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公开(公告)号：US20240008847A1
公开(公告)日：2024-01-11
申请号：US17858143
申请日：2022-07-06
Applicant: X Development LLC
Inventor： Joel Emilio Bregman Segre , Vladimir Miskovic
CPC classification number: A61B8/4488 , A61N7/00 , A61B8/0808 , A61B8/54 , A61B8/13 , G01S15/8915 , A61N2007/0026 , A61N2007/0052
Abstract: A system includes: an ultrasound array comprising a plurality of transducer elements, wherein: a first subset of the plurality of transducer elements are configured to emit ultrasound pulses through the subject's skull for performing a neuro-modulation of the subject's brain, and a second subset of the plurality of transducer elements are configured to receive ultrasound signals from the subject's skull and brain in response to the ultrasound pulses being emitted from the first subset of the plurality of transducer elements; and a controller coupled to the ultrasound array, wherein the controller is configured to: generate at least one image depicting at least a portion of the subject's skull and brain based on, at least in part, the ultrasound signals received by the second subset of the plurality of transducer elements, and adapt the neuro-modulation of the subject's brain based on, at least in part, the at least one image.
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公开(公告)号：US20220379142A1
公开(公告)日：2022-12-01
申请号：US17335426
申请日：2021-06-01
Applicant: X Development LLC
Inventor： Matthew Dixon Eisaman , Thomas Peter Hunt , Vladimir Miskovic , Benoit Schillings
Abstract: A system includes ultrasound transducers configured to generate and direct ultrasound beams at a region within a portion of a subject's brain, sensors configured to measure a response from the portion of the subject's brain in response to one or more ultrasound beams, and an electronic controller in communication with the ultrasound transducers configured to generate, based on a measured response from the portion of the subject's brain in response to two or more ultrasound beams generated from two or more different angles, a model of the portion of the subject's brain, wherein the model has a higher resolution than a maximum resolution of a single ultrasound beam, and generate, based on the model of the portion of the subject's brain, stimulation parameters for the ultrasound transducers to generate and direct a stimulation ultrasound beam at the region within the portion of the subject's brain.
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公开(公告)号：US11576601B2
公开(公告)日：2023-02-14
申请号：US16388709
申请日：2019-04-18
Applicant: X Development LLC
Inventor： Sarah Ann Laszlo , Nina Thigpen , Vladimir Miskovic , Yvonne Yip
Abstract: Methods, systems, and computer programs encoded on a computer storage medium, for improving EEG measurements by identifying artifacts present in EEG measurements and providing a real-time indication to a user of likely artifacts in EEG measurements are described. EEG measurements of a patient can be obtained by placing a wearable device or EEG cap on a patient's head. Sensors in the cap provide EEG data to a computing device that processes the data to identify one or more artifacts in the EEG data. The artifacts can be identified by conducting one or more operations of determining the signal to noise ratio of the line noise, calculating mutual information between sensor pairs, and applying the p-welch method. Based on the types of artifacts identified, the computing device can output an indicator that provides feedback to the technician performing an EEG test to make adjustments to the test setup.
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公开(公告)号：US20210391086A1
公开(公告)日：2021-12-16
申请号：US16897981
申请日：2020-06-10
Applicant: X Development LLC
Inventor： Vladimir Miskovic , Katherine Elise Link , Nina Thigpen , Mustafa Ispir , Garrett Raymond Honke , Pramod Gupta
Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for obtaining psychological data, generating a psychopathological analysis data structure (PADS), applying a latent factor analysis algorithm to the PADS to obtain a psychopathological latent factor space (PLFS), generating a latent factor graph, and outputting the latent factor graph.
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公开(公告)号：US20200329990A1
公开(公告)日：2020-10-22
申请号：US16388709
申请日：2019-04-18
Applicant: X Development LLC
Inventor： Sarah Ann Laszlo , Nina Thigpen , Vladimir Miskovic , Yvonne Yip
IPC: A61B5/0478 , A61B5/04 , A61B5/00 , G06N3/08
Abstract: Methods, systems, and computer programs encoded on a computer storage medium, for improving EEG measurements by identifying artifacts present in EEG measurements and providing a real-time indication to a user of likely artifacts in EEG measurements are described. EEG measurements of a patient can be obtained by placing a wearable device or EEG cap on a patient's head. Sensors in the cap provide EEG data to a computing device that processes the data to identify one or more artifacts in the EEG data. The artifacts can be identified by conducting one or more operations of determining the signal to noise ratio of the line noise, calculating mutual information between sensor pairs, and applying the p-welch method. Based on the types of artifacts identified, the computing device can output an indicator that provides feedback to the technician performing an EEG test to make adjustments to the test setup.
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Patent Agency Ranking
公开(公告)号：US11495333B2
公开(公告)日：2022-11-08
申请号：US16902422
申请日：2020-06-16
Applicant: X Development LLC
Inventor： Sarah Ann Laszlo , Nina Thigpen , Katherine Elise Link , Vladimir Miskovic
Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for receiving a plurality of answers to a first set of questions. The actions include generating an adjacency matrix based on the question-answer pairs. The actions include determining a network graph that includes question nodes and edges. The actions include identifying one or more clusters of question nodes by applying a community detection algorithm on the network graph. The actions include determining, for each cluster, i) a cluster centrality and ii) a cluster magnitude. The actions include ranking the clusters based on the cluster centralities and the cluster magnitudes of the one or more clusters. The actions include selecting a second set of questions for the user. And, the actions include causing the questions from the second set of questions to be presented to the user.
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公开(公告)号：US20220101997A1
公开(公告)日：2022-03-31
申请号：US17039303
申请日：2020-09-30
Applicant: X Development LLC
Inventor： Asim Iqbal , Mustafa Ispir , Garrett Raymond Honke , Nina Thigpen , Vladimir Miskovic , Pramod Gupta
Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for processing representations of EEG measurements. One of the methods includes obtaining a plurality of EEG signal measurements corresponding to respective EEG trials of a user; generating a time-domain representation from the plurality of EEG signal measurements, where the time-domain representation includes a plurality of rows, and where each row corresponds to a different set of one or more EEG signal measurements; applying the time-domain representation as input to a neural network having a plurality of network parameters, final values of the network parameters having been determined by a transfer learning process where the neural network is initially trained to perform an image processing task and the neural network is subsequently trained to perform EEG analysis; and obtaining, from the neural network, a mental health prediction for the user.
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公开(公告)号：US20210393991A1
公开(公告)日：2021-12-23
申请号：US17350542
申请日：2021-06-17
Applicant: X Development LLC
Inventor： Vladimir Miskovic , Thomas Peter Hunt , Matthew Dixon Eisaman
IPC: A61N7/00
Abstract: A transcranial ultrasonic stimulation headset includes a coupling system, one or more ultrasound transducers configured to generate and direct a first focused ultrasound beam at a region within a portion of a subject's brain, one or more sensors configured to measure a response from the portion of the subject's brain in response to the first focused ultrasound beam, and an electronic controller in communication with the one or more ultrasound transducers configured to dynamically adjust, based on the measured response from the portion of the subject's brain, a particular stimulation parameter for the one or more ultrasound transducers to generate and direct a second focused ultrasound beam at the region within a portion of the subject's brain.
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9.发明公开公开(公告)号：US20240009486A1
公开(公告)日：2024-01-11
申请号：US17858325
申请日：2022-07-06
Applicant: X Development LLC
Inventor： Vladimir Miskovic , Ningrui Li , Joel Emilio Bregman Segre
CPC classification number: A61N7/00 , A61B8/06 , A61B8/485 , A61B8/4488 , A61B8/54 , G01S15/8913 , G01S15/892 , G01S7/5202 , A61N2007/0026 , A61N2007/0052 , A61N2007/0095
Abstract: A system includes: an ultrasound array comprising a first subset of transducer elements are configured to emit ultrasound pulses through the subject's skull for performing a neuro-modulation of the subject's brain during use of the system, and a second subset of transducer elements configured to receive ultrasound signals from the subject's skull and brain in response to the ultrasound pulses being emitted from the first subset of transducer elements; and a controller coupled to the ultrasound array, wherein the controller is configured, during use of the system, to: detect a change of a physiological parameter in at least a portion of the subject's brain based on, at least in part, the ultrasound signals received by the second subset of transducer elements, and determine a dose of the neuro-modulation of the subject's brain based on, at least in part, the detected change of the physiological parameter.
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公开(公告)号：US20210391039A1
公开(公告)日：2021-12-16
申请号：US16902422
申请日：2020-06-16
Applicant: X Development LLC
Inventor： Sarah Ann Laszlo , Nina Thigpen , Katherine Elise Link , Vladimir Miskovic
Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for receiving a plurality of answers to a first set of questions. The actions include generating an adjacency matrix based on the question-answer pairs. The actions include determining a network graph that includes question nodes and edges. The actions include identifying one or more clusters of question nodes by applying a community detection algorithm on the network graph. The actions include determining, for each cluster, i) a cluster centrality and ii) a cluster magnitude. The actions include ranking the clusters based on the cluster centralities and the cluster magnitudes of the one or more clusters. The actions include selecting a second set of questions for the user. And, the actions include causing the questions from the second set of questions to be presented to the user.
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