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    Substituted 5-(phenoxyalkanoylamino)-uracil compounds, methods for making same and pharmaceutical compositions based on same
    1.
    发明授权
    Substituted 5-(phenoxyalkanoylamino)-uracil compounds, methods for making same and pharmaceutical compositions based on same 失效
    取代的5-（苯甲酰氨基）脲类化合物，其制备方法和基于同一物质的药物组合物

    公开(公告)号：US5185341A

    公开(公告)日：1993-02-09

    申请号：US787064

    申请日：1991-11-04

    申请人： Wolfgang Sauer ,  Hans-Joachim Jansch ,  Angelika Rostock ,  Gottfried Faust ,  Christine Siegemund ,  Dieter Lohmann ,  Reni Bartsch

    发明人： Wolfgang Sauer ,  Hans-Joachim Jansch ,  Angelika Rostock ,  Gottfried Faust ,  Christine Siegemund ,  Dieter Lohmann ,  Reni Bartsch

    IPC分类号： A61K31/505 ,  A61P25/28 ,  C07D239/54 ,  C07D239/545

    CPC分类号： C07D239/545

    摘要： The substituted 5-(phenoxyalkanoylamino)-uracil compounds have the following formula I: ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen; a branched or linear alkyl group having 1 to 6 carbon atoms; a branched or straight chain alkenyl or alkynyl group having 1 to 6 carbons atoms; a cycloalkyl group having from 3 to 7 carbon atoms or a cycloalkylmethyl group having a cycloalkyl residue of 3 to 7 carbon atoms; or a phenylalkyl group having an alkyl residue having from 1 to 3 carbon atoms and a phenyl residue, the phenyl residue being unsubstituted or having a halogen, methoxy, methyl or trifluoromethyl substituent; R.sub.3 is a hydrogen, methyl or amino groups; R.sub.4 is halogen, methoxy or methyl groups, and n is 1 or 2. Pharmaceutical compositions for treating cerebrovascular, neuronal-degenerative and senility-induced disorders associated with learning, memory and cognitive dysfunctions are described which contain a therapeutically effective amount of the substituted 5-(phenoxyalkanoylamino)-uracil in a pharmaceutically acceptable carrier.

    摘要翻译： 取代的5-（苯氧烷酰氨基） - 尿嘧啶化合物具有下式I：其中R 1和R 2各自独立地为氢; 具有1至6个碳原子的支链或直链烷基; 具有1至6个碳原子的支链或直链烯基或炔基; 具有3至7个碳原子的环烷基或具有3至7个碳原子的环烷基残基的环烷基甲基; 或具有1至3个碳原子的烷基残基和苯基残基的苯基烷基，所述苯基残基是未取代的或具有卤素，甲氧基，甲基或三氟甲基取代基; R3是氢，甲基或氨基; R4是卤素，甲氧基或甲基，n是1或2.描述了用于治疗与学习，记忆和认知功能障碍相关的脑血管，神经元退行性和衰老性疾病的药物组合物，其含有治疗有效量的取代的5 - （苯氧烷酰氨基） - 尿嘧啶。