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17 条记录 (耗时 0.024 秒)

    TISSUE PATCH
    1.
    发明申请
    TISSUE PATCH 有权
    组织派

    公开(公告)号：US20150231299A1

    公开(公告)日：2015-08-20

    申请号：US14630150

    申请日：2015-02-24

    申请人： Xcede Technologies, Inc.

    发明人： Daniel Grant Ericson

    IPC分类号： A61L15/32 ,  A61L15/58 ,  A61L15/24 ,  A61L15/28 ,  A61L15/34

    CPC分类号： A61L15/32 ,  A61K9/0014 ,  A61K9/7023 ,  A61L15/24 ,  A61L15/28 ,  A61L15/34 ,  A61L15/58 ,  A61L15/64 ,  A61L24/001 ,  A61L24/0042 ,  A61L24/106 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2400/06

    摘要： Tissue patches and associated systems and methods are described. Certain embodiments are related to inventive systems and methods in which tissue patches can be made quickly and robustly without the use of complicated fabrication or sterilization equipment. For example, in some embodiments, tissue patches are made by applying a compressive force to a liquid medium comprising fibrinogen (and/or fibrin) between two surfaces (e.g., within a syringe or other chamber). A filter can be placed within or near the volume in which the compressive force is applied to the liquid medium such that unwanted material (e.g., water, blood cells, and the like) is passed through the filter while desirable components (e.g., fibrin, fibrinogen, and/or other desirable components) are retained by the filter to form the patch. In this way, the concentration of fibrin (and/or fibrinogen) within the liquid medium can be increased, potentially dramatically, as the compressive force is applied to the liquid-containing composition. In addition, in some embodiments, at least a portion of the fibrinogen and/or fibrin can chemically react (e.g., the fibrinogen can polymerize to form fibrin and/or the fibrin can cross-link) during application of the compressive force. Reaction and concentration can lead to the formation of a highly-concentrated, mechanically robust patch that can be handled relatively easily and provide good structural reinforcement at a wet site, such as a bleeding wound.

    摘要翻译： 描述组织贴片及相关系统和方法。 某些实施方案涉及本发明的系统和方法，其中可以快速而鲁棒地制备组织块，而不需要使用复杂的制造或灭菌设备。 例如，在一些实施例中，通过在包括纤维蛋白原（和/或纤维蛋白）在两个表面之间（例如在注射器或其它腔室内）的液体介质施加压缩力来制造组织贴片。 过滤器可以放置在体积内或附近，其中压力施加到液体介质上，使得不需要的材料（例如水，血细胞等）通过过滤器，同时期望的组分（例如纤维蛋白， 纤维蛋白原和/或其它所需组分）被过滤器保留以形成贴剂。 以这种方式，当压缩力施加到含液体组合物时，液体介质中纤维蛋白（和/或纤维蛋白原）的浓度可能会显着增加。 此外，在一些实施方案中，在施加压缩力期间，纤维蛋白原和/或纤维蛋白的至少一部分可以发生化学反应（例如，纤维蛋白原可以聚合以形成纤维蛋白和/或纤维蛋白可以交联）。 反应和浓缩可导致形成高度集中，机械强度高的贴片，其可以相对容易地处理并在湿部位例如出血伤口提供良好的结构加强。

    Tissue patch
    5.
    发明授权
    Tissue patch 有权

    公开(公告)号：US09956311B2

    公开(公告)日：2018-05-01

    申请号：US15096576

    申请日：2016-04-12

    申请人： Xcede Technologies, Inc.

    发明人： Daniel Grant Ericson

    IPC分类号： A61L15/32 ,  A61L15/58 ,  A61K9/70 ,  A61K9/00 ,  A61L24/00 ,  A61L24/10 ,  A61L15/34 ,  A61L15/64 ,  A61L15/24 ,  A61L15/28

    CPC分类号： A61L15/32 ,  A61K9/0014 ,  A61K9/7023 ,  A61L15/24 ,  A61L15/28 ,  A61L15/34 ,  A61L15/58 ,  A61L15/64 ,  A61L24/001 ,  A61L24/0042 ,  A61L24/106 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2400/06

    摘要： Tissue patches and associated systems and methods are described. Certain embodiments are related to inventive systems and methods in which tissue patches can be made quickly and robustly without the use of complicated fabrication or sterilization equipment. For example, in some embodiments, tissue patches are made by applying a compressive force to a liquid medium comprising fibrinogen (and/or fibrin) between two surfaces (e.g., within a syringe or other chamber). A filter can be placed within or near the volume in which the compressive force is applied to the liquid medium such that unwanted material (e.g., water, blood cells, and the like) is passed through the filter while desirable components (e.g., fibrin, fibrinogen, and/or other desirable components) are retained by the filter to form the patch. In this way, the concentration of fibrin (and/or fibrinogen) within the liquid medium can be increased, potentially dramatically, as the compressive force is applied to the liquid-containing composition. In addition, in some embodiments, at least a portion of the fibrinogen and/or fibrin can chemically react (e.g., the fibrinogen can polymerize to form fibrin and/or the fibrin can cross-link) during application of the compressive force. Reaction and concentration can lead to the formation of a highly-concentrated, mechanically robust patch that can be handled relatively easily and provide good structural reinforcement at a wet site, such as a bleeding wound.

    Tissue patch
    8.
    发明授权
    Tissue patch 有权
    组织贴片

    公开(公告)号：US09352067B2

    公开(公告)日：2016-05-31

    申请号：US14630150

    申请日：2015-02-24

    申请人： Xcede Technologies, Inc.

    发明人： Daniel Grant Ericson

    IPC分类号： A61L15/32 ,  A61L15/28 ,  A61L15/34 ,  A61L15/24 ,  A61L15/58

    CPC分类号： A61L15/32 ,  A61K9/0014 ,  A61K9/7023 ,  A61L15/24 ,  A61L15/28 ,  A61L15/34 ,  A61L15/58 ,  A61L15/64 ,  A61L24/001 ,  A61L24/0042 ,  A61L24/106 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2400/06

    摘要： Tissue patches and associated systems and methods are described. Certain embodiments are related to inventive systems and methods in which tissue patches can be made quickly and robustly without the use of complicated fabrication or sterilization equipment. For example, in some embodiments, tissue patches are made by applying a compressive force to a liquid medium comprising fibrinogen (and/or fibrin) between two surfaces (e.g., within a syringe or other chamber). A filter can be placed within or near the volume in which the compressive force is applied to the liquid medium such that unwanted material (e.g., water, blood cells, and the like) is passed through the filter while desirable components (e.g., fibrin, fibrinogen, and/or other desirable components) are retained by the filter to form the patch. In this way, the concentration of fibrin (and/or fibrinogen) within the liquid medium can be increased, potentially dramatically, as the compressive force is applied to the liquid-containing composition. In addition, in some embodiments, at least a portion of the fibrinogen and/or fibrin can chemically react (e.g., the fibrinogen can polymerize to form fibrin and/or the fibrin can cross-link) during application of the compressive force. Reaction and concentration can lead to the formation of a highly-concentrated, mechanically robust patch that can be handled relatively easily and provide good structural reinforcement at a wet site, such as a bleeding wound.

    摘要翻译： 描述组织贴片及相关系统和方法。 某些实施方案涉及本发明的系统和方法，其中可以快速而鲁棒地制备组织块，而不需要使用复杂的制造或灭菌设备。 例如，在一些实施例中，通过在包括纤维蛋白原（和/或纤维蛋白）在两个表面之间（例如在注射器或其它腔室内）的液体介质施加压缩力来制造组织贴片。 过滤器可以放置在体积内或附近，其中压力施加到液体介质上，使得不需要的材料（例如水，血细胞等）通过过滤器，同时期望的组分（例如纤维蛋白， 纤维蛋白原和/或其它所需组分）被过滤器保留以形成贴剂。 以这种方式，当压缩力施加到含液体组合物时，液体介质中纤维蛋白（和/或纤维蛋白原）的浓度可能会显着增加。 此外，在一些实施方案中，在施加压缩力期间，纤维蛋白原和/或纤维蛋白的至少一部分可以发生化学反应（例如，纤维蛋白原可以聚合以形成纤维蛋白和/或纤维蛋白可以交联）。 反应和浓缩可导致形成高度集中，机械强度高的贴片，其可以相对容易地处理并在湿部位例如出血伤口提供良好的结构加强。

    TISSUE PATCH
    10.
    发明申请
    TISSUE PATCH 有权

    公开(公告)号：US20210038758A1

    公开(公告)日：2021-02-11

    申请号：US16906967

    申请日：2020-06-19

    申请人： Xcede Technologies, Inc.

    发明人： Daniel Grant Ericson

    IPC分类号： A61L15/32 ,  A61L24/00 ,  A61L15/34 ,  A61L15/58 ,  A61L15/64 ,  A61L24/10 ,  A61K9/70 ,  A61K9/00 ,  A61L15/24 ,  A61L15/28

    摘要： Tissue patches and associated systems and methods are described. Certain embodiments are related to inventive systems and methods in which tissue patches can be made quickly and robustly without the use of complicated fabrication or sterilization equipment. For example, in some embodiments, tissue patches are made by applying a compressive force to a liquid medium comprising fibrinogen (and/or fibrin) between two surfaces (e.g., within a syringe or other chamber). A filter can be placed within or near the volume in which the compressive force is applied to the liquid medium such that unwanted material (e.g., water, blood cells, and the like) is passed through the filter while desirable components (e.g., fibrin, fibrinogen, and/or other desirable components) are retained by the filter to form the patch. In this way, the concentration of fibrin (and/or fibrinogen) within the liquid medium can be increased, potentially dramatically, as the compressive force is applied to the liquid-containing composition. In addition, in some embodiments, at least a portion of the fibrinogen and/or fibrin can chemically react (e.g., the fibrinogen can polymerize to form fibrin and/or the fibrin can cross-link) during application of the compressive force. Reaction and concentration can lead to the formation of a highly-concentrated, mechanically robust patch that can be handled relatively easily and provide good structural reinforcement at a wet site, such as a bleeding wound.