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公开(公告)号：US20030206922A1
公开(公告)日：2003-11-06
申请号：US10454306
申请日：2003-06-03
IPC分类号： A61K031/739 , A61K039/02
CPC分类号： A61K39/0275 , A61K31/739 , A61K39/085 , A61K39/39 , A61K2039/552 , A61K2039/55572 , C07K14/24 , G01N33/53 , Y02A50/482 , Y10S424/823 , Y10S424/824 , Y10S424/825 , Y10S424/826 , Y10S424/827 , Y10S424/828 , Y10S424/829
摘要： The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions.
摘要翻译： 本发明提供包含来自革兰氏阴性微生物的铁载体受体多肽和孔蛋白的组合物，优选浓度不超过约10.0内毒素单位/毫升的脂多糖。 本发明还提供了制备方法和使用这些组合物的方法。
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公开(公告)号：US20030211118A1
公开(公告)日：2003-11-13
申请号：US10454305
申请日：2003-06-03
IPC分类号： A61K039/02
CPC分类号： A61K39/0275 , A61K31/739 , A61K39/085 , A61K39/39 , A61K2039/552 , A61K2039/55572 , C07K14/24 , G01N33/53 , Y02A50/482 , Y10S424/823 , Y10S424/824 , Y10S424/825 , Y10S424/826 , Y10S424/827 , Y10S424/828 , Y10S424/829
摘要： The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions.
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公开(公告)号：US20040197350A1
公开(公告)日：2004-10-07
申请号：US10830258
申请日：2004-04-22
IPC分类号： A61K039/02 , A61K031/739
CPC分类号： A61K39/0275 , A61K31/739 , A61K39/085 , A61K39/39 , A61K2039/552 , A61K2039/55572 , C07K14/24 , G01N33/53 , Y02A50/482 , Y10S424/823 , Y10S424/824 , Y10S424/825 , Y10S424/826 , Y10S424/827 , Y10S424/828 , Y10S424/829
摘要： The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions.
摘要翻译： 本发明提供包含来自革兰氏阴性微生物的铁载体受体多肽和孔蛋白的组合物，优选浓度不超过约10.0内毒素单位/毫升的脂多糖。 本发明还提供了制备方法和使用这些组合物的方法。
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公开(公告)号：US20040265329A1
公开(公告)日：2004-12-30
申请号：US10829838
申请日：2004-04-22
IPC分类号： A61K039/02 , C12P021/06 , C12N001/20
CPC分类号： A61K39/0275 , A61K31/739 , A61K39/085 , A61K39/39 , A61K2039/552 , A61K2039/55572 , C07K14/24 , G01N33/53 , Y02A50/482 , Y10S424/823 , Y10S424/824 , Y10S424/825 , Y10S424/826 , Y10S424/827 , Y10S424/828 , Y10S424/829
摘要： The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions.
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公开(公告)号：US20040197869A1
公开(公告)日：2004-10-07
申请号：US10829775
申请日：2004-04-22
IPC分类号： C07K014/245 , C07H021/04 , C12N001/21 , C12N015/74
CPC分类号： A61K39/0275 , A61K31/739 , A61K39/085 , A61K39/39 , A61K2039/552 , A61K2039/55572 , C07K14/24 , G01N33/53 , Y02A50/482 , Y10S424/823 , Y10S424/824 , Y10S424/825 , Y10S424/826 , Y10S424/827 , Y10S424/828 , Y10S424/829
摘要： The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions.
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公开(公告)号：US20030064073A1
公开(公告)日：2003-04-03
申请号：US10185498
申请日：2002-06-28
IPC分类号： A61K039/00 , A61K039/38
CPC分类号： C07K14/245 , A61K39/0258 , A61K39/0275 , A61K39/102 , G01N33/56911 , G01N33/56916 , Y02A50/474 , Y02A50/482 , Y10S424/823 , Y10S424/824 , Y10S424/825 , Y10S424/826 , Y10S530/825
摘要： The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine The vaccine may contain purified siderophore receptor proteins derived from a single strain or species of gram-negative bacteria or other organism, which are cross-reactive with siderophores produced by two or more strains, species or genera of gram-negative bacteria. The invention further provides a process for isolating and purifying the siderophore receptor proteins, and for preparing a vaccine containing the proteins. Also provided is a method for diagnosing gram-negative sepsis.
摘要翻译： 本发明提供了用于免疫家禽和其他动物免受革兰氏阴性细菌感染的疫苗以及使用疫苗免疫动物的方法疫苗可以含有衍生自单个菌株或革兰氏阴性细菌种类的纯化铁载体受体蛋白 或与由两种或多种菌株，革兰氏阴性细菌的种类或属产生的铁载体交叉反应的其它生物体。 本发明还提供了一种用于分离和纯化铁载体受体蛋白质的方法，以及用于制备含有蛋白质的疫苗。 还提供了用于诊断革兰氏阴性脓毒症的方法。
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