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    Fusion proteins useful for detecting analytes
    1.
    发明申请
    Fusion proteins useful for detecting analytes 审中-公开
    用于检测分析物的融合蛋白

    公开(公告)号：US20070136825A1

    公开(公告)日：2007-06-14

    申请号：US10490153

    申请日：2002-09-13

    申请人： Wolf-Bernd Frommer ,  Marcus Fehr ,  Sylvie Lalonde

    发明人： Wolf-Bernd Frommer ,  Marcus Fehr ,  Sylvie Lalonde

    IPC分类号： A01K67/027 ,  C07H21/04 ,  C12P21/04 ,  C12N15/82 ,  C12N5/04 ,  C07K14/435

    CPC分类号： C07K14/43595 ,  A01K2217/05 ,  C07K2319/00 ,  C07K2319/20 ,  C07K2319/60 ,  G01N33/542

    摘要： Disclosed are fusion proteins comprising two detection portions and a periplasmic binding protein (PBP) portion between this two detection portions which undergoes a conformational change upon binding of a compound. Also described are nucleic acid molecules comprising a nucleotide sequence encoding such a fusion protein as well as expression cassettes, vectors, transgenic plants and transgenic non-human animals comprising said nucleic acid molecules. In addition, described are methods for detecting an analyte in a sample or in a cell using said fusion protein, and optionally, a control sensor allowing a calibration of analyte detection made by said fusion protein. Also described are such control sensors and nucleic acid molecules encoding them, as well as diagnostic compositions, kits and uses of the fusion protein and the control sensor for in vitro or in vivo analyte detection and preparing a diagnostic composition.

    摘要翻译： 公开了在两个检测部分之间包含两个检测部分和周质结合蛋白（PBP）部分的融合蛋白，其在化合物结合时经历构象变化。 还描述了包含编码这种融合蛋白的核苷酸序列以及包含所述核酸分子的表达盒，载体，转基因植物和转基因非人动物的核酸分子。 此外，描述了使用所述融合蛋白检测样品或细胞中的分析物的方法，以及任选的允许校准由所述融合蛋白产生的分析物检测的控制传感器的方法。 还描述了这样的控制传感器和编码它们的核酸分子，以及用于体外或体内分析物检测和制备诊断组合物的融合蛋白和控制传感器的诊断组合物，试剂盒和用途。

    Sugar transporters
    2.
    发明授权
    Sugar transporters 有权
    糖运输商

    公开(公告)号：US09562081B2

    公开(公告)日：2017-02-07

    申请号：US12773500

    申请日：2010-05-04

    申请人： Wolf B. Frommer ,  Sylvie Lalonde

    发明人： Wolf B. Frommer ,  Sylvie Lalonde

    IPC分类号： C12N15/113 ,  C12N15/82 ,  C07K14/47 ,  C07K14/415 ,  C07K14/435

    CPC分类号： C12N15/8279 ,  C07K14/415 ,  C07K14/43545 ,  C07K14/47 ,  C12N15/8218 ,  C12N15/8245 ,  C12N15/8246

    摘要： A novel class of transporter protein, referred to as SWEET, GLUE or Glü, is disclosed. These transporters provide a novel system for the transportation of sugars across membranes within a cell and between the inside and outside of a cell. Such transporters are useful for understanding and altering the sugar concentration within certain organs of an organism, and within certain organelles within the cell. These transporters are also useful in protecting plants from a pathogen attack.

    摘要翻译： 公开了一类新颖的转运蛋白，称为SWEET，GLUE或Glü。 这些转运蛋白提供了一种用于在细胞内和细胞内部和外部的膜之间运输糖的新型系统。 这样的转运蛋白可用于理解和改变生物体的某些器官内和细胞内的某些细胞器内的糖浓度。 这些转运蛋白也可用于保护植物免受病原体攻击。