50 mJ/m2, a polar component of the total surface energy of from about 1 mJ/m2 to about 14 mJ/m2, a zeta-potential at a pH of about 5.0 of from about −40 mV to about 30 mV, and combinations thereof.

摘要翻译： 包括基材和涂层的制品。 涂层包括至少一种涂层材料，并且稳定地固定到基底上以形成稳定的涂覆表面。 涂覆的表面具有模拟哺乳动物角质组织的形貌的纹理，并且显示代表哺乳动物角质组织的至少一种物理性质，其选自总表面能为约15mJ / m 2至约50mJ / m 2 表面能的分散组分为约15mJ / m 2至约50mJ / m 2，总表面能的极性分数为约1mJ / m 2至约14mJ / m 2，ζ电位为 大约5.0的pH为约-40mV至约30mV，及其组合。

公开(公告)号：US07954392B2

公开(公告)日：2011-06-07

申请号：US11502858

申请日：2006-08-11

申请人： William Randal Belcher ,  Mannie Lee Clapp ,  Saswati Datta ,  Magda El-Nokaly ,  Sandra Lou Murawski ,  Steven Hardy Page ,  Sohini Paldey ,  Ronald Ray Warner ,  Raphael Warren

发明人： William Randal Belcher ,  Mannie Lee Clapp ,  Saswati Datta ,  Magda El-Nokaly ,  Sandra Lou Murawski ,  Steven Hardy Page ,  Sohini Paldey ,  Ronald Ray Warner ,  Raphael Warren

IPC分类号： G01N33/00

CPC分类号： C08J7/065 ,  A61L27/28 ,  A61L27/50 ,  A61L2400/18 ,  B82Y30/00 ,  C08J2375/04 ,  Y10T428/24479 ,  Y10T428/24802 ,  Y10T428/26 ,  Y10T428/31551 ,  Y10T442/2525

摘要： Article of manufacture comprising a substrate and a coating layer. The coating layer comprises at least one coating material, and is stably affixed to the substrate to form a stable, coated surface. The coated surface has a texture that mimics the topography of mammalian keratinous tissue and demonstrates at least one physical property representative of mammalian keratinous tissue, selected from the group consisting of a total surface energy of from about 15 mJ/m2 to about 50 mJ/m2, a dispersive component of the surface energy of from about 15 mJ/m2 to about 50 mJ/m2, a polar component of the total surface energy of from about 1 mJ/m2 to about 14 mJ/m2, a zeta-potential at a pH of about 5.0 of from about −40 mV to about 30 mV, and combinations thereof.

摘要翻译： 包括基材和涂层的制品。 涂层包括至少一种涂层材料，并且稳定地固定到基底上以形成稳定的涂覆表面。 涂覆的表面具有模拟哺乳动物角质组织的形貌的纹理，并且显示代表哺乳动物角质组织的至少一种物理性质，其选自总表面能为约15mJ / m 2至约50mJ / m 2 表面能的分散组分为约15mJ / m 2至约50mJ / m 2，总表面能的极性分数为约1mJ / m 2至约14mJ / m 2，ζ电位为 大约5.0的pH为约-40mV至约30mV，及其组合。

公开(公告)号：US08417474B2

公开(公告)日：2013-04-09

申请号：US11702404

申请日：2007-02-05

申请人： Saswati Datta ,  William Randal Belcher ,  Sandra Lou Murawski ,  Mannie Lee Clapp ,  Steven Hardy Page ,  Magda El-Nokaly ,  Richard Tweddell, III ,  Sohini Paldey ,  Louis Fay Wong ,  Ronald R. Warner ,  Kerstin Ann-Margret Nolkrantz ,  Chitra Laxmanan ,  Brian Naveen Ranade ,  Jianjun Justin Li ,  Randall Glenn Marsh ,  Maria Montserrat Sanchez Peña

发明人： Saswati Datta ,  William Randal Belcher ,  Sandra Lou Murawski ,  Mannie Lee Clapp ,  Steven Hardy Page ,  Magda El-Nokaly ,  Richard Tweddell, III ,  Sohini Paldey ,  Louis Fay Wong ,  Ronald R. Warner ,  Kerstin Ann-Margret Nolkrantz ,  Chitra Laxmanan ,  Brian Naveen Ranade ,  Jianjun Justin Li ,  Randall Glenn Marsh ,  Maria Montserrat Sanchez Peña

IPC分类号： G01N37/00 ,  G06G7/48

CPC分类号： G01N19/02 ,  G01N2030/025 ,  G01N2203/0246

摘要： Method of product evaluation comprising the steps of applying at least one substance to a surface of an artificial substrate to form a substance-coated surface, wherein the substrate surface demonstrates at least one physical property selected from the group consisting of a total surface energy of from about 15 mJ/m2 to about 50 mJ/m2, a polar component of the total surface energy of from about 0 mJ/m2 to about 15 mJ/m2, a zeta-potential at a pH of about 5.0 of from about −30 mV to about 30 mV, and combinations thereof, and performing at least one analysis of the substance-coated surface.

摘要翻译： 产品评估方法包括以下步骤：将至少一种物质施加到人造基底的表面以形成物质涂覆的表面，其中所述基底表面显示出至少一种物理性质，所述物理性质选自以下物质的总表面能： 约15mJ / m 2至约50mJ / m 2，总表面能的极性分数为约0mJ / m 2至约15mJ / m 2，pH约5.0的ζ电位为约-30mV 至约30mV，及其组合，并进行至少一种物质涂覆表面的分析。

公开(公告)号：US06287583B1

公开(公告)日：2001-09-11

申请号：US08969048

申请日：1997-11-12

申请人： Raphael Warren ,  Mannie Lee Clapp

发明人： Raphael Warren ,  Mannie Lee Clapp

IPC分类号： A61K3174

CPC分类号： A61Q19/10 ,  A61K8/0208 ,  A61K8/347 ,  A61K8/42 ,  A61K8/463 ,  A61K8/731 ,  A61K8/8147 ,  A61K8/8152 ,  A61K2800/5424 ,  A61Q17/005 ,  A61Q19/00

摘要： The preset invention relates to personal care compositions comprising from about 0.5% to about 80% of a surfactant, from about 0.1% to about 12% of a polymeric acid; and from about 3% to about 98.899% of water, wherein the composition is adjusted to a pH of from about 3.0 to about 6.0.

摘要翻译： 本发明涉及包含约0.5％至约80％的表面活性剂，约0.1％至约12％的聚合酸的个人护理组合物; 和约3％至约98.899％的水，其中将组合物调节至约3.0至约6.0的pH。

公开(公告)号：US06287577B1

公开(公告)日：2001-09-11

申请号：US08967972

申请日：1997-11-12

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken ,  Wei Cen ,  Mannie Lee Clapp ,  Raphael Warren

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken ,  Wei Cen ,  Mannie Lee Clapp ,  Raphael Warren

IPC分类号： A61K700

CPC分类号： A61Q19/00 ,  A61K8/347 ,  A61K8/365 ,  A61K8/463 ,  A61Q17/005

摘要： The present invention relates to a leave-on antimicrobial composition comprising from about 0.001% to about 5% of an antimicrobial active; from about 0.05% to about 10% of an anionic surfactant; from about 0.1% to about 10% of a proton donating agent; and from about 0% to about 99.85% of water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the leave-on antimicrobial composition has a Gram Positive Residual Effectiveness Index of greater than about 0.5; and wherein the leave-on antimicrobial composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.

摘要翻译： 本发明涉及一种留下抗微生物组合物，其包含约0.001％至约5％的抗微生物活性物质; 约0.05％至约10％的阴离子表面活性剂; 约0.1％至约10％的质子供体剂; 和约0％至约99.85％的水; 其中将组合物调节至约3.0至约6.0的pH; 其中所述留置抗微生物组合物具有大于约0.5的革兰氏阳性残留有效性指数; 并且其中所述留置的抗微生物组合物具有大于0.3的温和指数。 本发明还包括使用这些产品的用于清洁皮肤并提供残留效力的革兰氏阳性细菌的方法。

公开(公告)号：US06284259B1

公开(公告)日：2001-09-04

申请号：US08969057

申请日：1997-11-12

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken ,  Wei Cen ,  Mannie Lee Clapp ,  Raphael Warren

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken ,  Wei Cen ,  Mannie Lee Clapp ,  Raphael Warren

IPC分类号： A61K750

CPC分类号： A61Q17/005 ,  A61K8/0208

摘要： The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the antimicrobial cleansing composition has a Gram Positive Residual Effectiveness Index of greater than about 0.5; and wherein the antimicrobial cleansing composition has a Mildness Index of less than about 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.

摘要翻译： 本发明涉及一种抗微生物擦拭物，其包括浸渍有抗微生物清洁组合物的多孔或吸收性片材，其中所述抗微生物清洁组合物包含抗微生物清洁组合物的约0.001％至约5.0％的抗微生物活性成分; 约0.05％至约10％的抗微生物清洁组合物;阴离子表面活性剂; 约0.1重量％至约10重量％的抗微生物清洁组合物;质子供体剂; 和约3％至约99.85％的抗微生物清洁组合物，水; 其中将组合物调节至约3.0至约6.0的pH; 其中所述抗微生物清洁组合物具有大于约0.5的革兰氏阳性残留有效性指数; 并且其中所述抗微生物清洁组合物的温和指数小于约0.3。 本发明还包括使用这些产品的用于清洁皮肤并提供残留效力的革兰氏阳性细菌的方法。

公开(公告)号：US06214363B1

公开(公告)日：2001-04-10

申请号：US08969077

申请日：1997-11-12

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Robert Gregory Bartolo ,  Theresa Anne Bakken ,  Mary Elizabeth Carethers ,  Mark Richard Sine ,  Mannie Lee Clapp ,  Raphael Warren

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Robert Gregory Bartolo ,  Theresa Anne Bakken ,  Mary Elizabeth Carethers ,  Mark Richard Sine ,  Mannie Lee Clapp ,  Raphael Warren

IPC分类号： A01N2534

CPC分类号： A61Q17/005 ,  A61K8/347 ,  A61K8/442 ,  A61K8/463 ,  A61Q19/00

摘要： The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.001% to about 5% of an antimicrobial active, from about 1% to about 80% of an anionic surfactant, from about 0.1% to about 12% of a proton donating agent; from about 0.1% to about 30% of a deposition aid; and from about 3% to about 98.8% of water, wherein the composition is adjusted to a pH of from about 3.0 to about 6.0, wherein the rinse-off antimicrobial cleansing composition has a Gram Negative Residual Effectiveness Index of greater than about 0.3, and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.

摘要翻译： 本发明涉及一种漂洗抗微生物清洁组合物，其包含约0.001％至约5％的抗微生物活性剂，约1％至约80％的阴离子表面活性剂，约0.1％至约12％的质子 捐赠代理人 约0.1％至约30％的沉积助剂; 和约3％至约98.8％的水，其中将组合物调节至约3.0至约6.0的pH，其中冲洗抗微生物清洁组合物具有大于约0.3的革兰氏阴性残留有效性指数，以及 其中所述洗涤抗微生物清洁组合物的温和指数大于0.3。 本发明还包括使用这些产品的用于清洁皮肤并提供与革兰氏阴性细菌的残留效力的方法。

公开(公告)号：US06190675B1

公开(公告)日：2001-02-20

申请号：US08969049

申请日：1997-11-12

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Wei Cen ,  Theresa Anne Bakken ,  Mannie Lee Clapp ,  Raphael Warren

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Wei Cen ,  Theresa Anne Bakken ,  Mannie Lee Clapp ,  Raphael Warren

IPC分类号： A61K600

CPC分类号： A61K8/347 ,  A61K8/36 ,  A61K8/362 ,  A61K8/365 ,  A61K8/368 ,  A61K8/42 ,  A61K8/4933 ,  A61Q5/02 ,  A61Q17/005 ,  A61Q19/10 ,  Y10S514/975

摘要： The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.001% to about 5% of an antimicrobial active, from about 1% to about 80% of an anionic surfactant, from about 0.1% to about 12% of a proton donating agent; and from about 3% to about 98.899% of water, wherein the composition is adjusted to a pH of from about 3.0 to about 6.0, wherein the rinse-off antimicrobial cleansing composition has a Gram Positive Residual Effectiveness Index of greater than about 1.8, and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.

摘要翻译： 本发明涉及一种漂洗抗微生物清洁组合物，其包含约0.001％至约5％的抗微生物活性剂，约1％至约80％的阴离子表面活性剂，约0.1％至约12％的质子 捐赠代理人 和约3％至约98.899％的水，其中将组合物调节至约3.0至约6.0的pH，其中冲洗抗微生物清洁组合物具有大于约1.8的革兰氏阳性残留效力指数，以及 其中所述洗涤抗微生物清洁组合物的温和指数大于0.3。 本发明还包括使用这些产品的用于清洁皮肤并提供残留效力的革兰氏阳性细菌的方法。

公开(公告)号：US06280758B1

公开(公告)日：2001-08-28

申请号：US09294574

申请日：1999-04-20

申请人： Raphael Warren ,  Mannie Lee Clapp

发明人： Raphael Warren ,  Mannie Lee Clapp

IPC分类号： A01N2500

CPC分类号： A61Q19/10 ,  A61K8/0208 ,  A61K8/347 ,  A61K8/42 ,  A61K8/463 ,  A61K8/731 ,  A61K8/8147 ,  A61K8/8152 ,  A61K2800/5424 ,  A61Q17/005 ,  A61Q19/00

摘要： The present invention relates to personal care compositions comprising from about 0.5% to about 80% of a surfactant, from about 0.1% to about 12% of a polymeric acid; and from about 3% to about 98.899% of water, wherein the composition is adjusted to a pH of from about 3.0 to about 6.0.

摘要翻译： 本发明涉及包含约0.5％至约80％的表面活性剂，约0.1％至约12％的聚合酸的个人护理组合物; 和约3％至约98.899％的水，其中将组合物调节至约3.0至约6.0的pH。