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    HPTH-fragment-(1-37), the preparation thereof, medicaments containing same and the use thereof
    5.
    发明授权
    HPTH-fragment-(1-37), the preparation thereof, medicaments containing same and the use thereof 失效
    HPTH片段 - （1-37），其制备方法，含有其的药物及其用途

    公开(公告)号：US5744444A

    公开(公告)日：1998-04-28

    申请号：US440117

    申请日：1995-05-12

    申请人： Wolf-Georg Forssmann ,  Franz Herbst ,  Peter Schulz-Knappe ,  Knut Adermann ,  Michael Gagelmann

    发明人： Wolf-Georg Forssmann ,  Franz Herbst ,  Peter Schulz-Knappe ,  Knut Adermann ,  Michael Gagelmann

    IPC分类号： A61K38/00 ,  C07K14/635 ,  A61K38/17 ,  C07K4/635

    CPC分类号： C07K14/635 ,  A61K38/00

    摘要： The invention relates to a peptide from human blood, designated as hPTH-(1-37), the structure of which was elucidated for the purpose of the diagnostic, medical and commercial utilization thereof. The isolation of a fragment hPTH-(38-84) proves the existence of the hPTH-(1-37). A removal of amino-terminal amino acids from the hPTH fragment-(1-37) reduces its biological activity. The hPTH-(1-37) circulating in the blood is identical with the synthetic reference substance hPTH-(1-37), however not with fragments such as hPTH-(1-33), hPTH-(1-34) or hPTH-(1-38). The molecule form hPTH-(1-37) has been proven by mass spectrometry (plasma desorption method). A different biological activity and differences in the three-dimensional peptide structure of the hPTH fragment-(1-37) in comparison to other hPTH fragments furnish evidence of that this fragment is the preferential natural peptide of the parathormone family which should be used for the treatment of diseases of the parathyroid, circulatory system, respiratory system, male genital organ and kidneys.

    摘要翻译： 本发明涉及一种称为hPTH-（1-37）的人血液肽，其结构用于诊断，医学和商业应用的目的。 片段hPTH-（38-84）的分离证明了hPTH-（1-37）的存在。 从hPTH片段（1-37）去除氨基末端氨基酸降低其生物活性。 在血液中循环的hPTH-（1-37）与合成参考物质hPTH-（1-37）相同，但不与hPTH-（1-33），hPTH-（1-34）或hPTH - （1-38）。 分子形式的hPTH-（1-37）已经通过质谱法（血浆解吸法）证实。 与其他hPTH片段相比，hPTH片段（1-37）的三维肽结构的不同生物活性和差异提供了证据，证明该片段是parathormone家族的优选天然肽，其应用于 治疗甲状旁腺，循环系统，呼吸系统，男性生殖器官和肾脏的疾病。

    Tandem cDNAs encoding chemokines CC-1, CC-2, and CC-3
    7.
    发明授权
    Tandem cDNAs encoding chemokines CC-1, CC-2, and CC-3 失效
    编码趋化因子CC-1，CC-2和CC-3的串联cDNA

    公开(公告)号：US06180773B2

    公开(公告)日：2001-01-30

    申请号：US09180077

    申请日：1998-12-30

    申请人： Wolf-Georg Forssmann ,  Andreas Pardigol ,  Hans-J{umlaut over (u)}rgen M{umlaut over (a)}gert ,  Peter Schulz-Knappe

    发明人： Wolf-Georg Forssmann ,  Andreas Pardigol ,  Hans-J{umlaut over (u)}rgen M{umlaut over (a)}gert ,  Peter Schulz-Knappe

    IPC分类号： C12N1519

    CPC分类号： C07K14/523 ,  A61K38/00

    摘要： The CC type chemokines belong to a family of polypeptides which have proven to be mediators of immune reactions, and they have recently attracted attention due to their antiviral activity with respect to HIV. The cloning and molecular characterization of a human tandem gene is disclosed which contains the closely linked coding regions for two new CC type chemokines the sequences of which are highly homologous with that of MIP-1&agr;. The transcription of the tandem gene leads to a bicistronic mature transcript which contains the non-overlapping open reading frames for the recently described factor HCC-1 and an as yet unknown CC type chemokine, designated as CC-2. Moreover, alternative splicing of the primary transcript yields at least one additional CC type chemokine, cytokine CC-3. Two functional promoter regions were identified within the tandem gene. The disclosed data provide some basic knowledge about the structure and expression of the new human CC-2/HCC-1 tandem gene and describe a mechanism according to which the coexpression of closely linked genes could be regulated in higher eucaryotes.

    摘要翻译： CC型趋化因子属于被证明是免疫反应介质的多肽家族，并且由于它们对于HIV的抗病毒活性，它们最近引起关注。 公开了人串联基因的克隆和分子表征，其包含两个新的CC型趋化因子的紧密连锁的编码区，其序列与MIP-1α的序列高度同源。 串联基因的转录导致二顺反子成熟转录物，其包含最近描述的因子HCC-1的非重叠开放阅读框和称为CC-2的尚未知的CC型趋化因子。 此外，主要转录物的选择性剪接产生至少一种另外的CC型趋化因子，细胞因子CC-3。 在串联基因内鉴定了两个功能启动子区域。 所公开的数据提供了关于新型人CC-2 / HCC-1串联基因的结构和表达的一些基本知识，并描述了一种机制，根据该机制可以在较高的真核生物中调节紧密连锁的基因的共表达。