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1.发明授权Peptides for combating the autoantibodies that are responsible for dilatative cardiomyopathy (DCM) 失效用于对抗负责扩张性心肌病（DCM）的自身抗体的肽公开(公告)号：US06994970B1
公开(公告)日：2006-02-07
申请号：US10088681
申请日：2000-09-21
IPC分类号： A61K38/00
CPC分类号： C07K7/08 , A61K38/00 , C07K14/70571
摘要： Peptides which bind auto-antibodies being in a causally pathological relationship with dilatative cardiomyopathy are described. The peptides may be bound, for example, to a solid phase. Auto-antibodies can be removed by treating blood of patients suffering from DCM with the peptides according to the invention.
摘要翻译： 描述了结合与扩张性心肌病有病理关系的自身抗体的肽。 肽可以结合到例如固相。 通过用根据本发明的肽治疗患有DCM的患者的血液可以除去自身抗体。
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2.发明申请PEPTIDES HAVING BINDING AFFINITY TO AN ANTIBODY WHICH RECOGNIZES AN EPITOPE ON AN A1 LOOP 2 OR BETA2 LOOP 1 OF AN ADRENORECEPTOR 有权具有结合亲和性的肽可以识别在ADRENORECEPTOR的A1环2或BETA2环1上的抗原决定簇公开(公告)号：US20110104226A1
公开(公告)日：2011-05-05
申请号：US12735416
申请日：2009-01-15
申请人： Rudolf Kunze , Gerd Wallukat , Peter Rosenthal , Richard Straube
发明人： Rudolf Kunze , Gerd Wallukat , Peter Rosenthal , Richard Straube
IPC分类号： A61K9/00 , A61K39/00 , C07K16/18 , C07H21/04 , C07H21/02 , C12N15/63 , C12N5/10 , B01J20/22 , B01J20/26 , A61K31/7088 , A61K35/12 , A61P25/28 , A61K31/711 , A61K31/7105
CPC分类号： C07K17/08 , A61K38/08 , A61K38/1787 , B01J20/286 , B01J20/3251 , C07K14/723 , C07K16/28 , C07K2317/34
摘要： A peptide having an ED50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular α1 loop 2 or β2 loop 1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of γ-secretase activity, an increased release of β-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the ED50 value is measured by bioassay.
摘要翻译： 具有小于500nm的ED 50，特别是10nM的肽，其识别人肾上腺素受体的细胞外α1环2或第2环1上的表位的抗体，其中抗体与表位的结合导致增加 γ-分泌酶活性，增加的β-固体分子释放和/或脑血管细胞，神经胶质细胞或神经元的细胞功能障碍，其中通过生物测定法测量ED 50值。
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3.发明申请PEPTIDES AGAINST AUTOANTIBODIES ASSOCIATED WITH GLAUCOMA AND USE OF THESE PEPTIDES 审中-公开与GLAUCOMA相关的自身抗体和这些肽的使用的肽公开(公告)号：US20090220469A1
公开(公告)日：2009-09-03
申请号：US12282201
申请日：2007-03-09
申请人： Gerd Wallukat , Rudolf Kunze , Martin Herrmann , Reinhard Voll , Anselm Junemann , Ursula Schloetzer
发明人： Gerd Wallukat , Rudolf Kunze , Martin Herrmann , Reinhard Voll , Anselm Junemann , Ursula Schloetzer
IPC分类号： C07K7/06 , C12N15/63 , C12N5/00 , A61K31/7088 , A61K38/10 , A61K35/12 , A61K35/16 , C07K7/64 , C12N15/85 , C07H21/02 , C12N15/11 , B01D15/08 , C12Q1/02 , C12Q1/68
CPC分类号： C07K14/70571 , C07K7/64 , C07K17/00 , G01N33/6893 , G01N2800/168
摘要： The invention relates to nucleic acid molecules encoding peptides which interact with autoantibodies associated with glaucoma, to the peptides themselves, to a pharmaceutical composition comprising said nucleic acid molecules and peptides, and to the use of said peptides—especially in apheresis—for the treatment of glaucoma.
摘要翻译： 本发明涉及编码与青光眼相关的自身抗体与肽本身相互作用的肽的核酸分子，以及包含所述核酸分子和肽的药物组合物以及所述肽 - 特别是在血浆分离术中的用途 - 用于治疗 青光眼。
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4.发明授权Peptides having binding affinity to an antibody which recognizes an epitope on an α1 loop 2 or β2 loop 1 of an adrenoreceptor 有权具有与识别肾上腺素受体的α1环2或β2环1上的表位的抗体结合亲和力的肽公开(公告)号：US08455442B2
公开(公告)日：2013-06-04
申请号：US12735416
申请日：2009-01-15
申请人： Rudolf Kunze , Gerd Wallukat , Peter Rosenthal , Richard Straube
发明人： Rudolf Kunze , Gerd Wallukat , Peter Rosenthal , Richard Straube
CPC分类号： C07K17/08 , A61K38/08 , A61K38/1787 , B01J20/286 , B01J20/3251 , C07K14/723 , C07K16/28 , C07K2317/34
摘要： A peptide having an ED50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular α1 loop 2 or β2 loop 1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of γ-secretase activity, an increased release of β-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the ED50 value is measured by bioassay.
摘要翻译： 具有小于500nm的ED 50，特别是10nM的肽，其识别人肾上腺素受体的细胞外α1环2或β2环1上的表位的抗体，其中抗体与表位的结合导致γ- 分泌酶活性，β-固体分子的增加释放和/或脑血管细胞，神经胶质细胞或神经元的细胞功能障碍，其中ED 50值通过生物测定来测量。
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公开(公告)号：US07205382B2
公开(公告)日：2007-04-17
申请号：US10415665
申请日：2001-11-08
申请人： Wolfgang Rönspeck , Ralf Egner , Dirk Winkler , Rudolf Kunze
发明人： Wolfgang Rönspeck , Ralf Egner , Dirk Winkler , Rudolf Kunze
IPC分类号： C07K2/00 , C07K5/12 , C07K7/64 , C07K7/08 , C07K7/04 , C07K1/107 , G01N33/53 , G01N33/543 , G01N33/563 , G01N33/564 , C07K1/00
摘要： Peptides having the following amino acid sequence as well as peptides or proteins which contain this amino acid sequence: R1-X01-X02-X03-X04-X05-X06-X07-X08-X09-X10-X11-X12-X13-R2. These peptides have a high affinity for immunoglobulins. Applications of the peptides according to the invention are also described.
摘要翻译： 具有以下氨基酸序列的肽以及含有该氨基酸的肽或蛋白质
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公开(公告)号：US20110251220A1
公开(公告)日：2011-10-13
申请号：US12995741
申请日：2009-06-02
申请人： Özlem Acikgöz , Jessica Ahmed , Bernd Dörken , Cornelius Frömmel , Andrean Goede , Franziska Jundt , Rudolf Kunze , Robert Preissner
发明人： Özlem Acikgöz , Jessica Ahmed , Bernd Dörken , Cornelius Frömmel , Andrean Goede , Franziska Jundt , Rudolf Kunze , Robert Preissner
IPC分类号： A61K31/513 , C07D239/56 , A61K31/4412 , A61K31/44 , A61P35/00 , A61P35/02 , A61P25/28 , A61P25/00 , A61P9/10 , A61P27/02 , A61P13/12 , A61P13/08 , A61P1/18 , A61P1/16 , C07D213/76
CPC分类号： A61K31/44 , A61K31/513
摘要： The present invention relates to pharmaceutical compositions comprising gamma secretase modulators as well as to the use of gamma secretase modulators for treating renal disorders, cancer, neurodegenerative disorders as well as related disorders.
摘要翻译： 本发明涉及包含γ分泌酶调节剂的药物组合物以及γ分泌酶调节剂用于治疗肾脏疾病，癌症，神经变性疾病以及相关疾病的用途。
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7.发明授权Water-soluble low molecular weight beta-glucans for modulating immunological responses in mammalian system 失效用于调节哺乳动物系统免疫应答的水溶性低分子量β-葡聚糖
公开(公告)号：US6143883A
公开(公告)日：2000-11-07
申请号：US224145
申请日：1998-12-31
申请人： Joachim Lehmann , Rudolf Kunze
发明人： Joachim Lehmann , Rudolf Kunze
IPC分类号： A61K31/716 , C08B37/00 , C12P19/14 , C07H5/04 , C07H5/06
CPC分类号： A61K31/716 , C08B37/0024 , C12P19/14
摘要： A fractionated, water-soluble, readily absorbable, low molecular weight beta-glucan is usable as an immune-modulator in the mammalian system. A method is disclosed, which produces a fractionated beta-glucan that is water-soluble and has a molecular weight between 1,000 Daltons-30,000 Daltons (1 kD-30 kD) adaptable to affect changes in the immune responses in mammalian systems.
摘要翻译： 分级，水溶性，容易吸收的低分子量β-葡聚糖可用作哺乳动物系统中的免疫调节剂。 公开了一种方法，其产生水溶性分子量为1,000道尔顿-300道尔顿（1kD-30kD）的分解β-葡聚糖，其适应于影响哺乳动物系统中免疫应答的变化。
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8.发明授权
公开(公告)号：US5505942A
公开(公告)日：1996-04-09
申请号：US328289
申请日：1994-10-21
CPC分类号： A61K38/4826 , A61K31/7048 , A61K38/4873 , C12Y304/21001 , C12Y304/21004 , C12Y304/22002
摘要： The present invention relates to the use of hydrolytic enzymes for the prophylaxis of spontaneous abortion in pregnant women in need thereof with habitual idiophathic abortion in their anamneses.
摘要翻译： 本发明涉及水解酶用于预防在有需要的孕妇中自发流产的习惯性痴呆流产的用途。
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