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    PROBE HEAD FOR SPECTROSCOPIC ANALYSIS OF A FLUID
    2.
    发明申请
    PROBE HEAD FOR SPECTROSCOPIC ANALYSIS OF A FLUID 失效
    用于流体光谱分析的探头

    公开(公告)号：US20070213609A1

    公开(公告)日：2007-09-13

    申请号：US11568363

    申请日：2005-02-14

    申请人： Gerhardus Lucassen ,  Wouter Rensen ,  Michael Van Beek ,  Marjolein Van Der Voort ,  Bernardus Bakker

    发明人： Gerhardus Lucassen ,  Wouter Rensen ,  Michael Van Beek ,  Marjolein Van Der Voort ,  Bernardus Bakker

    IPC分类号： A61B5/1455 ,  G01J3/42

    CPC分类号： A61B5/0059 ,  A61B5/489 ,  A61B2562/0242

    摘要： The present invention provides a spectroscopic system for determining a property of a fluid flowing through a volume of interest underneath the surface of the skin of a patient. The spectroscopic system comprises a probe head that has at least an objective for directing an excitation beam into the volume of interest and for collecting return radiation. The spectroscopic system has further a base station having at least a spectroscopic analysis unit and a power supply. The system makes use of a beam combination unit, a filter unit and a focusing unit for combining and separating a variety of different optical signals and for precisely positioning the optical signals inside the volume of interest. The beam combination unit, the filter unit and the focusing unit can be variably implemented inside the probe head or inside the base station depending on a specific applications of the spectroscopic system, thereby allowing for a flexible and compact design of the probe head.

    摘要翻译： 本发明提供了一种用于确定流过患者皮肤表面下方的感兴趣体积的流体的性质的光谱系统。 分光系统包括探头，该探头至少具有将激发光束引导到感兴趣体积中并用于收集返回辐射的目的。 光谱系统还具有至少具有光谱分析单元和电源的基站。 该系统利用光束组合单元，滤光器单元和聚焦单元，用于组合和分离各种不同的光信号，并将光信号精确地定位在感兴趣的体积内。 根据分光系统的具体应用，光束组合单元，滤光器单元和聚焦单元可以可变地实现在探头内部或基站内部，从而允许探头的灵活且紧凑的设计。

    Analysis of a composition with monitoring
    3.
    发明申请
    Analysis of a composition with monitoring 审中-公开
    分析一个组成与监测

    公开(公告)号：US20070049830A1

    公开(公告)日：2007-03-01

    申请号：US10549056

    申请日：2004-03-15

    申请人： Robert Hendriks ,  Gerhardus Lucassen ,  Marjolein Van Der Voort ,  Gerwin Puppels ,  Michael Van Beek

    发明人： Robert Hendriks ,  Gerhardus Lucassen ,  Marjolein Van Der Voort ,  Gerwin Puppels ,  Michael Van Beek

    IPC分类号： A61B6/00

    CPC分类号： A61B5/441 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/14532 ,  G01N21/65

    摘要： An analysis apparatus, in particular a spectroscopic analysis apparatus, comprises an excitation system for emitting an excitation beam to excite a target region. A a monitoring system images the target region. The monitoring system being arranged to produce a contrast image in a contrast wavelength range and produce a reference image in a reference wavelength range. the contrast image and the reference image are compared to accurately identify the target region, notably a capillary blood vessel in the patient's skin.

    摘要翻译： 分析装置，特别是光谱分析装置，包括用于发射激发光束以激发目标区域的激发系统。 监控系统对目标区域进行成像。 所述监视系统被布置成产生对比度波长范围内的对比度图像并产生参考波长范围内的参考图像。 比较对比图像和参考图像以精确地识别目标区域，特别是患者皮肤中的毛细血管血管。

    Aberration Correction for Spectroscopic Analysis
    4.
    发明申请
    Aberration Correction for Spectroscopic Analysis 有权
    光谱分析的畸变校正

    公开(公告)号：US20080002199A1

    公开(公告)日：2008-01-03

    申请号：US11570133

    申请日：2005-06-13

    申请人： Michael Van Beek ,  Wouter Rensen ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Bernardus Leonardus Bakker

    发明人： Michael Van Beek ,  Wouter Rensen ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Bernardus Leonardus Bakker

    IPC分类号： G01J3/30 ,  G06F19/00

    CPC分类号： G02B27/0025 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/28

    摘要： The present invention provides a spectroscopic system (100) for determining of a property of a biological structure in a volume of interest (120) of a person. The spectroscopic system (100) comprises a low cost objective lens (118) for directing an excitation beam into a volume of interest (120) and for collecting return radiation (124) from the volume of interest (120). After detection of the return radiation (124), i.e. the spectroscopic signals, a correction unit (106) performs the compensation of the aberrations of the spectroscopic signals introduced by the low cost objective lens (118). Since the aberrations of the objective lens (118) strongly depend on the lateral distance (122) of the volume of interest (120) from the optical axis (116) of the objective lens (118), the correction unit (106) makes effective use of a correction table (110) providing an assignment between correction values and various lateral positions (122) of the volume of interest (120).

    摘要翻译： 本发明提供一种用于确定人的感兴趣体积（120）中的生物结构的性质的光谱系统（100）。 分光系统（100）包括用于将激发光束引导到感兴趣体积（120）中并用于从感兴趣体积（120）收集返回辐射（124）的低成本物镜（118）。 在检测到返回辐射（124）即分光信号之后，校正单元（106）执行由低成本物镜（118）引入的分光信号的像差的补偿。 由于物镜（118）的像差强烈地取决于物镜（118）的光轴（116）的感兴趣体积（120）的横向距离（122），所以校正单元（106）有效 使用校正表（110）提供校正值与感兴趣体积（120）的各种侧向位置（122）之间的分配。

    Autofocus Mechanism for Spectroscopic System
    7.
    发明申请
    Autofocus Mechanism for Spectroscopic System 有权
    光谱系统的自动聚焦机制

    公开(公告)号：US20070252984A1

    公开(公告)日：2007-11-01

    申请号：US11570132

    申请日：2005-06-07

    申请人： Michael Van Beek ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Wouter Rensen ,  Durk De Vries

    发明人： Michael Van Beek ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Wouter Rensen ,  Durk De Vries

    IPC分类号： G01B11/14 ,  G01J3/00

    CPC分类号： G02B21/247 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/44 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/6463 ,  G01N2021/653 ,  G01N2021/655

    摘要： The present invention provides an autofocus mechanism for a spectroscopic system that is adapted to determine a property of a volume of interest. The volume of interest has an optical property that varies with time. The invention provides measurement means that are adapted to measure the fluctuations of the optical property of the volume of interest for determining the position of the volume of interest. The spectroscopic system being further adapted to focus an excitation beam into the determined volume of interest and for collecting return radiation emanating from the volume of interest for spectroscopic analysis. Preferably, inelastically scattered radiation of an excitation beam is separated from elastically scattered radiation for spectroscopic analysis. The elastically scattered radiation of the excitation beam is in turn exploited in order to measure the fluctuations of the optical property of the volume of interest. Making use of a control loop allows for maximization of the amplitude and/or intensity of the fluctuation inherently specifying the position of a volume of interest e.g. the center of a capillary vessel.

    摘要翻译： 本发明提供一种用于分光系统的自动对焦机构，其适于确定感兴趣体积的性质。 感兴趣的体积随着时间而变化。 本发明提供了测量装置，其适于测量感兴趣体积的光学性质的波动以确定感兴趣体积的位置。 光谱系统还适于将激发光束聚焦到所确定的感兴趣体积中，并用于收集从感兴趣体积发出的用于光谱分析的返回辐射。 优选地，激发光束的非弹性散射辐射与用于光谱分析的弹性散射辐射分离。 激发光束的弹性散射辐射又被利用来测量感兴趣体积的光学特性的波动。 利用控制回路允许最大化固有地指定感兴趣体积的位置的波动的幅度和/或强度， 毛细血管的中心。

    Transmission Based Imaging for Spectroscopic Analysis
    8.
    发明申请
    Transmission Based Imaging for Spectroscopic Analysis 审中-公开
    基于透射的光谱分析成像

    公开(公告)号：US20070293766A1

    公开(公告)日：2007-12-20

    申请号：US11574163

    申请日：2005-08-24

    申请人： Bernardus Bakker ,  Gerald Lucassen ,  Michael Van Beek ,  Marjolein Van Der Voort ,  Robert Hendriks ,  Frank Schuurmans

    发明人： Bernardus Bakker ,  Gerald Lucassen ,  Michael Van Beek ,  Marjolein Van Der Voort ,  Robert Hendriks ,  Frank Schuurmans

    IPC分类号： G01J3/28

    CPC分类号： A61B5/489 ,  A61B5/0059 ,  A61B2562/0238 ,  G01J3/36 ,  G01J3/42 ,  G01N21/31 ,  G01N21/35 ,  G01N21/59

    摘要： The present invention provides a spectroscopic system and a transmission based imaging system for a spectroscopic system as well as a probe head for a transmission based imaging system for a spectroscopic system and a corresponding transmission based imaging method. The spectroscopic system is preferably applicable to in vivo noninvasive blood analysis. Transmission based imaging makes use of a transmitted portion of an imaging or monitoring beam that has been transmitted through biological tissue. By means of transmission based imaging, a contrast decreasing impact of scattered radiation can be effectively reduced. Additionally, by arranging the imaging light source opposite to an objective lens of the spectroscopic system, unintended propagation of spectroscopic excitation radiation into free space can be effectively prevented.

    摘要翻译： 本发明提供了一种用于分光系统的光谱系统和基于透射的成像系统以及用于分光系统的基于透射的成像系统和相应的基于透射的成像方法的探针头。 光谱系统优选适用于体内非侵入性血液分析。 基于传输的成像利用已经通过生物组织传输的成像或监视光束的透射部分。 通过基于传输的成像，可以有效降低散射辐射的对比度减小的影响。 此外，通过将成像光源与分光系统的物镜相对设置，可以有效地防止光谱激发辐射的非预期传播进入自由空间。

    Apparatus and method for blood analysis
    9.
    发明申请
    Apparatus and method for blood analysis 审中-公开
    血液分析仪器及方法

    公开(公告)号：US20060135861A1

    公开(公告)日：2006-06-22

    申请号：US10544293

    申请日：2004-01-19

    申请人： Gerhardus Lucassen ,  Gerwin Puppels ,  Marjolein Van Der Voort ,  Rolf Wolthuis

    发明人： Gerhardus Lucassen ,  Gerwin Puppels ,  Marjolein Van Der Voort ,  Rolf Wolthuis

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0059 ,  A61B5/0066 ,  G01N21/65 ,  G01N2021/656

    摘要： The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for blood analysis on vessels. An excitation system (exs) emits an excitation beam to excite a target region. A detection system (dsy) is provided for detecting and analyzing scattered radiation from the target region. Those areas are selected or predetermined so that only scattered radiation from blood in capillaries having a diameter below a predetermined diameter value and/or including an amount of red blood cells below a predetermined cell amount is analyzed. Thus, in contrast to analysis on whole blood or large amounts of blood cells less reabsorption and scattering of Raman light due to red blood cells is obtained. Further, the possibility to directly measure in the blood plasma without interference of the red blood cells, thereby yielding a higher signal-to-noise ratio, is given.

    摘要翻译： 本发明涉及用于血管分析的分析装置，特别是光谱分析装置。 激发系统（exs）发射激发光束以激发目标区域。 提供了一种用于检测和分析来自目标区域的散射辐射的检测系统（dsy）。 选择或预定那些区域，以便仅分析具有低于预定直径值的直径的毛细血管和/或包括低于预定细胞量的红细胞量的来自血液的散射辐射。 因此，与全血或大量血细胞的分析相反，获得了由于红细胞引起的拉曼光的再吸收和散射较少。 此外，给出了在血浆中直接测量而不干扰红细胞，从而产生更高的信噪比的可能性。

    Analysis apparatus and method
    10.
    发明申请
    Analysis apparatus and method 审中-公开
    分析装置和方法

    公开(公告)号：US20060100524A1

    公开(公告)日：2006-05-11

    申请号：US10541176

    申请日：2003-12-04

    申请人： Gerhardus Lucassen ,  Gerwin Puppels ,  Marjolein Van Der Voort

    发明人： Gerhardus Lucassen ,  Gerwin Puppels ,  Marjolein Van Der Voort

    IPC分类号： A61B6/00

    CPC分类号： G01J3/44 ,  A61B5/0059 ,  A61B5/0068 ,  G01N21/65 ,  G01N2021/656

    摘要： The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for analysing an object, such as the blood of a patient, and a corresponding analysis method. An excitation system (exs) emits an excitation beam (exb) to excite a target region and a beam separation unit (hm) separates at least part of elastically scattered radiation from inelastically scattered radiation, said scattered radiation being generated by the excitation beam (exb) at the target region. A monitoring system (lso) generates an image of the target region using the elastically scattered or the inelastically scattered radiation and defines a region of interest in said image. To increase efficiency of the recording of Raman spectra, a control unit (ctrl) is provided for controlling the excitation system (exs) such that the defined region of interest of the target region is excited and/or for controlling the detection system (dsy) such that only signals from the defined region of interest are detected, and a detection system (dsy) is provided for detecting scattered radiation from the defined region of interest generated by the excitation beam. Preferably the signal from the defined region of interest is averaged by distributing the laser excitation power over the defined region of interest area.

    摘要翻译： 本发明涉及一种用于分析诸如患者血液的物体的分析装置，特别是光谱分析装置和相应的分析方法。 激发系统（exs）发射激发光束（exb）以激发目标区域，光束分离单元（hm）将弹性散射辐射的至少一部分与非弹性散射辐射分离，所述散射辐射由激发光束（exb ）在目标区域。 监测系统（lso）使用弹性散射或非弹性散射的辐射产生目标区域的图像，并且定义所述图像中的感兴趣区域。 为了提高拉曼光谱记录的效率，提供控制单元（ctrl）以控制激励系统（exs），使得目标区域的限定的目标区域被激发和/或用于控制检测系统（dsy） 使得仅检测到来自限定的感兴趣区域的信号，并且提供检测系统（dsy），用于检测来自由激发光束产生的所定义的感兴趣区域的散射辐射。 优选地，通过在所定义的感兴趣区域区域上分布激光激发功率来平均来自限定的感兴趣区域的信号。