公开(公告)号：US20080002199A1

公开(公告)日：2008-01-03

申请号：US11570133

申请日：2005-06-13

申请人： Michael Van Beek ,  Wouter Rensen ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Bernardus Leonardus Bakker

发明人： Michael Van Beek ,  Wouter Rensen ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Bernardus Leonardus Bakker

IPC分类号： G01J3/30 ,  G06F19/00

CPC分类号： G02B27/0025 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/28

摘要： The present invention provides a spectroscopic system (100) for determining of a property of a biological structure in a volume of interest (120) of a person. The spectroscopic system (100) comprises a low cost objective lens (118) for directing an excitation beam into a volume of interest (120) and for collecting return radiation (124) from the volume of interest (120). After detection of the return radiation (124), i.e. the spectroscopic signals, a correction unit (106) performs the compensation of the aberrations of the spectroscopic signals introduced by the low cost objective lens (118). Since the aberrations of the objective lens (118) strongly depend on the lateral distance (122) of the volume of interest (120) from the optical axis (116) of the objective lens (118), the correction unit (106) makes effective use of a correction table (110) providing an assignment between correction values and various lateral positions (122) of the volume of interest (120).

摘要翻译： 本发明提供一种用于确定人的感兴趣体积（120）中的生物结构的性质的光谱系统（100）。 分光系统（100）包括用于将激发光束引导到感兴趣体积（120）中并用于从感兴趣体积（120）收集返回辐射（124）的低成本物镜（118）。 在检测到返回辐射（124）即分光信号之后，校正单元（106）执行由低成本物镜（118）引入的分光信号的像差的补偿。 由于物镜（118）的像差强烈地取决于物镜（118）的光轴（116）的感兴趣体积（120）的横向距离（122），所以校正单元（106）有效 使用校正表（110）提供校正值与感兴趣体积（120）的各种侧向位置（122）之间的分配。

公开(公告)号：US20070252984A1

公开(公告)日：2007-11-01

申请号：US11570132

申请日：2005-06-07

申请人： Michael Van Beek ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Wouter Rensen ,  Durk De Vries

发明人： Michael Van Beek ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Wouter Rensen ,  Durk De Vries

IPC分类号： G01B11/14 ,  G01J3/00

CPC分类号： G02B21/247 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/44 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/6463 ,  G01N2021/653 ,  G01N2021/655

摘要： The present invention provides an autofocus mechanism for a spectroscopic system that is adapted to determine a property of a volume of interest. The volume of interest has an optical property that varies with time. The invention provides measurement means that are adapted to measure the fluctuations of the optical property of the volume of interest for determining the position of the volume of interest. The spectroscopic system being further adapted to focus an excitation beam into the determined volume of interest and for collecting return radiation emanating from the volume of interest for spectroscopic analysis. Preferably, inelastically scattered radiation of an excitation beam is separated from elastically scattered radiation for spectroscopic analysis. The elastically scattered radiation of the excitation beam is in turn exploited in order to measure the fluctuations of the optical property of the volume of interest. Making use of a control loop allows for maximization of the amplitude and/or intensity of the fluctuation inherently specifying the position of a volume of interest e.g. the center of a capillary vessel.

摘要翻译： 本发明提供一种用于分光系统的自动对焦机构，其适于确定感兴趣体积的性质。 感兴趣的体积随着时间而变化。 本发明提供了测量装置，其适于测量感兴趣体积的光学性质的波动以确定感兴趣体积的位置。 光谱系统还适于将激发光束聚焦到所确定的感兴趣体积中，并用于收集从感兴趣体积发出的用于光谱分析的返回辐射。 优选地，激发光束的非弹性散射辐射与用于光谱分析的弹性散射辐射分离。 激发光束的弹性散射辐射又被利用来测量感兴趣体积的光学特性的波动。 利用控制回路允许最大化固有地指定感兴趣体积的位置的波动的幅度和/或强度， 毛细血管的中心。

公开(公告)号：US20070213609A1

公开(公告)日：2007-09-13

申请号：US11568363

申请日：2005-02-14

申请人： Gerhardus Lucassen ,  Wouter Rensen ,  Michael Van Beek ,  Marjolein Van Der Voort ,  Bernardus Bakker

发明人： Gerhardus Lucassen ,  Wouter Rensen ,  Michael Van Beek ,  Marjolein Van Der Voort ,  Bernardus Bakker

IPC分类号： A61B5/1455 ,  G01J3/42

CPC分类号： A61B5/0059 ,  A61B5/489 ,  A61B2562/0242

摘要： The present invention provides a spectroscopic system for determining a property of a fluid flowing through a volume of interest underneath the surface of the skin of a patient. The spectroscopic system comprises a probe head that has at least an objective for directing an excitation beam into the volume of interest and for collecting return radiation. The spectroscopic system has further a base station having at least a spectroscopic analysis unit and a power supply. The system makes use of a beam combination unit, a filter unit and a focusing unit for combining and separating a variety of different optical signals and for precisely positioning the optical signals inside the volume of interest. The beam combination unit, the filter unit and the focusing unit can be variably implemented inside the probe head or inside the base station depending on a specific applications of the spectroscopic system, thereby allowing for a flexible and compact design of the probe head.

摘要翻译： 本发明提供了一种用于确定流过患者皮肤表面下方的感兴趣体积的流体的性质的光谱系统。 分光系统包括探头，该探头至少具有将激发光束引导到感兴趣体积中并用于收集返回辐射的目的。 光谱系统还具有至少具有光谱分析单元和电源的基站。 该系统利用光束组合单元，滤光器单元和聚焦单元，用于组合和分离各种不同的光信号，并将光信号精确地定位在感兴趣的体积内。 根据分光系统的具体应用，光束组合单元，滤光器单元和聚焦单元可以可变地实现在探头内部或基站内部，从而允许探头的灵活且紧凑的设计。

公开(公告)号：US20070070328A1

公开(公告)日：2007-03-29

申请号：US10595358

申请日：2004-10-15

申请人： Wouter Rensen ,  Michael Van Beek ,  Marjolein Van Der Voort ,  Bernardus Bakker ,  Gerhardus Lucassen ,  Teunis Tukker

发明人： Wouter Rensen ,  Michael Van Beek ,  Marjolein Van Der Voort ,  Bernardus Bakker ,  Gerhardus Lucassen ,  Teunis Tukker

IPC分类号： G01N33/48 ,  A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/0068 ,  A61B5/489

摘要： The present invention enables to determine the property of a fluid, such as for the purposes of in vivo blood analysis. First the position of a volume of interest through which the fluid flows is determined by means of an optical detection step by making use of an objective. Preferably the optical detection step is an imaging step. Next the objective is moved to bring the focal point of the objective to the volume of interest. In this position an optical spectroscopic step is performed. This has the advantage that the measurement beam for performing the optical spectroscopy travels along the optical axis for optimum efficiency.

摘要翻译： 本发明能够确定流体的性质，例如用于体内血液分析的目的。 首先，通过利用目标的光学检测步骤来确定流体流过的感兴趣体积的位置。 优选地，光学检测步骤是成像步骤。 接下来，将目标转移到目标的焦点。 在该位置，进行光学分光步骤。 这具有以下优点：用于执行光学光谱的测量光束沿着光轴行进以获得最佳效率。

公开(公告)号：US07511812B2

公开(公告)日：2009-03-31

申请号：US11570133

申请日：2005-06-13

申请人： Michael Cornelis Van Beek ,  Wouter Rensen ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker

发明人： Michael Cornelis Van Beek ,  Wouter Rensen ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker

IPC分类号： G01J3/30

CPC分类号： G02B27/0025 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/28

摘要： A spectroscopic system which determines a property of a biological structure in a volume of interest of a person includes a low cost objective lens for directing an excitation beam into a volume of interest and for collecting return radiation from the volume of interest. After detection of the return radiation and generation of spectroscopic signals, a correction unit performs a compensation for aberrations of the spectroscopic signals introduced by the low cost objective lens. Since the aberrations of the objective lens strongly depend on the lateral distance of the volume of interest from the optical axis of the objective lens, the correction unit uses a correction table providing an assignment between correction values and various lateral positions of the volume of interest.

摘要翻译： 确定人的感兴趣体积的生物结构的性质的光谱系统包括用于将激发光束引导到感兴趣体积中并用于从感兴趣体积收集返回辐射的低成本物镜。 在检测到返回辐射和产生分光信号之后，校正单元对由低成本物镜引入的分光信号的像差进行补偿。 由于物镜的像差强烈地取决于物镜的光轴的感兴趣的体积的横向距离，所以校正单元使用校正表，该校正表提供校正值与感兴趣体积的各个横向位置之间的分配。

公开(公告)号：US20070291251A1

公开(公告)日：2007-12-20

申请号：US11574181

申请日：2005-08-24

申请人： Wouter Rensen ,  Bernardus Leonardus Bakker ,  Michael Van Beek

发明人： Wouter Rensen ,  Bernardus Leonardus Bakker ,  Michael Van Beek

IPC分类号： G01N33/48 ,  G01N21/00 ,  G06F19/00

CPC分类号： G01J3/30 ,  G01J3/02 ,  G01J3/0229 ,  G01J3/32 ,  G01J3/44

摘要： The invention provides an optical analysis system for efficient compensation of spectroscopic broadband back-ground, such as spectroscopic fluorescence background or background signals that are due to the dark current of a detector. The optical analysis system effectively provides multivariate optical analysis of a spectroscopic signal. It provides wavelength selective detection of various spectral components that are indicative of a superposition of spectroscopic peaks or bands and their broadband background. Additionally, the optical analysis system is adapted to acquire spectral components that predominantly correspond to the broadband background of the spectroscopic peaks or bands. Wavelength selective selection of various spectral components is performed on the basis of reconfigurable multivariate optical elements or on the basis of a position displacement of a spatial optical transmission mask.

摘要翻译： 本发明提供了一种用于有效补偿光谱宽带背景的光学分析系统，例如由于检测器的暗电流引起的分光荧光背景或背景信号。 光学分析系统有效地提供了光谱信号的多变量光学分析。 它提供各种光谱分量的波长选择性检测，这些光谱分量指示光谱峰或带的叠加及其宽带背景。 此外，光学分析系统适于获取主要对应于光谱峰或带的宽带背景的光谱分量。 基于可重构多变量光学元件或者基于空间光学透射掩模的位置位移来执行各种光谱分量的波长选择性选择。

公开(公告)号：US20070010727A1

公开(公告)日：2007-01-11

申请号：US10554352

申请日：2004-04-23

申请人： Michael Van Beek ,  Coen Theodorus Hubertus Liedenbaum ,  Wouter Rensen

发明人： Michael Van Beek ,  Coen Theodorus Hubertus Liedenbaum ,  Wouter Rensen

IPC分类号： A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/1459 ,  A61B6/481 ,  A61B6/504 ,  A61B2562/0238

摘要： The present invention relates to a catheter head comprising: means (104, 108; 306, 304; 320, 322; 326; 338) for directing of radiation to a blood detection volume (220, 310), means (104, 108; 306, 304; 320; 322; 326; 332, 334, 330; 338) for receiving of return radiation from the blood detection volume, means (104; 306; 330) for transmitting of the return radiation to means (122) for analysis of the return radiation for determination of at least one property of the blood.

摘要翻译： 本发明涉及一种导管头，其包括：用于将辐射引导到血液检测体积（220,310）的装置（104,108; 306,304; 320,322; 326; 338），装置（104,108; 306 用于从所述血液检测体积接收返回辐射的装置，用于将所述返回辐射传送到装置（122）的装置（104; 306; 330）用于分析 用于确定血液的至少一种性质的返回辐射。

公开(公告)号：US20060158734A1

公开(公告)日：2006-07-20

申请号：US10539540

申请日：2003-12-19

申请人： Frank Schuurmans ,  Michael Van Beek ,  Levinus Bakker ,  Wouter Rensen ,  Bernardus Hendrikus Hendriks ,  Robert Hendriks ,  Thomas Steffen

发明人： Frank Schuurmans ,  Michael Van Beek ,  Levinus Bakker ,  Wouter Rensen ,  Bernardus Hendrikus Hendriks ,  Robert Hendriks ,  Thomas Steffen

IPC分类号： G02B27/28

CPC分类号： G01J3/02 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/10 ,  G01J3/28 ,  G01J3/36 ,  G01N21/274 ,  G01N21/31 ,  G01N2021/3196 ,  G01N2201/129

摘要： The optical analysis system (20) for determining an amplitude of a principal component of an optical signal comprises a multivariate optical element (10) for reflecting the optical signal and thereby weighing the optical signal by a spectral weighing function, and a detector (9, 9P, 9N) for detecting the weighed optical signal. The optical analysis system (20) may further comprise a dispersive element (2) for spectrally dispersing the optical signal, the multivariate optical element being arranged to receive the dispersed optical signal. The blood analysis system (40) comprises the optical analysis system (20) according to the invention.

摘要翻译： 用于确定光信号的主分量的幅度的光学分析系统（20）包括用于反射光信号并由此通过光谱称重功能称重光信号的多元光学元件（10） 9 P，9 N），用于检测加权的光信号。 光学分析系统（20）还可以包括用于光谱分散光学信号的色散元件（2），所述多元光学元件被布置成接收分散的光信号。 血液分析系统（40）包括根据本发明的光学分析系统（20）。

公开(公告)号：US20060193187A1

公开(公告)日：2006-08-31

申请号：US10548847

申请日：2004-03-11

申请人： Wouter Rensen ,  Ralph Kurt ,  Michael Van Der AA

发明人： Wouter Rensen ,  Ralph Kurt ,  Michael Van Der AA

IPC分类号： G11C7/02

CPC分类号： G11B19/20

摘要： A disk drive unit for a disk, e.g. for use in a mobile device, comprises a spindle (1) positioned within the disk drive unit and adapted to support the disk rotatably in an operating position. An electric motor (2) is operatively coupled to the spindle (1) to rotate it. An auxiliary electric motor (3) is connectable to the spindle to accelerate the spindle during start-up. This auxiliary motor can be selected to work efficiently at zero speed. The electric motor may be a low-power motor, resulting in a reduced power consumption.

摘要翻译： 用于盘的磁盘驱动器单元 用于移动设备中，包括定位在盘驱动单元内的主轴（1），并且适于在可操作的位置上可旋转地支撑盘。 电动机（2）可操作地联接到主轴（1）以使其旋转。 辅助电动机（3）可连接到主轴，以在启动期间加速主轴。 该辅助电机可以选择在零速度下有效工作。 电动机可以是低功率电动机，从而降低功耗。

公开(公告)号：US20060256468A1

公开(公告)日：2006-11-16

申请号：US10546400

申请日：2004-02-12

申请人： Ralph Kurt ,  Michael Van Der Aa ,  Wouter Rensen

发明人： Ralph Kurt ,  Michael Van Der Aa ,  Wouter Rensen

IPC分类号： G11B5/016

CPC分类号： G11B19/20 ,  G11B25/043

摘要： A disk drive unit for a removable disk (D), in particular for use in mobile devices, comprises a spindle (1) driven by an electric motor (2) and supporting the disk (D) in its operating position. It further comprises one or two loading mechanisms (4A and 4B) to load mechanical energy into a storage mechanism (5) for storing the loaded energy. A release mechanism (6) is provided to release the stored energy stepwise to the spindle in order to assist during a plurality of start-ups of the disk rotation. The two loading mechanisms (4A and 4B) are adapted to load mechanical energy provided by the user during insertion of the disk and energy released during the deceleration of the rotation of the disk, respectively. The electrical power consumption of the disk drive unit is reduced by the storage of the mechanical energy and its stepwise release.

摘要翻译： 用于可移动盘（D）的磁盘驱动器单元（D）特别用于移动设备中，包括由电动机（2）驱动并将盘（D）支撑在其操作位置的主轴（1）。 它还包括一个或两个加载机构（4A和4B），以将机械能装载到用于存储所加载的能量的存储机构（5）中。 提供释放机构（6）以逐步释放存储的能量到主轴，以便在盘旋转的多次启动期间进行协助。 两个装载机构（4A和4B）分别适用于在盘的插入期间分别由用户提供的机械能和在盘的旋转减速期间释放的能量。 通过存储机械能及其逐步释放来减少磁盘驱动单元的电力消耗。